Routing of spike series by dynamic circuits in the hippocampus
Abstract
Recurrent inhibitory loops are simple neuronal circuits found in the central nervous system, yet little is known about the physiological rules governing their activity. Here we use simultaneous somatic and dendritic recordings in rat hippocampal slices to show that during a series of action potentials in pyramidal cells recurrent inhibition rapidly shifts from their soma to the apical dendrites. Two distinct inhibitory circuits are sequentially recruited to produce this shift: one, time-locked with submillisecond precision to the onset of the action potential series, transiently inhibits the somatic and perisomatic regions of pyramidal cells; the other, activated in proportion to the rate of action potentials in the series, durably inhibits the distal apical dendrites. These two operating modes result from the synergy between pre- and postsynaptic properties of excitatory synapses onto recurrent inhibitory neurons with distinct projection patterns. Thus, the onset of a series of action potentials and the rate of action potentials in the series are selectively captured and transformed into different spatial patterns of recurrent inhibition.
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Excitatory inputs onto Sst interneurons, apparently regardless of subtype, are strongly facilitating.
“excitatory inputs onto Sst INs, apparently regardless of subtypes, are strongly facilitating”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Pouille and Scanziani, 2004
The restriction of horizontally oriented O-LM soma and spiny dendrites within s.o. and the alveus dictates that the dominant source of excitatory recruitment is from CA1 pyramidal cell collaterals while the preferential axonal targeting to s.l.m. then distributes inhibition back to the distal apical dendritic tufts of CA1 pyramidal cells to gate excitatory input from the entorhinal cortex and reni
“Indeed, the restriction of horizontally oriented O-LM soma and spiny dendrites within s.o. and the alveus dictates that the dominant source of excitatory recruitment is from CA1 pyramidal cell collaterals while the preferential axonal targeting to s.l.m. then distributes inhibition back to the distal apical dendritic tufts of CA1 pyramidal cells to gate excitatory input from the entorhinal cortex”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [923]
Trains of action potentials from CA1 pyramidal cells drive excitation onto two populations of interneurons termed "onset transient" and "late persistent" interneurons.
“Trains of action potentials from CA1 pyramidal cells drive excitation onto two populations of interneurons termed “onset transient” and “late persistent” interneurons (923).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [923]
Recurrent inhibition onto CA1 pyramidal cells occurs via a dynamic rerouting of inhibitory drive that commences via perisomatic inhibitory input followed by delayed primarily dendritic inhibition.
“Pouille and Scanziani (923) provided the first demonstration that recurrent inhibition onto CA1 pyramidal cells occurs via a dynamic rerouting of inhibitory drive that commences via perisomatic inhibitory input followed by a delayed primarily dendritic inhibition.”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [923]
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- Authors
- Pouille, F., & Scanziani, M.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Scanziani, Massimo
- ORCID
- Scanziani, Massimo
- Venue
- Nature
- Published
- 2004-05-30
- Volume
- 429
- Issue
- 6993
- Pages
- 717-723
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2047403459
- Cited by
- 434
- References
- 33
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 13 · 2023: 24 · 2022: 20 · 2021: 28 · 2020: 14 · 2019: 24 · 2018: 22 · 2017: 12 · 2016: 12 · 2015: 17 · 2014: 23 · 2013: 17 · 2012: 25
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Foundation for the National Institutes of Health
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- recurrent inhibition, hippocampus, pyramidal neurons, dendritic inhibition, inhibitory interneurons, excitatory synapses, synaptic plasticity, rat hippocampal slices
- MeSH terms
- Action Potentials, Animals, Dendrites, Electrophysiology, Hippocampus, Interneurons, Rats, Wistar, Excitatory Postsynaptic Potentials, Rats, In Vitro Techniques
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