The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Physiological Properties and Behavioral Correlates of Hippocampal Granule Cells and Mossy Cells
Open accessAbstract
Summary The hippocampal dentate gyrus is often viewed as a segregator of upstream information. Physiological support for such function has been hampered by a lack of well-defined characteristics that can identify granule cells and mossy cells. We developed an electrophysiology-based classification of dentate granule cells and mossy cells in mice that we validated by optogenetic tagging of mossy cells. Granule cells exhibited sparse firing, had a single place field, and showed only modest changes when the mouse was tested in different mazes in the same room. In contrast, mossy cells were more active, had multiple place fields and showed stronger remapping of place fields under the same conditions. Although granule cell-mossy cell synapse was strong and facilitating, mossy cells rarely ‘inherited’ place fields from single granule cells. Our findings suggest that the granule cells and mossy cells could be modulated separately and their joint action may be critical for pattern separation.
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Cites
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“Histological verification of the electrode tip in the granule cell layer is often used as an argument for granule cell identity (Buzsáki et al., 1983; Jung and McNaughton, 1993; Leutgeb et al., 2007).”
MethodInfluentialThe effects of changes in the environment on the spatial firing of hippocampal complex-spike cells
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Cited by
Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories
Hainmueller, T., & Bartos, M. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0260-z · Cited by 506
Functionally Distinct Neuronal Ensembles within the Memory Engram
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Breathing coordinates cortico-hippocampal dynamics in mice during offline states
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Neural correlates of sparse coding and dimensionality reduction
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Metadata
- Authors
- Senzai, Y., & Buzsáki, G.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 93
- Issue
- 3
- Pages
- 691-704.e5
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2581980900
- Cited by
- 328
- References
- 95
- FWCI
- 17.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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