Selective Routing of Spatial Information Flow from Input to Output in Hippocampal Granule Cells
Open accessAbstract
Dentate gyrus granule cells (GCs) connect the entorhinal cortex to the hippocampal CA3 region, but how they process spatial information remains enigmatic. To examine the role of GCs in spatial coding, we measured excitatory postsynaptic potentials (EPSPs) and action potentials (APs) in head-fixed mice running on a linear belt. Intracellular recording from morphologically identified GCs revealed that most cells were active, but activity level varied over a wide range. Whereas only ∼5% of GCs showed spatially tuned spiking, ∼50% received spatially tuned input. Thus, the GC population broadly encodes spatial information, but only a subset relays this information to the CA3 network. Fourier analysis indicated that GCs received conjunctive place-grid-like synaptic input, suggesting code conversion in single neurons. GC firing was correlated with dendritic complexity and intrinsic excitability, but not extrinsic excitatory input or dendritic cable properties. Thus, functional maturation may control input-output transformation and spatial code conversion.
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Burst or superburst activity in GCs may lead to detonation, but sparse activation of GCs with neuromodulatory pathways may also efficiently activate the CA3 network.
“Thus, burst or superburst activity in GCs [104] may lead to detonation but sparse activation of GCs in conjunction with activation of neuromodulatory pathways may also efficiently activate the CA3 network.”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [104]
The Discussion (§Sparse, Heterogeneous Activity of Identified GCs; page unavailable) mentions bursts of granule-cell spikes, and §Role of Sparsely and Heterogeneously Active GCs in the Dentate Gyrus Network proposes neuromodulator-mediated recruitment of granule cells. But the copy does not describe superbursts or establish that bursts cause detonation or that neuromodulation efficiently activates the CA3 network. (LLM, conf=0.82)
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Cites
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- Authors
- Zhang, X., Schlögl, A., & Jonas, P.
- Affiliations
- Institute of Science and Technology Austria (AT)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 107
- Issue
- 6
- Pages
- 1212-1225.e7
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC7523402
- OpenAlex
- W3047385882
- Cited by
- 44
- References
- 7
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 7 · 2022: 8 · 2021: 11 · 2020: 3
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Horizon 2020 (692692)
- Horizon 2020 Framework Programme
- European Research Council
- Austrian Science Fund (Z 312-B27)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- dentate gyrus granule cells, spatial coding, place cells, grid cells, entorhinal cortex, CA3, program translation, dendritic complexity, intrinsic excitability, functional maturation, excitatory postsynaptic potentials, action potential, head-fixed mice
- MeSH terms
- Action Potentials, Animals, Cells, Cultured, Female, Male, Mice, Inbred C57BL, Neurons, Dentate Gyrus, Excitatory Postsynaptic Potentials, Mice, CA3 Region, Hippocampal, Spatial Navigation
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