The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Functionally Distinct Neuronal Ensembles within the Memory Engram
Open accessAbstract
Summary: Memories are believed to be encoded by sparse ensembles of neurons in the brain. However, it remains unclear whether there is functional heterogeneity within individual memory engrams, i.e., if separate neuronal subpopulations encode distinct aspects of the memory and drive memory expression differently. Here we show that contextual fear memory engrams in the mouse dentate gyrus contain functionally distinct neuronal ensembles, genetically defined by the Fos- or Npas4-dependent transcriptional pathways. The Fos-dependent ensemble promotes memory generalization and receives enhanced excitatory synaptic inputs from the medial entorhinal cortex, which we find itself also mediates generalization. The Npas4-dependent ensemble promotes memory discrimination and receives enhanced inhibitory drive from local cholecystokinin-expressing interneurons, the activity of which is required for discrimination. Our study provides causal evidence for functional heterogeneity within the memory engram, and reveals synaptic and circuit mechanisms used by each ensemble to regulate the memory discrimination-generalization balance.
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Optogenetic stimulation of a hippocampal engram activates fear memory recall
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Forgetting as a form of adaptive engram cell plasticity
Ryan, T. J., & Frankland, P. W. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00548-3 · Cited by 182
Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory
Sun, W., Liu, Z., Jiang, X., Chen, M. B., Dong, H., Liu, J., Südhof, T. C., & Quake, S. R. (2024) · Nature · doi:10.1038/s41586-023-07011-6 · Cited by 165
Marco, A., Meharena, H. S., Dileep, V., Raju, R. M., Davila-Velderrain, J., Zhang, A. L., Adaikkan, C., Young, J. Z., Gao, F., Kellis, M., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00717-0 · Cited by 159
Hippocampal-amygdala memory circuits govern experience-dependent observational fear
Terranova, J. I., Yokose, J., Osanai, H., Marks, W. D., Yamamoto, J., Ogawa, S. K., & Kitamura, T. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.019 · Cited by 117
Metadata
- Authors
- Sun, X., Bernstein, M. J., Meng, M., Rao, S., Sørensen, A. T., Yao, L., Zhang, X., Anikeeva, P. O., & Lin, Y.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 181
- Issue
- 2
- Pages
- 410-423.e17
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W3011353299
- Cited by
- 269
- References
- 98
- FWCI
- 15.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sun, X., Bernstein, M. J., Meng, M., Rao, S., Sørensen, A. T., Yao, L., Zhang, X., Anikeeva, P. O., & Lin, Y. (2020). Functionally Distinct Neuronal Ensembles within the Memory Engram. Cell. https://doi.org/10.1016/j.cell.2020.02.055
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