The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn
Open accessAbstract
The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic tools for defining neuronal components and functions of the dorsal horn LTMR-recipient zone (LTMR-RZ), a role for LTMR-RZ processing in tactile perception, and the basic logic of LTMR-RZ organization. We found an unexpectedly high degree of neuronal diversity in the LTMR-RZ: seven excitatory and four inhibitory subtypes of interneurons exhibiting unique morphological, physiological, and synaptic properties. Remarkably, LTMRs form synapses on between four and 11 LTMR-RZ interneuron subtypes, while each LTMR-RZ interneuron subtype samples inputs from at least one to three LTMR classes, as well as spinal cord interneurons and corticospinal neurons. Thus, the LTMR-RZ is a somatosensory processing region endowed with a neuronal complexity that rivals the retina and functions to pattern the activity of ascending touch pathways that underlie tactile perception.
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The Rorb and Adamts5 dorsal inhibitory family comprised Inhib-1, Inhib-2, Inhib-3, Inhib-4, and Inhib-5, with markers of neurons involved in dampening of dynamic touch.
“The Rorb and Adamts5 dorsal, the inhibitory family was comprised of Inhib-1, Inhib-2, Inhib-3, Inhib-4, and Inhib-5, with markers of neurons involved in the dampening of dynamic touch48,68,69.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [48]
The Maf dorsal excitatory family comprised Excit-5, Excit-6, and Excit-7, which expressed markers of neurons involved in light touch.
“The Maf dorsal, the excitatory family was comprised of Excit-5, Excit-6, and Excit-7 which expressed markers of neurons involved in light touch46,48,50,56,57.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [48]
The Prkcg dorsal excitatory family comprised Excit-3 and Excit-4 and likely corresponded to neurons involved in light static touch and allodynic pain in pathological situations.
“The Prkcg dorsal, excitatory family was comprised of Excit-3 and Excit-4 and likely corresponded to neurons involved in light static touch and allodynic pain in pathological situations46,48–56.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [48]
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Self-citation
- Authors
- Abraira, V. E., Kuehn, E. D., Chirila, A. M., Springel, M. W., Toliver, A. A., Zimmerman, A. L., Orefice, L. L., Boyle, K. A., Bai, L., Song, B. J., Bashista, K. A., O'Neill, T. G., Zhuo, J., Tsan, C., Hoynoski, J., Rutlin, M., Kus, L., Niederkofler, V., Watanabe, M., Dymecki, S. M., Nelson, S. B., Heintz, N., Hughes, D. I., & Ginty, D. D.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Glasgow (GB)
- Brandeis University (US)
- Harvard University (US)
- Hokkaido University (JP)
- Corresponding author
- Ginty, David D.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 168
- Issue
- 1-2
- Pages
- 295-310.e19
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC5236062
- OpenAlex
- W2561827989
- Cited by
- 409
- References
- 58
- Citations by year
- 2026: 25 · 2025: 53 · 2024: 44 · 2023: 46 · 2022: 53 · 2021: 50 · 2020: 57 · 2019: 38 · 2018: 34 · 2017: 9
- FWCI
- 17.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Cell (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- NINDS P30 Core Center (NS072030)
- Goldenson Postdoctoral Fellowship (F32 NS077836-01)
- NIDA (1-P30-DA-035756)
- Wellcome Trust (102645)
- BBSRC (J000620)
- NIH (DE022750, NS97344)
- Edward R. and Anne G. Lefler Center
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- low-threshold mechanoreceptors, spinal interneurons, neuronal heterogeneity, synaptic connectivity, tactile perception, somatosensory processing, corticospinal neurons, interneuron subtypes
- MeSH terms
- Animals, Axons, Dendrites, Interneurons, Mechanoreceptors, Molecular Biology, Neural Pathways, Spinal Cord, Synapses, Mice, Touch Perception
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