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Cited by 41Neurobiology and Insect Physiology ResearchRegulation of Appetite and ObesityNeuroscience and Neuropharmacology Research

A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive in Drosophila

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Musso, Pierre-Yves, Junca, Pierre, Gordon, Michael D.·2021·Science Advances
DOI 10.1126/sciadv.abj0186PMC PMC8635442

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Abstract

Satiety-encoding Drosophila neurons detect hemolymph glucose and signal to fructose sensors to regulate sugar feeding.

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Crossref · 10.1126/sciadv.abj0186

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  • In the fly brain, the asymmetric body is reproducibly around 4 times larger on the right hemisphere than on the left, except in rare cases of situs inversus.

    “In the fly brain, the asymmetric body is reproducibly around 4 times larger on the right hemisphere than on the left112–114, except in rare cases of situs inversus114,115.”

    From Whole-brain annotation and multi-connectome cell typing of Drosophila (2024) · cites this paper as [115]

    The Discussion section, “dFB and Janus neurons provide insight into asymmetric body function” (page unavailable), supports right-sided asymmetry: it says 92.4% of flies have an asymmetric body only on the right, while 7.6% also have one on the left. It gives no fourfold size comparison and does not describe the exceptions as situs inversus. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • dFMRFa is expressed in layer 4, and SIFamide and proctolin are expressed in layer 5.

    “but we note that dFMRFa is expressed in layer 4, and SIFamide and proctolin are expressed in layer 5.175,186”

    From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [186]

    The Discussion section describes the fan-shaped body's layers, and the Results section places the neurons studied in layers 8 and 9, but neither gives the claimed peptide-expression locations. Searches for dFMRFa, SIFamide, proctolin, and their proposed layers found no passage addressing the claim. Page numbers are unavailable in our copy. (LLM, conf=0.74)

    Experimental — accuracy not yet measured

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Authors
Musso, P.-Y., Junca, P., & Gordon, M. D.
Affiliations
University of British Columbia (CA)
Corresponding author
Gordon, Michael D.
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2021-12-03
Volume
7
Issue
49
Pages
eabj0186-eabj0186
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.abj0186
PMC
PMC8635442
OpenAlex
W3155169680
Cited by
41
References
12
Citations by year
2026: 6 · 2025: 6 · 2024: 12 · 2023: 11 · 2022: 4 · 2021: 2
FWCI
3.34
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by-nc)
Funders
  • Michael Smith Health Research BC
  • Natural Sciences and Engineering Research Council of Canada (RGPAS-49246-16, rgpin-2016-03857)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
satiety, neural circuits, hemolymph glucose, glutamatergic input, protocerebrum, tachykinins, neuropeptide signaling, feeding behavior, Drosophila

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