Conditional viral tracing reveals that steroidogenic factor 1-positive neurons of the dorsomedial subdivision of the ventromedial hypothalamus project to autonomic centers of the hypothalamus and hindbrain

Lindberg, Daniel; Chen, Peilin; Li, Chien

doi:10.1002/cne.23338

Cited by 125Regulation of Appetite and ObesityNeuroscience of respiration and sleepHeart Rate Variability and Autonomic Control

Conditional viral tracing reveals that steroidogenic factor 1-positive neurons of the dorsomedial subdivision of the ventromedial hypothalamus project to autonomic centers of the hypothalamus and hindbrain

Lindberg, Daniel, Chen, Peilin, Li, Chien·2013·Journal of Comparative Neurology

DOI 10.1002/cne.23338

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Abstract

Excitation of neurons in the ventromedial hypothalamus (VMH), especially those residing in the dorsomedial part of the nucleus (VMHdm), evokes sympathetic nervous system (SNS) outflow, modulating a number of physiological functions including feeding and blood glucose homeostasis. However, the anatomical basis of VMH-mediated SNS activation has thus far proved elusive. To understand how VMH neurons exercise output functions and describe an anatomical link between these neurons and the SNS, we identified downstream neural targets of the VMHdm by injecting an adenoviral vector encoding Cre recombinase (Cre)-regulated farnesylated green fluorescent protein (GFPf ) into the VMHdm of mice that express Cre in neurons expressing the VMH-specific transcription factor steroidogenic factor 1 (SF1). We confirm previously described projection patterns of the VMHdm and report the existence of a formerly unidentified projection pathway to a number of autonomic centers in the brainstem. These VMH efferents travel caudally through the periaqueductal gray (PAG) and then ventrally through the lateral lemniscus to the ventral surface of the brain, where they eventually reach caudal autonomic centers including the C1 catecholamine cell group of the rostral ventrolateral medulla (RVLM) and the nucleus of the solitary tract (NTS), where VMH efferents make close contacts with catecholaminergic neurons. We also found that VMHdm fibers reach a number of brainstem areas, including the retrotrapezoid nucleus (RTN), which are important in regulating respiration. Thus, the present study indicates that the VMH may modulate sympathetic and autonomic activity via synaptic contacts in the RTN, NTS, and RVLM and provides significant anatomical evidence to support a role of the VMH in respiratory regulation.

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The projection of SF1 neurons from the VMH to the LHA may provide an anatomical basis for the interaction of AMPK(VMH)-glutamate-OX(LHA).
“which may provide an anatomical basis for the interaction of AMPK(VMH)-glutamate-OX(LHA).”
From A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance (2016) · cites this paper as Lindberg et al., 2013
SF1 neurons, a major cell population inside the VMH, project and terminate in the LHA.
“it has been revealed recently, by using conditional viral tracing, that SF1 neurons, a major cell population inside the VMH, project and terminate in the LHA (Lindberg et al., 2013)”
From A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance (2016) · cites this paper as Lindberg et al., 2013

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Elmquist (1998) · doi:10.1002/(sici)1096-9861(19980615)395:4

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Authors: Lindberg, D., Chen, P., & Li, C.
Affiliations: University of Virginia Health System (US)
Corresponding author: Li, Chien
ORCID: Lindberg, Daniel
Chen, Peilin
Li, Chien
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 2013-07-25
Volume: 521
Issue: 14
Pages: 3167-3190
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.23338
OpenAlex: W1630480449
Cited by: 125
References: 162
Citations by year: 2026: 4 · 2025: 7 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 11 · 2020: 14 · 2019: 10 · 2018: 7 · 2017: 12 · 2016: 20 · 2015: 12 · 2014: 6 · 2013: 2
FWCI: 7.18
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078049)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords: ventromedial hypothalamus, steroidogenic factor 1, sympathetic nervous system, autonomic centers, periaqueductal gray, lateral lemniscus, rostral ventrolateral medulla, nucleus tractus solitarius, retrotrapezoid nucleus, respiratory control, catecholaminergic neurons, brainstem
MeSH terms: Animals, Hypothalamus, Luminescent Proteins, Mice, Transgenic, Melanocyte-Stimulating Hormones, Nerve Net, Neural Pathways, Neurons, Transduction, Genetic, Tyrosine 3-Monooxygenase, Autonomic Pathways, RNA, Untranslated, Vesicular Glutamate Transport Protein 2, Mice, Steroidogenic Factor 1

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Conditional viral tracing reveals that steroidogenic factor 1-positive neurons of the dorsomedial subdivision of the ventromedial hypothalamus project to autonomic centers of the hypothalamus and hindbrain

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