The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes
Open accessAbstract
Summary The precise regulation of cerebral blood flow is critical for normal brain function and its disruption underlies many neuropathologies. The extent to which smooth muscle-covered arterioles or pericyte-covered capillaries control vasomotion during neurovascular coupling remains controversial. We found that capillary pericytes in mice and humans do not express smooth muscle actin and are morphologically and functionally distinct from adjacent precapillary smooth muscle cells (SMCs). Using optical imaging we investigated blood flow regulation at various sites on the vascular tree in living mice. Optogenetic, whisker stimulation or cortical spreading depolarization caused microvascular diameter or flow changes in SMC but not pericyte-covered microvessels. During early stages of brain ischemia, transient SMC but not pericyte constrictions were a major cause of hypoperfusion leading to thrombosis and distal microvascular occlusions. Thus, capillary pericytes are not contractile and regulation of cerebral blood flow in physiological and pathological conditions is mediated by arteriolar smooth muscle cells.
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1 retracted
RETRACTED ARTICLE: Pericyte loss influences Alzheimer-like neurodegeneration in mice
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Capillary pericytes regulate cerebral blood flow in health and disease
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Cited by
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
Iadecola, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.030 · Cited by 2,480
A molecular atlas of cell types and zonation in the brain vasculature
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Molecular diversity and specializations among the cells of the adult mouse brain
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“Mural cells have two subtypes: pericytes, which associate with capillaries, and smooth muscle alpha actin (SMA) cells, which associate with larger-bore vasculature and control blood flow (Hill et al., 2015; Hughes and Chan-Ling, 2004; Nehls and Drenckhahn, 1991).”
BackgroundCerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.48 · Cited by 1,243
Pericytes of the neurovascular unit: key functions and signaling pathways
Sweeney, M. D., Ayyadurai, S., & Zlokovic, B. V. (2016) · Nature Neuroscience · doi:10.1038/nn.4288 · Cited by 1,125
Metadata
- Authors
- Hill, R. A., Tong, L., Yuan, P., Murikinati, S., Gupta, S., & Grutzendler, J.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 87
- Issue
- 1
- Pages
- 95-110
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1540025214
- Cited by
- 722
- References
- 15
- FWCI
- 25.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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