The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Collateral Pathways from the Ventromedial Hypothalamus Mediate Defensive Behaviors
Open accessAbstract
Summary The ventromedial hypothalamus (VMH) was thought to be essential for coping with threat, although its circuit mechanism remains unclear. To investigate this, we optogenetically activated steroidogenic factor 1 (SF1)-expressing neurons in the dorsomedial and central part of VMH (VMHdm/c), and observed a range of context dependent somatomotor and autonomic responses resembling animals' natural defensive behaviors. By activating independent pathways emanating from VMHdm/c, we demonstrated that VMHdm/c projection to the dorsolateral periaqueductal gray (dlPAG) induces inflexible immobility, while the VMHdm/c to anterior hypothalamic nucleus (AHN) pathway promotes avoidance. Furthermore, consistent with the behavior changes induced by VMH to AHN pathway activation, direct activation of the AHN elicited avoidance and escape jumping but not immobility. Finally, retrograde tracing studies revealed that nearly 50% of PAG- projecting VMHdm/c neurons send collateral projection to the AHN and vice versa. Thus, VMHdm/c neurons employ a one-to-many wiring configuration to orchestrate multiple aspects of defensive behaviors.
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Cites
Amygdala circuitry mediating reversible and bidirectional control of anxiety
Tye, K. M., Prakash, R., Kim, S.-Y., Fenno, L. E., Grosenick, L., Zarabi, H., Thompson, K. R., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2011) · Nature · doi:10.1038/nature09820 · Cited by 1,289
Functional identification of an aggression locus in the mouse hypothalamus
Lin, D., Boyle, M. P., Dollar, P., Lee, H., Lein, E. S., Perona, P., & Anderson, D. J. (2011) · Nature · doi:10.1038/nature09736 · Cited by 914 · cited 4×
“However, the VMHvl is unlikely to be responsible for the induced defensive behavior, as our previous studies showed that VMHvl activation elicits aggressive behaviors (Lin et al., 2011).”
InfluentialSelf-citationDhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791
Distinct extended amygdala circuits for divergent motivational states
Jennings, J. H., Sparta, D. R., Stamatakis, A. M., Ung, R. L., Pleil, K. E., Kash, T. L., & Stuber, G. D. (2013) · Nature · doi:10.1038/nature12041 · Cited by 704 · cited 2×
“…could cause spiking activity in cell bodies, if VMHdm/c cells bifurcate to both AHN and PAG, the VMH/AHN-like response elicited by VMH/ PAG stimulation could be caused by the backpropagation of action potentials from PAG to VMH cell bodies, which in turn recruit AHN (Jennings et al., 2013).”
Lindberg, D., Chen, P., & Li, C. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23338 · Cited by 125
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Evans, D. A., Stempel, A. V., Vale, R., Ruehle, S., Lefler, Y., & Branco, T. (2018) · Nature · doi:10.1038/s41586-018-0244-6 · Cited by 449
Multimodal analysis of cell types in a hypothalamic node controlling social behavior
Kim, D.-W., Yao, Z., Graybuck, L. T., Kim, T. K., Nguyen, T. N., Smith, K. A., Fong, O., Yi, L., Koulena, N., Pierson, N., et al. (2019) · Cell · doi:10.1016/j.cell.2019.09.020 · Cited by 259
Daviu, N., Füzesi, T., Rosenegger, D. G., Rasiah, N. P., Sterley, T.-L., Peringod, G., & Bains, J. S. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0591-0 · Cited by 217
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Gungor, N. Z., & Pare, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0856-16.2016 · Cited by 214
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Metadata
- Authors
- Wang, L., Chen, I. Z., & Lin, D.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 85
- Issue
- 6
- Pages
- 1344-1358
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2042656725
- Cited by
- 322
- References
- 5
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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