DREADDs for neuroscientists

Crystal structure of the β2 adrenergic receptor–Gs protein complex

Rasmussen, S. G. F., DeVree, B. T., Zou, Y., Kruse, A. C., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., et al. (2011) · Nature · doi:10.1038/nature10361 · Cited by 3,009 · see citing works

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

DeLÉAN, A., Munson, P. J., & Rodbard, D. (1978) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1978.235.2.e97 · Cited by 2,384 · see citing works

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046 · see citing works

Predicting new molecular targets for known drugs

Keiser, M. J., Setola, V., Irwin, J. J., Laggner, C., Abbas, A. I., Hufeisen, S. J., Jensen, N. H., Kuijer, M. B., Matos, R. C., Tran, T. B., et al. (2009) · Nature · doi:10.1038/nature08506 · Cited by 1,667 · see citing works

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

Léan, A. D., Stadel, J. M., & Lefkowitz, R. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)79672-9 · Cited by 1,619 · see citing works

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46229 · Cited by 1,578 · see citing works

β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes

Luttrell, L. M., Ferguson, S. S. G., Daaka, Y., Miller, W. E., Maudsley, S. R., Rocca, G. J. D., Lin, F., Kawakatsu, H., Owada, K. M., Luttrell, D. K., et al. (1999) · Science · doi:10.1126/science.283.5402.655 · Cited by 1,473 · see citing works

β-Arrestins and Cell Signaling

DeWire, S. M., Ahn, S., Lefkowitz, R. J., & Shenoy, S. K. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.022405.154749 · Cited by 1,397 · see citing works

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

Samama, P., Cotecchia, S., Costa, T., & Lefkowitz, R. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53442-6 · Cited by 1,256 · see citing works

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

Aponte, Y., Atasoy, D., & Sternson, S. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2739 · Cited by 1,157 · see citing works

A chemical switch for inhibitor-sensitive alleles of any protein kinase

Bishop, A. C., Ubersax, J. A., Petsch, D. T., Matheos, D. P., Gray, N. S., Blethrow, J. D., Shimizu, E., Tsien, J. Z., Schultz, P. G., Rose, M. D., et al. (2000) · Nature · doi:10.1038/35030148 · Cited by 1,033 · see citing works

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

Gradinaru, V., Zhang, F., Ramakrishnan, C., Mattis, J., Prakash, R., Diester, I., Goshen, I., Thompson, K. R., & Deisseroth, K. A. (2010) · Cell · doi:10.1016/j.cell.2010.02.037 · Cited by 999 · see citing works

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

Alexander, G. M., Rogan, S. C., Abbas, A. I., Armbruster, B. N., Pei, Y., Allen, J., Nonneman, R. J., Hartmann, J. F., Moy, S. S., Nicolelis, M. A. L., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.014 · Cited by 996 · see citing works

Deconstruction of a neural circuit for hunger

Atasoy, D., Betley, J. N., Su, H. H., & Sternson, S. M. (2012) · Nature · doi:10.1038/nature11270 · Cited by 969 · see citing works

Structural insights into µ-opioid receptor activation

Huang, W., Manglik, A., Venkatakrishnan, A., Laeremans, T., Feinberg, E. N., Sanborn, A. L., KATO, H. E., Livingston, K. E., Thorsen, T. S., Kling, R. C., et al. (2015) · Nature · doi:10.1038/nature14886 · Cited by 895 · see citing works

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Kruse, A. C., Ring, A. M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hübner, H., Pardon, E., Valant, C., Sexton, P. M., et al. (2013) · Nature · doi:10.1038/nature12735 · Cited by 895 · see citing works

The promise and peril of chemical probes

Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., et al. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1867 · Cited by 839 · see citing works

Automated design of ligands to polypharmacological profiles

Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X.-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., et al. (2012) · Nature · doi:10.1038/nature11691 · Cited by 832 · see citing works

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

Kang, Y., Zhou, X. E., Gao, X., He, Y., Liu, W., Ishchenko, A., Barty, A., White, T. A., Yefanov, O. M., Han, G. W., et al. (2015) · Nature · doi:10.1038/nature14656 · Cited by 804 · see citing works

The Dynamic Process of β2-Adrenergic Receptor Activation

Nygaard, R., Zou, Y., Dror, R. O., Mildorf, T. J., Arlow, D. H., Manglik, A., Pan, A. C., Liu, C. W., Fung, J. J., Bokoch, M. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.008 · Cited by 797 · see citing works

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

Kroeze, W. K., Sassano, M. F., Huang, X.-P., Lansu, K., McCorvy, J. D., Giguère, P. M., Sciaky, N., & Roth, B. L. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3014 · Cited by 755 · see citing works

Structural Features for Functional Selectivity at Serotonin Receptors

Wacker, D., Wang, C., Katritch, V., Han, G. W., Huang, X., Vardy, E., McCorvy, J. D., Jiang, Y., Chu, M., Siu, F., et al. (2013) · Science · doi:10.1126/science.1232808 · Cited by 705 · see citing works

Neurons for hunger and thirst transmit a negative-valence teaching signal

Betley, J. N., Xu, S., Cao, Z. F. H., Gong, R., Magnus, C. J., Yu, Y., & Sternson, S. M. (2015) · Nature · doi:10.1038/nature14416 · Cited by 704 · see citing works

Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling

Manglik, A., Kim, T. H., Masureel, M., Altenbach, C., Yang, Z., Hilger, D., Lerch, M. T., Kobilka, T. S., Thian, F. S., Hubbell, W. L., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.043 · Cited by 667 · see citing works

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

Urban, D. J., & Roth, B. L. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124803 · Cited by 660 · see citing works

A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping

Atasoy, D., Aponte, Y., Su, H. H., & Sternson, S. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1954-08.2008 · Cited by 614 · see citing works

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors

Choudhary, M. S., Craigo, S. C., Sibley, D. R., Roth, B. L., Monsma, F. J., Shen, Y., Uluer, A., & Meltzer, H. Y. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/74zp-ze10 · Cited by 592 · see citing works

Genetic identification of a neural circuit that suppresses appetite

Carter, M. E., Soden, M. E., Zweifel, L. S., & Palmiter, R. D. (2013) · Nature · doi:10.1038/nature12596 · Cited by 587 · see citing works

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.

Costa, T., & Herz, A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7321 · Cited by 537 · see citing works

Structural Basis for Molecular Recognition at Serotonin Receptors

Wang, C., Jiang, Y., Ma, J., Wu, H., Wacker, D., Katritch, V., Han, G. W., Liu, W., Huang, X., Vardy, E., et al. (2013) · Science · doi:10.1126/science.1232807 · Cited by 529 · see citing works

Allosteric sodium in class A GPCR signaling

Katritch, V., Fenalti, G., Abola, E. E., Roth, B. L., Cherezov, V., & Stevens, R. C. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.03.002 · Cited by 516 · see citing works

Visualization of arrestin recruitment by a G-protein-coupled receptor

Shukla, A. K., Westfield, G., Xiao, K., Reis, R. I., Huang, L.-Y., Tripathi‐Shukla, P., Qian, J. X., Li, S., Blanc, A., Oleskie, A. N., et al. (2014) · Nature · doi:10.1038/nature13430 · Cited by 510 · see citing works

Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors

Cohen, M. S., Zhang, C., Shokat, K. M., & Taunton, J. (2005) · Science · doi:10.1126/science1108367 · Cited by 509 · see citing works

Chemogenetic Tools to Interrogate Brain Functions

Sternson, S. M., & Roth, B. L. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014048 · Cited by 506 · see citing works

Molecular control of δ-opioid receptor signalling

Fenalti, G., Giguère, P. M., Katritch, V., Huang, X., Thompson, A. A., Cherezov, V., Roth, B. L., & Stevens, R. C. (2014) · Nature · doi:10.1038/nature12944 · Cited by 501 · see citing works

Chemogenetic Synaptic Silencing of Neural Circuits Localizes a Hypothalamus→Midbrain Pathway for Feeding Behavior

Stachniak, T. J., Ghosh, A., & Sternson, S. M. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.008 · Cited by 427 · see citing works

Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization

Ferguson, S. M., Eskenazi, D., Ishikawa, M., Wanat, M. J., Phillips, P. E. M., Dong, Y., Roth, B. L., & Neumaier, J. F. (2011) · Nature Neuroscience · doi:10.1038/nn.2703 · Cited by 418 · see citing works

A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse

Schnütgen, F., Doerflinger, N., Calleja, C., Wendling, O., Chambon, P., & Ghyselinck, N. B. (2003) · Nature Biotechnology · doi:10.1038/nbt811 · Cited by 401 · see citing works

Generation of a synthetic memory trace

Garner, A. R., Rowland, D. C., Hwang, S. Y., Baumgaertel, K., Roth, B. L., Kentros, C., & Mayford, M. (2012) · Science · doi:10.1126/science.1214985 · Cited by 387 · see citing works

Exogenous and evoked oxytocin restores social behavior in the <i>Cntnap2</i> mouse model of autism

Peñagarikano, O., Lázaro, M. T., Lu, X.-H., Gordon, A., Dong, H., Lam, H. A., Peles, E., Maidment, N. T., Murphy, N. P., Yang, X. W., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010257 · Cited by 378 · see citing works

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

Vardy, E., Robinson, J. E., Li, C., Olsen, R. H. J., DiBerto, J. F., Giguère, P. M., Sassano, F. M., Huang, X., Zhu, H., Urban, D. J., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.065 · Cited by 374 · see citing works

Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP

Krashes, M. J., Shah, B. P., Koda, S., & Lowell, B. B. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.009 · Cited by 373 · see citing works

Central amygdala PKC-δ+ neurons mediate the influence of multiple anorexigenic signals

Cai, H., Haubensak, W. E., Anthony, T. E., & Anderson, D. J. (2014) · Nature Neuroscience · doi:10.1038/nn.3767 · Cited by 369 · see citing works

Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition

Ray, R. S., Corcoran, A. E., Brust, R. D., Kim, J. C., Richerson, G. B., Nattie, E., & Dymecki, S. M. (2011) · Science · doi:10.1126/science.1205295 · Cited by 363 · see citing works

Discovery of β-Arrestin–Biased Dopamine D 2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

Allen, J., Yost, J. M., Setola, V., Chen, X., Sassano, M. F., Chen, M., Peterson, S. M., Yadav, P. N., Huang, X., Feng, B., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104807108 · Cited by 352 · see citing works

A chemical-genetic approach to study G protein regulation of β cell function in vivo

Guettier, J., Gautam, D., Scarselli, M., de Azúa, I. R., Li, J. H., Rosemond, E., Ma, X., Gonzalez, F. J., Armbruster, B. N., Lü, H., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906593106 · Cited by 345 · see citing works

Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking

Mahler, S. V., Vazey, E. M., Beckley, J. T., Keistler, C., McGlinchey, E. M., Kaufling, J., Wilson, S. P., Deisseroth, K. A., Woodward, J. J., & Aston‐Jones, G. (2014) · Nature Neuroscience · doi:10.1038/nn.3664 · Cited by 344 · see citing works

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

Dar, A. C., Das, T. K., Shokat, K. M., & Cagan, R. L. (2012) · Nature · doi:10.1038/nature11127 · Cited by 334 · see citing works

Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination

Lee, G., & Saito, I. (1998) · Gene · doi:10.1016/s0378-1119(98)00325-4 · Cited by 326 · see citing works

Comprehensive characterization of the Published Kinase Inhibitor Set

Elkins, J. M., Fedele, V., Szklarz, M., Abdul Azeez, K. R., Salah, E., Mikolajczyk, J., Romanov, S., Sepetov, N., Huang, X.-P., Roth, B. L., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3374 · Cited by 323 · see citing works

Ligand discovery from a dopamine D3 receptor homology model and crystal structure

Carlsson, J., Coleman, R. G., Setola, V., Irwin, J. J., Fan, H., Schlessinger, A., Šali, A., Roth, B. L., & Shoichet, B. K. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.662 · Cited by 305 · see citing works

Chemical and Genetic Engineering of Selective Ion Channel–Ligand Interactions

Magnus, C. J., Lee, P. H., Atasoy, D., Su, H. H., Looger, L. L., & Sternson, S. M. (2011) · Science · doi:10.1126/science.1206606 · Cited by 296 · see citing works

Gate control of mechanical itch by a subpopulation of spinal cord interneurons

Bourane, S., Duan, B., Koch, S. C., Dalet, A., Britz, O., Garcia-Campmany, L., Kim, E., Cheng, L., Ghosh, A., Ma, Q., et al. (2015) · Science · doi:10.1126/science.aac8653 · Cited by 296 · see citing works

Structure-based drug screening for G-protein-coupled receptors

Shoichet, B. K., & Kobilka, B. K. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.03.007 · Cited by 295 · see citing works

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

Huang, X.-P., Karpiak, J., Kroeze, W. K., Zhu, H., Chen, X., Moy, S. S., Saddoris, K. A., Nikolova, V. D., Farrell, M. S., Wang, S., et al. (2015) · Nature · doi:10.1038/nature15699 · Cited by 284 · see citing works

Fluorescent Labeling of Purified β2 Adrenergic Receptor

Gether, U., Lin, S., & Kobilka, B. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.47.28268 · Cited by 280 · see citing works

Designer receptor manipulations reveal a role of the locus coeruleus noradrenergic system in isoflurane general anesthesia

Vazey, E. M., & Aston-Jones, G. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310025111 · Cited by 279 · see citing works

Controlling signaling with a specifically designed Gi-coupled receptor.

Coward, P., Wada, H., Falk, M., Chan, S. D., Meng, F., Akil, H., & Conklin, B. R. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.1.352 · Cited by 262 · see citing works

Artificial Metalloenzymes for Enantioselective Catalysis Based on Biotin−Avidin

Collot, J., Gradinaru, J. I., Humbert, N., et al. (2003) · Journal of the American Chemical Society · doi:10.1021/ja035545i · Cited by 260 · see citing works

Propagation of conformational changes during μ-opioid receptor activation

Sounier, R., Mas, C., Steyaert, J., Laeremans, T., Manglik, A., Huang, W., Kobilka, B. K., Déméné, H., & Granier, S. (2015) · Nature · doi:10.1038/nature14680 · Cited by 259 · see citing works

IMPORTANT CONCEPTS OF RECEPTOR THEORY

Ruffolo, R. R., Jr. (1982) · Journal of Autonomic Pharmacology · doi:10.1111/j.1474-8673.1982.tb00520.x · Cited by 258 · see citing works

Acute Optogenetic Silencing of Orexin/Hypocretin Neurons Induces Slow-Wave Sleep in Mice

Tsunematsu, T., Kilduff, T. S., Boyden, E. S., Takahashi, S., Tominaga, M., & Yamanaka, A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0784-11.2011 · Cited by 256 · see citing works

Engineering GPCR signaling pathways with RASSLs

Conklin, B. R., Hsiao, E. C., Claeysen, S., Dumuis, A., Srinivasan, S., Forsayeth, J., Guettier, J., Chang, W. C., Pei, Y., McCarthy, K. D., et al. (2008) · Nature Methods · doi:10.1038/nmeth.1232 · Cited by 256 · see citing works

Pharmacogenetic Modulation of Orexin Neurons Alters Sleep/Wakefulness States in Mice

Sasaki, K., Suzuki, M., Mieda, M., Tsujino, N., Roth, B. L., & Sakurai, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020360 · Cited by 248 · see citing works

A Chemical-Genetic Approach to Studying Neurotrophin Signaling

Chen, X., Ye, H., Kuruvilla, R., Ramanan, N., Scangos, K. W., Zhang, C., Johnson, N. M., England, P. M., Shokat, K. M., & Ginty, D. D. (2005) · Neuron · doi:10.1016/j.neuron.2005.03.009 · Cited by 246 · see citing works

Photochemical gating of heterologous ion channels: Remote control over genetically designated populations of neurons

Zemelman, B. V., Nesnas, N., Lee, G. A., & Miesenböck, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242738899 · Cited by 244 · see citing works

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.

Samama, P., Pei, G., Costa, T., Cotecchia, S., & Lefkowitz, R. J. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10009-6 · Cited by 236 · see citing works

Allele-specific activation of genetically engineered receptors.

Strader, C. D., Gaffney, T., Sugg, E. E., Candelore, M. R., Keys, R., Patchett, A. A., & Dixon, R. A. F. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52392-9 · Cited by 228 · see citing works

Design of allele-specific inhibitors to probe protein kinase signaling

Bishop, A. C., Shah, K., Liu, Y., Witucki, L. A., Kung, C.-Y., & Shokat, K. M. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70198-8 · Cited by 226 · see citing works

BindingDB Entry 4895: Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.

BindingDB (2011) · PubMed · doi:10.7270/q2154fjq · Cited by 224 · see citing works

GOLFα Mediates Dopamine D1 Receptor Signaling

Zhuang, X., Belluscio, L., & Hen, R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-j0001.2000 · Cited by 219 · see citing works

Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors

Allen, J. A., & Roth, B. L. (2011) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010510-100553 · Cited by 216 · see citing works

GABAergic RIP-Cre Neurons in the Arcuate Nucleus Selectively Regulate Energy Expenditure

Kong, D., Tong, Q., Ye, C., Koda, S., Fuller, P. M., Krashes, M. J., Vong, L., Ray, R. S., Olson, D. P., & Lowell, B. B. (2012) · Cell · doi:10.1016/j.cell.2012.09.020 · Cited by 215 · see citing works

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.

Roth, B. L., Craigo, S. C., Choudhary, M. S., Uluer, A., Monsma, F. J., Shen, Y., Meltzer, H. Y., & Sibley, D. R. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38596-4 · Cited by 214 · see citing works

Salvinorin A, an Active Component of the Hallucinogenic Sage Salvia divinorum Is a Highly Efficacious κ-Opioid Receptor Agonist: Structural and Functional Considerations

Chavkin, C., Sud, S., Jin, W., Stewart, J., Zjawiony, J. K., Siebert, D. J., Compton-Toth, B. A., Hufeisen, S. J., & Roth, B. L. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.059394 · Cited by 210 · see citing works

Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors.

Roth, B. L., Ciaranello, R. D., & Meltzer, H. Y. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11452-3 · Cited by 199 · see citing works

Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking

Scofield, M. D., Boger, H. A., Smith, R. J., Li, H., Haydon, P. G., & Kalivas, P. W. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.016 · Cited by 197 · see citing works

Activity of Raphé serotonergic neurons controls emotional behaviors

Teissier, A., Chemiakine, A., Inbar, B., Bagchi, S., Ray, R. S., Palmiter, R. D., Dymecki, S. M., Moore, H., & Ansorge, M. S. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.061 · Cited by 197 · see citing works

A Gq-Ca2+ Axis Controls Circuit-Level Encoding of Circadian Time in the Suprachiasmatic Nucleus

Brancaccio, M., Maywood, E. S., Chesham, J. E., Loudon, A. S. I., & Hastings, M. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.011 · Cited by 196 · see citing works

NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking

Pleil, K. E., Rinker, J. A., Lowery-Gionta, E. G., Mazzone, C. M., McCall, N. M., Kendra, A. M., Olson, D. P., Lowell, B. B., Grant, K. A., Thiele, T. E., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3972 · Cited by 195 · see citing works

Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice

Hayashi, Y., Kashiwagi, M., Yasuda, K., Ando, R., Kanuka, M., Sakai, K., & Itohara, S. (2015) · Science · doi:10.1126/science.aad1023 · Cited by 191 · see citing works

Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy.

Redfern, C. H., Degtyarev, M. Y., Kwa, A., Salomonis, N., Cotte, N., Nanevicz, T., Fidelman, N., Desai, K. H., Vranizan, K., Lee, E. K., et al. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.97.9.4826 · Cited by 187 · see citing works

Engineering Src family protein kinases with unnatural nucleotide specificity

Liu, Y., Shah, K., Yang, F., et al. (1998) · Chemistry & Biology · doi:10.1016/s1074-5521(98)90143-0 · Cited by 180 · see citing works

Htr2a-Expressing Cells in the Central Amygdala Control the Hierarchy between Innate and Learned Fear

Isosaka, T., Matsuo, T., Yamaguchi, T., Funabiki, K., Nakanishi, S., Kobayakawa, R., & Kobayakawa, K. (2015) · Cell · doi:10.1016/j.cell.2015.10.047 · Cited by 179 · see citing works

Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice

Redfern, C. H., Coward, P., Degtyarev, M. Y., et al. (1999) · Nature Biotechnology · doi:10.1038/6165 · Cited by 178 · see citing works

Recurrent network activity drives striatal synaptogenesis

Kozorovitskiy, Y., Saunders, A., Johnson, C. A., Lowell, B. B., & Sabatini, B. L. (2012) · Nature · doi:10.1038/nature11052 · Cited by 176 · see citing works

Untitled work

Dunlop (2016) · doi:10.1038/npp.2015.293 · Cited by 166 · see citing works

Palatability Can Drive Feeding Independent of AgRP Neurons

Denis, R. G. P., Joly-Amado, A., Webber, E., Langlet, F., Schaeffer, M., Padilla, S. L., Cansell, C., Dehouck, B., Castel, J., Delbès, A.-S., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.011 · Cited by 164 · see citing works

RNA Editing Induces Variation in Desensitization and Trafficking of 5-Hydroxytryptamine 2c Receptor Isoforms

Marion, S., Weiner, D. M., & Caron, M. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308742200 · Cited by 163 · see citing works

Chemogenetic Inactivation of Ventral Hippocampal Glutamatergic Neurons Disrupts Consolidation of Contextual Fear Memory

Zhu, H., Pleil, K. E., Urban, D. J., Moy, S. S., Kash, T. L., & Roth, B. L. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.35 · Cited by 162 · see citing works

Reversible Silencing of Neuronal Excitability in Behaving Mice by a Genetically Targeted, Ivermectin-Gated Cl− Channel

Lerchner, W., Xiao, C., Nashmi, R., Slimko, E. M., van Trigt, L., Lester, H. A., & Anderson, D. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.030 · Cited by 162 · see citing works

The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs

Chen, X., Choo, H., Huang, X., Yang, X., Stone, O. J., Roth, B. L., & Jin, J. J. (2015) · ACS Chemical Neuroscience · doi:10.1021/cn500325v · Cited by 153 · see citing works

Chemical–genetic attenuation of focal neocortical seizures

Kätzel, D., Nicholson, E., Schorge, S., Walker, M. C., & Kullmann, D. M. (2014) · Nature Communications · doi:10.1038/ncomms4847 · Cited by 151 · see citing works

Modulation of the autonomic nervous system and behaviour by acute glial cell G _q protein‐coupled receptor activation <i>in vivo</i>

Agulhon, C., Boyt, K. M., Xie, A. X., Friocourt, F., Roth, B. L., & McCarthy, K. D. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.261289 · Cited by 147 · see citing works

The Dynamic Process of b 2 -Adrenergic Receptor Activation

Nygaard, R., Zou, Y., Dror, R. O., Mildorf, T. J., Arlow, D. H., Manglik, A., Pan, A. C., Liu, C. W., Bokoch, M. P., Thian, F. S., et al. (2013) · Cited by 146 · see citing works

Rat Nucleus Accumbens Core Astrocytes Modulate Reward and the Motivation to Self-Administer Ethanol after Abstinence

Bull, C., Freitas, K. C., Zou, S., Poland, R. S., Syed, W. A., Urban, D. J., Minter, S. C., Shelton, K. L., Hauser, K. F., Negus, S. S., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.135 · Cited by 145 · see citing works

D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs

Roth, B. L., Tandra, S., Burgess, L. H., Sibley, D. R., & Meltzer, H. Y. (1995) · Psychopharmacology · doi:10.1007/bf02311185 · Cited by 143 · see citing works

Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs

Dong, S., Rogan, S. C., & Roth, B. L. (2010) · Nature Protocols · doi:10.1038/nprot.2009.239 · Cited by 140 · see citing works

Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)

Strachan, R. T., Sun, J., Rominger, D. H., Violin, J. D., Ahn, S., Thomsen, A. R. B., Zhu, X., Kleist, A. B., Costa, T., & Lefkowitz, R. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.548131 · Cited by 135 · see citing works

Hippocampal Remapping after Partial Inactivation of the Medial Entorhinal Cortex

Miao, C., Cao, Q., Ito, H., Yamahachi, H., Witter, M. P., Moser, M., & Moser, E. I. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.051 · Cited by 131 · see citing works

Functional and Developmental Identification of a Molecular Subtype of Brain Serotonergic Neuron Specialized to Regulate Breathing Dynamics

Brust, R. D., Corcoran, A. E., Richerson, G. B., Nattie, E., & Dymecki, S. M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.027 · Cited by 131 · see citing works

Design and Functional Characterization of a Novel, Arrestin-Biased Designer G Protein-Coupled Receptor

Nakajima, K., & Wess, J. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.080358 · Cited by 131 · see citing works

Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value

Eldridge, M. A. G., Lerchner, W., Saunders, R. C., Kaneko, H., Krausz, K. W., Gonzalez, F. J., Ji, B., Higuchi, M., Minamimoto, T., & Richmond, B. J. (2015) · Nature Neuroscience · doi:10.1038/nn.4192 · Cited by 130 · see citing works

A Gαs DREADD Mouse for Selective Modulation of cAMP Production in Striatopallidal Neurons

Farrell, M. S., Pei, Y., Wan, Y., Yadav, P. N., Daigle, T. L., Urban, D. J., Lee, H.-M., Sciaky, N., Simmons, A., Nonneman, R. J., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.251 · Cited by 129 · see citing works

The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine?s actions?

Davies, M. A., Compton-Toth, B. A., Hufeisen, S. J., Meltzer, H. Y., & Roth, B. L. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2017-1 · Cited by 126 · see citing works

Chronic activation of a designer Gq-coupled receptor improves β cell function

Jain, S., de Azúa, I. R., Lü, H., White, M. F., Guettier, J., & Wess, J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66432 · Cited by 123 · see citing works

Optogenetic activation of serotonergic neurons enhances anxiety-like behaviour in mice

Ohmura, Y., Tanaka, K. F., Tsunematsu, T., Yamanaka, A., & Yoshioka, M. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000637 · Cited by 122 · see citing works

Remote control of induced dopaminergic neurons in parkinsonian rats

Dell’Anno, M. T., Caiazzo, M., Leo, D., Dvoretskova, E., Medrihan, L., Colasante, G., Giannelli, S. G., Theka, I., Russo, G., Mus, L., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74664 · Cited by 118 · see citing works

Genetic control of chalcone isomerase activity in flowers of Dianthus caryophyllus

Forkmann, G., & Dangelmayr, B. (1980) · Biochemical Genetics · doi:10.1007/bf00484399 · Cited by 113 · see citing works

Tailoring the Active Site of Chemzymes by Using a Chemogenetic‐Optimization Procedure: Towards Substrate‐Specific Artificial Hydrogenases Based on the Biotin–Avidin Technology

Klein, G., Humbert, N., Gradinaru, J. I., et al. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200502000 · Cited by 111 · see citing works

Conformation Guides Molecular Efficacy in Docking Screens of Activated β-2 Adrenergic G Protein Coupled Receptor

Weiss, D. R., Ahn, S., Sassano, M. F., Kleist, A. B., Zhu, X., Strachan, R. T., Roth, B. L., Lefkowitz, R. J., & Shoichet, B. K. (2013) · ACS Chemical Biology · doi:10.1021/cb400103f · Cited by 109 · see citing works

Osteoblast expression of an engineered G s -coupled receptor dramatically increases bone mass

Hsiao, E. C., Boudignon, B. M., Chang, W. C., Bencsik, M., Peng, J. C., Nguyen, T., Manalac, C., Halloran, B. P., Conklin, B. R., & Nissenson, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707457105 · Cited by 109 · see citing works

Combined Use of the Canine Adenovirus-2 and DREADD-Technology to Activate Specific Neural Pathways In Vivo

Boender, A. J., de Jong, J. W., Boekhoudt, L., Luijendijk, M. C. M., Plasse, G., & Adan, R. A. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095392 · Cited by 107 · see citing works

Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal

Park, J. S., Rhau, B., Hermann, A., McNally, K. A., Zhou, C., Gong, D., Weiner, O. D., Conklin, B. R., Onuffer, J., & Lim, W. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402087111 · Cited by 103 · see citing works

Synthesis of n.c.a. carbon-11 labelled clozapine and its major metabolite clozapine-N-oxide and comparison of their biodistribution in mice

Bender, D., Holschbach, M. H., & Stöcklin, G. (1994) · Nuclear Medicine and Biology · doi:10.1016/0969-8051(94)90080-9 · Cited by 90 · see citing works

Rapid formation of clozapine in guinea-pigs and man following clozapine-N-oxide administration.

Jann, M. W., Lam, Y. W. F., & Chang, W. H. (1995) · PubMed · Cited by 89 · see citing works

Genetic control of neuronal activity in mice conditionally expressing TRPV1

Arenkiel, B. R., Klein, M. E., Davison, I. G., Katz, L. C., & Ehlers, M. (2008) · Nature Methods · doi:10.1038/nmeth.1190 · Cited by 86 · see citing works

Direct-Pathway Striatal Neurons Regulate the Retention of Decision-Making Strategies

Ferguson, S. M., Phillips, P. E. M., Roth, B. L., Wess, J., & Neumaier, J. F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4783-12.2013 · Cited by 78 · see citing works

Development of Hydrocephalus in Mice Expressing the Gi-Coupled GPCR Ro1 RASSL Receptor in Astrocytes

Sweger, E. J., Casper, K. B., Scearce-Levie, K. A., Conklin, B. R., & McCarthy, K. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4565-06.2007 · Cited by 78 · see citing works

A Novel Experimental Strategy to Assess the Metabolic Effects of Selective Activation of a Gq-Coupled Receptor in Hepatocytes In Vivo

Li, J. H., Jain, S., McMillin, S. M., Cui, Y., Gautam, D., Sakamoto, W., Lü, H., Jou, W., McGuinness, O. P., Gavrilova, O., et al. (2013) · Endocrinology · doi:10.1210/en.2012-2127 · Cited by 71 · see citing works

Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats

Marchant, N. J., Ramsey, L. A., Bossert, J. M., Harvey, B. K., Hope, B. T., Kaganovsky, K., Adhikary, S., Prisinzano, T. E., Vardy, E., Roth, B. L., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.149 · Cited by 63 · see citing works

Chemogenetics—A Transformational and Translational Platform

English, J. G., & Roth, B. L. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1921 · Cited by 44 · see citing works

DREADDs in Drosophila: A Pharmacogenetic Approach for Controlling Behavior, Neuronal Signaling, and Physiology in the Fly

Becnel, J., Johnson, O., Majeed, Z. R., Tran, V., Yu, B., Roth, B. L., Cooper, R. L., Kerut, E. K., & Nichols, C. D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.003 · Cited by 44 · see citing works

A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development

Soskis, M. J., Ho, H. H., Bloodgood, B. L., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3249 · Cited by 42 · see citing works

Enzymes by Design: Chemogenetic Assembly of Transamination Active Sites Containing Lysine Residues for Covalent Catalysis

Häring, D., & Distefano, M. D. (2001) · Bioconjugate Chemistry · doi:10.1021/bc000117c · Cited by 39 · see citing works

Conformational Ensembles in GPCR Activation

Vardy, E., & Roth, B. L. (2013) · Cell · doi:10.1016/j.cell.2013.01.025 · Cited by 30 · see citing works

Engineering a region of bulk tolerance in the 5-HT2A receptor

Westkaemper, R. B., Hyde, E. G., Choudhary, M. S., et al. (1999) · European Journal of Medicinal Chemistry · doi:10.1016/s0223-5234(99)80094-4 · Cited by 21 · see citing works

Studies of a ubiquitous receptor family

Roth, B. L., & Marshall, F. H. (2012) · Nature · doi:10.1038/492057a · Cited by 18 · see citing works

Inhibiting the Activity of CA1 Hippocampal Neurons Prevents the Recall of Contextual Fear Memory in Inducible ArchT Transgenic Mice

Sakaguchi, M., Kim, K., Yu, L. M. Y., Hashikawa, Y., Sekine, Y., Okumura, Y., Kawano, M., Hayashi, M., Kumar, D., Boyden, E. S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130163 · Cited by 13 · see citing works

Untitled work

(1998) · doi:10.1002/(sici)1097-0282(1998)48:1

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

Chai, H., Diaz-Castro, B., Shigetomi, E., Monte, E., Octeau, J. C., Yu, X., Cohn, W., Rajendran, P. S., Vondriska, T. M., Whitelegge, J. P., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.029 · Cited by 769 · see citing works

Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement

Adamsky, A., Kol, A., Kreisel, T., Doron, A., Ozeri-Engelhard, N., Melcer, T., Refaeli, R., Horn, H., Regev, L., Groysman, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.002 · Cited by 631 · see citing works

Function and therapeutic value of astrocytes in neurological diseases

Lee, H.-G., Wheeler, M. A., & Quintana, F. J. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00390-x · Cited by 662 · see citing works

A viral strategy for targeting and manipulating interneurons across vertebrate species

Dimidschstein, J., Chen, Q., Tremblay, R., Rogers, S. L., Saldi, G.-A., Guo, L., Xu, Q., Liu, R., Lu, C., Chu, J., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4430 · Cited by 541 · see citing works

How Ligands Illuminate GPCR Molecular Pharmacology

Wacker, D., Stevens, R. C., & Roth, B. L. (2017) · Cell · doi:10.1016/j.cell.2017.07.009 · Cited by 560 · see citing works

Light Affects Mood and Learning through Distinct Retina-Brain Pathways

Fernandez, D. C., Fogerson, P. M., Lazzerini Ospri, L., Thomsen, M. B., Layne, R. M., Severin, D., Zhan, J., Singer, J. H., Kirkwood, A., Zhao, H., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.004 · Cited by 505 · see citing works

Brain control of humoral immune responses amenable to behavioural modulation

Zhang, X., Lei, B., Yuan, Y., Zhang, L., Hu, L., Jin, S., Kang, B., Liao, X., Sun, W., Xu, F., et al. (2020) · Nature · doi:10.1038/s41586-020-2235-7 · Cited by 367 · see citing works

Dopaminergic dynamics underlying sex-specific cocaine reward

Calipari, E. S., Juarez, B., Morel, C., Walker, D. M., Cahill, M. E., Ribeiro, E., Roman-Ortiz, C., Ramakrishnan, C., Deisseroth, K., Han, M.-H., et al. (2017) · Nature Communications · doi:10.1038/ncomms13877 · Cited by 359 · see citing works

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Asboth, L., Friedli, L., Beauparlant, J., Martinez-Gonzalez, C., Anil, S., Rey, E., Baud, L., Pidpruzhnykova, G., Anderson, M. A., Shkorbatova, P., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0093-5 · Cited by 324 · see citing works

Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice

Jendryka, M., Palchaudhuri, M., Ursu, D., van der Veen, B., Liss, B., Kätzel, D., Nissen, W., & Pekcec, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-41088-2 · Cited by 296 · see citing works

Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive

Eban-Rothschild, A., Appelbaum, L., & de Lecea, L. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.294 · Cited by 282 · see citing works

Pyramidal cell regulation of interneuron survival sculpts cortical networks

Wong, F. K., Bercsenyi, K., Sreenivasan, V., Portalés, A., Fernández-Otero, M., & Marín, O. (2018) · Nature · doi:10.1038/s41586-018-0139-6 · Cited by 286 · see citing works

Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits

Kelly, E., Meng, F., Fujita, H., Morgado, F., Kazemi, Y., Rice, L. C., Ren, C., Escamilla, C. O., Gibson, J. M., Sajadi, S., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0665-z · Cited by 280 · see citing works

Optogenetic inhibition of behavior with anion channelrhodopsins

Mohammad, F., Stewart, J. C., Ott, S., Chlebikova, K., Chua, J. Y., Koh, T.-W., Ho, J., & Claridge-Chang, A. (2017) · Nature Methods · doi:10.1038/nmeth.4148 · Cited by 276 · see citing works

Circuit dissection of the role of somatostatin in itch and pain

Huang, J., Polgár, E., Solinski, H. J., Mishra, S. K., Tseng, P.-Y., Iwagaki, N., Boyle, K. A., Dickie, A. C., Kriegbaum, M. C., Wildner, H., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0119-z · Cited by 257 · see citing works

Pain-induced negative affect is mediated via recruitment of the nucleus accumbens kappa opioid system

Massaly, N., Copits, B. A., Wilson-Poe, A. R., Hipólito, L., Markovic, T., Yoon, H. J., Liu, S., Walicki, M. C., Bhatti, D. L., Sirohi, S., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.029 · Cited by 200 · see citing works

Preproglucagon neurons in the nucleus of the solitary tract are the main source of brain GLP-1, mediate stress-induced hypophagia, and limit unusually large intakes of food

Holt, M. K., Richards, J. E., Cook, D. R., Brierley, D. I., Williams, D. L., Reimann, F., Gribble, F. M., & Trapp, S. (2019) · Diabetes · doi:10.2337/db18-0729 · Cited by 212 · see citing works

Recent advances in neurotechnologies with broad potential for neuroscience research

Vázquez-Guardado, A., Yang, Y., Bandodkar, A. J., & Rogers, J. A. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00739-8 · Cited by 202 · see citing works

Altered Cortical Ensembles in Mouse Models of Schizophrenia

Hamm, J. P., Peterka, D. S., Gogos, J. A., & Yuste, R. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.019 · Cited by 175 · see citing works

Thalamic Control of Cognition and Social Behavior Via Regulation of Gamma-Aminobutyric Acidergic Signaling and Excitation/Inhibition Balance in the Medial Prefrontal Cortex

Ferguson, B. R., & Gao, W.-J. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.033 · Cited by 186 · see citing works

A common neuroendocrine substrate for diverse general anesthetics and sleep

Jiang-Xie, L.-F., Yin, L., Zhao, S., Prevosto, V., Han, B.-X., Dzirasa, K., & Wang, F. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.033 · Cited by 173 · see citing works

Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain

Zhang, M.-M., Geng, A.-Q., Chen, K., Wang, J., Wang, P., Qiu, X.-T., Gu, J.-X., Fan, H.-W., Zhu, D.-Y., Yang, S.-M., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.03.030 · Cited by 151 · see citing works

Adeno-Associated Virus Toolkit to Target Diverse Brain Cells

Challis, R. C., Ravindra Kumar, S., Chen, X., Goertsen, D., Coughlin, G. M., Hori, A. M., Chuapoco, M. R., Otis, T. S., Miles, T. F., & Gradinaru, V. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-111020-100834 · Cited by 148 · see citing works

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Kathe, C., Michoud, F., Schönle, P., Rowald, A., Brun, N., Ravier, J., Furfaro, I., Paggi, V., Kim, K., Soloukey, S., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-021-01019-x · Cited by 119 · see citing works

Neuronal activity increases translocator protein (TSPO) levels

Notter, T., Schalbetter, S. M., Clifton, N. E., Mattei, D., Richetto, J., Thomas, K., Meyer, U., & Hall, J. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-0745-1 · Cited by 118 · see citing works

Hippocampal-amygdala memory circuits govern experience-dependent observational fear

Terranova, J. I., Yokose, J., Osanai, H., Marks, W. D., Yamamoto, J., Ogawa, S. K., & Kitamura, T. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.019 · Cited by 117 · see citing works

An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury

Hilton, B. J., Husch, A., Schaffran, B., Lin, T.-C., Burnside, E. R., Dupraz, S., Schelski, M., Kim, J., Müller, J. A., Schoch, S., et al. (2022) · Neuron · doi:10.1016/j.neuron.2021.10.007 · Cited by 116 · see citing works

HCN2 Channels in Cholinergic Interneurons of Nucleus Accumbens Shell Regulate Depressive Behaviors

Cheng, J., Umschweif, G., Leung, J., Sagi, Y., & Greengard, P. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.018 · Cited by 110 · see citing works

Discovery of new GPCR ligands to illuminate new biology

Roth, B. L., Irwin, J. J., & Shoichet, B. K. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2490 · Cited by 94 · see citing works

Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake

Singh, I., Wang, L., Xia, B., Liu, J., Tahiri, A., El Ouaamari, A., Wheeler, M. B., & Pang, Z. P. (2022) · Cell &amp; Bioscience · doi:10.1186/s13578-022-00914-3 · Cited by 98 · see citing works

Fast, furious and enduring: Sensitive versus critical periods in sexual differentiation of the brain

McCarthy, M. M., Herold, K., & Stockman, S. L. (2018) · Physiology &amp; Behavior · doi:10.1016/j.physbeh.2017.10.030 · Cited by 97 · see citing works

Different dendritic domains of the GnRH neuron underlie the pulse and surge modes of GnRH secretion in female mice

Wang, L., Guo, W., Shen, X., Yeo, S., Long, H., Wang, Z., Lyu, Q., Herbison, A. E., & Kuang, Y. (2020) · eLife · doi:10.7554/elife.53945 · Cited by 80 · see citing works

Insular cortex projections to nucleus accumbens core mediate social approach to stressed juvenile rats

Rogers-Carter, M. M., Djerdjaj, A., Gribbons, K. B., Varela, J. A., & Christianson, J. P. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0316-19.2019 · Cited by 79 · see citing works

Chemogenetic Activation of Prefrontal Cortex Rescues Synaptic and Behavioral Deficits in a Mouse Model of 16p11.2 Deletion Syndrome

Wang, W., Rein, B., Zhang, F., Tan, T., Zhong, P., Qin, L., & Yan, Z. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.0149-18.2018 · Cited by 74 · see citing works

Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors

Fernandez, S. P., Broussot, L., Marti, F., Contesse, T., Mouska, X., Soiza-Reilly, M., Marie, H., Faure, P., & Barik, J. (2018) · Nature Communications · doi:10.1038/s41467-018-06809-7 · Cited by 75 · see citing works

A brainstem circuit for nausea suppression

Zhang, C., Vincelette, L. K., Reimann, F., & Liberles, S. D. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110953 · Cited by 68 · see citing works

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

van der Westhuizen, E. T., Choy, K. H. C., Valant, C., McKenzie-Nickson, S., Bradley, S. J., Tobin, A. B., Sexton, P. M., & Christopoulos, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.606656 · Cited by 63 · see citing works

Selective stimulation of colonic L cells improves metabolic outcomes in mice

Lewis, J. E., Miedzybrodzka, E. L., Foreman, R. E., Woodward, O. R. M., Kay, R. G., Goldspink, D. A., Gribble, F. M., & Reimann, F. (2020) · Diabetologia · doi:10.1007/s00125-020-05149-w · Cited by 59 · see citing works

A thalamic-hippocampal CA1 signal for contextual fear memory suppression, extinction, and discrimination

Ratigan, H. C., Krishnan, S., Smith, S., & Sheffield, M. E. J. (2023) · Nature Communications · doi:10.1038/s41467-023-42429-6 · Cited by 60 · see citing works

A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior

Tashima, R., Koga, K., Yoshikawa, Y., Sekine, M., Watanabe, M., Tozaki-Saitoh, H., Furue, H., Yasaka, T., & Tsuda, M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021220118 · Cited by 54 · see citing works

Lost in translation: How to upgrade fear memory research

Flores, Á., Fullana, M. À., Soriano-Mas, C., & Andero, R. (2018) · Molecular Psychiatry · doi:10.1038/s41380-017-0006-0 · Cited by 59 · see citing works

Translational opportunities for circuit-based social neuroscience: advancing 21st century psychiatry

Ford, C. L., & Young, L. J. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.11.007 · Cited by 46 · see citing works

cAMP-Dependent Synaptic Plasticity at the Hippocampal Mossy Fiber Terminal

Shahoha, M., Cohen, R., Ben-Simon, Y., & Ashery, U. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.861215 · Cited by 46 · see citing works

The Mesencephalic Locomotor Region: Multiple Cell Types, Multiple Behavioral Roles, and Multiple Implications for Disease

Ryczko, D. (2024) · The Neuroscientist · doi:10.1177/10738584221139136 · Cited by 31 · see citing works

A dual-pathway architecture for stress to disrupt agency and promote habit

Giovanniello, J. R., Paredes, N., Wiener, A., Ramírez-Armenta, K., Oragwam, C., Uwadia, H. O., Yu, A. L., Lim, K., Pimenta, J. S., Vilchez, G. E., et al. (2025) · Nature · doi:10.1038/s41586-024-08580-w · Cited by 30 · see citing works

Chemogenetic stimulation of the parasympathetic nervous system lowers hepatic lipid accumulation and inflammation in a nonalcoholic steatohepatitis mouse model

Hur, M. H., Song, W., Cheon, D.-H., Chang, Y., Cho, Y. Y., Lee, Y. B., Yu, S. J., Kim, Y. J., Yoon, J.-H., Choi, H. J., et al. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121533 · Cited by 17 · see citing works

Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior

Lyman, K. A., Han, Y., Zhou, C., Renteria, I., Besing, G.-L., Kurz, J. E., & Chetkovich, D. M. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abl4580 · Cited by 17 · see citing works

A Comparative Study of the Pharmacokinetics of Clozapine N-Oxide and Clozapine N-Oxide Hydrochloride Salt in Rhesus Macaques

Allen, D. C., Carlson, T. L., Xiong, Y., Jin, J., Grant, K. A., & Cuzon Carlson, V. C. (2019) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.252031 · Cited by 17 · see citing works

Ethanol modulation of cortico-basolateral amygdala circuits: Neurophysiology and behavior

McCool, B. A. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108750 · Cited by 7 · see citing works

Single-cell resolution analysis of the crosstalk between chemogenically activated astrocytes and microglia

Philtjens, S., Turnbull, M. T., Thedy, B. P., Moon, Y., & Kim, J. (2020) · doi:10.1101/2020.04.27.064881 · Cited by 7 · see citing works

PC analysis of key words — And key key words

Scott, M. (1997) · System · doi:10.1016/s0346-251x(97)00011-0 · Cited by 634 · see citing works

Study on the Effect of Key-to-Key Distance on Touch-Sensitive Key Operation

Fan, X., Hu, H., Zhao, C., et al. (2019) · Advances in intelligent systems and computing · doi:10.1007/978-3-030-20227-9_16

Few-key text entry revisited

Wobbrock, J. O., Myers, B. A., & Rothrock, B. (2006) · CHI Conference on Human Factors in Computing Systems · doi:10.1145/1124772.1124846 · Cited by 37 · see citing works

Identifying sets of key players in a social network

Borgatti, S. P. (2006) · Computational and Mathematical Organization Theory · doi:10.1007/s10588-006-7084-x · Cited by 1,176 · see citing works

Key Section Search Method Based on Key Branches

Zuo, Y., & Xia, Y. (2024) · IEEE International Conference on Control, Electronics and Computer Technology (ICCECT) · doi:10.1109/iccect60629.2024.10545971