The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors
Open accessAbstract
Summary Basolateral amygdala (BLA) principle cells are capable of driving and antagonizing behaviors of opposing valence. BLA neurons project to the central amygdala (CeA), which also participates in negative and positive behaviors. However, the CeA has primarily been studied as the site for negative behaviors and the causal role for CeA circuits underlying appetitive behaviors is poorly understood. Here we identified several genetically distinct populations of CeA neurons that mediate appetitive behaviors and dissected the BLA to CeA circuit for appetitive behaviors. Protein phosphatase 1 regulatory subunit 1B+ BLA pyramidal neurons to dopamine receptor 1+ CeA neurons define a pathway for promoting appetitive behaviors, while R-spondin 2+ BLA pyramidal neurons to dopamine receptor 2+ CeA neurons define a pathway for suppressing appetitive behaviors. These data reveal genetically defined neural circuits in the amygdala that promote and suppress appetitive behaviors analogous to the direct and indirect pathway of the basal ganglia.
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Cited by
Initiative, A. N. G., Watson, H. J., Eating Disorders Working Group of the Psychiatric Genomics Consortium, Yilmaz, Z., Thornton, L. M., Hübel, C., Coleman, J. R. I., Gaspar, H. A., Bryois, J., Hinney, A., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0439-2 · Cited by 1,109
Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man
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Overlapping Brain Circuits for Homeostatic and Hedonic Feeding
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Neuromodulation by the immune system: a focus on cytokines
Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389
“Liking” and “wanting” in eating and food reward: Brain mechanisms and clinical implications
Morales, I., & Berridge, K. C. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113152 · Cited by 346
Metadata
- Authors
- Kim, J., Zhang, X., Muralidhar, S., LeBlanc, S. A., & Tonegawa, S.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 93
- Issue
- 6
- Pages
- 1464-1479.e5
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2602799162
- Cited by
- 458
- References
- 70
- FWCI
- 24.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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