Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
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Dorsal and ventral hippocampus regions exert cognition and emotion-related functions, respectively. Since both regions display rhythmic activity, specific neural oscillatory pacemakers may underlie their functional dichotomy. Type 1 theta oscillations are independent of cholinergic transmission and are observed in the dorsal hippocampus during movement and exploration. In contrast, type 2 theta depends on acetylcholine and appears when animals are exposed to emotionally laden contexts such as a predator presence. Despite its involvement in emotions, type 2 theta has not been associated with the ventral hippocampus. Here, we show that optogenetic activation of oriens-lacunosum moleculare (OLM) interneurons in the ventral hippocampus drives type 2 theta. Moreover, we found that type 2 theta generation is associated with increased risk-taking behavior in response to predator odor. These results demonstrate that two theta oscillations subtypes originate in the two hippocampal regions that predominantly underlie either cognitive or emotion-related functions.
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Classical work in rodents demonstrated two mechanistically distinct types of theta oscillations: fast Type-1 (atropine-insensitive) theta oscillations (7-11 Hz) during locomotion, and slower Type-2 (atropine-sensitive) oscillations (4-7 Hz) thought to occur preferentially during immobility.
“Classical work in rodents has demonstrated the existence of two mechanistically distinct types of theta oscillations: fast Type-1 (atropine-insensitive) theta oscillations (7–11 Hz), which are observed during locomotion, and slower Type-2 (atropine-sensitive) oscillations (4–7 Hz), which are thought to preferentially occur during immobility26–28,42,50,97.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [28]
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Experimental — accuracy not yet measuredEarlier work indicated that LFP theta bouts can be evoked by emotionally salient stimuli and are associated with specific body movements.
“Although earlier work indicated that LFP theta bouts can be evoked by emotionally salient stimuli26–28 and being associated with specific body movements29, the behavioral correlates of these theta oscillations have remained largely unresolved.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [28]
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“In contrast to the large body of knowledge on theta oscillations during locomotion, comparatively little is known about immobility-related theta 25 – 28 .”
- Authors
- Mikulovic, S., Restrepo, C. E., Siwani, S., Bauer, P., Pupe, S., Tort, A. B. L., Kullander, K., & Leão, R. N.
- Affiliations
- Uppsala University (SE)
- Universidade Federal do Rio Grande do Norte (BR)
- Corresponding author
- Mikulovic, Sanja
- Leão, Richardson N.
- Venue
- Nature Communications
- Published
- 2018-09-07
- Volume
- 9
- Issue
- 1
- Pages
- 3638-3638
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6128904
- OpenAlex
- W2889629520
- Cited by
- 114
- References
- 60
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 19 · 2023: 16 · 2022: 13 · 2021: 20 · 2020: 15 · 2019: 6 · 2018: 2
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Uppsala University Publications (Uppsala University) (submittedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Swedish Foundation for International Cooperation in Research and Higher Education
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Svenska Sällskapet för Medicinsk Forskning
- Vetenskapsrådet
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- ventral hippocampus, oriens-lacunosum moleculare interneurons, acetylcholine, predator odor, risk-taking, emotional arousal, hippocampal oscillations, optogenetic stimulation
- MeSH terms
- Animals, Hippocampus, Interneurons, Male, Mice, Transgenic, Odorants, Receptors, Nicotinic, Risk-Taking, Theta Rhythm, Mice, Optogenetics
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