The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Cross-Modality Sharpening of Visual Cortical Processing through Layer-1-Mediated Inhibition and Disinhibition
Open accessAbstract
Summary Cross-modality interaction in sensory perception is advantageous for animals’ survival. How cortical sensory processing is cross-modally modulated and what are the underlying neural circuits remain poorly understood. In mouse primary visual cortex (V1), we discovered that orientation selectivity of layer (L)2/3 but not L4 excitatory neurons was sharpened in the presence of sound or optogenetic activation of projections from primary auditory cortex (A1) to V1. The effect was manifested by decreased average visual responses yet increased responses at the preferred orientation. It was more pronounced at lower visual contrast, and was diminished by suppressing L1 activity. L1 neurons were strongly innervated by A1-V1 axons and excited by sound, while visual responses of L2/3 vasoactive intestinal peptide (VIP) neurons were suppressed by sound, both preferentially at the cell's preferred orientation. These results suggest that the cross-modality modulation is achieved primarily through L1 neuron and L2/3 VIP-cell mediated inhibitory and disinhibitory circuits.
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Cites
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Cited by
Four Unique Interneuron Populations Reside in Neocortical Layer 1
Schuman, B., Machold, R. P., Hashikawa, Y., Fuzik, J., Fishell, G. J., & Rudy, B. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1613-18.2018 · Cited by 184
“Although the precise composition of L1 INs has been difficult to establish (Table 1), there is evidence that they are direct targets of L1 projections and are important for processing long-range inputs (Letzkus et al., 2011; Cruikshank et al., 2012; Palmer et al., 2012; Ibrahim et al., 2016).”
BackgroundLaminar fMRI: applications for cognitive neuroscience
Lawrence, S. J. D., Formisano, E., Muckli, L., & de Lange, F. P. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2017.07.004 · Cited by 186
Neocortical Layer 1: an elegant solution to top-down and bottom-up integration
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Mechanisms of Homeostatic Synaptic Plasticity in vivo
Lee, H.-K., & Kirkwood, A. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00520 · Cited by 101
Call, C. L., & Bergles, D. E. (2021) · Nature Communications · doi:10.1038/s41467-021-25035-2 · Cited by 95
Metadata
- Authors
- Ibrahim, L. A., Mesik, L., Ji, X.-Y., Fang, Q., Li, H.-F., Li, Y.-T., Zingg, B., Zhang, L. I., & Tao, H. W.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 89
- Issue
- 5
- Pages
- 1031-1045
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2278347664
- Cited by
- 299
- References
- 82
- FWCI
- 37.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ibrahim, L. A., Mesik, L., Ji, X.-Y., Fang, Q., Li, H.-F., Li, Y.-T., Zingg, B., Zhang, L. I., & Tao, H. W. (2016). Cross-Modality Sharpening of Visual Cortical Processing through Layer-1-Mediated Inhibition and Disinhibition. Neuron. https://doi.org/10.1016/j.neuron.2016.01.027
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