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Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila
Open accessAbstract
Summary Animals can detect and consume nutritive sugars without the influence of taste. However, the identity of the taste-independent nutrient sensor and the mechanism by which animals respond to the nutritional value of sugar are unclear. Here, we report that six neurosecretory cells in the Drosophila brain that produce Diuretic hormone 44 (Dh44), a homologue of the mammalian corticotropin-releasing hormone (CRH), were specifically activated by nutritive sugars. Flies in which the activity of these neurons or the expression of Dh44 was disrupted failed to select nutritive sugars. Manipulation of the function of Dh44 receptors had a similar effect. Notably, artificial activation of Dh44 receptor-1 neurons resulted in proboscis extensions, and frequent episodes of excretion. Conversely, reduced Dh44 activity led to decreased excretion. Together, these actions facilitate ingestion and digestion of nutritive foods. We propose that the Dh44 system directs the detection and consumption of nutritive sugars through a positive feedback loop.
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Cites
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
Parton, L. E., Ye, C. P., Coppari, R., Enriori, P. J., Choi, B., Zhang, C.-Y., Xu, C., Vianna, C. R., Balthasar, N., Lee, C. E., et al. (2007) · Nature · doi:10.1038/nature06098 · Cited by 700
Motor neurons controlling fluid ingestion in Drosophila
Manzo, A., Silies, M., Gohl, D. M., & Scott, K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120305109 · Cited by 69
Cited by
Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster
Miguel-Aliaga, I., Jasper, H., & Lemaitre, B. (2018) · Genetics · doi:10.1534/genetics.118.300224 · Cited by 491
Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
Nässel, D. R., & Zandawala, M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.02.003 · Cited by 355
Tsao, C.-H., Chen, C.-C., Lin, C.-H., Yang, H.-Y., & Lin, S. (2018) · eLife · doi:10.7554/elife.35264 · Cited by 214
Coupled sensing of hunger and thirst signals balances sugar and water consumption
Jourjine, N., Mullaney, B. C., Mann, K., & Scott, K. (2016) · Cell · doi:10.1016/j.cell.2016.06.046 · Cited by 154
A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive in Drosophila
Musso, P.-Y., Junca, P., & Gordon, M. D. (2021) · Science Advances · doi:10.1126/sciadv.abj0186 · Cited by 41
Metadata
- Authors
- Dus, M., Lai, J. S.-Y., Gunapala, K. M., Min, S., Tayler, T. D., Hergarden, A. C., Geraud, E., Joseph, C. M., & Suh, G. S. B.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 87
- Issue
- 1
- Pages
- 139-151
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1580426270
- Cited by
- 265
- References
- 2
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dus, M., Lai, J. S.-Y., Gunapala, K. M., Min, S., Tayler, T. D., Hergarden, A. C., Geraud, E., Joseph, C. M., & Suh, G. S. B. (2015). Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila. Neuron. https://doi.org/10.1016/j.neuron.2015.05.032
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