The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties
Open accessAbstract
SUMMARY Dorsal root ganglion (DRG) sensory neuron subtypes defined by their in vivo properties display distinct intrinsic electrical properties. We used bulk RNA-sequencing of genetically-labeled neurons and electrophysiological analyses to define ion channel contributions to the intrinsic electrical properties of DRG neuron subtypes. The transcriptome profiles of eight DRG neuron subtypes revealed differentially expressed and functionally relevant genes, including voltage-gated ion channels. Guided by these data, electrophysiological analyses using pharmacological and genetic manipulations as well as computational modeling of DRG neuron subtypes were undertaken to assess the functions of select voltage-gated potassium channels (Kv1, Kv2, Kv3, and Kv4) in shaping action potential (AP) waveforms and firing patterns. Our findings show that the transcriptome profiles have predictive value for defining ion channel contributions to sensory neuron subtype-specific intrinsic physiological properties. The distinct ensembles of voltage-gated ion channels predicted to underlie the unique intrinsic physiological properties of eight DRG neuron subtypes are presented.
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Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
Usoskin, D., Furlan, A., Islam, S., Abdo, H., Lönnerberg, P., Lou, D., Hjerling-Leffler, J., Haeggström, J., Kharchenko, O., Kharchenko, P. V., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3881 · Cited by 2,136
Coding of pleasant touch by unmyelinated afferents in humans
Löken, L. S., Wessberg, J., Morrison, I., McGlone, F., & Olausson, H. (2009) · Nature Neuroscience · doi:10.1038/nn.2312 · Cited by 1,120
Südhof, T. C. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.012 · Cited by 1,062 · cited 1×
“The gene categories explored are: transcription factors (TFs), cell adhesion molecules (CAMs), neuropeptides, synaptic exocytosis machinery, G protein-coupled receptors (GPCRs), and ion channels (Chawla et al., 2013; Földy et al., 2016; Paul et al., 2017; Südhof, 2012).”
BackgroundThe Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn
Abraira, V. E., Kuehn, E. D., Chirila, A. M., Springel, M. W., Toliver, A. A., Zimmerman, A. L., Orefice, L. L., Boyle, K. A., Bai, L., Song, B. J., et al. (2017) · Cell · doi:10.1016/j.cell.2016.12.010 · Cited by 409
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Cited by
Targeting peripheral somatosensory neurons to improve tactile-related phenotypes in ASD models
Orefice, L. L., Mosko, J. R., Morency, D. T., Wells, M. F., Tasnim, A., Mozeika, S. M., Ye, M., Chirila, A. M., Emanuel, A. J., Rankin, G., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.024 · Cited by 247
Self-citationThe cellular and molecular basis of somatosensory neuron development
Meltzer, S., Santiago, C., Sharma, N., & Ginty, D. D. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.004 · Cited by 149
Self-citationWu, H., Petitpré, C., Fontanet, P., Sharma, A., Bellardita, C., Quadros, R. M., Jannig, P. R., Wang, Y., Heimel, J. A., Cheung, K. K. Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21173-9 · Cited by 86
Metadata
- Authors
- Zheng, Y., Liu, P., Bai, L., Trimmer, J. S., Bean, B. P., & Ginty, D. D.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 103
- Issue
- 4
- Pages
- 598-616.e7
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2950162000
- Cited by
- 339
- References
- 5
- FWCI
- 9.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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