Memory engrams: Recalling the past and imagining the future

The Organization of Behavior

Hebb, D. O. (2005) · doi:10.4324/9781410612403 · Cited by 9,825 · see citing works

The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat

O'Keefe, J., & Dostrovsky, J. (1971) · Brain Research · doi:10.1016/0006-8993(71)90358-1 · Cited by 6,151 · see citing works

Millisecond-timescale, genetically targeted optical control of neural activity

Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 4,831 · see citing works

The memory function of sleep

Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760 · see citing works

Reactivation of hippocampal ensemble memories during sleep

Wilson, M. A., & McNaughton, B. L. (1994) · Science · doi:10.1126/science.8036517 · Cited by 3,118 · see citing works

Synaptic Plasticity and Memory: An Evaluation of the Hypothesis

Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794 · see citing works

Simple memory: a theory for archicortex

Marr, D. (1971) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1971.0078 · Cited by 2,771 · see citing works

Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval

Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706 · see citing works

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

Greenberg, M., & Ziff, E. (1984) · Nature · doi:10.1038/311433a0 · Cited by 2,650 · see citing works

Modality-Specific Retrograde Amnesia of Fear

Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483 · see citing works

Dynamics of the Hippocampal Ensemble Code for Space

Wilson, M. A., & McNaughton, B. L. (1993) · Science · doi:10.1126/science.8351520 · Cited by 2,350 · see citing works

The organization of recent and remote memories

Frankland, P. W., & Bontempi, B. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1607 · Cited by 2,138 · see citing works

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046 · see citing works

Structural and molecular interrogation of intact biological systems

Chung, K., Wallace, J., Kim, S.-Y., Kalyanasundaram, S., Andalman, A. S., Davidson, T. J., Mirzabekov, J. J., Zalocusky, K. A., Mattis, J., Denisin, A. K., et al. (2013) · Nature · doi:10.1038/nature12107 · Cited by 2,008 · see citing works

Context and Behavioral Processes in Extinction: Table 1.

Bouton, M. E. (2004) · Learning & Memory · doi:10.1101/lm.78804 · Cited by 1,808 · see citing works

Effects of an expanding-spaced vs massed exposure schedule on fear reduction and return of fear

Rowe, M. K., & Craske, M. G. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(97)10016-x · Cited by 1,778 · see citing works

Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning

Buzsáki, G. (2015) · Hippocampus · doi:10.1002/hipo.22488 · Cited by 1,759 · see citing works

The Neurobiology of Consolidations, Or, How Stable is the Engram?

Dudai, Y. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.142050 · Cited by 1,671 · see citing works

Optogenetic stimulation of a hippocampal engram activates fear memory recall

Liu, X., Ramirez, S., Pang, P. T., Puryear, C. B., Govindarajan, A., Deisseroth, K. A., & Tonegawa, S. (2012) · Nature · doi:10.1038/nature11028 · Cited by 1,669 · see citing works

Neural Mechanisms of Extinction Learning and Retrieval

Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645 · see citing works

Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus

Leutgeb, J. K., Leutgeb, S., Moser, M.-B., & Moser, E. I. (2007) · Science · doi:10.1126/science.1135801 · Cited by 1,601 · cited 1× · see citing works

Selective suppression of hippocampal ripples impairs spatial memory

Girardeau, G., Benchenane, K., Wiener, S. I., Buzsáki, G., & Zugaro, M. B. (2009) · Nature Neuroscience · doi:10.1038/nn.2384 · Cited by 1,560 · see citing works

Availability versus accessibility of information in memory for words

Tulving, E., & Pearlstone, Z. (1966) · Journal of Verbal Learning and Verbal Behavior · doi:10.1016/s0022-5371(66)80048-8 · Cited by 1,512 · see citing works

Remembering can cause forgetting: Retrieval dynamics in long-term memory.

Anderson, M. C., Bjork, R. A., & Bjork, E. L. (1994) · Journal of Experimental Psychology: Learning, Memory, and Cognition · doi:10.1037/0278-7393.20.5.1063 · Cited by 1,482 · see citing works

Selective stabilisation of developing synapses as a mechanism for the specification of neuronal networks

Changeux, J.-P., & Danchin, A. (1976) · Nature · doi:10.1038/264705a0 · Cited by 1,448 · see citing works

Synaptic plasticity and addiction

Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397 · see citing works

Synaptic plasticity: LTP and LTD

Bear, M. F., & Malenka, R. C. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90101-5 · Cited by 1,355 · see citing works

Modeling hippocampal and neocortical contributions to recognition memory: a complementary-learning-systems approach

Norman, K. A., & O'Reilly, R. C. (2003) · Psychological Review · doi:10.1037/0033-295x.110.4.611 · Cited by 1,312 · see citing works

Mechanisms of fear extinction

Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277 · see citing works

Preventing the return of fear in humans using reconsolidation update mechanisms

Schiller, D., Monfils, M.-H., Raio, C. M., Johnson, D. C., LeDoux, J. E., & Phelps, E. A. (2010) · Nature · doi:10.1038/nature08637 · Cited by 1,248 · see citing works

Schemas and Memory Consolidation.

Tse, D., Langston, R. F., Kakeyama, M., Bethus, I., Spooner, P. A., Wood, E. R., Witter, M. P., & Morris, R. G. M. (2007) · Science · doi:10.1126/science.1135935 · Cited by 1,244 · see citing works

Engrams and circuits crucial for systems consolidation of a memory

Kitamura, T., Ogawa, S. K., Roy, D. S., Okuyama, T., Morrissey, M. D., Smith, L. M., Redondo, R. L., & Tonegawa, S. (2017) · Science · doi:10.1126/science.aam6808 · Cited by 1,104 · see citing works

Episodic memory and beyond: the hippocampus and neocortex in transformation

Moscovitch, M., Cabeza, R., Winocur, G., & Nadel, L. (2016) · Annual Review of Psychology · doi:10.1146/annurev-psych-113011-143733 · Cited by 1,062 · see citing works

Coordinated interactions between hippocampal Ripples and Cortical Spindles during Slow-Wave Sleep

Siapas, A. G., & Wilson, M. A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80629-7 · Cited by 1,052 · see citing works

Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses

Zhou, Q., Homma, K. J., & Poo, M.-M. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.011 · Cited by 1,025 · see citing works

Engineering a memory with LTD and LTP

Nabavi, S., Fox, R., Proulx, C. D., Lin, J. Y., Tsien, R. Y., & Malinow, R. (2014) · Nature · doi:10.1038/nature13294 · Cited by 980 · see citing works

The hippocampal CA2 region is essential for social memory

Hitti, F. L., & Siegelbaum, S. A. (2014) · Nature · doi:10.1038/nature13028 · Cited by 976 · see citing works

Creating a False Memory in the Hippocampus

Ramirez, S., Liu, X., Lin, P.-A., Suh, J., Pignatelli, M., Redondo, R. L., Ryan, T. J., & Tonegawa, S. (2013) · Science · doi:10.1126/science.1239073 · Cited by 968 · see citing works

Sparse Distributed Memory

Kanerva, P. (1988) · Medical Entomology and Zoology · Cited by 967 · see citing works

Extinction-Reconsolidation Boundaries: Key to Persistent Attenuation of Fear Memories

Monfils, M.-H., Cowansage, K. K., Klann, E., & LeDoux, J. E. (2009) · Science · doi:10.1126/science.1167975 · Cited by 960 · see citing works

Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval

Carr, M. F., Jadhav, S. P., & Frank, L. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2732 · Cited by 958 · see citing works

Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network

McHugh, T. J., Jones, M. W., Quinn, J. J., Balthasar, N., Coppari, R., Elmquist, J. K., Lowell, B. B., Fanselow, M. S., Wilson, M. A., & Tonegawa, S. (2007) · Science · doi:10.1126/science.1140263 · Cited by 958 · see citing works

The Involvement of the Anterior Cingulate Cortex in Remote Contextual Fear Memory

Frankland, P., Bontempi, B., Talton, L., Kaczmarek, L., & Silva, A. J. (2004) · Science · doi:10.1126/science.1094804 · Cited by 952 · see citing works

A shared neural ensemble links distinct contextual memories encoded close in time

Cai, D. J., Aharoni, D. B., Shuman, T., Shobe, J. L., Biane, J. S., Song, W., Wei, B., Veshkini, M., La-Vu, M. Q., Lou, J. J., et al. (2016) · Nature · doi:10.1038/nature17955 · Cited by 947 · see citing works

Awake hippocampal sharp-wave ripples support spatial memory

Jadhav, S. P., Kemere, C., German, P. W., & Frank, L. M. (2012) · Science · doi:10.1126/science.1217230 · Cited by 924 · see citing works

Retrieval and reconsolidation: Toward a neurobiology of remembering

Sara, S. J. (2000) · Learning & Memory · doi:10.1101/lm.7.2.73 · Cited by 919 · see citing works

Balancing Structure and Function at Hippocampal Dendritic Spines

Bourne, J. N., & Harris, K. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125646 · Cited by 916 · see citing works

Amnesic Syndrome: Consolidation or Retrieval?

Warrington, E. K., & Weiskrantz, L. (1970) · Nature · doi:10.1038/228628a0 · Cited by 863 · see citing works

Localization of a Stable Neural Correlate of Associative Memory

Reijmers, L. G. J. E., Perkins, B. L., Matsuo, N., & Mayford, M. R. (2007) · Science · doi:10.1126/science.1143839 · Cited by 853 · see citing works

Disruption of ripple‐associated hippocampal activity during rest impairs spatial learning in the rat

Ego‐Stengel, V., & Wilson, M. A. (2010) · Hippocampus · doi:10.1002/hipo.20707 · Cited by 842 · see citing works

Beyond extinction: erasing human fear responses and preventing the return of fear

Kindt, M., Soeter, M., & Vervliet, B. (2009) · Nature Neuroscience · doi:10.1038/nn.2271 · Cited by 826 · see citing works

Latent inhibition: The effect of nonreinforced pre-exposure to the conditional stimulus.

Lubow, R. E., & Moore, A. U. (1959) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0046700 · Cited by 806 · see citing works

The reorganization and reactivation of hippocampal maps predict spatial memory performance

Dupret, D., O'Neill, J., Pleydell-Bouverie, B., & Csicsvari, J. (2010) · Nature Neuroscience · doi:10.1038/nn.2599 · Cited by 769 · see citing works

Reinstatement of fear to an extinguished conditioned stimulus.

Rescorla, R. A., & Heth, C. D. (1975) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.1.1.88 · Cited by 768 · see citing works

Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats

Maren, S., Aharonov, G., & Fanselow, M. S. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00088-0 · Cited by 765 · see citing works

Memory traces unbound

Nader, K. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)00042-5 · Cited by 763 · see citing works

Reactivation of hippocampal cell assemblies: effects of behavioral state, experience, and EEG dynamics

Kudrimoti, H. S., Barnes, C. A., & McNaughton, B. L. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-10-04090.1999 · Cited by 753 · see citing works

From the neuron doctrine to neural networks

Yuste, R. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3962 · Cited by 748 · see citing works

Engram cells retain memory under retrograde amnesia

Ryan, T. J., Roy, D. S., Pignatelli, M., Arons, A. L., & Tonegawa, S. (2015) · Science · doi:10.1126/science.aaa5542 · Cited by 745 · see citing works

Neurobiology of Schemas and Schema-Mediated Memory

Gilboa, A., & Marlatte, H. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.04.013 · Cited by 742 · see citing works

Neuronal correlate of visual associative long-term memory in the primate temporal cortex

Miyashita, Y. (1988) · Nature · doi:10.1038/335817a0 · Cited by 741 · see citing works

Finding the engram

Josselyn, S. A., Köhler, S., & Frankland, P. W. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4000 · Cited by 687 · see citing works

Neuronal competition and selection during memory formation

Han, J.-H., Kushner, S. A., Yiu, A. P., Cole, C. J., Matynia, A., Brown, R. A., Neve, R. L., Guzowski, J. F., Silva, A. J., & Josselyn, S. A. (2007) · Science · doi:10.1126/science.1139438 · Cited by 682 · see citing works

Contextual and temporal modulation of extinction: behavioral and biological mechanisms

Bouton, M. E., Westbrook, R. F., Corcoran, K. A., & Maren, S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.015 · Cited by 671 · see citing works

Ventral CA1 neurons store social memory

Okuyama, T., Kitamura, T., Roy, D. S., Itohara, S., & Tonegawa, S. (2016) · Science · doi:10.1126/science.aaf7003 · Cited by 657 · see citing works

The Restless Engram: Consolidations Never End

Dudai, Y. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150500 · Cited by 644 · see citing works

Labelling and optical erasure of synaptic memory traces in the motor cortex

Hayashi-Takagi, A., Yagishita, S., Nakamura, M., Shirai, F., Wu, Y. I., Loshbaugh, A. L., Kuhlman, B., Hahn, K. M., & Kasai, H. (2015) · Nature · doi:10.1038/nature15257 · Cited by 624 · see citing works

CREB required for the stability of new and reactivated fear memories

Kida, S., Josselyn, S. A., de Ortı́z, S. P., Kogan, J. H., Chévere-Torres, I., Masushige, S., & Silva, A. J. (2002) · Nature Neuroscience · doi:10.1038/nn819 · Cited by 624 · see citing works

Temporal evolution of cortical ensembles promoting remote memory retrieval

DeNardo, L. A., Liu, C. D., Allen, W. E., Adams, E. L., Friedmann, D., Dadgar‐Kiani, E., Fu, L., Guenthner, C. J., Lee, J. H., Tessier‐Lavigne, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0318-7 · Cited by 615 · see citing works

Memory Engram Cells Have Come of Age

Tonegawa, S., Liu, X., Ramirez, S., & Redondo, R. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.002 · Cited by 613 · see citing works

Memory Consolidation of Auditory Pavlovian Fear Conditioning Requires Protein Synthesis and Protein Kinase A in the Amygdala

Schafe, G. E., & LeDoux, J. E. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-j0003.2000 · Cited by 611 · see citing works

Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease

Roy, D. S., Arons, A. L., Mitchell, T. I., Pignatelli, M., Ryan, T. J., & Tonegawa, S. (2016) · Nature · doi:10.1038/nature17172 · Cited by 604 · see citing works

CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala

Zhou, Y., Won, J., Karlsson, M. G., Zhou, M., Rogerson, T., Balaji, J., Neve, R. L., Poirazi, P., & Silva, A. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2405 · Cited by 577 · see citing works

Selective Erasure of a Fear Memory

Han, J., Kushner, S. A., Yiu, A. P., Hsiang, H., Buch, T., Waisman, A., Bontempi, B., Neve, R. L., Frankland, P. W., & Josselyn, S. A. (2009) · Science · doi:10.1126/science.1164139 · Cited by 570 · see citing works

Hippocampal Memory Traces Are Differentially Modulated by Experience, Time, and Adult Neurogenesis

Denny, C. A., Kheirbek, M. A., Alba, E. L., Tanaka, K. F., Brachman, R. A., Laughman, K. B., Tomm, N. K., Turi, G. F., Losonczy, A., & Hen, R. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.018 · Cited by 558 · see citing works

Memory Transformation and Systems Consolidation

Winocur, G., & Moscovitch, M. (2011) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617711000683 · Cited by 557 · see citing works

Hippocampal-Neocortical Interactions in Memory Formation, Consolidation, and Reconsolidation

Wang, S., & Morris, R. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100523 · Cited by 536 · see citing works

Stability of retrieved memory: Inverse correlation with trace dominance

Eisenberg, M., Kobilo, T., Berman, D. E., & Dudai, Y. (2003) · Science · doi:10.1126/science.1086881 · Cited by 518 · see citing works

Searching for the Memory Trace in a Mini-Brain, the HoneybeePreprint

Menzel, R. (2001) · Learning & Memory · doi:10.1101/lm.38801 · Cited by 518 · see citing works

Bidirectional switch of the valence associated with a hippocampal contextual memory engram

Redondo, R. L., Kim, J., Arons, A. L., Ramirez, S., Liu, X., & Tonegawa, S. (2014) · Nature · doi:10.1038/nature13725 · Cited by 512 · cited 1× · see citing works

Reconsolidation of memory after its reactivation

Przybyslawski, J., & Sara, S. J. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)00153-2 · Cited by 493 · see citing works

Psychobiology of active and inactive memory.

Lewis, D. J. (1979) · Psychological Bulletin · doi:10.1037/0033-2909.86.5.1054 · Cited by 486 · see citing works

Superinduction of c- fos by Nerve Growth Factor in the Presence of Peripherally Active Benzodiazepines

Curran, T., & Morgan, J. I. (1985) · Science · doi:10.1126/science.4035354 · Cited by 479 · see citing works

The Developing Brain

Shatz, C. J. (1992) · Scientific American · doi:10.1038/scientificamerican0992-60 · Cited by 462 · see citing works

Rites of Passage of the Engram

Dudai, Y., & Eisenberg, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.003 · Cited by 455 · see citing works

The role of engram cells in the systems consolidation of memory

Tonegawa, S., Morrissey, M. D., & 北村, 貴. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0031-2 · Cited by 454 · see citing works

CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models

Benito, E., & Barco, Á. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.02.001 · Cited by 450 · see citing works

Introduction and removal of reward, and maze performance in rats.

Tolman, E. C., & Honzik, C. H. (1930) · Cited by 447 · see citing works

Neurons Are Recruited to a Memory Trace Based on Relative Neuronal Excitability Immediately before Training

Yiu, A. P., Mercaldo, V., Chen, Y., Richards, B. A., Rashid, A. J., Hsiang, H., Pressey, J. C., Mahadevan, V., Tran, M. M., Kushner, S. A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.017 · Cited by 442 · see citing works

New life in an old idea: The synaptic plasticity and memory hypothesis revisited

Martin, S. J., & Morris, R. (2002) · Hippocampus · doi:10.1002/hipo.10107 · Cited by 440 · see citing works

Inferotemporal Neurons Distinguish and Retain Behaviorally Relevant Features of Visual Stimuli

Fuster, J. M., & Jervey, J. P. (1981) · Science · doi:10.1126/science.7233192 · Cited by 436 · see citing works

The hippocampal sharp wave-ripple in memory retrieval for immediate use and consolidation

Joo, H. R., & Frank, L. M. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0077-1 · Cited by 430 · see citing works

Neural and cellular mechanisms of fear and extinction memory formation

Orsini, C. A., & Maren, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.014 · Cited by 429 · see citing works

Protection of tissue physicochemical properties using polyfunctional crosslinkers

Park, Y.-G., Sohn, C. H., Chen, R., McCue, M., Yun, D. H., Drummond, G. T., Ku, T., Evans, N. B., Oak, H. C., Trieu, W., et al. (2019) · Nature Biotechnology · doi:10.1038/nbt.4281 · Cited by 421 · see citing works

Memory Consolidation for Contextual and Auditory Fear Conditioning Is Dependent on Protein Synthesis, PKA, and MAP KinasePreprint

Schafe, G. E., Nadel, N. V., Sullivan, G. M., Harris, A. Z., & LeDoux, J. E. (1999) · Learning & Memory · doi:10.1101/lm.6.2.97 · Cited by 407 · see citing works

Memory integration: neural mechanisms and implications for behavior

Schlichting, M. L., & Preston, A. R. (2014) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2014.07.005 · Cited by 404 · see citing works

Cortical Representations Are Reinstated by the Hippocampus during Memory Retrieval

Tanaka, K. Z., Pevzner, A., Hamidi, A., Nakazawa, Y., Graham, J. A., & Wiltgen, B. J. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.037 · Cited by 403 · see citing works

Calcium-Mediated Reduction of Ionic Currents: A Biophysical Memory Trace

Alkon, D. L. (1984) · Science · doi:10.1126/science.6093258 · Cited by 393 · see citing works

Generation of a synthetic memory trace

Garner, A. R., Rowland, D. C., Hwang, S. Y., Baumgaertel, K., Roth, B. L., Kentros, C., & Mayford, M. (2012) · Science · doi:10.1126/science.1214985 · Cited by 387 · see citing works

Interregional synaptic maps among engram cells underlie memory formation

Choi, J., Sim, S.-E., Kim, J., Choi, D. I., Oh, J., Ye, S., Lee, J., Kim, T., Ko, H., Lim, C., et al. (2018) · Science · doi:10.1126/science.aas9204 · Cited by 382 · see citing works

Competition between engrams influences fear memory formation and recall

Rashid, A., Yan, C., Mercaldo, V., Hsiang, H., Park, S., Cole, C. J., Cristofaro, A. D., Yu, J., Ramakrishnan, C., Lee, S., et al. (2016) · Science · doi:10.1126/science.aaf0594 · Cited by 371 · see citing works

Activity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila

Owald, D., Felsenberg, J., Talbot, C. B., Das, G., Perisse, E., Huetteroth, W., & Waddell, S. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.025 · Cited by 367 · see citing works

Overcoming interference: An fMRI investigation of pattern separation in the medial temporal lobePreprint

Kirwan, C. B., & Stark, C. E. L. (2007) · Learning & Memory · doi:10.1101/lm.663507 · Cited by 361 · see citing works

Direct Reactivation of a Coherent Neocortical Memory of Context

Cowansage, K. K., Shuman, T., Dillingham, B. C., Chang, A., Golshani, P., & Mayford, M. R. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.022 · Cited by 359 · see citing works

CREB modulates excitability of nucleus accumbens neurons

Dong, Y., Green, T. A., Saal, D. B., Marie, H., Neve, R. L., Nestler, E. J., & Malenka, R. C. (2006) · Nature Neuroscience · doi:10.1038/nn1661 · Cited by 356 · see citing works

Memory reconsolidation: sensitivity of spatial memory to inhibition of protein synthesis in dorsal hippocampus during encoding and retrieval

Morris, R. G. M., Inglis, J., Ainge, J. A., Olverman, H. J., Tulloch, J., Dudai, Y., & Kelly, P. A. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.012 · Cited by 342 · see citing works

Consolidation and Reconsolidation: Two Lives of Memories?

McKenzie, S., & Eichenbaum, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.037 · Cited by 338 · see citing works

Simultaneous cellular-resolution optical perturbation and imaging of place cell firing fields

Rickgauer, J. P., Deisseroth, K. A., & Tank, D. W. (2014) · Nature Neuroscience · doi:10.1038/nn.3866 · Cited by 323 · see citing works

Memory for context becomes less specific with timePreprint

Wiltgen, B. J., & Silva, A. J. (2007) · Learning & Memory · doi:10.1101/lm.430907 · Cited by 319 · see citing works

Identification of a Functional Connectome for Long-Term Fear Memory in Mice

Wheeler, A. L., Teixeira, C. M., Wang, A. H., Xiong, X., Kovacevic, N., Lerch, J. P., McIntosh, A. R., Parkinson, J., & Frankland, P. W. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002853 · Cited by 315 · see citing works

Genealogy of the “Grandmother Cell”

Gross, C. G. (2002) · The Neuroscientist · doi:10.1177/107385802237175 · Cited by 314 · see citing works

Distinct hippocampal engrams control extinction and relapse of fear memory

Lacagnina, A. F., Brockway, E. T., Crovetti, C. R., Shue, F., McCarty, M. J., Sattler, K. P., Lim, S. C., Santos, S. L., Denny, C. A., & Drew, M. R. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0361-z · Cited by 311 · see citing works

New Circuits for Old Memories

Wiltgen, B. J., Brown, R. A. M., Talton, L. E., & Silva, A. J. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.015 · Cited by 309 · see citing works

Intracellular Determinants of Hippocampal CA1 Place and Silent Cell Activity in a Novel Environment

Epsztein, J., Brecht, M., & Lee, A. K. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.006 · Cited by 306 · see citing works

Tracking the flow of hippocampal computation: Pattern separation, pattern completion, and attractor dynamics

Knierim, J. J., & Neunuebel, J. P. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.10.008 · Cited by 305 · see citing works

Synaptic tagging during memory allocation

Rogerson, T., Cai, D. J., Frank, A. C., Sano, Y., Shobe, J. L., López‐Aranda, M. F., & Silva, A. J. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3667 · Cited by 305 · see citing works

The Hippocampus Plays a Selective Role in the Retrieval of Detailed Contextual Memories

Wiltgen, B. J., Zhou, M., Cai, Y., Balaji, J., Karlsson, M. G., Parivash, S. N., Li, W., & Silva, A. J. (2010) · Current Biology · doi:10.1016/j.cub.2010.06.068 · Cited by 300 · see citing works

Hippocampal involvement in contextual modulation of fear extinction

Ji, J., & Maren, S. (2007) · Hippocampus · doi:10.1002/hipo.20331 · Cited by 297 · see citing works

Reactivation of Neural Ensembles during the Retrieval of Recent and Remote Memory

Tayler, K. K., Tanaka, K. Z., Reijmers, L. G. J. E., & Wiltgen, B. J. (2012) · Current Biology · doi:10.1016/j.cub.2012.11.019 · Cited by 296 · see citing works

Chemogenetic Interrogation of a Brain-wide Fear Memory Network in Mice

Vetere, G., Kenney, J. W., Tran, L. M., Xia, F., Steadman, P. E., Parkinson, J., Josselyn, S. A., & Frankland, P. W. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.037 · Cited by 293 · see citing works

The operation of pattern separation and pattern completion processes associated with different attributes or domains of memory

Hunsaker, M. R., & Kesner, R. P. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.09.014 · Cited by 283 · see citing works

Amygdala Reward Neurons Form and Store Fear Extinction Memory

Zhang, X., Kim, J., & Tonegawa, S. (2019) · Neuron · doi:10.1016/j.neuron.2019.12.025 · Cited by 279 · see citing works

The engram found? Role of the cerebellum in classical conditioning of nictitating membrane and eyelid responses

McCormick, D. A., Lavond, D. G., Clark, G. A., Kettner, R. E., Rising, C. E., & Thompson, R. F. (1981) · Bulletin of the Psychonomic Society · doi:10.3758/bf03333573 · Cited by 277 · see citing works

Role of Secondary Sensory Cortices in Emotional Memory Storage and Retrieval in Rats

Sacco, T., & Sacchetti, B. (2010) · Science · doi:10.1126/science.1183165 · Cited by 272 · see citing works

The hippocampus and inferential reasoning: building memories to navigate future decisions

Zeithamova, D., Schlichting, M. L., & Preston, A. R. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00070 · Cited by 266 · see citing works

Molecular and Cellular Approaches to Memory Allocation in Neural Circuits

Silva, A. J., Zhou, Y., Rogerson, T., Shobe, J. L., & Balaji, J. (2009) · Science · doi:10.1126/science.1174519 · Cited by 266 · see citing works

Hippocampal ensemble dynamics timestamp events in long-term memory

Rubin, A., Geva, N., Sheintuch, L., & Ziv, Y. (2015) · eLife · doi:10.7554/elife.12247 · Cited by 266 · see citing works

The role of protein synthesis in memory consolidation: Progress amid decades of debate

Hernandez, P. J., & Abel, T. G. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.09.010 · Cited by 264 · see citing works

Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization

Koya, E., Golden, S. A., Harvey, B. K., Guez‐Barber, D., Berkow, A., Simmons, D. E., Bossert, J. M., Nair, S. G., Uejima, J. L., Marin, M. T., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2364 · Cited by 264 · see citing works

Hippocampal ripples down-regulate synapses

Norimoto, H., Makino, K., Gao, M., Shikano, Y., Okamoto, K., Ishikawa, T., Sasaki, T., Hioki, H., Fujisawa, S., & Ikegaya, Y. (2018) · Science · doi:10.1126/science.aao0702 · Cited by 262 · see citing works

Engram Cell Excitability State Determines the Efficacy of Memory Retrieval

Pignatelli, M., Ryan, T. J., Roy, D. S., Lovett, C., Smith, L. M., Muralidhar, S., & Tonegawa, S. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.029 · Cited by 259 · see citing works

Hippocampal Somatostatin Interneurons Control the Size of Neuronal Memory Ensembles

Stefanelli, T., Bertollini, C., Lüscher, C., Müller, D., & Méndez, P. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.024 · Cited by 255 · see citing works

Amygdala depotentiation and fear extinction

Kim, J., Lee, S., Park, K., Hong, I., Song, B., Son, G. H., Park, H., Kim, W. R., Park, E. J., Choe, H. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710548105 · Cited by 252 · see citing works

Hippocampal Place Fields Emerge upon Single-Cell Manipulation of Excitability During Behavior

Lee, D., Lin, B., & Lee, A. K. (2012) · Science · doi:10.1126/science.1221489 · Cited by 251 · see citing works

The hippocampal engram maps experience but not place

Tanaka, K. Z., He, H., Tomar, A., Niisato, K., Huang, A. J. Y., & McHugh, T. J. (2018) · Science · doi:10.1126/science.aat5397 · Cited by 237 · see citing works

Inhibitory Plasticity: Balance, Control, and Codependence

Hennequin, G., Agnes, E. J., & Vogels, T. P. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031005 · Cited by 234 · see citing works

Driving Opposing Behaviors with Ensembles of Piriform Neurons

Choi, G. B., Stettler, D. D., Kallman, B. R., Bhaskar, S., Fleischmann, A., & Axel, R. (2011) · Cell · doi:10.1016/j.cell.2011.07.041 · Cited by 232 · see citing works

Encoding and storage of spatial information in the retrosplenial cortex

Czajkowski, R., Jayaprakash, B., Wiltgen, B. J., Rogerson, T., Karlsson, M. G., Barth, A. L., Trachtenberg, J. T., & Silva, A. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313222111 · Cited by 229 · see citing works

Primary Changes of Membrane Currents During Retention of Associative Learning

Alkon, D. L., Lederhendler, I., & Shoukimas, J. J. (1982) · Science · doi:10.1126/science.7058334 · Cited by 228 · see citing works

The neurobiological foundation of memory retrieval

Frankland, P. W., Josselyn, S. A., & Köhler, S. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0493-1 · Cited by 228 · see citing works

Fast track to the neocortex: A memory engram in the posterior parietal cortex

Brodt, S., Gais, S., Beck, J., Erb, M., Scheffler, K., & Schönauer, M. (2018) · Science · doi:10.1126/science.aau2528 · Cited by 224 · see citing works

Memory Allocation: Mechanisms and Function

Josselyn, S. A., & Frankland, P. W. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061956 · Cited by 221 · see citing works

Generation of Silent Synapses by Acute In Vivo Expression of CaMKIV and CREB

Marie, H., Morishita, W., Yu, X., Calakos, N., & Malenka, R. C. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.039 · Cited by 219 · see citing works

Integration of Parallel Opposing Memories Underlies Memory Extinction

Felsenberg, J., Jacob, P. F., Walker, T. M., Barnstedt, O., Edmondson-Stait, A. J., Pleijzier, M. W., Otto, N., Schlegel, P., Sharifi, N., Perisse, E., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.021 · Cited by 217 · see citing works

Neuronal Ensembles in Amygdala, Hippocampus, and Prefrontal Cortex Track Differential Components of Contextual Fear

Zelikowsky, M., Hersman, S., Chawla, M. K., Barnes, C. A., & Fanselow, M. S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3624-13.2014 · Cited by 216 · see citing works

Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body

Perisse, E., Owald, D., Barnstedt, O., Talbot, C. B., Huetteroth, W., & Waddell, S. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.034 · Cited by 216 · see citing works

Does Reconsolidation Occur in Humans?

Schiller, D., & Phelps, E. A. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00024 · Cited by 211 · see citing works

Parvalbumin-positive interneurons mediate neocortical-hippocampal interactions that are necessary for memory consolidation

Xia, F., Richards, B. A., Tran, M. M., Josselyn, S. A., Takehara‐Nishiuchi, K., & Frankland, P. W. (2017) · eLife · doi:10.7554/elife.27868 · Cited by 202 · see citing works

A robust activity marking system for exploring active neuronal ensembles

Sørensen, A. T., Cooper, Y. A., Baratta, M. V., Weng, F., Zhang, Y., Ramamoorthi, K., Fropf, R., LaVerriere, E., Xue, J., Young, A., et al. (2016) · eLife · doi:10.7554/elife.13918 · Cited by 189 · see citing works

Memory and law: what can cognitive neuroscience contribute?

Schacter, D. L., & Loftus, E. F. (2013) · Nature Neuroscience · doi:10.1038/nn.3294 · Cited by 188 · see citing works

Synapse-specific representation of the identity of overlapping memory engrams

Abdou, K., Shehata, M., Choko, K., Nishizono, H., Matsuo, M., Muramatsu, S., & Inokuchi, K. (2018) · Science · doi:10.1126/science.aat3810 · Cited by 188 · see citing works

Selective synaptic remodeling of amygdalocortical connections associated with fear memory

Yang, Y., Liu, D., Huang, W., Deng, J., Sun, Y.-G., Zuo, Y., & Poo, M. (2016) · Nature Neuroscience · doi:10.1038/nn.4370 · Cited by 187 · see citing works

cAMP Response Element-Binding Protein-Mediated Gene Expression Increases the Intrinsic Excitability of CA1 Pyramidal Neurons

de Armentia, M. L., Jančić, D., Olivares, R., Alarcón, J. M., Kandel, E. R., & Barco, Á. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3850-07.2007 · Cited by 184 · see citing works

Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding

Abbas, A. I., Sundiang, M. J. M., Henoch, B., Morton, M. P., Bolkan, S. S., Park, A. J., Harris, A. Z., Kellendonk, C., & Gordon, J. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.029 · Cited by 183 · see citing works

Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice

Deng, W., Mayford, M. R., & Gage, F. H. (2013) · eLife · doi:10.7554/elife.00312 · Cited by 182 · see citing works

Neuronal Allocation to a Hippocampal Engram

Park, S., Kramer, E. E., Mercaldo, V., Rashid, A. J., Insel, N., Frankland, P. W., & Josselyn, S. A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.73 · Cited by 179 · see citing works

Large environments reveal the statistical structure governing hippocampal representations

Rich, P. D., Liaw, H.-P., & Lee, A. K. (2014) · Science · doi:10.1126/science.1255635 · Cited by 177 · see citing works

Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization

Guo, N., Soden, M. E., Herber, C. S., Kim, M. T., Besnard, A., Lin, P., Ma, X., Cepko, C. L., Zweifel, L. S., & Sahay, A. (2018) · Nature Medicine · doi:10.1038/nm.4491 · Cited by 173 · see citing works

Music Enhances Autobiographical Memory in Mild Alzheimer's Disease

Haj, M. E., Postal, V., & Allain, P. (2011) · Educational Gerontology · doi:10.1080/03601277.2010.515897 · Cited by 172 · see citing works

Building concepts one episode at a time: The hippocampus and concept formation

Mack, M. L., Love, B. C., & Preston, A. R. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.07.061 · Cited by 172 · see citing works

Long-Term Sensitization in Aplysia : Biophysical Correlates in Tail Sensory Neurons

Scholz, K. P., & Byrne, J. H. (1987) · Science · doi:10.1126/science.2433766 · Cited by 169 · see citing works

A test of Hebb's postulate at identified synapses which mediate classical conditioning in Aplysia

Carew, T., Hawkins, R. D., Abrams, T. W., & Kandel, E. R. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-05-01217.1984 · Cited by 166 · see citing works

Fear extinction causes target-specific remodeling of perisomatic inhibitory synapses

Trouche, S., Sasaki, J. M., Tu, T., & Reijmers, L. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.047 · Cited by 166 · see citing works

Mass Action in Cerebral Function

Lashley, K. S. (1931) · Science · doi:10.1126/science.73.1888.245 · Cited by 164 · see citing works

Richard Semon's theory of memory

Schacter, D. L., Eich, J. E., & Tulving, E. (1978) · Journal of Verbal Learning and Verbal Behavior · doi:10.1016/s0022-5371(78)90443-7 · Cited by 163 · see citing works

Orchestrated ensemble activities constitute a hippocampal memory engram

Ghandour, K., Ohkawa, N., Fung, C. C. A., Asai, H., Saitoh, Y., Takekawa, T., Okubo-Suzuki, R., Soya, S., Nishizono, H., Matsuo, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10683-2 · Cited by 162 · see citing works

Recovery of “Lost” Infant Memories in Mice

Guskjolen, A. J., Kenney, J. W., de la Parra, J., Yeung, B.-R. A., Josselyn, S. A., & Frankland, P. W. (2018) · Current Biology · doi:10.1016/j.cub.2018.05.059 · Cited by 160 · see citing works

Involvement of a Calcineurin Cascade in Amygdala Depotentiation and Quenching of Fear Memory

Lin, C.-H., Lee, C.-C., & Gean, P. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.1.44 · Cited by 158 · see citing works

Memory Reconsolidation Mediates the Updating of Hippocampal Memory Content

Lee, J. L. C. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00168 · Cited by 153 · see citing works

Inhibitory engrams in perception and memory

Barron, H. C., Vogels, T. P., Behrens, T. E., & Ramaswami, M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701812114 · Cited by 147 · see citing works

Constructive memory: past and future

Schacter, D. L. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.1/dschacter · Cited by 146 · see citing works

Reactivation of recall-induced neurons contributes to remote fear memory attenuation

Khalaf, O., Resch, S., Dixsaut, L., Gorden, V., Glauser, L., & Gräff, J. (2018) · Science · doi:10.1126/science.aas9875 · Cited by 146 · see citing works

Engram-specific transcriptome profiling of contextual memory consolidation

Rao‐Ruiz, P., Couey, J. J., Marcelo, I. M., Bouwkamp, C. G., Slump, D. E., Matos, M. R., van der Loo, R. J., Martins, G. J., van den Hout, M. C. G. N., van IJcken, W. F. J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09960-x · Cited by 146 · see citing works

Experience-dependent shaping of hippocampal CA1 intracellular activity in novel and familiar environments

Cohen, J. D., Bolstad, M., & Lee, A. K. (2017) · eLife · doi:10.7554/elife.23040 · Cited by 144 · see citing works

Role of cAMP Response Element-Binding Protein in the Rat Locus Ceruleus: Regulation of Neuronal Activity and Opiate Withdrawal Behaviors

Han, M., Bolaños, C. A., Green, T. A., Olson, V. G., Neve, R. L., Liu, R.-J., Aghajanian, G. K., & Nestler, E. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4701-05.2006 · Cited by 139 · see citing works

Context-specificity of target versus feature inhibition in a feature-negative discrimination.

Bouton, M. E., & Nelson, J. B. (1994) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.20.1.51 · Cited by 138 · see citing works

The precision of remote context memories does not require the hippocampus

Wang, S., Teixeira, C. M., Wheeler, A. L., & Frankland, P. W. (2009) · Nature Neuroscience · doi:10.1038/nn.2263 · Cited by 138 · see citing works

Inducible repression of CREB function disrupts amygdala-dependent memory

Josselyn, S. A. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.05.008 · Cited by 136 · see citing works

Memory recall and modifications by activating neurons with elevated CREB

Kim, J., Kwon, J.-T., Kim, H.-S., Josselyn, S. A., & Han, J. (2013) · Nature Neuroscience · doi:10.1038/nn.3592 · Cited by 136 · see citing works

Memory formation in the absence of experience

Vetere, G., Tran, L. M., Moberg, S., Steadman, P. E., Restivo, L., Morrison, F. G., Ressler, K. J., Josselyn, S. A., & Frankland, P. W. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0389-0 · Cited by 136 · see citing works

Manipulating a “Cocaine Engram” in Mice

Hsiang, H.-L. (., Epp, J. R., van den Oever, M. C., Yan, C., Rashid, A. J., Insel, N., Ye, L., Niibori, Y., Deisseroth, K., Frankland, P. W., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-14.2014 · Cited by 131 · see citing works

Synaptic Targeting of Double-Projecting Ventral CA1 Hippocampal Neurons to the Medial Prefrontal Cortex and Basal Amygdala

Kim, W. B., & Cho, J.-H. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3579-16.2017 · Cited by 131 · see citing works

Unmasking Latent Inhibitory Connections in Human Cortex to Reveal Dormant Cortical Memories

Barron, H. C., Vogels, T. P., Emir, U. E., Makin, T. R., O’Shea, J., Clare, S., Jbabdi, S., Dolan, R. J., & Behrens, T. E. J. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.031 · Cited by 127 · see citing works

Increasing CREB in the auditory thalamus enhances memory and generalization of auditory conditioned fearPreprint

Han, J., Yiu, A. P., Cole, C. J., Hsiang, H., Neve, R. L., & Josselyn, S. A. (2008) · Learning & Memory · doi:10.1101/lm.993608 · Cited by 124 · see citing works

Memory reactivation during rest supports upcoming learning of related content

Schlichting, M. L., & Preston, A. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404396111 · Cited by 122 · see citing works

Heroes of the Engram

Josselyn, S. A., Köhler, S., & Frankland, P. W. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0056-17.2017 · Cited by 122 · see citing works

Arc expression identifies the lateral amygdala fear memory trace

Gouty‐Colomer, L., Hosseini, B., Marcelo, I. M., Schreiber, J., Slump, D. E., Yamaguchi, S., Houweling, A. R., Jaarsma, D., Elgersma, Y., & Kushner, S. A. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.18 · Cited by 120 · see citing works

Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory

Ohkawa, N., Saitoh, Y., Suzuki, A. Z., Tsujimura, S., Murayama, E., Kosugi, S., Nishizono, H., Matsuo, M., Takahashi, Y., Nagase, M., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.017 · Cited by 120 · see citing works

Silent memory engrams as the basis for retrograde amnesia

Roy, D. S., Muralidhar, S., Smith, L. M., & Tonegawa, S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714248114 · Cited by 120 · see citing works

Computation in the Learning System of Cephalopods

Young, J. Z. (1991) · The Biological Bulletin · doi:10.2307/1542389 · Cited by 119 · see citing works

Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory

Matos, M. R., Visser, E., Kramvis, I., van der Loo, R. J., Gebuis, T., Zalm, R., Rao‐Ruiz, P., Mansvelder, H. D., Smit, A. B., & van den Oever, M. C. (2019) · Nature Communications · doi:10.1038/s41467-019-10266-1 · Cited by 119 · see citing works

Parvalbumin interneurons constrain the size of the lateral amygdala engram

Morrison, D. J., Rashid, A. J., Yiu, A. P., Yan, C., Frankland, P. W., & Josselyn, S. A. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.07.007 · Cited by 117 · see citing works

Continuing the search for the engram: examining the mechanism of fear memories

Josselyn, S. A. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100015 · Cited by 116 · see citing works

Optogenetic stimulation of dentate gyrus engrams restores memory in Alzheimer's disease mice

Perusini, J. N., Cajigas, S. A., Cohensedgh, O., Lim, S. C., Pavlova, I. P., Donaldson, Z. R., & Denny, C. A. (2017) · Hippocampus · doi:10.1002/hipo.22756 · Cited by 115 · see citing works

Overlapping memory trace indispensable for linking, but not recalling, individual memories

Yokose, J., Okubo-Suzuki, R., Nomoto, M., Ohkawa, N., Nishizono, H., Suzuki, A. Z., Matsuo, M., Tsujimura, S., Takahashi, Y., Nagase, M., et al. (2017) · Science · doi:10.1126/science.aal2690 · Cited by 113 · see citing works

Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling

Miyashita, T., Kikuchi, E., Horiuchi, J., & Saitoe, M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.022 · Cited by 108 · see citing works

Imaging neural activity with temporal and cellular resolution using FISH

Guzowski, J. F., McNaughton, B. L., Barnes, C. A., & Worley, P. F. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00252-x · Cited by 106 · see citing works

Stranger behind the Engram: Theories of Memory and the Psychology of Science

D., C. P., & Schacter, D. L. (1983) · The American Journal of Psychology · doi:10.2307/1422334 · Cited by 104 · see citing works

Dorsal hippocampal CREB is both necessary and sufficient for spatial memoryPreprint

Sekeres, M. J., Neve, R. L., Frankland, P. W., & Josselyn, S. A. (2010) · Learning & Memory · doi:10.1101/lm.1785510 · Cited by 104 · see citing works

Protein synthesis in the amygdala, but not the auditory thalamus, is required for consolidation of Pavlovian fear conditioning in rats

Maren, S., Ferrario, C. R., Corcoran, K. A., Desmond, T. J., & Frey, K. A. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03063.x · Cited by 102 · see citing works

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity

Nguyen, P. T., Dorman, L. C., Pan, S., Vainchtein, I. D., Han, R. T., Nakao-Inoue, H., Taloma, S. E., Barron, J. J., Molofsky, A. B., Kheirbek, M. A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.050 · Cited by 615 · see citing works

Non-invasive, opsin-free mid-infrared modulation activates cortical neurons and accelerates associative learning

Zhang, J., He, Y., Liang, S., Liao, X., Li, T., Qiao, Z., Chang, C., Jia, H., & Chen, X. (2021) · Nature Communications · doi:10.1038/s41467-021-23025-y · Cited by 373 · see citing works

Insular cortex neurons encode and retrieve specific immune responses

Koren, T., Yifa, R., Amer, M., Krot, M., Boshnak, N., Ben-Shaanan, T. L., Azulay-Debby, H., Zalayat, I., Avishai, E., Hajjo, H., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.013 · Cited by 334 · see citing works

Attractor and integrator networks in the brain

Khona, M., & Fiete, I. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00642-0 · Cited by 314 · see citing works

Encouraging an excitable brain state: mechanisms of brain repair in stroke

Joy, M. T., & Carmichael, S. T. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-00396-7 · Cited by 284 · see citing works

Encoding of contextual fear memory in hippocampal–amygdala circuit

Kim, W. B., & Cho, J.-H. (2020) · Nature Communications · doi:10.1038/s41467-020-15121-2 · Cited by 289 · see citing works

Amygdala Reward Neurons Form and Store Fear Extinction Memory

Zhang, X., Kim, J., & Tonegawa, S. (2019) · Neuron · doi:10.1016/j.neuron.2019.12.025 · Cited by 279 · see citing works

Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila

Hervás, R., Rau, M., Park, Y., Zhang, W., Murzin, A. G., Fitzpatrick, J. A. J., Scheres, S. H. W., & Si, K. (2020) · Science · doi:10.1126/science.aba3526 · Cited by 189 · see citing works

No consolidation without representation: Correspondence between neural and psychological representations in recent and remote memory

Gilboa, A., & Moscovitch, M. (2021) · Neuron · doi:10.1016/j.neuron.2021.04.025 · Cited by 174 · see citing works

Forgetting as a form of adaptive engram cell plasticity

Ryan, T. J., & Frankland, P. W. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00548-3 · Cited by 182 · see citing works

An Integrated Index: Engrams, Place Cells, and Hippocampal Memory

Goode, T. D., Tanaka, K. Z., Sahay, A., & McHugh, T. J. (2020) · Neuron · doi:10.1016/j.neuron.2020.07.011 · Cited by 158 · see citing works

The role of inhibitory circuits in hippocampal memory processing

Topolnik, L., & Tamboli, S. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00599-0 · Cited by 156 · see citing works

Representational drift: Emerging theories for continual learning and experimental future directions

Driscoll, L. N., Duncker, L., & Harvey, C. D. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102609 · Cited by 154 · see citing works

Hypothalamus-habenula potentiation encodes chronic stress experience and drives depression onset

Zheng, Z., Guo, C., Li, M., Yang, L., Liu, P., Zhang, X., Liu, Y., Guo, X., Cao, S., Dong, Y., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.011 · Cited by 142 · see citing works

Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network

Yap, E.-L., Pettit, N. L., Davis, C. P., Nagy, M. A., Harmin, D. A., Golden, E., Dağliyan, O., Lin, C., Rudolph, S., Sharma, N., et al. (2020) · Nature · doi:10.1038/s41586-020-3031-0 · Cited by 149 · see citing works

Neuronal circuitry for recognition memory of object and place in rodent models

Chao, O. Y.-H., Nikolaus, S., Yang, Y., & Huston, J. P. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104855 · Cited by 157 · see citing works

Fos ensembles encode and shape stable spatial maps in the hippocampus

Pettit, N. L., Yap, E.-L., Greenberg, M. E., & Harvey, C. D. (2022) · Nature · doi:10.1038/s41586-022-05113-1 · Cited by 146 · see citing works

Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory

Guskjolen, A. J., & Cembrowski, M. S. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02137-5 · Cited by 148 · see citing works

Assessments of dentate gyrus function: discoveries and debates

Borzello, M., Ramirez, S., Treves, A., Lee, I., Scharfman, H. E., Stark, C. E. L., Knierim, J. J., & Rangel, L. M. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00710-z · Cited by 138 · see citing works

Neuronal ensembles: Building blocks of neural circuits

Yuste, R., Cossart, R., & Yaksi, E. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.008 · Cited by 127 · see citing works

Adult hippocampal neurogenesis shapes adaptation and improves stress response: a mechanistic and integrative perspective

Surget, A., & Belzung, C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01136-8 · Cited by 122 · see citing works

Olfactory Circuitry and Behavioral Decisions

Mori, K., & Sakano, H. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-031820-092824 · Cited by 120 · see citing works

Hippocampal-amygdala memory circuits govern experience-dependent observational fear

Terranova, J. I., Yokose, J., Osanai, H., Marks, W. D., Yamamoto, J., Ogawa, S. K., & Kitamura, T. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.019 · Cited by 117 · see citing works

Short-Term Plasticity at Hippocampal Mossy Fiber Synapses Is Induced by Natural Activity Patterns and Associated with Vesicle Pool Engram Formation

Vandael, D., Borges-Merjane, C., Zhang, X., & Jonas, P. (2020) · Neuron · doi:10.1016/j.neuron.2020.05.013 · Cited by 114 · see citing works

Motor Learning Selectively Strengthens Cortical and Striatal Synapses of Motor Engram Neurons

Hwang, F.-J., Roth, R. H., Wu, Y., Sun, Y., Kwon, D. K., Liu, Y., & Ding, J. (2021) · Neuron · doi:10.1016/j.neuron.2022.06.006 · Cited by 108 · see citing works

Selection of experience for memory by hippocampal sharp wave ripples

Yang, W., Sun, C., Huszár, R., Hainmueller, T., Kiselev, K., & Buzsáki, G. (2024) · Science · doi:10.1126/science.adk8261 · Cited by 116 · see citing works

Transforming the Concept of Memory Reactivation

Favila, S. E., Lee, H., & Kuhl, B. A. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.09.006 · Cited by 111 · see citing works

Neuronal types in the mouse amygdala and their transcriptional response to fear conditioning

Hochgerner, H., Singh, S., Tibi, M., Lin, Z., Skarbianskis, N., Admati, I., Ophir, O., Reinhardt, N., Netser, S., Wagner, S., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01469-3 · Cited by 110 · see citing works

Learning-associated astrocyte ensembles regulate memory recall

Williamson, M. R., Kwon, W., Woo, J., Ko, Y., Maleki, E., Yu, K., Murali, S., Sardar, D., & Deneen, B. (2024) · Nature · doi:10.1038/s41586-024-08170-w · Cited by 108 · see citing works

Amygdala-hippocampal interactions in synaptic plasticity and memory formation

Roesler, R., Parent, M. B., LaLumiere, R. T., & McIntyre, C. K. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107490 · Cited by 108 · see citing works

Synaptic correlates of associative fear memory in the lateral amygdala

Choi, D. I., Kim, J., Lee, H., Kim, J., Sung, Y., Choi, J. E., Venkat, S. J., Park, P., Jung, H., & Kaang, B. (2021) · Neuron · doi:10.1016/j.neuron.2021.07.003 · Cited by 103 · see citing works

The neural bases for timing of durations

Tsao, A., Yousefzadeh, S. A., Meck, W. H., Moser, M., & Moser, E. I. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00623-3 · Cited by 109 · see citing works

Top-down regulation of motivated behaviors via lateral septum sub-circuits

Besnard, A., & Leroy, F. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01599-3 · Cited by 108 · see citing works

Brain foods - the role of diet in brain performance and health

Ekstrand, B., Scheers, N., Rasmussen, M. K., Young, J. F., Ross, A. B., & Landberg, R. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa091 · Cited by 110 · see citing works

Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens

Zinsmaier, A. K., Dong, Y., & Huang, Y. H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01112-2 · Cited by 97 · see citing works

Understanding the physical basis of memory: Molecular mechanisms of the engram

Luis, C. O. S., & Ryan, T. J. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101866 · Cited by 103 · see citing works

Cardiovascular Brain Circuits

Mohanta, S. K., Yin, C., Weber, C., Godinho‐Silva, C., Veiga‐Fernandes, H., Xu, Q. J., Chang, R. B., & Habenicht, A. J. R. (2023) · Circulation Research · doi:10.1161/circresaha.123.322791 · Cited by 93 · see citing works

Microcircuits for spatial coding in the medial entorhinal cortex

Tukker, J. J., Beed, P. S., Brecht, M., Kempter, R., Moser, E. I., & Schmitz, D. (2021) · Physiological Reviews · doi:10.1152/physrev.00042.2020 · Cited by 89 · see citing works

Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core

Bobadilla, A., Dereschewitz, E., Vaccaro, L., Heinsbroek, J. A., Scofield, M. D., & Kalivas, P. W. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00888-z · Cited by 86 · see citing works

Optimization-Inspired Cross-Attention Transformer for Compressive Sensing

Song, J., Mou, C., Wang, S., Ma, S., & Zhang, J. (2023) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr52729.2023.00598 · Cited by 86 · see citing works

Coupled sleep rhythms for memory consolidation

Staresina, B. P. (2024) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2024.02.002 · Cited by 86 · see citing works

Excitation–transcription coupling, neuronal gene expression and synaptic plasticity

Ma, H., Khaled, H. G., Wang, X., Mandelberg, N. J., Cohen, S. M., He, X., & Tsien, R. W. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00742-5 · Cited by 83 · see citing works

Bio‐Inspired 3D Artificial Neuromorphic Circuits

Liu, X., Wang, F., Su, J., Zhou, Y., & Ramakrishna, S. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202113050 · Cited by 82 · see citing works

Covert capture and attenuation of a hippocampus-dependent fear memory

Ressler, R. L., Goode, T. D., Kim, S., Ramanathan, K. R., & Maren, S. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00825-5 · Cited by 82 · see citing works

Glucocorticoids Promote Fear Generalization by Increasing the Size of a Dentate Gyrus Engram Cell Population

Lesuis, S. L., Brosens, N., Immerzeel, N., van der Loo, R. J., Mitrić, M. M., Bielefeld, P., Fitzsimons, C. P., Lucassen, P. J., Kushner, S. A., van den Oever, M. C., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.04.010 · Cited by 82 · see citing works

Excitability mediates allocation of pre-configured ensembles to a hippocampal engram supporting contextual conditioned threat in mice

Mocle, A. J., Ramsaran, A. I., Jacob, A. D., Rashid, A. J., Luchetti, A., Tran, L. M., Richards, B. A., Frankland, P. W., & Josselyn, S. A. (2024) · Neuron · doi:10.1016/j.neuron.2024.02.007 · Cited by 82 · see citing works

Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target

Okada, T., Kato, D., Nomura, Y., Obata, N., Quan, X., Morinaga, A., Yano, H., Guo, Z., Aoyama, Y., Tachibana, Y., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd8261 · Cited by 81 · see citing works

Arc/Arg3.1 function in long‐term synaptic plasticity: Emerging mechanisms and unresolved issues

Zhang, H., & Bramham, C. R. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14958 · Cited by 71 · see citing works

The hippocampus converts dynamic entorhinal inputs into stable spatial maps

Cholvin, T., Hainmueller, T., & Bartos, M. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.019 · Cited by 75 · see citing works

Hippocampal cells segregate positive and negative engrams

Shpokayte, M., McKissick, O. P., Guan, X., Yuan, B., Rahsepar, B., Fernandez, F. R., Ruesch, E. A., Grella, S. L., White, J. A., Liu, X. S., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03906-8 · Cited by 75 · see citing works

An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation

Hou, J. F., Nayeem, M. O. G., Caplan, K. A., Ruesch, E. A., Caban, A. J., Criado-Hidalgo, E., Ornellas, S. B., Williams, B., Pearce, A. A., Dağdeviren, H. E., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48748-6 · Cited by 84 · see citing works

Intercellular Communication in the Nervous System goes Viral

Hantak, M. P., Einstein, J., Kearns, R. B., & Shepherd, J. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2020.12.003 · Cited by 49 · see citing works

Non-coding RNA in the wiring and remodeling of neural circuits

Soutschek, M., & Schratt, G. M. (2023) · Neuron · doi:10.1016/j.neuron.2023.04.031 · Cited by 72 · see citing works

Metastable dynamics of neural circuits and networks

Brinkman, B. A. W., Yan, H., Maffei, A., Park, I. M., Fontanini, A., Wang, J., & La Camera, G. (2022) · Applied Physics Reviews · doi:10.1063/5.0062603 · Cited by 64 · see citing works

The Intriguing Contribution of Hippocampal Long-Term Depression to Spatial Learning and Long-Term Memory

Stacho, M., & Manahan‐Vaughan, D. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.806356 · Cited by 70 · see citing works

Control of fear by discrete prefrontal GABAergic populations encoding valence-specific information

Cummings, K. A., Bayshtok, S., Dong, T. N., Kenny, P. J., & Clem, R. L. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.004 · Cited by 70 · see citing works

Linking Social Cognition to Learning and Memory

Leblanc, H., & Ramirez, S. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1280-20.2020 · Cited by 69 · see citing works

Spike timing-dependent plasticity and memory

Debanne, D., & Inglebert, Y. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102707 · Cited by 68 · see citing works

Dynamic and selective engrams emerge with memory consolidation

Tomé, D. F., Zhang, Y., Aida, T., Mosto, O., Lu, Y., Chen, M., Sadeh, S., Roy, D. S., & Clopath, C. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01551-w · Cited by 76 · see citing works

PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

Park, P., Georgiou, J., Sanderson, T. M., Ko, K., Kang, H., Kim, J., Bradley, C. A., Bortolotto, Z. A., Zhuo, M., Kaang, B., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20523-3 · Cited by 67 · see citing works

Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice

Lesuis, S. L., Park, S., Hoorn, A., Rashid, A. J., Mocle, A. J., Salter, E. W., Vislavski, S., Gray, M. T., Torelli, A. M., Cristofaro, A. D., et al. (2024) · Cell · doi:10.1016/j.cell.2024.10.034 · Cited by 65 · see citing works

Interfacing with the Brain: How Nanotechnology Can Contribute

Ahmed, A. A. A., Alegret, N., Almeida, B., Álvarez‐Puebla, R. A., Andrews, A. M., Ballerini, L., Barrios‐Capuchino, J. J., Becker, C., Blick, R. H., Bonakdar, S., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c10525 · Cited by 68 · see citing works

A Synaptic Framework for the Persistence of Memory Engrams

Rao‐Ruiz, P., Visser, E., Mitrić, M. M., Smit, A. B., & van den Oever, M. C. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.661476 · Cited by 65 · see citing works

Homeostatic synaptic scaling establishes the specificity of an associative memory

Wu, C.-H., Ramos, R., Katz, D. B., & Turrigiano, G. G. (2021) · Current Biology · doi:10.1016/j.cub.2021.03.024 · Cited by 64 · see citing works

Systems consolidation, transformation and reorganization: Multiple Trace Theory, Trace Transformation Theory and their CompetitorsPreprint

Moscovitch, M., & Gilboa, A. (2021) · doi:10.31234/osf.io/yxbrs · Cited by 62 · see citing works

Synaptic plasticity-dependent competition rule influences memory formation

Jeong, Y., Cho, H.-Y., Kim, M., Oh, J.-P., Kang, M. S., Yoo, M., Lee, H.-S., & Han, J. (2021) · Nature Communications · doi:10.1038/s41467-021-24269-4 · Cited by 64 · see citing works

Time-tagged ticker tapes for intracellular recordings

Lin, D.-C., Li, X., Moult, E. M., Park, P., Tang, B., Shen, H., Grimm, J., Falco, N., Jia, B. Z., Baker, D., et al. (2021) · bioRxiv · doi:10.1038/s41587-022-01524-7 · Cited by 48 · see citing works

Cellular sentience as the primary source of biological order and evolution

Baluška, F., Reber, A. S., & Miller, W. B. (2022) · Biosystems · doi:10.1016/j.biosystems.2022.104694 · Cited by 62 · see citing works

Immunoception: the insular cortex perspective

Rolls, A. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01051-8 · Cited by 62 · see citing works

Cognitive epigenetic priming: leveraging histone acetylation for memory amelioration

Burns, A. M., & Gräff, J. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.08.011 · Cited by 62 · see citing works

Role of Wnt signaling in synaptic plasticity and memory

Narvaes, R. F., & Furini, C. R. G. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107558 · Cited by 61 · see citing works

Sensing fear: Fast-and-precise threat evaluation in human sensory cortex

Li, W., & Keil, A. (2022) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2023.01.001 · Cited by 59 · see citing works

Inkjet‐Printed Tungsten Oxide Memristor Displaying Non‐Volatile Memory and Neuromorphic Properties

Hu, H., Scholz, A. S., Dolle, C., Zintler, A., Quintilla, A., Liu, Y., Tang, Y., Breitung, B., Marques, G. C., Eggeler, Y. M., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202302290 · Cited by 58 · see citing works

How Do Living Systems Create Meaning?

Fields, C., & Levin, M. G. (2020) · Philosophies · doi:10.3390/philosophies5040036 · Cited by 57 · see citing works

High frequency oscillations in human memory and cognition: a neurophysiological substrate of engrams?

Kucewicz, M. T., Cimbálník, J., García‐Salinas, J. S., Brázdil, M., & Worrell, G. A. (2024) · Brain · doi:10.1093/brain/awae159 · Cited by 57 · see citing works

The essence of the engram: Cellular or synaptic?

Han, D. H., Park, P., Choi, D. I., Bliss, T., & Kaang, B. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.033 · Cited by 53 · see citing works

High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning

Getz, A. M., Ducros, M., Breillat, C., Lampin-Saint-Amaux, A., Daburon, S., François, U., Nowacka, A., Fernández-Monreal, M., Hosy, E., Lanore, F., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm5298 · Cited by 55 · see citing works

Synaptic architecture of a memory engram in the mouse hippocampus

Uytiepo, M., Zhu, Y., Bushong, E. A., Chou, K., Polli, F. S., Zhao, E., Keun-young Kim, A., Luu, D., Chang, L., Yang, D. U., et al. (2025) · Science · doi:10.1126/science.ado8316 · Cited by 54 · see citing works

Construction of complex memories via parallel distributed cortical–subcortical iterative integration

McNaughton, N., & Vann, S. D. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.04.006 · Cited by 52 · see citing works

Drug-activated cells: From immediate early genes to neuronal ensembles in addiction

Salery, M., Godino, A., & Nestler, E. J. (2021) · Advances in pharmacology · doi:10.1016/bs.apha.2020.09.006 · Cited by 46 · see citing works

Hippocampal neuronal activity is aligned with action plans

Zutshi, I., Apostolelli, A., Yang, W., Zheng, Z. S., Dohi, T., Balzani, E., Williams, A. H., Savin, C., & Buzsáki, G. (2025) · Nature · doi:10.1038/s41586-024-08397-7 · Cited by 59 · see citing works

Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation

Baltruschat, L., Prisco, L., Ranft, P., Lauritzen, J. S., Fiala, A., Bock, D. D., & Tavosanis, G. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108871 · Cited by 52 · see citing works

The astrocytic ensemble acts as a multiday trace to stabilize memory

Dewa, K., Kaseda, K., Kuwahara, A., Kubotera, H., Yamasaki, A., Awata, N., Komori, A., Holtz, M. A., Kasai, A., Skibbe, H., et al. (2025) · Nature · doi:10.1038/s41586-025-09619-2 · Cited by 55 · see citing works

Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke

Campos, B., Choi, H., DeMarco, A. T., Seydell‐Greenwald, A., Hussain, S. J., Joy, M. T., Turkeltaub, P. E., & Zeiger, W. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1425-23.2023 · Cited by 48 · see citing works

Dynamic and heterogeneous neural ensembles contribute to a memory engram

Sweis, B. M., Mau, W., Rabinowitz, S., & Cai, D. J. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.11.017 · Cited by 50 · see citing works

Microbial memories: Sex‐dependent impact of the gut microbiome on hippocampal plasticity

Darch, H. T., Collins, M., O’Riordan, K. J., & Cryan, J. F. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15119 · Cited by 49 · see citing works

Brain-Inspired Learning, Perception, and Cognition: A Comprehensive Review

Jiao, L., Ma, M., He, P., Geng, X., Liu, X., Liu, F., Ma, W., Yang, S., Hou, B., & Tang, X. (2024) · IEEE Transactions on Neural Networks and Learning Systems · doi:10.1109/tnnls.2024.3401711 · Cited by 50 · see citing works

My Neighbour Hetero — deconstructing the mechanisms underlying heterosynaptic plasticity

Chater, T. E., & Goda, Y. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.10.007 · Cited by 44 · see citing works

Deep Memory-Augmented Proximal Unrolling Network for Compressive Sensing

Song, J., Chen, B., & Zhang, J. (2023) · International Journal of Computer Vision · doi:10.1007/s11263-023-01765-2 · Cited by 49 · see citing works

Formation of an expanding memory representation in the hippocampus

Vaidya, S. P., Li, G., Chitwood, R. A., Li, Y., & Magee, J. C. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01986-3 · Cited by 53 · see citing works

Enkephalin release from VIP interneurons in the hippocampal CA2/3a region mediates heterosynaptic plasticity and social memory

Leroy, F., de Solis, C. A., Boyle, L. M., Bock, T., Lofaro, O. M., Buss, E. W., Asok, A., Kandel, E. R., & Siegelbaum, S. A. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01124-y · Cited by 48 · see citing works

On the principles of Parsimony and Self-consistency for the emergence of intelligence

Ma, Y., Tsao, D. Y., & Shum, H. (2022) · Frontiers of Information Technology & Electronic Engineering · doi:10.1631/fitee.2200297 · Cited by 46 · see citing works

Fear extinction learning modulates large-scale brain connectivity

Wen, Z., Chen, Z. S., & Milad, M. R. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118261 · Cited by 46 · see citing works

Naïve to expert: Considering the role of previous knowledge in memory

Alonso, A., van der Meij, J., Tse, D., & Genzel, L. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820948686 · Cited by 46 · see citing works

In Vivo Multi-Day Calcium Imaging of CA1 Hippocampus in Freely Moving Rats Reveals a High Preponderance of Place Cells with Consistent Place Fields

Wirtshafter, H. S., & Disterhoft, J. F. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1750-21.2022 · Cited by 44 · see citing works

Structure, biophysics, and circuit function of a “giant” cortical presynaptic terminal

Vandael, D., & Jonas, P. (2024) · Science · doi:10.1126/science.adg6757 · Cited by 45 · see citing works

From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health

Mews, P., Calipari, E. S., Day, J. J., Lobo, M. K., Bredy, T. W., & Abel, T. G. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1649-20.2020 · Cited by 42 · see citing works

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Couto, A., Young, F. J., Atzeni, D., Marty, S., Melo-Flórez, L., Hebberecht, L., Monllor, M., Neal, C. R., Cicconardi, F., McMillan, W. O., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39618-8 · Cited by 43 · see citing works

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Jiao, L., Huang, Z., Liu, X., Yang, Y., Ma, M., Zhao, J., You, C., Hou, B., Yang, S., Liu, F., et al. (2023) · IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing · doi:10.1109/jstars.2023.3247455 · Cited by 44 · see citing works

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Poo, M.-M., Pignatelli, M., Ryan, T. J., Tonegawa, S., Bonhoeffer, T., Martin, K. C., Rudenko, A., Tsai, L., Tsien, R. W., Fishell, G., et al. (2016) · BMC Biology · doi:10.1186/s12915-016-0261-6 · Cited by 391 · see citing works

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Tonegawa, S., Liu, X., Ramirez, S., & Redondo, R. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.002 · Cited by 613 · see citing works