Pattern separation in the hippocampus

Yassa, Michael A.; Stark, Craig E.L.

doi:10.1016/j.tins.2011.06.006

Cited by 1,544Memory and Neural MechanismsNeurogenesis and neuroplasticity mechanismsMemory Processes and Influences

Pattern separation in the hippocampus

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Yassa, Michael A., Stark, Craig E.L.·2011·Trends in Neurosciences

DOI 10.1016/j.tins.2011.06.006PMC PMC3183227

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Abstract

The ability to discriminate among similar experiences is a crucial feature of episodic memory. This ability has long been hypothesized to require the hippocampus, and computational models suggest that it is dependent on pattern separation. However, empirical data for the role of the hippocampus in pattern separation have not been available until recently. This review summarizes data from electrophysiological recordings, lesion studies, immediate-early gene imaging, transgenic mouse models, as well as human functional neuroimaging, that provide convergent evidence for the involvement of particular hippocampal subfields in this key process. We discuss the impact of aging and adult neurogenesis on pattern separation, and also highlight several challenges to linking across species and approaches, and suggest future directions for investigation.

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Mossy fiber "detonator" synapses arising from DG granule cells strongly activate the CA3 region and are involved in a variety of neurological functions, including memory and spatial representations.
“Mossy fiber “detonator” synapses arising from DG granule cells strongly activate the CA3 region and are involved in a variety of neurological functions, including memory and spatial representations [6], [64].”
From Arf4 Determines Dentate Gyrus-Mediated Pattern Separation by Regulating Dendritic Spine Development (2012) · cites this paper as [6]
The ability to discriminate among similar experiences is a crucial feature of episodic memory.
“Additionally, the ability to discriminate among similar experiences is a crucial feature of episodic memory [127].”
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“A process known as pattern separation [G] 65,66 keeps cognitive maps and gists distinct from one another, but they can work in concert with schemas to aid in navigation 38 .”
From From cognitive maps to spatial schemas (2023) · cites this paper as [66]
The hippocampus, and particularly the dentate gyrus, is crucial in selecting and separating similar events in space and time.
“Also, the hippocampus, and particularly the DG, is crucial in selecting and separating similar events in space and time, and hence pattern separation is a main function attributed to the hippocampus (Yassa and Stark, 2011; Oomen et al., 2013, 2014).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Yassa and Stark, 2011
Pattern separation is a main function attributed to the hippocampus.
“Also, the hippocampus, and particularly the DG, is crucial in selecting and separating similar events in space and time, and hence pattern separation is a main function attributed to the hippocampus (Yassa and Stark, 2011; Oomen et al., 2013, 2014).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Yassa and Stark, 2011

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Authors: Yassa, M. A., & Stark, C. E. L.
Affiliations: Johns Hopkins University (US)
University of California, Irvine (US)
Corresponding author: Yassa, Michael A.
Stark, Craig E.L.
ORCID: Yassa, Michael A.
Stark, Craig E.L.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2011-10
Volume: 34
Issue: 10
Pages: 515-525
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2011.06.006
PMC: PMC3183227
OpenAlex: W2105089471
Cited by: 1,544
References: 113
Citations by year: 2026: 137 · 2025: 133 · 2024: 140 · 2023: 126 · 2022: 138 · 2021: 134 · 2020: 114 · 2019: 90 · 2018: 108 · 2017: 101 · 2016: 77 · 2015: 83 · 2014: 74 · 2013: 50 · 2012: 33
FWCI: 4.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG034613)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: pattern separation, hippocampus, episodic memory, hippocampal subfields, aging, adult neurogenesis, lesion studies, electrophysiology, immediate early genes, transgenic mouse model, functional neuroimaging
MeSH terms: Animals, Electrophysiology, Hippocampus, Humans, Memory, Models, Neurological, Nerve Net, Genes, Immediate-Early, Functional Neuroimaging

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