Adult-born neurons boost odor-reward association
Open accessAbstract
Olfaction is an important sensory modality driving fundamental behaviors. During odor-dependent learning, a positive value is commonly assigned to an odorant, and multiple forms of plasticity are involved when such odor-reward associations are formed. In rodents, one of the mechanisms underlying plasticity in the olfactory bulb consists in recruiting new neurons daily throughout life. However, it is still unknown whether adult-born neurons might participate in encoding odor value. Here, we demonstrate that exposure to reward-associated odors specifically increases activity of adult-born neurons but not preexisting neurons. Remarkably, adult-born neuron activation during rewarded odor presentation heightens discrimination learning and enhances the ability to update the odor value during reversal association. Moreover, in some cases, activation of this interneuron population can trigger olfactory learning without sensory stimulation. Taken together, our results show a specific involvement of adult-born neurons in facilitating odor-reward association during adaptive learning.
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Adult-born granule cells support flexible olfactory behaviors in adulthood.
“while adult-born GCs are well-known to support flexible olfactory behaviors in adulthood [19,50–52]”
From Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system (2026) · cites this paper as [50]
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“At the neuronal level, while adult-born GCs are well-known to support flexible olfactory behaviors in adulthood [19,50–52], neonatal-born GCs have been primarily associated with innate olfactory responses [14,20,21,53,54].”
- Authors
- Grelat, A., Benoit, L., Wagner, S., Moigneu, C., Lledo, P.-M., & Alonso, M.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Lledo, Pierre-Marie
- Alonso, Mariana
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-02-21
- Volume
- 115
- Issue
- 10
- Pages
- 2514-2519
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5877928
- OpenAlex
- W2791493345
- Cited by
- 72
- References
- 48
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 6 · 2023: 7 · 2022: 10 · 2021: 8 · 2020: 12 · 2019: 8 · 2018: 7
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- Funders
- Agence Nationale de la Recherche (ANR-15-CE37-0004-01, ANR-15-NEUC-0004-02, ANR-10-LABX-73)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- adult neurogenesis, adult-born neurons, olfactory bulb, olfactory learning, reversal learning, interneurons
- MeSH terms
- Animals, Discrimination Learning, Female, Male, Models, Neurological, Odorants, Olfactory Bulb, Reward, Smell, Olfactory Receptor Neurons, Rats
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