The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated Rest
Open accessAbstract
Neural stem cells in the adult mammalian brain are the source of new neurons that contribute to complex sensory and cognitive functions. Most adult neural stem cells are maintained in a state of reversible cell cycle arrest, also called quiescence. Quiescent neural stem cells present a low rate of metabolic activity and a high sensitivity to their local signaling environment, and they can be activated by diverse physiological stimuli. The balance between stem cell quiescence and activity determines not only the rate of neurogenesis but also the long-term maintenance of the stem cell pool and the neurogenic capacity of the aging brain. In recent years, significant progress has been made in characterizing quiescent stem cells thanks to the introduction of new genomic and imaging techniques. We discuss in this review our current understanding of neural stem cell quiescence and its regulation by intrinsic and systemic factors.
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Cited by
Cellular Mechanisms and Regulation of Quiescence
Marescal, O., & Cheeseman, I. M. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.09.029 · Cited by 292
Xu, G., Jin, J., Fu, Z., Wang, G., Lei, X., Xu, J., & Wang, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02312-w · Cited by 269
Early stem cell aging in the mature brain
Ibrayeva, A., Bay, M., Pu, E., Jörg, D. J., Peng, L., Jun, H., Zhang, N., Aaron, D., Lin, C., Resler, G., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.03.018 · Cited by 137
Lysosomes and signaling pathways for maintenance of quiescence in adult neural stem cells
Kobayashi, T., & Kageyama, R. (2021) · The FEBS Journal · doi:10.1111/febs.15555 · Cited by 28
Maybury‐Lewis, S. Y., Brown, A. K., Yeary, M., Sloutskin, A., Dhakal, S., Juven‐Gershon, T., & Webb, A. E. (2021) · Aging Cell · doi:10.1111/acel.13499 · Cited by 27
Metadata
- Authors
- Urbán, N., Blomfield, I. M., & Guillemot, F.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 104
- Issue
- 5
- Pages
- 834-848
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2993849398
- Cited by
- 373
- References
- 149
- FWCI
- 10.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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