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NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS
Abstract
Glial progenitor cells of the developing CNS committed to the oligodendrocyte lineage (OPCs) express the chondroitin sulfate proteoglycan, NG2. A proportion of OPCs fail to differentiate past the stage at which they express NG2 and the lipid antigen O4 and persist in the adult CNS in a phenotypically immature form. However, the physiological function of NG2(+) cells in the adult CNS is unknown. Using antibodies against NG2 we show that NG2 is expressed by a distinct cell population in the mature CNS with the homogeneous antigenic phenotype of oligodendrocyte progenitors. The morphology of NG2(+) OPCs varies from region to region, reflecting the different structural environments, but they appear to represent a homogeneous population within any one gray or white matter region. A study of nine CNS regions showed that NG2(+) OPCs are numerous throughout the CNS and numbers in the white matter are only 1.5 times that in the gray. Whereas the ratio of OPCs to myelinating oligodendrocytes in the spinal cord gray and white matter approximates 1:4, gray matter regions of the forebrain have a 1:1 ratio, a phenomenon that will have consequences for oligodendrocyte replacement following demyelination. BrdU incorporation experiments showed that NG2(+) cells are the major dividing cell population of the adult rat CNS. Since very little apoptosis was detected and BrdU became increasingly present in oligodendrocytes after a 10-day pulse chase, with a concomitant decrease in NG2(+) BrdU incorporating cells, we suggest that the size of the oligodendrocyte population may actually increase during adult life.
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The adult mammalian CNS is known to harbor significant numbers of oligodendrocyte precursor cells in white matter.
“The adult mammalian CNS is known to harbor significant numbers of oligodendrocyte precursor cells in white matter”
From Preclinical biodistribution, tropism, and efficacy of oligotropic AAV/Olig001 in a mouse model of congenital white matter disease (2021) · cites this paper as [16]
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Metadata
- Authors
- Dawson, M.
- Affiliations
- Charing Cross Hospital (GB)
- Corresponding author
- Dawson, M
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 24
- Issue
- 2
- Pages
- 476-488
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W1985286185
- Cited by
- 927
- References
- 43
- Citations by year
- 2026: 25 · 2025: 27 · 2024: 56 · 2023: 54 · 2022: 38 · 2021: 71 · 2020: 57 · 2019: 46 · 2018: 51 · 2017: 59 · 2016: 40 · 2015: 48 · 2014: 43 · 2013: 52 · 2012: 28
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- NG2, oligodendrocyte precursor cells, cell cycling, oligodendrocyte lineage, myelination, demyelination, white matter, gray matter, BrdU incorporation, apoptosis, O4, chondroitin sulfate proteoglycans
- MeSH terms
- Chondroitin Sulfate Proteoglycan 4, Animals, Antigens, Cell Cycle, Central Nervous System, Gene Expression Regulation, Male, Neuroglia, Proteoglycans, Stem Cells, Rats, Sprague-Dawley, Rats
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