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Cited by 205

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like Behaviors through Reduced Secretion of FGF2

Open access
Birey, Fikri, Kloc, Michelle, Chavali, Manideep, Hussein, Israa, Wilson, Michael, Christoffel, Daniel J., Chen, Tony, Frohman, Michael A., Robinson, John K., Russo, Scott J., Maffei, Arianna, Aguirre, Adan·2015·Neuron
DOI 10.1016/j.neuron.2015.10.046
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Abstract

SUMMARY NG2-expressing glia (NG2 glia) are a uniformly distributed and mitotically active pool of cells in the central nervous system (CNS). In addition to serving as progenitors of myelinating oligodendrocytes, NG2 glia might also fulfill physiological roles in CNS homeostasis, although the mechanistic nature of such roles remains unclear. Here, we report that ablation of NG2 glia in the prefrontal cortex (PFC) of the adult brain causes deficits in excitatory glutamatergic neurotransmission and astrocytic extracellular glutamate uptake and induces depressive-like behaviors in mice. We show in parallel that chronic social stress causes NG2 glia density to decrease in areas critical to Major Depressive Disorder (MDD) pathophysiology at the time of symptom emergence in stress-susceptible mice. Finally, we demonstrate that loss of NG2 glial secretion of fibroblast growth factor 2 (FGF2) suffices to induce the same behavioral deficits. Our findings outline a pathway and role for NG2 glia in CNS homeostasis and mood disorders.

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Metadata

Authors
Birey, F., Kloc, M., Chavali, M., Hussein, I., Wilson, M., Christoffel, D. J., Chen, T., Frohman, M. A., Robinson, J. K., Russo, S. J., Maffei, A., & Aguirre, A.
Venue
Neuron
Publisher
Elsevier BV
Published
2015-12
Volume
88
Issue
5
Pages
941-956
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2015.10.046
OpenAlex
W2176978669
Cited by
205
References
22
FWCI
5.85
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like Behaviors through Reduced Secretion of FGF2. https://app.cochat.ai/papers/10.1016/j.neuron.2015.10.046
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Birey, F., Kloc, M., Chavali, M., Hussein, I., Wilson, M., Christoffel, D. J., Chen, T., Frohman, M. A., Robinson, J. K., Russo, S. J., Maffei, A., & Aguirre, A. (2015). Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like Behaviors through Reduced Secretion of FGF2. Neuron. https://doi.org/10.1016/j.neuron.2015.10.046

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.