Pericytes of the neurovascular unit: key functions and signaling pathways

Sweeney, Melanie D; Ayyadurai, Shiva; Zlokovic, Berislav V

doi:10.1038/nn.4288

Cited by 1,125Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration MechanismsAngiogenesis and VEGF in Cancer

Pericytes of the neurovascular unit: key functions and signaling pathways

Open access

Sweeney, Melanie D, Ayyadurai, Shiva, Zlokovic, Berislav V·2016·Nature Neuroscience

DOI 10.1038/nn.4288PMC PMC5745011

Open this paper in CoChat — free account

Abstract

Pericytes are vascular mural cells embedded in the basement membrane of blood microvessels. They extend their processes along capillaries, pre-capillary arterioles and post-capillary venules. CNS pericytes are uniquely positioned in the neurovascular unit between endothelial cells, astrocytes and neurons. They integrate, coordinate and process signals from their neighboring cells to generate diverse functional responses that are critical for CNS functions in health and disease, including regulation of the blood-brain barrier permeability, angiogenesis, clearance of toxic metabolites, capillary hemodynamic responses, neuroinflammation and stem cell activity. Here we examine the key signaling pathways between pericytes and their neighboring endothelial cells, astrocytes and neurons that control neurovascular functions. We also review the role of pericytes in CNS disorders including rare monogenic diseases and complex neurological disorders such as Alzheimer's disease and brain tumors. Finally, we discuss directions for future studies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nn.4288

Cites

176 of 176 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Pericyte-derived angiopoietin acts on endothelial Tie2 receptor and maintains BBB function.
“pericyte-derived angiopoietin acts on endothelial Tie2 receptor and maintains BBB function (26, 570, 648);”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [570]
The Ang/Tie2 pathway section states that pericyte-secreted Ang1 binds the endothelial Tie2 receptor and that Ang/Tie2 signaling regulates vascular permeability. The neurological-disorders section associates reduced Ang1 and Tie2 expression with BBB breakdown after ischemic stroke in a diabetic mouse model; it does not establish that this signaling maintains BBB function generally. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Pericyte-endothelial interaction plays a key role in the establishment and maintenance of the BBB.
“Pericyte-endothelial interaction plays a key role in the establishment and maintenance of the BBB (27, 570, 648, 682).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [570]
At the capillary level, BBB integrity is maintained by pericytes.
“At the capillary level, BBB integrity is maintained by pericytes (28, 59, 130, 570).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [570]
Pericytes share a common basement membrane with brain capillary endothelial cells.
“Pericytes share a common basement membrane with brain capillary endothelial cells (570).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [570]
Pericyte-deficient mouse models caused by aberrant PDGF-BB/PDGFRβ signaling exhibit impaired BBB formation and maintenance.
“Pericytedeficient mouse models caused by aberrant PDGF-BB/ PDGFR𝛃 signaling (365, 419, 436, 570, 575) exhibit impaired BBB formation (28, 59, 130) and maintenance (59, 436).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [570]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED ARTICLE: Pericyte loss influences Alzheimer-like neurodegeneration in mice
Sagare, A. P., Bell, R. D., Zhao, Z., Ma, Q., Winkler, E. A., Ramanathan, A., & Zlokovic, B. V. (2013) · Nature Communications · doi:10.1038/ncomms3932 · Cited by 589 · see citing works
Retracted
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824 · see citing works
Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
DeJesus-Hernandez, M., Mackenzie, I. R., Boeve, B. F., Boxer, A. L., Baker, M., Rutherford, N. J., Nicholson, A. M., Finch, N. A., Flynn, H., Adamson, J., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.011 · Cited by 4,936 · see citing works
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., & Ferrara, N. (1993) · Nature · doi:10.1038/362841a0 · Cited by 3,605 · see citing works
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Zeisel, A., Muñoz-Manchado, A. B., Codeluppi, S., Lönnerberg, P., La Manno, G., Juréus, A., Marques, S., Munguba, H., He, L., Betsholtz, C., et al. (2015) · Science · doi:10.1126/science.aaa1934 · Cited by 3,124 · see citing works
Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders
Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969 · see citing works
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894 · see citing works
Pericytes regulate the blood–brain barrier
Armulik, A., Genové, G., Mäe, M., Nisancioglu, M. H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., et al. (2010) · Nature · doi:10.1038/nature09522 · Cited by 2,843 · see citing works
Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis
Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,831 · see citing works
Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653 · see citing works
Glial and neuronal control of brain blood flow
Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511 · see citing works
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226 · see citing works
Pericytes are required for blood–brain barrier integrity during embryogenesis
Daneman, R., Zhou, L., Kebede, A. A., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09513 · Cited by 2,128 · see citing works
Blood-brain barrier breakdown in the aging human hippocampus
Montagne, A., Barnes, S. R., Sweeney, M. D., Halliday, M. R., Sagare, A. P., Zhao, Z., Toga, A. W., Jacobs, R. E., Liu, C. Y., Amezcua, L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.032 · Cited by 2,102 · see citing works
Self-citation
Capillary pericytes regulate cerebral blood flow in health and disease
Hall, C. N., Reynell, C., Gesslein, B., Hamilton, N. B., Mishra, A., Sutherland, B. A., O’Farrell, F. M., Buchan, A. M., Lauritzen, M., & Attwell, D. (2014) · Nature · doi:10.1038/nature13165 · Cited by 1,870 · see citing works
The Pathobiology of Vascular Dementia
Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857 · see citing works
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
Hellström, M., Phng, L.-K., Hofmann, J. J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A.-K., Karlsson, L., Gaiano, N., et al. (2007) · Nature · doi:10.1038/nature05571 · Cited by 1,775 · see citing works
Establishment and Dysfunction of the Blood-Brain Barrier
Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell · doi:10.1016/j.cell.2015.10.067 · Cited by 1,670 · see citing works
Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging
Bell, R. D., Winkler, E. A., Sagare, A. P., Singh, I., LaRue, B., Deane, R., & Zlokovic, B. V. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.043 · Cited by 1,448 · see citing works
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
Bergers, G., Song, S., Meyer-Morse, N., Bergsland, E. K., & Hanahan, D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17929 · Cited by 1,361 · see citing works
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
Bell, R. D., Winkler, E. A., Singh, I., Sagare, A. P., Deane, R., Wu, Z., Holtzman, D. M., Betsholtz, C., Armulik, A., Sallstrom, J., et al. (2012) · Nature · doi:10.1038/nature11087 · Cited by 1,293 · see citing works
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
Bergers, G., Song, S., Meyer-Morse, N., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317929 · Cited by 1,192 · see citing works
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Rogaeva, E., Meng, Y., Lee, J. H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C. T., Cheng, R., Hasegawa, H., et al. (2007) · Nature Genetics · doi:10.1038/ng1943 · Cited by 1,167 · see citing works
Glial regulation of the cerebral microvasculature
Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn2003 · Cited by 1,153 · see citing works
Bidirectional control of CNS capillary diameter by pericytes
Peppiatt, C. M., Howarth, C., Mobbs, P., & Attwell, D. (2006) · Nature · doi:10.1038/nature05193 · Cited by 1,150 · see citing works
Astrocyte-mediated control of cerebral blood flow
Takano, T., Tian, G.-F., Peng, W., Lou, N., Libionka, W., Han, X., & Nedergaard, M. (2005) · Nature Neuroscience · doi:10.1038/nn1623 · Cited by 1,137 · see citing works
Lack of Pericytes Leads to Endothelial Hyperplasia and Abnormal Vascular Morphogenesis
Hellström, M., Gerhardt, H., Kalén, M., Li, X., Eriksson, U., Wolburg, H., & Betsholtz, C. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.3.543 · Cited by 1,103 · see citing works
Cerebral microvascular pathology in aging and Alzheimer's disease
Farkas, E., & Luiten, P. G. M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00068-x · Cited by 1,102 · see citing works
Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
Nguyen, L. N., Ma, D., Shui, G., Wong, P., Cazenave-Gassiot, A., Zhang, X., Wenk, M. R., Goh, E. L. K., & Silver, D. L. (2014) · Nature · doi:10.1038/nature13241 · Cited by 1,048 · see citing works
Mfsd2a is critical for the formation and function of the blood-brain barrier
Ben-Zvi, A., Lacoste, B., Kur, E., Andreone, B. J., Mayshar, Y., Yan, H., & Gu, C. (2014) · Nature · doi:10.1038/nature13324 · Cited by 1,037 · see citing works
Central nervous system pericytes in health and disease
Winkler, E. A., Bell, R. D., & Zlokovic, B. V. (2011) · Nature Neuroscience · doi:10.1038/nn.2946 · Cited by 962 · see citing works
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesisPreprint
Ruhrberg, C., Gerhardt, H., Golding, M., Watson, R., Ioannidou, S., Fujisawa, H., Betsholtz, C., & Shima, D. T. (2002) · Genes & Development · doi:10.1101/gad.242002 · Cited by 918 · see citing works
Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.
Sato, Y., & Rifkin, D. B. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.1.309 · Cited by 908 · see citing works
Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth
Cheng, L., Huang, Z., Zhou, W., Wu, Q., Donnola, S., Liu, J. K., Fang, X., Sloan, A. E., Mao, Y., Lathia, J. D., et al. (2013) · Cell · doi:10.1016/j.cell.2013.02.021 · Cited by 905 · see citing works
Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery
Yemişçi, M., Özdemir, Y., Vural, A., Can, A., Topalkara, K., & Dalkara, T. (2009) · Nature Medicine · doi:10.1038/nm.2022 · Cited by 780 · see citing works
Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes
Hill, R., Тонг, Л., Yuan, P., Murikinati, S. R., Gupta, S., & Grutzendler, J. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.001 · Cited by 704 · see citing works
Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease
Halliday, M. R., Rege, S. V., Ma, Q., Zhao, Z., Miller, C. A., Winkler, E. A., & Zlokovic, B. V. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.44 · Cited by 649 · see citing works
What is a pericyte?
Attwell, D., Mishra, A., Hall, C. N., O’Farrell, F. M., & Dalkara, T. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15610340 · Cited by 648 · see citing works
A role for VEGF as a negative regulator of pericyte function and vessel maturation
Greenberg, J. I., Shields, D. J., Barillas, S. G., Acevedo, L. M., Murphy, E. A., Huang, J., Scheppke, L., Stockmann, C., Johnson, R. S., Angle, N., et al. (2008) · Nature · doi:10.1038/nature07424 · Cited by 630 · see citing works
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development
Gale, N. W., Dominguez, M. G., Noguera, I., Pan, L., Hughes, V., Valenzuela, D. M., Murphy, A. J., Adams, N. C., Lin, H. C., Holash, J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407290101 · Cited by 600 · see citing works
The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow
Blinder, P., Tsai, P. S., Kaufhold, J. P., Knutsen, P. M., Suhl, H., & Kleinfeld, D. (2013) · Nature Neuroscience · doi:10.1038/nn.3426 · Cited by 573 · see citing works
Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
Davalos, D., Kyu Ryu, J., Merlini, M., Baeten, K. M., Le Moan, N., Petersen, M. A., Deerinck, T. J., Smirnoff, D. S., Bedard, C., Hakozaki, H., et al. (2012) · Nature Communications · doi:10.1038/ncomms2230 · Cited by 568 · see citing works
Deficiency in Mural Vascular Cells Coincides with Blood–Brain Barrier Disruption in <scp>A</scp> lzheimer's Disease
Sengillo, J. D., Winkler, E. A., Walker, C. T., Sullivan, J. S., Johnson, M., & Zlokovic, B. V. (2013) · Brain Pathology · doi:10.1111/bpa.12004 · Cited by 553 · see citing works
PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
Song, S., Ewald, A. J., Stallcup, W. B., Werb, Z., & Bergers, G. (2005) · Nature Cell Biology · doi:10.1038/ncb1288 · Cited by 551 · see citing works
VEGF Inhibits Tumor Cell Invasion and Mesenchymal Transition through a MET/VEGFR2 Complex
Lu, K. V., Chang, J. P., Parachoniak, C. A., Pandika, M. M., Aghi, M. K., Meyronet, D., Isachenko, N., Fouse, S. D., Phillips, J. J., Cheresh, D. A., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.037 · Cited by 550 · see citing works
Targeting the PDGF signaling pathway in tumor treatment
Heldin, C. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-97 · Cited by 541 · see citing works
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutantsPreprint
Krebs, L. T., Shutter, J. R., Tanigaki, K., Honjo, T., Stark, K. L., & Gridley, T. (2004) · Genes & Development · doi:10.1101/gad.1239204 · Cited by 532 · see citing works
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
DIAGRAM, Kooner, J. S., MuTHER, Saleheen, D., Sim, X., Sehmi, J., Zhang, W., Frossard, P., Been, L. F., Chia, K., et al. (2011) · Nature Genetics · doi:10.1038/ng.921 · Cited by 531 · see citing works
Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease
Hamilton, N. B. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00005 · Cited by 513 · see citing works
EndMT contributes to the onset and progression of cerebral cavernous malformations
Maddaluno, L., Rudini, N., Cuttano, R., Bravi, L., Giampietro, C., Corada, M., Ferrarini, L., Orsenigo, F., Papa, E., Boulday, G., et al. (2013) · Nature · doi:10.1038/nature12207 · Cited by 486 · see citing works
Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling
Felcht, M., Luck, R., Schering, A., Seidel, P., Srivastava, K., Hu, J., Bartol, A., Kienast, Y., Vettel, C., Loos, E. K., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58832 · Cited by 479 · see citing works
ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration
Zhong, Z., Deane, R., Ali, Z., Parisi, M., Shapovalov, Y., O'Banion, M. K., Stojanovic, K., Sagare, A., Boillee, S., Cleveland, D. W., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2073 · Cited by 476 · see citing works
Alzheimer’s Disease Genetics: From the Bench to the Clinic
Karch, C. M., Cruchaga, C., & Goate, A. M. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.041 · Cited by 473 · see citing works
High TGFβ-Smad Activity Confers Poor Prognosis in Glioma Patients and Promotes Cell Proliferation Depending on the Methylation of the PDGF-B Gene
Bruna, A., Darken, R. S., Rojo, F., Ocaña, A., Peñuelas, S., Arias, A., Parı́s, R., Tortosa, A., Mora, J., Baselga, J. M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.023 · Cited by 472 · see citing works
Mutations within the Programmed Cell Death 10 Gene Cause Cerebral Cavernous Malformations
Bergametti, F., Denier, C., Labauge, P. M., Arnoult, M., Boetto, S., Clanet, M., Coubes, P. A., Échenne, B., Ibrahim, R., Irthum, B., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/426952 · Cited by 449 · see citing works
Ephrin-B2 Controls Cell Motility and Adhesion during Blood-Vessel-Wall Assembly
Foo, S. S. C., Turner, C. J., Adams, S., Compagni, A., Aubyn, D., Kogata, N., Lindblom, P., Shani, M., Zicha, D., & Adams, R. H. (2006) · Cell · doi:10.1016/j.cell.2005.10.034 · Cited by 439 · see citing works
Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy
Geraldes, P., Hiraoka‐Yamamoto, J., Matsumoto, M., Clermont, A. C., Leitges, M., Marette, A., Aiello, L. P., Kern, T. S., & King, G. L. (2009) · Nature Medicine · doi:10.1038/nm.2052 · Cited by 424 · see citing works
Astrocyte Regulation of Blood Flow in the BrainPreprint
MacVicar, B. A., & Newman, E. A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020388 · Cited by 420 · see citing works
Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis
Wang, C., Li, Y., Shi, L., Ren, J., Patti, M., Wang, T., de Oliveira, J. R. M., Sobrido, M. J., Quintáns, B., Baquero, M., et al. (2012) · Nature Genetics · doi:10.1038/ng.1077 · Cited by 417 · see citing works
Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain
Fernández-Klett, F., Offenhauser, N., Dirnagl, U., Priller, J., & Lindauer, U. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011321108 · Cited by 399 · see citing works
Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice
Goumans, M., & Mummery, C. L. (2000) · The International Journal of Developmental Biology · doi:10.1387/ijdb.10853822 · Cited by 376 · see citing works
Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium
Yuan, H. T., Khankin, E. V., Karumanchi, S. A., & Parikh, S. M. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01472-08 · Cited by 374 · see citing works
Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils
Wang, S., Voisin, M.-B., Larbi, K. Y., Dangerfield, J. A., Scheiermann, C., Tran, M. G. B., Maxwell, P. H., Sorokin, L. M., & Nourshargh, S. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051210 · Cited by 374 · see citing works
Ephrin-B2 Selectively Marks Arterial Vessels and Neovascularization Sites in the Adult, with Expression in Both Endothelial and Smooth-Muscle Cells
Gale, N. W., Bałuk, P., Pan, L., Kwan, M. L., Holash, J. A., DeChiara, T. M., McDonald, D. M., & Yancopoulos, G. D. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0112 · Cited by 363 · see citing works
Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy
Hawkes, C. A., Härtig, W., Kacza, J., Schliebs, R., Weller, R. O., Nicoll, J. A. R., & Carare, R. O. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0801-7 · Cited by 359 · see citing works
Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis
Winkler, E. A., Sengillo, J. D., Sullivan, J. S., Henkel, J. S., Appel, S. H., & Zlokovic, B. V. (2013) · Acta Neuropathologica · doi:10.1007/s00401-012-1039-8 · Cited by 354 · see citing works
Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling
Winkler, E. A., Bell, R. D., & Zloković, B. V. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-32 · Cited by 346 · see citing works
Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice
Keller, A., Westenberger, A., Sobrido, M. J., García-Murias, M., Domingo, A., Sears, R. L., Lemos, R. R., Ordoñez-Ugalde, A., Nicolas, G., da Cunha, J. E. G., et al. (2013) · Nature Genetics · doi:10.1038/ng.2723 · Cited by 324 · see citing works
Production of 20-HETE and Its Role in Autoregulation of Cerebral Blood Flow
Gebremedhin, D., Lange, A. R., Lowry, T. F., Taheri, M. R., Birks, E. K., Hudetz, A. G., Narayanan, J., Falck, J. R., Okamoto, H., Roman, R. J., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.1.60 · Cited by 318 · see citing works
Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression
Franco, M., Roswall, P., Cortez, E., Hanahan, D., & Pietras, K. (2011) · Blood · doi:10.1182/blood-2011-01-331694 · Cited by 310 · see citing works
Two-photon imaging of capillary blood flow in olfactory bulb glomeruli
Chaigneau, E. M., Oheim, M., Audinat, É., & Charpak, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2133652100 · Cited by 306 · see citing works
Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice
Hartmann, D. A., Underly, R. G., Grant, R. I., Watson, A. N., Lindner, V., & Shih, A. Y. (2015) · Neurophotonics · doi:10.1117/1.nph.2.4.041402 · Cited by 306 · see citing works
The Transforming Growth Factor‐βs
Bottner, M. B., KRIEGLSTEIN, K. G., & Unsicker, K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752227.x · Cited by 302 · see citing works
Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex
Johnson, M. B., Wang, P. P., Atabay, K. D., Murphy, E. A., Doan, R. N., Hecht, J. L., & Walsh, C. A. (2015) · Nature Neuroscience · doi:10.1038/nn.3980 · Cited by 288 · see citing works
Pericytes: Pluripotent Cells of the Blood Brain Barrier
Dore‐Duffy, P. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784705469 · Cited by 286 · see citing works
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells
Uemura, A., Ogawa, M., Hirashima, M., Fujiwara, T., Koyama, S., Takagi, H., Honda, Y., Wiegand, S. J., Yancopoulos, G. D., & Nishikawa, S.-I. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15621 · Cited by 282 · see citing works
Mutation of the <i>PDGFRB</i> gene as a cause of idiopathic basal ganglia calcification
Nicolas, G., Pottier, C., Maltête, D., Coutant, S., Rovelet-Lecrux, A., Legallic, S., Rousseau, S., Vaschalde, Y., Guyant-Maréchal, L., Augustin, J., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e31827ccf34 · Cited by 279 · see citing works
Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in an in Vitro Blood-Brain Barrier Model
Nishitsuji, K., Hosono, T., Nakamura, T., Bu, G., & Michikawa, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.225532 · Cited by 275 · see citing works
Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells
Kim, K., Lee, H. W., Lee, H., Kim, S. C., Seo, Y. J., Chung, W., Eum, H. H., Nam, D., Kim, J., Joo, K. M., et al. (2015) · Genome biology · doi:10.1186/s13059-015-0692-3 · Cited by 266 · see citing works
Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer.
Zhang, L., Yang, N., Park, J.-W., Katsaros, D., Fracchioli, S., Cao, G., O’Brien-Jenkins, A., Randall, T. C., Rubin, S. C., & Coukos, G. (2003) · PubMed · Cited by 263 · see citing works
Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain
Zlokovic, B. V., Deane, R., Sagare, A. P., Bell, R. D., & Winkler, E. A. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07002.x · Cited by 261 · see citing works
Endothelial Smad4 Maintains Cerebrovascular Integrity by Activating N-Cadherin through Cooperation with Notch
Li, F., Lan, Y., Wang, Y., Wang, J., Yang, G., Meng, F., Han, H., Meng, A., Wang, Y., & Yang, X. Y. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.01.011 · Cited by 259 · see citing works
Brain Vascular Pericytes Following Ischemia Have Multipotential Stem Cell Activity to Differentiate Into Neural and Vascular Lineage Cells
Nakagomi, T., Kubo, S., Nakano‐Doi, A., Sakuma, R., Lu, S., Narita, A., Kawahara, M., Taguchi, A., & Matsuyama, T. (2015) · Stem Cells · doi:10.1002/stem.1977 · Cited by 257 · see citing works
CNS pericytes: Concepts, misconceptions, and a way out
Krueger, M. W., & Bechmann, I. (2009) · Glia · doi:10.1002/glia.20898 · Cited by 246 · see citing works
Blood–spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice
Winkler, E. A., Sengillo, J. D., Sagare, A. P., Zhao, Z., Ma, Q., Zuniga, E., Wang, Y., Zhong, Z., Sullivan, J. S., Griffin, J. H., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401595111 · Cited by 238 · see citing works
Serial Measurement of Vascular Endothelial Growth Factor and Transforming Growth Factor-β1 in Serum of Patients With Acute Ischemic Stroke
SLEVIN, M. A., Krupiński, J., Słowik, A., Kumar, P., Szczudlik, A., & Gaffney, J. J. (2000) · Stroke · doi:10.1161/01.str.31.8.1863 · Cited by 233 · see citing works
Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide
Kováč, A., Erickson, M. A., & Banks, W. A. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-139 · Cited by 227 · see citing works
Blood–Spinal Cord Barrier Pericyte Reductions Contribute to Increased Capillary Permeability
Winkler, E. A., Sengillo, J. D., Bell, R. D., Wang, J., & Zlokovic, B. V. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.113 · Cited by 226 · see citing works
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells
Uemura, A., Ogawa, M., Hirashima, M., Fujiwara, T., Koyama, S., Takagi, H., Honda, Y., Wiegand, S. J., Yancopoulos, G. D., & Nishikawa, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215621 · Cited by 226 · see citing works
Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome
Guemez-Gamboa, A., Nguyen, L. N., Yang, H., Zaki, M. S., Kara, M., Ben-Omran, T., Akizu, N., Rosti, R. O., Rosti, B., Scott, E., et al. (2015) · Nature Genetics · doi:10.1038/ng.3311 · Cited by 225 · see citing works
Integrin α4β1–VCAM-1–mediated adhesion between endothelial and mural cells is required for blood vessel maturation
Garmy-Susini, B. H., Jin, H., Zhu, Y., Sung, R.-J., Hwang, R. F., & Varner, J. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23445 · Cited by 216 · see citing works
TGFβ is required for the formation of capillary-like structures in three-dimensional cocultures of 10T1/2 and endothelial cells
Darland, D. C., & D'Amore, P. A. (2001) · Angiogenesis · doi:10.1023/a:1016611824696 · Cited by 208 · see citing works
Notch Signaling Regulates Platelet-Derived Growth Factor Receptor-β Expression in Vascular Smooth Muscle Cells
Jin, S., Hansson, E. M., Tikka, S., Lanner, F., Sahlgren, C., Farnebo, F. A., Baumann, M., Kalimo, H., & Lendahl, U. (2008) · Circulation Research · doi:10.1161/circresaha.107.167965 · Cited by 197 · see citing works
PDGFRβ Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development
Olson, L. E., & Soriano, P. M. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.04.019 · Cited by 194 · see citing works
Microarray analysis of blood microvessels from PDGF‐B and PDGF‐Rβ mutant mice identifies novel markers for brain pericytes
Bondjers, C., He, L., Takemoto, M., Norlin, J., Asker, N., Hellström, M., Lindahl, P., Betsholtz, C., Bondjers, C., He, L., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-4944fje · Cited by 193 · see citing works
Additive Effects of PDGF Receptor β Signaling Pathways in Vascular Smooth Muscle Cell Development
Tallquist, M. D., French, W. J., & Soriano, P. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000052 · Cited by 192 · see citing works
Neurodegeneration and the neurovascular unit
Zloković, B. V. (2010) · Nature Medicine · doi:10.1038/nm1210-1370 · Cited by 190 · see citing works
Wnt signaling in the vasculature
Reis, M., & Liebner, S. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.12.023 · Cited by 188 · see citing works
The <i>APOE</i> ε4/ε4 Genotype Potentiates Vascular Fibrin(Ogen) Deposition in Amyloid-Laden Vessels in the Brains of Alzheimer's Disease Patients
Hultman, K., Strickland, S., & Norris, E. H. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.76 · Cited by 183 · see citing works
Angiopoietin-2 Is Critical for Cytokine-Induced Vascular Leakage
Benest, A. V., Kruse, K., Savant, S., Thomas, M., Laib, A. M., Loos, E. K., Fiedler, U., & Augustin, H. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070459 · Cited by 178 · see citing works
Gap Junction Communication Mediates Transforming Growth Factor-β Activation and Endothelial-Induced Mural Cell Differentiation
Hirschi, K. K., Burt, J. M., Hirschi, K. D., & Dai, C. (2003) · Circulation Research · doi:10.1161/01.res.0000091259.84556.d5 · Cited by 176 · see citing works
Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
Ghosh, M., Balbi, M., Hellal, F., Dichgans, M., Lindauer, U., & Plesnila, N. (2015) · Annals of Neurology · doi:10.1002/ana.24512 · Cited by 171 · see citing works
Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier
Reyahi, A., Nik, A. M., Ghiami, M., Gritli-Linde, A., Pontén, F., Johansson, B. R., & Carlsson, P. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.05.008 · Cited by 170 · see citing works
Endosialin (Tem1) Is a Marker of Tumor-Associated Myofibroblasts and Tumor Vessel-Associated Mural Cells
Christian, S., Winkler, R., Helfrich, I., Boos, A. M., Besemfelder, E., Schadendorf, D., & Augustin, H. G. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070623 · Cited by 169 · see citing works
A role for human brain pericytes in neuroinflammation
Jansson, D., Rustenhoven, J., Feng, S. X., Hurley, D., Oldfield, R. L., Bergin, P., Mee, E. W., Faull, R. L. M., & Dragunow, M. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-104 · Cited by 168 · see citing works
Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF‐A and TGFβ2 in vascular abnormalization
Dieterich, L. C., Mellberg, S., Langenkamp, E., Zhang, L., Zieba, A., Salomäki, H., Teichert, M., Huang, H., Edqvist, P.-H. D., Kraus, T. F. J., et al. (2012) · The Journal of Pathology · doi:10.1002/path.4072 · Cited by 167 · see citing works
Cell‐specific blood–brain barrier regulation in health and disease: a focus on hypoxia
Engelhardt, S., Patkar, S., & Ogunshola, O. O. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12489 · Cited by 165 · see citing works
Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms.
Shaheen, R. M., Tseng, W. W., Davis, D. W., Liu, W., Reinmuth, N., Vellagas, R., Wieczorek, A. A., Ogura, Y., McConkey, D. J., Drazan, K. E., et al. (2001) · PubMed · Cited by 162 · see citing works
Meta-analysis of the Association Between Variants in SORL1 and Alzheimer Disease
Reitz, C. (2011) · Archives of Neurology · doi:10.1001/archneurol.2010.346 · Cited by 162 · see citing works
Human Apolipoprotein E ε4 Expression Impairs Cerebral Vascularization and Blood—Brain Barrier Function in Mice
Alata, W., Ye, Y., St‐Amour, I., Vandal, M., & Calon, F. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.172 · Cited by 160 · see citing works
EphB4 controls blood vascular morphogenesis during postnatal angiogenesis
Erber, R., Eichelsbacher, U., Powajbo, V., Korn, T., Djonov, V., Lin, J., Hammes, H., Grobholz, R., Ullrich, A., & Vajkoczy, P. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600949 · Cited by 158 · see citing works
The complex mural cell: Pericyte function in health and disease
Dijk, C. V., Nieuweboer, F. E., Pei, J. Y., Xu, Y. J., Bürgisser, P. E., van Mulligen, E., el Azzouzi, H., Duncker, D. J., Verhaar, M. C., & Cheng, C. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.03.258 · Cited by 154 · see citing works
The vascular factor in Alzheimer's disease: A study in Golgi technique and electron microscopy
Baloyannis, S. J., & Baloyannis, I. S. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.07.010 · Cited by 150 · see citing works
Notch3 Is Necessary for Blood Vessel Integrity in the Central Nervous System
Henshall, T. L., Keller, A., He, L., Johansson, B. R., Wallgard, E., Raschperger, E., Mäe, M. A., Jin, S., Betsholtz, C., & Lendahl, U. (2015) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.304849 · Cited by 145 · see citing works
A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome
Alakbarzade, V., Hameed, A., Quek, D. Q. Y., Chioza, B. A., Baple, E. L., Cazenave-Gassiot, A., Nguyen, L. N., Wenk, M. R., Ahmad, A. Q., Sreekantan-Nair, A., et al. (2015) · Nature Genetics · doi:10.1038/ng.3313 · Cited by 144 · see citing works
Pericyte-derived Glial Cell Line-derived Neurotrophic Factor Increase the Expression of Claudin-5 in the Blood–brain Barrier and the Blood-nerve Barrier
Shimizu, F., Sano, Y., Saito, K., Abe, M., Maeda, T., Haruki, H., & Kanda, T. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0626-8 · Cited by 144 · see citing works
Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes
Sagare, A. P., Sweeney, M. D., Makshanoff, J., & Zlokovic, B. V. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.09.025 · Cited by 142 · see citing works
Self-citation
Extracellular lactate as a dynamic vasoactive signal in the rat retinal microvasculature
Yamanishi, S., Katsumura, K., Kobayashi, T., & Puro, D. G. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01012.2005 · Cited by 142 · see citing works
Venular Basement Membranes Ubiquitously Express Matrix Protein Low-Expression Regions
Voisin, M.-B., Pröbstl, D., & Nourshargh, S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090510 · Cited by 141 · see citing works
Cholinergic modulation of the cortical microvascular bed
Hamel, É. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)45012-7 · Cited by 140 · see citing works
Maintaining blood–brain barrier integrity: Pericytes perform better than astrocytes during prolonged oxygen deprivation
Al-Ahmad, A. J., Gassmann, M., & Ogunshola, O. O. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21638 · Cited by 140 · see citing works
FOXO1 Plays an Important Role in Enhanced Microvascular Cell Apoptosis and Microvascular Cell Loss in Type 1 and Type 2 Diabetic Rats
Behl, Y., Krothapalli, P., Desta, T., Roy, S., & Graves, D. T. (2009) · Diabetes · doi:10.2337/db08-0537 · Cited by 138 · see citing works
Differentiation of the brain vasculature: the answer came blowing by the Wnt
Liebner, S., & Plate, K. H. (2010) · Vascular Cell · doi:10.1186/2040-2384-2-1 · Cited by 138 · see citing works
Early Pericyte Response to Brain Hypoxia in Cats: An Ultrastructural Study
Gönül, E., Düz, B., Kahraman, S., Kayali, H., Kubar, A., & Timurkaynak, E. (2002) · Microvascular Research · doi:10.1006/mvre.2002.2413 · Cited by 137 · see citing works
Evaluation of a Previously Suggested Plasma Biomarker Panel to Identify Alzheimer's Disease
Björkqvist, M., Ohlsson, M., Minthon, L., & Hansson, O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029868 · Cited by 135 · see citing works
Brain capillary pericytes contribute to the immune defense in response to cytokines or LPS in vitro
Pieper, C., Marek, J. J., Unterberg, M., Schwerdtle, T., & Galla, H. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.004 · Cited by 132 · see citing works
Cerebrovascular Permeability to Peptides: Manipulations of Transport Systems at the Blood-Brain Barrier
Zloković, B. V. (1995) · Pharmaceutical Research · doi:10.1023/a:1016254514167 · Cited by 131 · see citing works
Innate immunity receptor CD36 promotes cerebral amyloid angiopathy
Park, L., Zhou, J., Zhou, P., Pistick, R., Jamal, S. E., Younkin, L. H., Pierce, J. P., Arreguin, A. J., Anrather, J., Younkin, S. G., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300021110 · Cited by 130 · see citing works
Notch1 Stimulation Induces a Vascularization Switch With Pericyte-Like Cell Differentiation of Glioblastoma Stem Cells
Guichet, P., Guelfi, S., Teigell, M., Hoppe, L., Bakalara, N., Bauchet, L., Duffau, H., Lamszus, K., Rothhut, B., & Hugnot, J. (2014) · Stem Cells · doi:10.1002/stem.1767 · Cited by 129 · see citing works
Cerebrospinal Fluid Biomarkers of Neurovascular Dysfunction in Mild Dementia and Alzheimer'S Disease
Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.76 · Cited by 122 · see citing works
Self-citation
A Computational Model Predicting Disruption of Blood Vessel Development
Kleinstreuer, N., Dix, D. J., Rountree, M. R., Baker, N., Sipes, N. S., Reif, D. M., Spencer, R. M., & Knudsen, T. B. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002996 · Cited by 122 · see citing works
Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown
Halliday, M. R., Pomara, N., Sagare, A. P., Mack, W. J., Frangione, B., & Zlokovic, B. V. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.3841 · Cited by 119 · see citing works
Transport of Leucine‐Enkephalin Across the Blood‐Brain Barrier in the Perfused Guinea Pig Brain
Zloković, B. V., Lipovac, M. N., Begley, D. J., Davson, H., & Rakić, L. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb03431.x · Cited by 118 · see citing works
Tumour necrosis factor α-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members
Hermey, G., Sjøgaard, S. S., Petersen, C. M., Nykjær, A., & Gliemann, J. (2006) · Biochemical Journal · doi:10.1042/bj20051364 · Cited by 116 · see citing works
Adenosine activates ATP-sensitive K+ currents in pericytes of rat retinal microvessels: role of A1 and A2a receptors
Li, Q., & Puro, D. G. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02607-5 · Cited by 116 · see citing works
Endosialin (CD248) is a marker of tumor-associated pericytes in high-grade glioma
Simonavicius, N., Robertson, D. M., Bax, D. A., Jones, C., Huijbers, I. J., & Isacke, C. M. (2008) · Modern Pathology · doi:10.1038/modpathol.3801006 · Cited by 115 · see citing works
Blood-brain barrier permeability to leucine-enkephalin,d-Alanine2-d-leucine5-enkephalin and their N-terminal amino acid (tyrosine)
Zlokovic, B. V., Begley, D. J., & Chain-Eliash, D. G. (1985) · Brain Research · doi:10.1016/0006-8993(85)90423-8 · Cited by 114 · see citing works
Presenilins Mediate Phosphatidylinositol 3-Kinase/AKT and ERK Activation via Select Signaling Receptors
Kang, D. E., Yoon, I., Repetto, E., Busse, T., Yermian, N., Ie, L., & Koo, E. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500833200 · Cited by 107 · see citing works
Impaired pericyte recruitment and abnormal retinal angiogenesis as a result of angiopoietin-2 overexpression
Feng, Y., Hagen, F. V., Pfister, F., Djokic, S., Hoffmann, S., de Back, W., Wagner, P., Lin, J., Deutsch, U., & Hammes, H. (2007) · Thrombosis and Haemostasis · doi:10.1160/th06-05-0277 · Cited by 107 · see citing works
EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures
Salvucci, O., Maric, D., Economopoulou, M., Sakakibara, S., Merlin, S., Follenzi, A., & Tosato, G. (2009) · Blood · doi:10.1182/blood-2008-12-192294 · Cited by 107 · see citing works
Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain
Arnold, T. D., Niaudet, C., Pang, M.-F., Siegenthaler, J. A., Gaengel, K., Jung, B., Ferrero, G. M., Mukouyama, Y., Fuxe, J., Akhurst, R. J., et al. (2014) · Development · doi:10.1242/dev.107193 · Cited by 102 · see citing works
Neurovascular relationships in hippocampal slices: physiological and anatomical studies of mechanisms underlying flow-metabolism coupling in intraparenchymal microvessels
Lovick, T. A., Brown, L. A., & Key, B. J. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00737-4 · Cited by 99 · see citing works
Endosialin is expressed on stromal fibroblasts and CNS pericytes in mouse embryos and is downregulated during development
MacFadyen, J. R., Savage, K., Wienke, D., & Isacke, C. M. (2006) · Gene Expression Patterns · doi:10.1016/j.modgep.2006.07.006 · Cited by 97 · see citing works
Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone
Zloković, B. V., Segal, M. B., Begley, D. J., Davson, H., & Rakić, L. (1985) · Brain Research · doi:10.1016/0006-8993(85)90963-1 · Cited by 92 · see citing works
Age-Related Vascular Pathology in Transgenic Mice Expressing Presenilin 1-Associated Familial Alzheimer's Disease Mutations
Gama Sosa, M. A., Gasperi, R. D., Rocher, A. B., Wang, A. C.-J., Janssen, W. G. M., Flores, T., Perez, G. M., Schmeidler, J., Dickstein, D. L., Hof, P. R., et al. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090482 · Cited by 92 · see citing works
N-cadherin deficiency impairs pericyte recruitment, and not endothelial differentiation or sprouting, in embryonic stem cell-derived angiogenesis
Tillet, E., Vittet, D., Féraud, O., Moore, R. H., Kemler, R., & Huber, P. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.08.021 · Cited by 91 · see citing works
Neurovascular unit on a chip: implications for translational applications
Alcendor, D. J., Block, F. E., Cliffel, D. E., Daniels, J. S., Ellacott, K. L. J., Goodwin, C. R., Hofmeister, L. H., Li, D., Markov, D. A., May, J. C., et al. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt379 · Cited by 90 · see citing works
Cerebrovascular Remodeling and Epilepsy
Marchi, N., & Lerner‐Natoli, M. (2012) · The Neuroscientist · doi:10.1177/1073858412462747 · Cited by 90 · see citing works
Differential TGF-β Signaling in Retinal Vascular Cells: A Role in Diabetic Retinopathy?
van Geest, R. J., Klaassen, I., Vogels, I. M. C., Noorden, C. J. F. V., & Schlingemann, R. O. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4181 · Cited by 88 · see citing works
Effect of Prenatal Glucocorticoids on Cerebral Vasculature of the Developing Brain
Vinukonda, G., Dummula, K., Malik, S., Hu, F.-R., Thompson, C. I., Csiszar, A., Ungvari, Z., & Ballabh, P. (2010) · Stroke · doi:10.1161/strokeaha.110.588400 · Cited by 85 · see citing works
Update and Mutational Analysis ofSLC20A2: A Major Cause of Primary Familial Brain Calcification
de Lemos, R. R., Ramos, E. M., Legati, A., Nicolas, G., Jenkinson, E. M., Livingston, J. H., Crow, Y. J., Campion, D., Coppola, G., & de Oliveira, J. R. M. (2015) · Human Mutation · doi:10.1002/humu.22778 · Cited by 80 · see citing works
Cerebral Cavernous Malformation-1 Protein Controls DLL4-Notch3 Signaling Between the Endothelium and Pericytes
Schulz, G. B., Wieland, E., Wüstehube‐Lausch, J., Boulday, G., Moll, I., Tournier‐Lasserve, E., & Fischer, A. (2015) · Stroke · doi:10.1161/strokeaha.114.007512 · Cited by 75 · see citing works
Angiopoietin/Tie2 pathway mediates type 2 diabetes induced vascular damage after cerebral stroke
Cui, X., Chopp, M., Zacharek, A., Ye, X., Roberts, C. J., & Chen, J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.04.005 · Cited by 71 · see citing works
EphB receptors and ephrinB ligands: regulators of vascular assembly and homeostasis
Augustin, H. G., & Reiss, Y. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0770-9 · Cited by 68 · see citing works
FOXO1 plays an essential role in apoptosis of retinal pericytes.
Alikhani, M., Roy, S., & Graves, D. T. (2010) · PubMed Central · Cited by 63 · see citing works
Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca2+waves
Mufti, R. E., Brett, S. E., Tran, C. H. T., El-Rahman, R. R. A., Anfinogenova, Y., EL‐Yazbi, A. F., Cole, W. C., Jones, P. P., Chen, S. R. W., & Welsh, D. G. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.193300 · Cited by 61 · see citing works
MR Perfusion–derived Hemodynamic Parametric Response Mapping of Bevacizumab Efficacy in Recurrent Glioblastoma
Kickingereder, P., Radbruch, A., Burth, S., Wick, A., Heiland, S., Schlemmer, H.-P., Wick, W., Bendszus, M., & Bonekamp, D. (2015) · Radiology · doi:10.1148/radiol.2015151172 · Cited by 60 · see citing works
Differential expression of capillary VEGF isoforms following traumatic brain injury
Dore‐Duffy, P., Wang, X., Mehedi, A., Kreipke, C. W., & Rafols, J. A. (2007) · Neurological Research · doi:10.1179/016164107x204729 · Cited by 59 · see citing works
Tat 101-Mediated Enhancement of Brain Pericyte Migration Involves Platelet-Derived Growth Factor Subunit B Homodimer: Implications for Human Immunodeficiency Virus-Associated Neurocognitive Disorders
Niu, F., Yao, H., Zhang, W., Sutliff, R. L., & Buch, S. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1139-14.2014 · Cited by 58 · see citing works
Calcium influx pathways in rat CNS pericytes
Kamouchi, M., Kitazono, T., Ago, T., Wakisaka, M., Ooboshi, H., Ibayashi, S., & Iida, M. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.03.008 · Cited by 58 · see citing works
The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand
GLIEMANN, J., HERMEY, G., NYKJÆR, A., PETERSEN, C. M., JACOBSEN, C., & ANDREASEN, P. A. (2004) · Biochemical Journal · doi:10.1042/bj20040149 · Cited by 58 · see citing works
Nitric Oxide/cGMP-Induced Inhibition of Calcium and Chloride Currents in Retinal Pericytes
Sakagami, K., Kawamura, H., Wu, D. M., & Puro, D. G. (2001) · Microvascular Research · doi:10.1006/mvre.2001.2343 · Cited by 57 · see citing works
Endogenous Brain Pericytes Are Widely Activated and Contribute to Mouse Glioma Microvasculature
Svensson, A., Özen, Í., Genové, G., Paul, G., & Bengzon, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123553 · Cited by 53 · see citing works
Visualization and contractile activity of cochlear pericytes in the capillaries of the spiral ligament
Dai, M., Nuttall, A. L., Yang, Y., & Shi, X. (2009) · Hearing Research · doi:10.1016/j.heares.2009.04.018 · Cited by 53 · see citing works
Blood-brain barrier modeling: challenges and perspectives
Ruck, T., Bittner, S., & Meuth, S. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.158342 · Cited by 50 · see citing works
Dopamine activates ATP-sensitive K+ currents in rat retinal pericytes
Wu, D. M., Kawamura, H., Li, Q., & Puro, D. G. (2001) · Visual Neuroscience · doi:10.1017/s0952523801186104 · Cited by 49 · see citing works
CytoSolve: A Scalable Computational Method for Dynamic Integration of Multiple Molecular Pathway Models
Ayyadurai, V. A. S., & Dewey, C. F. (2010) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-010-0143-x · Cited by 43 · see citing works
Molecular Recognition of Leucine-Aspartate Repeat (LD) Motifs by the Focal Adhesion Targeting Homology Domain of Cerebral Cavernous Malformation 3 (CCM3)
Li, X., Ji, W., Zhang, R., Folta‐Stogniew, E. J., Wang, M., & Boggon, T. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.211250 · Cited by 37 · see citing works
Membrane potentials in retinal capillary pericytes: excitability and effect of vasoactive substances.
Helbig, H., Kornacker, S., Berweck, S., Stahl, F., Lepple-Wienhues, A., & Wiederholt, M. (1992) · PubMed · Cited by 27 · see citing works
A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma
Wang, F., Remke, M., Bhat, K., Wong, E. T., Zhou, S. Y., Ramaswamy, V., Dubuc, A. M., Fonkem, E., Salem, S., Zhang, H., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2779 · Cited by 27 · see citing works
Amiloride inhibits hydrogen peroxide-induced Ca2+ responses in human CNS pericytes
Nakamura, K., Kamouchi, M., Kitazono, T., Kuroda, J., Shono, Y., Hagiwara, N., Ago, T., Ooboshi, H., Ibayashi, S., & Iida, M. (2008) · Microvascular Research · doi:10.1016/j.mvr.2008.12.001 · Cited by 22 · see citing works
Platelet-derived growth factor-induced signaling pathways interconnect to regulate the temporal pattern of Erk1/2 phosphorylation
Jurek, A., Heldin, C., & Lennartsson, J. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.09.013 · Cited by 20 · see citing works
Spatial correlations between beta-amyloid (Abeta) deposits and blood vessels in familial Alzheimer's disease.
Armstrong, R. A. (2008) · PubMed · Cited by 19 · see citing works
Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons
Takahashi, H., Takata, F., Matsumoto, J., Machida, T., Yamauchi, A., Dohgu, S., & Kataoka, Y. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.016 · Cited by 15 · see citing works
The Role of Intracellular Trafficking and the Vps10D Receptors In Alzheimer‘s Disease
Reitz, C. (2012) · Future Neurology · doi:10.2217/fnl.12.31 · Cited by 15 · see citing works
Untitled work
(2000) · doi:10.1002/1097-0177(200007)218:3

Flagged first, then by citations

Sorted by citations

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076 · see citing works
Self-citation
Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works
Self-citation
Molecular diversity and specializations among the cells of the adult mouse brain
Saunders, A., Macosko, E. Z., Wysoker, A., Goldman, M., Krienen, F. M., de Rivera, H., Bien, E., Baum, M., Bortolin, L., Wang, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.028 · Cited by 1,847 · see citing works
“Mural cells are intrinsic to the endothelium and control vascular development, stability, and homeostasis (Sweeney et al., 2016; Trost et al., 2016).”
Background
Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.48 · Cited by 1,243 · see citing works
The role of brain vasculature in neurodegenerative disorders
Sweeney, M. D., Kisler, K., Montagne, A., Toga, A. W., & Zlokovic, B. V. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0234-x · Cited by 998 · see citing works
Self-citation
The hypoxic tumour microenvironment
Petrova, V., Annicchiarico‐Petruzzelli, M., Melino, G., & Amelio, I. (2018) · Oncogenesis · doi:10.1038/s41389-017-0011-9 · Cited by 1,035 · see citing works
Functional morphology of the blood–brain barrier in health and disease
Liebner, S., Dijkhuizen, R. M., Reiss, Y., Plate, K. H., Agalliu, D., & Constantin, G. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1815-1 · Cited by 872 · see citing works
Post-Stroke Cognitive Impairment and Dementia
Rost, N. S., Brodtmann, A. G., Pase, M. P., van Veluw, S. J., Biffi, A., Duering, M., Hinman, J. D., & Dichgans, M. (2022) · Circulation Research · doi:10.1161/circresaha.122.319951 · Cited by 837 · see citing works
The blood-brain barrier in aging and neurodegeneration
Knox, E. G., Aburto, M. R., Clarke, G., Cryan, J. F., & O’Driscoll, C. M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01511-z · Cited by 738 · see citing works
“Endothelial cells directly communicate with pericytes by secreting platelet-derived growth factor B (PDGF-B) which binds to its receptor expressed by pericytes, PDGF receptor beta (PDGFRβ) [32].”
Background
Peripheral inflammation and blood–brain barrier disruption: effects and mechanisms
Huang, X., Hussain, B., & Chang, J. (2020) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13569 · Cited by 732 · see citing works
3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes
Campisi, M., Shin, Y., Osaki, T., Hajal, C., Chiono, V., & Kamm, R. D. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.014 · Cited by 718 · see citing works
The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease
Oliver, G. C., Kipnis, J., Randolph, G. J., & Harvey, N. L. (2020) · Cell · doi:10.1016/j.cell.2020.06.039 · Cited by 685 · see citing works
Alzheimer’s disease: A matter of blood–brain barrier dysfunction?
Montagne, A., Zhao, Z., & Zlokovic, B. V. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20171406 · Cited by 672 · see citing works
Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications
Vatine, G. D., Barrile, R., Workman, M. J., Sances, S., Barriga, B. K., Rahnama, M., Barthakur, S., Kasendra, M., Lucchesi, C., Kerns, J., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.05.011 · Cited by 632 · see citing works
The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains
Chen, R., Wang, K., Yu, J., Howard, D., French, L., Chen, Z., Wen, C., & Xu, Z. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.573095 · Cited by 562 · see citing works
Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles
Saint-Pol, J., Gosselet, F., Duban-Deweer, S., Pottiez, G., & Karamanos, Y. (2020) · Cells · doi:10.3390/cells9040851 · Cited by 503 · see citing works
Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain
Kisler, K., Nelson, A. R., Rege, S. V., Ramanathan, A., Wang, Y., Ahuja, A., Lazic, D., Tsai, P. S., Zhao, Z., Zhou, Y., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4489 · Cited by 497 · see citing works
Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease
Yamazaki, Y., & Kanekiyo, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091965 · Cited by 451 · see citing works
Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke
Hu, X., Silva, T. M. D., Chen, J., & Faraci, F. M. (2017) · Circulation Research · doi:10.1161/circresaha.116.308427 · Cited by 444 · see citing works
Neuronal regulation of the blood–brain barrier and neurovascular coupling
Kaplan, L., Chow, B. W., & Gu, C. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0322-2 · Cited by 431 · see citing works
Gut Microbiota Interact With the Brain Through Systemic Chronic Inflammation: Implications on Neuroinflammation, Neurodegeneration, and Aging
Mou, Y., Du, Y., Zhou, L., Yue, J., Hu, X., Liu, Y., Chen, S., Lin, X., Zhang, G., Xiao, H., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.796288 · Cited by 432 · see citing works
Microvascular Dysfunction in Diabetes Mellitus and Cardiometabolic Disease
Horton, W. B., & Barrett, E. J. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa025 · Cited by 441 · see citing works
Drug delivery to the central nervous system
Nance, E. A., Pun, S. H., Saigal, R., & Sellers, D. L. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00394-w · Cited by 436 · see citing works
Pericytes and Neurovascular Function in the Healthy and Diseased Brain
Brown, L. S., Foster, C. G., Courtney, J.-M., King, N. E., Howells, D. W., & Sutherland, B. A. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00282 · Cited by 406 · see citing works
Mechanisms of Blood–Brain Barrier Protection by Microbiota-Derived Short-Chain Fatty Acids
Fock, E. M., & Parnova, R. G. (2023) · Cells · doi:10.3390/cells12040657 · Cited by 418 · see citing works
Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss
Nikolakopoulou, A. M., Montagne, A., Kisler, K., Dai, Z., Wang, Y., Huuskonen, M. T., Sagare, A. P., Lazić, D., Sweeney, M. D., Kong, P., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0434-z · Cited by 382 · see citing works
Self-citation
Regulation of blood-brain barrier integrity by microglia in health and disease: A therapeutic opportunity
Ronaldson, P. T., & Davis, T. P. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20951995 · Cited by 392 · see citing works
Brain Pericytes As Mediators of Neuroinflammation
Rustenhoven, J., Jansson, D., Smyth, L. C., & Dragunow, M. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.12.001 · Cited by 371 · see citing works
The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications
Arranz, A. M., & Strooper, B. D. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30490-3 · Cited by 348 · see citing works
RETRACTED ARTICLE: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system
Montagne, A., Nikolakopoulou, A. M., Zhao, Z., Sagare, A. P., Si, G., Lazic, D., Barnes, S. R., Daianu, M., Ramanathan, A., Go, A., et al. (2018) · Nature Medicine · doi:10.1038/nm.4482 · Cited by 344 · see citing works
Retracted
Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease
Inoue, Y., Shue, F., Bu, G., & Kanekiyo, T. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00640-5 · Cited by 356 · see citing works
Myeloid Cells in the Central Nervous System
Herz, J., Filiano, A. J., Wiltbank, A. T., Yogev, N., & Kipnis, J. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.007 · Cited by 332 · see citing works
Mechanisms of Blood–Brain Barrier Dysfunction in Traumatic Brain Injury
Cash, A., & Theus, M. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093344 · Cited by 324 · see citing works
The Translational Significance of the Neurovascular Unit
McConnell, H. L., Kersch, C. N., Woltjer, R. L., & Neuwelt, E. A. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.760215 · Cited by 314 · see citing works
Mechanisms of cytokine release syndrome and neurotoxicity of CAR T-cell therapy and associated prevention and management strategies
Xiao, X., Huang, S., Chen, S., Wang, Y., Sun, Q., Xu, X., & Li, Y. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02148-6 · Cited by 326 · see citing works
Blood-Brain Barrier Overview: Structural and Functional Correlation
Alahmari, A. (2021) · Neural Plasticity · doi:10.1155/2021/6564585 · Cited by 299 · see citing works
Healthy aging and the blood–brain barrier
Banks, W. A., Reed, M. J., Logsdon, A. F., Rhea, E. M., & Erickson, M. A. (2021) · Nature Aging · doi:10.1038/s43587-021-00043-5 · Cited by 293 · see citing works
Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
Ma, Q., Zhao, Z., Sagare, A. P., Wu, Y., Wang, M., Owens, N. C., Verghese, P. B., Herz, J., Holtzman, D. M., & Zlokovic, B. V. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0286-0 · Cited by 281 · see citing works
Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy
Peng, X., Luo, Z., He, S., Zhang, L., & Li, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.768108 · Cited by 271 · see citing works
Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance
Rhea, E. M., & Banks, W. A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00521 · Cited by 263 · see citing works
Bridging barriers: a comparative look at the blood–brain barrier across organismsPreprint
O’Brown, N. M., Pfau, S. J., & Gu, C. (2018) · Genes & Development · doi:10.1101/gad.309823.117 · Cited by 261 · see citing works
Blood–Brain Barrier Breakdown: An Emerging Biomarker of Cognitive Impairment in Normal Aging and Dementia
Hussain, B., Fang, C., & Chang, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.688090 · Cited by 251 · see citing works
Fatigue, Sleep, and Autoimmune and Related Disorders
Zielinski, M. R., Systrom, D. M., & Rose, N. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01827 · Cited by 266 · see citing works
Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration
Li, R., Li, D.-H., Zhang, H., Wang, J., Li, X., & Xiao, J. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0338-1 · Cited by 256 · see citing works
A spatially resolved single-cell genomic atlas of the adult human breast
Kumar, T., Nee, K., Wei, R., He, S., Nguyen, Q., Bai, S., Blake, K., Pein, M., Gong, Y., Sei, E., et al. (2023) · Nature · doi:10.1038/s41586-023-06252-9 · Cited by 250 · see citing works
A Novel Transwell Blood Brain Barrier Model Using Primary Human Cells
Stone, N. L., England, T. J., & O’Sullivan, S. E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00230 · Cited by 251 · see citing works
Markers for human brain pericytes and smooth muscle cells
Smyth, L. C. D., Rustenhoven, J., Scotter, E. L., Schweder, P. M., Faull, R. L. M., Park, T., & Dragunow, M. (2018) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2018.06.001 · Cited by 248 · see citing works
Targeting pericytes for therapeutic approaches to neurological disorders
Cheng, J., Korte, N., Nortley, R., Sethi, H., Tang, Y., & Attwell, D. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1893-0 · Cited by 242 · see citing works
Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia
Uemura, M. T., Maki, T., Ihara, M., Lee, V. M. ‐., & Trojanowski, J. Q. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00080 · Cited by 239 · see citing works
Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain
Berthiaume, A.-A., Grant, R. I., McDowell, K. P., Underly, R. G., Hartmann, D. A., Levy, M., Bhat, N. R., & Shih, A. Y. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.016 · Cited by 223 · see citing works
Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson’s disease-like neurodegeneration by causing energy metabolism disorders in mice
Liang, B., Huang, Y., Zhong, Y., Li, Z., Ye, R., Wang, B., Zhang, B., Meng, H., Lin, X., Du, J., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128459 · Cited by 245 · see citing works
Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop
Zloković, B. V., Gottesman, R. F., Bernstein, K. E., Seshadri, S. S., McKee, A. C., Snyder, H. M., Greenberg, S. M., Yaffe, K. S., Schaffer, C. B., Yuan, C., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12157 · Cited by 241 · see citing works
Cognitive impact of COVID-19: looking beyond the short term
Miners, J. S., Kehoe, P. G., & Love, S. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00744-w · Cited by 248 · see citing works
Impairment of pericyte-endothelium crosstalk leads to blood-brain barrier dysfunction following traumatic brain injury
Bhowmick, S., D’Mello, V., Caruso, D., Wallerstein, A., & Muneer, P. M. A. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.03.014 · Cited by 223 · see citing works
PDGFRβ Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2
Duan, L., Zhang, X., Miao, W., Sun, Y., Xiong, G., Wu, Q.-Z., Li, G., Yang, P., Yu, H., Li, H., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.030 · Cited by 210 · see citing works
Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke
Patabendige, A., Singh, A., Jenkins, S. I., Sen, J., & Chen, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084280 · Cited by 216 · see citing works
CD146 coordinates brain endothelial cell–pericyte communication for blood–brain barrier development
Chen, J., Luo, Y., Hui, H., Cai, T., Huang, H., Yang, F., Feng, J., Zhang, J., & Yan, X. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710848114 · Cited by 212 · see citing works
Intracellular transport and regulation of transcytosis across the blood–brain barrier
Villaseñor, R., Lampe, J., Schwaninger, M., & Collin, L. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2982-x · Cited by 210 · see citing works
The energetic brain—A review from students to students
Bordone, M. P., Salman, M. M., Titus, H. E., Amini, E., Andersen, J. V., Chakraborti, B., Diuba, A. V., Dubouskaya, T. G., Ehrke, E., Espindola de Freitas, A., et al. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14829 · Cited by 205 · see citing works
Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss
Mäe, M. A., He, L., Nordling, S., Vázquez-Liébanas, E., Nahar, K., Jung, B., Li, X., Tan, B. C., Foo, J. C., Cazenave‐Gassiot, A., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.317473 · Cited by 203 · see citing works
Brain arteriolosclerosis
Blevins, B. L., Vinters, H. V., Love, S., Wilcock, D. M., Grinberg, L. T., Schneider, J. A., Kalaria, R. N., Katsumata, Y., Gold, B. T., Wang, D. J. J., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02235-6 · Cited by 204 · see citing works
Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier
Li, J., Zheng, M., Shimoni, O., Banks, W. A., Bush, A. I., Gamble, J. R., & Shi, B. (2021) · Advanced Science · doi:10.1002/advs.202101090 · Cited by 202 · see citing works
The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis
Zhang, Q., Abdo, R., Iosef, C., Kaneko, T., Cecchini, M. J., Han, V. K. M., & Li, S. S. ‐. (2022) · Nature Communications · doi:10.1038/s41467-022-33365-y · Cited by 202 · see citing works
Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions
Erickson, M. A., & Banks, W. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071632 · Cited by 192 · see citing works
Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin
Kim, H., Leng, K., Park, J., Sorets, A. G., Kim, S., Shostak, A., Embalabala, R. J., Mlouk, K., Katdare, K. A., Rose, I. V. L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34412-4 · Cited by 201 · see citing works
Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases
Chen, T., Dai, Y., Hu, C., Lin, Z., Wang, S., Yang, J., Zeng, L., Li, S., & Li, W. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-024-00557-1 · Cited by 201 · see citing works
Alzheimer’s Disease: The Link Between Amyloid-β and Neurovascular Dysfunction
Solis, E., Hascup, K. N., & Hascup, E. R. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200473 · Cited by 186 · see citing works
Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation
Chow, B. W., & Gu, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.043 · Cited by 177 · see citing works
Bone Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Recovery Following Spinal Cord Injury via Improvement of the Integrity of the Blood-Spinal Cord Barrier
Lu, Y., Zhou, Y., Zhang, R., Wen, L., Wu, K., Li, Y., Yao, Y., Duan, R., & Jia, Y. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00209 · Cited by 177 · see citing works
Vascular contributions to Alzheimer's disease
Eisenmenger, L. B., Peret, A., Famakin, B. M., Spahic, A., Roberts, G. S., Bockholt, J. H., Johnson, K. M., & Paulsen, J. S. (2022) · Translational research · doi:10.1016/j.trsl.2022.12.003 · Cited by 179 · see citing works
Challenges in the Treatment of Glioblastoma: Multisystem Mechanisms of Therapeutic Resistance
Noch, E., Ramakrishna, R. R., & Magge, R. (2018) · World Neurosurgery · doi:10.1016/j.wneu.2018.04.022 · Cited by 174 · see citing works
Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction
Jiang, Q. L., Liu, C., Li, C., Xu, S., Yao, M.-D., Ge, H., Sun, Y., Li, X., Zhang, S., Shan, K. Y., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci123353 · Cited by 173 · see citing works
CD146, from a melanoma cell adhesion molecule to a signaling receptor
Wang, Z., Xu, Q., Zhang, N., Du, X., Xu, G., & Yan, X. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00259-8 · Cited by 178 · see citing works
Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity
Navarro, R., Compte, M., Álvarez‐Vallina, L., & Sanz, L. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00480 · Cited by 172 · see citing works
Shaping the brain vasculature in development and disease in the single-cell era
Wälchli, T., Bisschop, J., Carmeliet, P., Zadeh, G. M., Monnier, P. P., Bock, K. D., & Radovanovic, I. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00684-y · Cited by 163 · see citing works
Biomaterials and 3D Bioprinting Strategies to Model Glioblastoma and the Blood–Brain Barrier
Tang, M., Rich, J. N., & Chen, S. (2020) · Advanced Materials · doi:10.1002/adma.202004776 · Cited by 163 · see citing works
The extracellular matrix of the blood–brain barrier: structural and functional roles in health, aging, and Alzheimer’s disease
Reed, M. J., Damodarasamy, M., & Banks, W. A. (2019) · Tissue Barriers · doi:10.1080/21688370.2019.1651157 · Cited by 158 · see citing works
Glial Connexins and Pannexins in the Healthy and Diseased Brain
Giaume, C., Naus, C. C., Sáez, J. C., & Leybaert, L. (2021) · Physiological Reviews · doi:10.1152/physrev.00043.2018 · Cited by 154 · see citing works
A human three-dimensional neural-perivascular ‘assembloid’ promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology
Wang, L., Sievert, D., Clark, A. E., Lee, S., Federman, H. G., Gastfriend, B. D., Shusta, E. V., Palecek, S. P., Carlin, A. F., & Gleeson, J. G. (2021) · Nature Medicine · doi:10.1038/s41591-021-01443-1 · Cited by 156 · see citing works
Angiogenesis in the ischemic core: A potential treatment target?
Kanazawa, M., Takahashi, T., Ishikawa, M., Onodera, O., Shimohata, T., & del Zoppo, G. J. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19834158 · Cited by 152 · see citing works
Interactions of SARS-CoV-2 with the Blood–Brain Barrier
Erickson, M. A., Rhea, E. M., Knopp, R. C., & Banks, W. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052681 · Cited by 150 · see citing works
Focusing on claudin-5: A promising candidate in the regulation of BBB to treat ischemic stroke
Lv, J., Hu, W., Yang, Z., Li, T., Jiang, S., Ma, Z., Chen, F., & Yang, Y. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.12.001 · Cited by 148 · see citing works
In vitro modeling of the neurovascular unit: advances in the field
Bhalerao, A., Sivandzade, F., Archie, S. R., Chowdhury, E. A., Noorani, B., & Cucullo, L. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00183-7 · Cited by 148 · see citing works
A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke
Lyu, Z., Park, J., Kim, K., Jin, H.-J., Wu, H., Rajadas, J., Kim, D., Steinberg, G. K., & Lee, W. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00744-7 · Cited by 148 · see citing works
Postnatal development of cerebrovascular structure and the neurogliovascular unit
Coelho‐Santos, V., & Shih, A. Y. (2019) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.363 · Cited by 147 · see citing works
Macroautophagy in CNS health and disease
Griffey, C. J., & Yamamoto, A. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00588-3 · Cited by 144 · see citing works
Benchmarking in vitro tissue-engineered blood–brain barrier models
DeStefano, J. G., Jamieson, J. J., Linville, R. M., & Searson, P. C. (2018) · Fluids and Barriers of the CNS · doi:10.1186/s12987-018-0117-2 · Cited by 142 · see citing works
Current and emerging avenues for Alzheimer's disease drug targets
Loera‐Valencia, R., Cedazo-Mı́nguez, Á., Kenigsberg, P.-A., Page, G., Duarte, A. I., Giusti, P., Zusso, M., Robert, P. H., Frisoni, G. B., Cattaneo, A., et al. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12959 · Cited by 139 · see citing works
β-amyloid protein induces mitophagy-dependent ferroptosis through the CD36/PINK/PARKIN pathway leading to blood–brain barrier destruction in Alzheimer’s disease
Li, J., Li, M., Ge, Y., Chen, J., Ma, J., Wang, C., Sun, M., Wang, L., Yao, S., & Yao, C. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00807-5 · Cited by 144 · see citing works
Serum-borne bioactivity caused by pulmonary multiwalled carbon nanotubes induces neuroinflammation via blood–brain barrier impairment
Aragon, M. J., Topper, L. A., Steadman, C. R., Sanchez, B., Zychowski, K. E., Young, T. L., Herbert, G., Hall, P. R., Erdely, A., Eye, T., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616070114 · Cited by 138 · see citing works
Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure
Berthiaume, A., Schmid, F., Stamenković, S., Coelho‐Santos, V., Nielson, C. D., Weber, B., Majesky, M. W., & Shih, A. Y. (2022) · Nature Communications · doi:10.1038/s41467-022-33464-w · Cited by 136 · see citing works
Microvascular Mural Cell Organotypic Heterogeneity and Functional Plasticity
Holm, A., Heumann, T., & Augustin, H. G. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.12.002 · Cited by 133 · see citing works
Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development
van Lessen, M., Shibata-Germanos, S., van Impel, A., Hawkins, T. A., Rihel, J., & Schulte‐Merker, S. (2017) · eLife · doi:10.7554/elife.25932 · Cited by 134 · see citing works
Pericytes in Microvessels: From “Mural” Function to Brain and Retina Regeneration
Caporarello, N., D’Angeli, F., Cambria, M. T., Candido, S., Giallongo, C., Salmeri, M., Lombardo, C., Longo, A., Giurdanella, G., Anfuso, C. D., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246351 · Cited by 135 · see citing works
Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice
Sun, J., Huang, Y., Gong, J., Wang, J., Fan, Y., Cai, J., Wang, Y., Qiu, Y., Wei, Y., Xiong, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19042-y · Cited by 135 · see citing works
Reductions in brain pericytes are associated with arteriovenous malformation vascular instability
Winkler, E. A., Birk, H. S., Burkhardt, J., Chen, X., Yue, J. K., Guo, D. E., Rutledge, C., Lasker, G. F., Partow, C. P., Tihan, T., et al. (2018) · Journal of neurosurgery · doi:10.3171/2017.6.jns17860 · Cited by 134 · see citing works
Recent advances in drug delivery and targeting to the brain
Sethi, B., Kumar, V., Mahato, K., Coulter, D. W., & Mahato, R. I. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.051 · Cited by 134 · see citing works
PDGF/PDGFR axis in the neural systems
Sil, S., Periyasamy, P., Thangaraj, A., Chivero, E. T., & Buch, S. J. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.01.006 · Cited by 134 · see citing works
Separating vascular and neuronal effects of age on fMRI BOLD signals
Tsvetanov, K. A., Henson, R. N., & Rowe, J. B. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0631 · Cited by 127 · see citing works
Biomaterials for Bioprinting Microvasculature
Barrs, R. W., Jia, J., Silver, S. E., Yost, M. J., & Mei, Y. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00027 · Cited by 133 · see citing works

The Complex and Integral Roles of Pericytes Within the Neurovascular Unit in Health and Disease
Sutherland, B. A. (2021) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-030-62129-2_2 · Cited by 2 · see citing works
Emerging Roles of Pericytes in the Regulation of the Neurovascular Unit in Health and Disease
Hill, J. D., Rom, S., Ramirez, S. H., & Persidsky, Y. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9557-x · Cited by 134 · see citing works
Microvascular pericytes in brain-associated vascular disease
Liu, Q., Yang, Y., & Fan, X. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109633 · Cited by 45 · see citing works
What Are the Roles of Pericytes in the Neurovascular Unit and Its Disorders?
Benarroch, E. E. (2023) · Neurology · doi:10.1212/wnl.0000000000207379 · Cited by 53 · see citing works
[Pericytes of the Nervous System: Physiological and Pathological Role].
Shimizu, F., & Kanda, T. (2020) · PubMed · doi:10.11477/mf.1416201495 · Cited by 4 · see citing works

Authors: Sweeney, M. D., Ayyadurai, S., & Zlokovic, B. V.
Affiliations: University of Southern California (US)
ORCID: Sweeney, Melanie D
Zlokovic, Berislav V
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2016-05-26
Volume: 19
Issue: 6
Pages: 771-783
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.4288
PMC: PMC5745011
OpenAlex: W2399776559
Cited by: 1,125
References: 175
Citations by year: 2026: 108 · 2025: 113 · 2024: 140 · 2023: 121 · 2022: 132 · 2021: 127 · 2020: 123 · 2019: 89 · 2018: 92 · 2017: 67 · 2016: 13
FWCI: 7.63
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG023084, R01AG039452, RF1AG039452)
National Institute of Neurological Disorders and Stroke (R01NS090904, R01NS034467)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: pericytes, neurovascular unit, signaling pathways, blood-brain barrier permeability, angiogenesis, capillary hemodynamics, neuroinflammation, stem cell activity, Alzheimer's disease, brain tumors, central nervous system disorders
MeSH terms: Animals, Blood-Brain Barrier, Brain, Brain Diseases, Cerebrovascular Circulation, Humans, Signal Transduction, Pericytes, Microvessels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pericytes of the neurovascular unit: key functions and signaling pathways

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks