Distinct contribution of adult-born hippocampal granule cells to context encoding
Open accessAbstract
Adult-born granule cells (abGCs) have been implicated in cognition and mood; however, it remains unknown how these cells behave in vivo. Here, we have used two-photon calcium imaging to monitor the activity of young abGCs in awake behaving mice. We find that young adult-born neurons fire at a higher rate in vivo but paradoxically exhibit less spatial tuning than their mature counterparts. When presented with different contexts, mature granule cells underwent robust remapping of their spatial representations, and the few spatially tuned adult-born cells remapped to a similar degree. We next used optogenetic silencing to confirm the direct involvement of abGCs in context encoding and discrimination, consistent with their proposed role in pattern separation. These results provide the first in vivo characterization of abGCs and reveal their participation in the encoding of novel information.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
New neurons participate in pattern separation, the process of making similar neural inputs distinct.
“Furthermore, new neurons, presumably through their unique electrophysiological properties and sparse connections to CA3 neurons (Amaral et al., 2007), have been found to participate in pattern separation (Clelland et al., 2009; Danielson et al., 2016; Sahay et al., 2011), the process of making similar neural inputs distinct.”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Danielson et al., 2016
Elimination or optogenetic silencing of adult-born neurons impairs pattern separation-like behaviors, while transgenic increases in adult neurogenesis enhance the ability of mice to distinguish between highly similar contexts.
“Elimination or optogenetic silencing of adult-born neurons impairs pattern separation-like behaviors (Clelland et al., 2009; Danielson et al., 2016), while transgenic increases in adult neurogenesis enhance the ability of mice to distinguish between highly similar contexts (Sahay et al., 2011).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Danielson et al., 2016
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works
Self-citationMechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007 · see citing works
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853 · see citing works
Dynamics of hippocampal neurogenesis in adult humans
Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841 · see citing works
Advances in Neural Information Processing Systems 19 (NIPS 2006)
Simonotto, E., Whalley, H. C., Lawrie, S. M., Murray, L. M., McGonigle, D. J., & Storkey, A. (2006) · Cited by 1,651 · see citing works
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., et al. (2009) · Science · doi:10.1126/science.1173215 · Cited by 1,642 · see citing works
Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus
Leutgeb, J. K., Leutgeb, S., Moser, M.-B., & Moser, E. I. (2007) · Science · doi:10.1126/science.1135801 · Cited by 1,601 · cited 4× · see citing works
“The level of activity was dependent on the animal’s behavioral state (Leutgeb et al., 2007; Neunuebel and Knierim, 2012), as calcium transients during running were observed at nearly 2-fold higher rate than during nonrunning epochs (Figure S2C).”
InfluentialIncreasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567 · see citing works
Self-citationAdult hippocampal neurogenesis buffers stress responses and depressive behaviour
Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473 · see citing works
Estimation of entropy and mutual information
Paninski, L. (2003) · Neural Computation · doi:10.1162/089976603321780272 · Cited by 1,442 · see citing works
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
Madisen, L., Mao, T., Koch, H., Zhuo, J.-M., Berenyi, A., Fujisawa, S., Hsu, Y.-W. A., Garcia, A. J., Gu, X., Zanella, S., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3078 · Cited by 1,398 · see citing works
Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
Schmidt-Hieber, C., Jonas, P., & Bischofberger, J. (2004) · Nature · doi:10.1038/nature02553 · Cited by 1,292 · see citing works
David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267 · see citing works
Self-citationGABA regulates synaptic integration of newly generated neurons in the adult brain
Ge, S., Goh, E. L. K., Sailor, K. A., Kitabatake, Y., Ming, G., & Song, H. (2005) · Nature · doi:10.1038/nature04404 · Cited by 1,261 · see citing works
Hippocampal ‘time cells’ bridge the gap in memory for discontiguous events
MacDonald, C. J., Lepage, K. Q., Eden, U. T., & Eichenbaum, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.012 · Cited by 1,193 · see citing works
Long-term dynamics of CA1 hippocampal place codes
Ziv, Y., Burns, L. D., Cocker, E. D., Hamel, E. O., Ghosh, K. K., Kitch, L. J., Gamal, A. E., & Schnitzer, M. J. (2013) · Nature Neuroscience · doi:10.1038/nn.3329 · Cited by 1,155 · see citing works
Imaging large-scale neural activity with cellular resolution in awake, mobile mice
Dombeck, D. A., Khabbaz, A. N., Collman, F., Adelman, T. L., & Tank, D. W. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.003 · Cited by 1,099 · see citing works
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., & Kageyama, R. (2008) · Nature Neuroscience · doi:10.1038/nn.2185 · Cited by 1,054 · see citing works
A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain
Ge, S., Yang, C.-H., Hsu, K.-S., Ming, G.-L., & Song, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.002 · Cited by 927 · see citing works
Nakashiba, T., Cushman, J. D., Pelkey, K. A., Renaudineau, S., Buhl, D. L., McHugh, T. J., Barrera, V. R., Chittajallu, R., Iwamoto, K. S., McBain, C. J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.046 · Cited by 805 · see citing works
Spatial selectivity of unit activity in the hippocampal granular layer
Jung, M. W., & McNaughton, B. L. (1993) · Hippocampus · doi:10.1002/hipo.450030209 · Cited by 789 · see citing works
Neurons born in the adult dentate gyrus form functional synapses with target cells
Toni, N., Laplagne, D. A., Zhao, C., Lombardi, G., Ribak, C. E., Gage, F. H., & Schinder, A. F. (2008) · Nature Neuroscience · doi:10.1038/nn.2156 · Cited by 741 · see citing works
Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus
Kheirbek, M. A., Drew, L. J., Burghardt, N. S., Costantini, D. O., Tannenholz, L., Ahmari, S. E., Zeng, H., Fenton, A. A., & Hen, R. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.038 · Cited by 713 · see citing works
Self-citationNeuronal differentiation in the adult hippocampus recapitulates embryonic development
Espósito, M. S., Piatti, V. C., Laplagne, D. A., Morgenstern, N. A., Ferrari, C. C., Pitossi, F. J., & Schinder, A. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3114-05.2005 · Cited by 679 · see citing works
Speed cells in the medial entorhinal cortex
Kropff, E., Carmichael, J. E., Moser, M.-B., & Moser, E. I. (2015) · Nature · doi:10.1038/nature14622 · Cited by 668 · see citing works
Aimone, J. B., Deng, W., & Gage, F. H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.010 · Cited by 663 · see citing works
Synapse formation on neurons born in the adult hippocampus
Toni, N., Teng, E. M., Bushong, E. A., Aimone, J. B., Zhao, C., Consiglio, A., van Praag, H., Martone, M. E., Ellisman, M. H., & Gage, F. H. (2007) · Nature Neuroscience · doi:10.1038/nn1908 · Cited by 579 · see citing works
Hippocampal Memory Traces Are Differentially Modulated by Experience, Time, and Adult Neurogenesis
Denny, C. A., Kheirbek, M. A., Alba, E. L., Tanaka, K. F., Brachman, R. A., Laughman, K. B., Tomm, N. K., Turi, G. F., Losonczy, A., & Hen, R. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.018 · Cited by 558 · see citing works
Self-citationNeurogenesis and generalization: a new approach to stratify and treat anxiety disorders
Kheirbek, M., Klemenhagen, K. C., Sahay, A., & Hen, R. (2012) · Nature Neuroscience · doi:10.1038/nn.3262 · Cited by 543 · see citing works
Self-citationAn Information-Theoretic Approach to Deciphering the Hippocampal Code
Skaggs, W. E., McNaughton, B. L., & Gothard, K. M. (1992) · Cited by 536 · see citing works
Hippocampal “Time Cells”: Time versus Path Integration
Kraus, B. J., Robinson, R. J., White, J. A., Eichenbaum, H., & Hasselmo, M. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.015 · Cited by 526 · see citing works
Pattern separation: a common function for new neurons in hippocampus and olfactory bulb
Sahay, A., Wilson, D. A., & Hen, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.012 · Cited by 514 · see citing works
Self-citationDendritic Inhibition in the Hippocampus Supports Fear Learning
Lovett-Barron, M., Kaifosh, P., Kheirbek, M. A., Danielson, N., Zaremba, J. D., Reardon, T. R., Turi, G. F., Hen, R., Zemelman, B. V., & Losonczy, A. (2014) · Science · doi:10.1126/science.1247485 · Cited by 509 · see citing works
Self-citationBrandt, M., Jessberger, S., Steiner, B., Kronenberg, G., Reuter, K., Bick‐Sander, A., von der Behrens, W., & Kempermann, G. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00207-0 · Cited by 498 · see citing works
Age-related memory deficits linked to circuit-specific disruptions in the hippocampus
Yassa, M. A., Mattfeld, A. T., Stark, S. M., & Stark, C. E. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101567108 · Cited by 436 · see citing works
Optical controlling reveals time-dependent roles for adult-born dentate granule cells
Gu, Y., Arruda-Carvalho, M., Wang, J., Janoschka, S., Josselyn, S. A., Frankland, P. W., & Ge, S. (2012) · Nature Neuroscience · doi:10.1038/nn.3260 · Cited by 423 · see citing works
Unique Processing During a Period of High Excitation/Inhibition Balance in Adult-Born Neurons
Marín‐Burgin, A., Mongiat, L. A., Pardi, M. B., & Schinder, A. F. (2012) · Science · doi:10.1126/science.1214956 · Cited by 367 · see citing works
Grid cells require excitatory drive from the hippocampus
Bonnevie, T., Dunn, B. A., Fyhn, M., Hafting, T., Derdikman, D., Kubie, J. L., Roudi, Y., Moser, E. I., & Moser, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3311 · Cited by 345 · see citing works
Adult‐born hippocampal neurons promote cognitive flexibility in mice
Burghardt, N. S., Park, E. H., Hen, R., & Fenton, A. A. (2012) · Hippocampus · doi:10.1002/hipo.22013 · Cited by 311 · see citing works
Self-citationSIMA: Python software for analysis of dynamic fluorescence imaging data
Kaifosh, P., Zaremba, J. D., Danielson, N., & Losonczy, A. (2014) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2014.00080 · Cited by 225 · see citing works
Self-citationPernía‐Andrade, A. J., & Jónás, P. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.046 · Cited by 217 · see citing works
Experience Dictates Stem Cell Fate in the Adult Hippocampus
Dranovsky, A., Picchini, A. M., Moadel, T., Sisti, A. C., Yamada, A., Kimura, S., Leonardo, E. D., & Hen, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.022 · Cited by 207 · see citing works
Self-citationTemprana, S. G., Mongiat, L. A., Yang, S. M., Trinchero, M. F., Alvarez, D. D., Kropff, E., Giacomini, D., Beltramone, N., Lanuza, G. M., & Schinder, A. F. (2014) · Neuron · doi:10.1016/j.neuron.2014.11.023 · Cited by 200 · see citing works
Denny, C. A., Burghardt, N. S., Schachter, D., Hen, R., & Drew, M. R. (2011) · Hippocampus · doi:10.1002/hipo.20964 · Cited by 199 · see citing works
Self-citationIn vivo two-photon imaging of sensory-evoked dendritic calcium signals in cortical neurons
Jia, H., Rochefort, N. L., Chen, X., & Konnerth, A. (2010) · Nature Protocols · doi:10.1038/nprot.2010.169 · Cited by 199 · see citing works
Adult neurogenesis modifies excitability of the dentate gyrus
Ikrar, T., Guo, N., He, K., Besnard, A., Levinson, S., Hill, A., Lee, H.-K., Hen, R., Xu, X., & Sahay, A. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00204 · Cited by 192 · see citing works
Self-citationEffects of adult-generated granule cells on coordinated network activity in the dentate gyrus
Lacefield, C. O., Itskov, V., Reardon, T., Hen, R., & Gordon, J. A. (2012) · Hippocampus · doi:10.1002/hipo.20860 · Cited by 188 · see citing works
Self-citationHippocampal granule cells opt for early retirement
Alme, C. B., Buzzetti, R. A., Marrone, D. F., Leutgeb, J. K., Chawla, M. K., Schaner, M. J., Bohanick, J. D., Khoboko, T., Leutgeb, S., Moser, E. I., et al. (2010) · Hippocampus · doi:10.1002/hipo.20810 · Cited by 170 · see citing works
Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons
Drew, L. J., Kheirbek, M. A., Luna, V. M., Denny, C. A., Cloidt, M. A., Wu, M. V., Jain, S., Scharfman, H. E., & Hen, R. (2016) · Hippocampus · doi:10.1002/hipo.22557 · Cited by 169 · see citing works
Self-citationNR2B-Dependent Plasticity of Adult-Born Granule Cells is Necessary for Context Discrimination
Kheirbek, M. A., Tannenholz, L., & Hen, R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1692-12.2012 · Cited by 167 · see citing works
Self-citationStone, S. S. D., Teixeira, C. M., Zaslavsky, K., Wheeler, A. L., Martínez-Canabal, A., Wang, A. H., Sakaguchi, M., Lozano, A. M., & Frankland, P. W. (2010) · Hippocampus · doi:10.1002/hipo.20845 · Cited by 167 · see citing works
Spatial Firing Correlates of Physiologically Distinct Cell Types of the Rat Dentate Gyrus
Neunuebel, J. P., & Knierim, J. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6038-11.2012 · Cited by 163 · see citing works
Septo-hippocampal GABAergic signaling across multiple modalities in awake mice
Kaifosh, P., Lovett-Barron, M., Turi, G. F., Reardon, T. R., & Losonczy, A. (2013) · Nature Neuroscience · doi:10.1038/nn.3482 · Cited by 155 · see citing works
Self-citationNeurogenesis in the dentate gyrus: carrying the message or dictating the tone
Piatti, V. C., Ewell, L. A., & Leutgeb, J. K. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00050 · Cited by 142 · see citing works
Adult neurogenesis in the mammalian hippocampus: Why the dentate gyrus?Preprint
Drew, L., Fusi, S., & Hen, R. (2013) · Learning & Memory · doi:10.1101/lm.026542.112 · Cited by 141 · see citing works
Self-citationPattern Separation of Emotional Information in Hippocampal Dentate and CA3
Leal, S. L., Tighe, S. K., Jones, C. K., & Yassa, M. (2014) · Hippocampus · doi:10.1002/hipo.22298 · Cited by 123 · see citing works
Restivo, L., Niibori, Y., Mercaldo, V., Josselyn, S. A., & Frankland, P. W. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3238-14.2015 · Cited by 112 · see citing works
Distinct Determinants of Sparse Activation during Granule Cell Maturation
Dieni, C. V., Nietz, A. K., Panichi, R., Wadiche, J. I., & Overstreet‐Wadiche, L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2289-13.2013 · Cited by 104 · see citing works
Singer, B. H., Gamelli, A., Fuller, C. L., Temme, S. J., Parent, J. M., & Murphy, G. G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015425108 · Cited by 88 · see citing works
Experience-Dependent Regulation of Dentate Gyrus Excitability by Adult-Born Granule Cells
Park, E., Burghardt, N. S., Dvořák, D., Hen, R., & Fenton, A. A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0885-15.2015 · Cited by 78 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior
Gonçalves, J. T., Schafer, S. T., & Gage, F. H. (2016) · Cell · doi:10.1016/j.cell.2016.10.021 · Cited by 1,122 · see citing works
Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood
Anacker, C., & Hen, R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.45 · Cited by 1,014 · see citing works
Self-citationThe role of adult hippocampal neurogenesis in brain health and disease
Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719 · see citing works
Anxiety Cells in a Hippocampal-Hypothalamic Circuit
Jimenez, J., Su, K., Goldberg, A., Luna, V. M., Biane, J. S., Ordek, G., Zhou, P., Ong, S. K., Wright, M. A., Zweifel, L. S., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.016 · Cited by 606 · see citing works
Self-citationMicroglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity
Nguyen, P. T., Dorman, L. C., Pan, S., Vainchtein, I. D., Han, R. T., Nakao-Inoue, H., Taloma, S. E., Barron, J. J., Molofsky, A. B., Kheirbek, M. A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.050 · Cited by 615 · see citing works
Self-citationHippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus
Anacker, C., Luna, V. M., Stevens, G. S., Millette, A., Shores, R., Jimenez, J. C., Chen, B., & Hen, R. (2018) · Nature · doi:10.1038/s41586-018-0262-4 · Cited by 605 · see citing works
Self-citationDentate gyrus circuits for encoding, retrieval and discrimination of episodic memories
Hainmueller, T., & Bartos, M. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0260-z · Cited by 474 · see citing works
What is memory? The present state of the engram
Poo, M.-M., Pignatelli, M., Ryan, T. J., Tonegawa, S., Bonhoeffer, T., Martin, K. C., Rudenko, A., Tsai, L., Tsien, R. W., Fishell, G., et al. (2016) · BMC Biology · doi:10.1186/s12915-016-0261-6 · Cited by 391 · see citing works
Parallel emergence of stable and dynamic memory engrams in the hippocampus
Hainmueller, T., & Bartos, M. (2018) · Nature · doi:10.1038/s41586-018-0191-2 · Cited by 383 · see citing works
Physiological Properties and Behavioral Correlates of Hippocampal Granule Cells and Mossy Cells
Senzai, Y., & Buzsáki, G. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.011 · Cited by 322 · see citing works
Illuminating dendritic function with computational models
Poirazi, P., & Papoutsi, A. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0301-7 · Cited by 303 · see citing works
Sublayer-Specific Coding Dynamics during Spatial Navigation and Learning in Hippocampal Area CA1
Danielson, N. B., Zaremba, J. D., Kaifosh, P., Bowler, J., Ladow, M., & Losonczy, A. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.020 · Cited by 288 · see citing works
Self-citationFormation and integration of new neurons in the adult hippocampus
Denoth‐Lippuner, A., & Jessberger, S. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00433-z · Cited by 274 · see citing works
Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus
GoodSmith, D., Chen, X., Wang, C., Kim, S. H., Song, H., Burgalossi, A., Christian, K. M., & Knierim, J. J. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.026 · Cited by 267 · see citing works
Review: adult neurogenesis contributes to hippocampal plasticity
Toda, T., & Gage, F. H. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2735-4 · Cited by 262 · see citing works
Engram Cell Excitability State Determines the Efficacy of Memory Retrieval
Pignatelli, M., Ryan, T. J., Roy, D. S., Lovett, C., Smith, L. M., Muralidhar, S., & Tonegawa, S. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.029 · Cited by 259 · see citing works
Adult neurogenesis, glia, and the extracellular matrix
Cope, E. C., & Gould, E. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.03.023 · Cited by 236 · see citing works
Re-evaluating Circuit Mechanisms Underlying Pattern Separation
Cayco-Gajic, N. A., & Silver, R. A. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.044 · Cited by 220 · see citing works
Integrating new findings and examining clinical applications of pattern separation
Leal, S. L., & Yassa, M. A. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0065-1 · Cited by 213 · see citing works
Remote Memory and the Hippocampus: A Constructive Critique
Barry, D. N., & Maguire, E. A. (2018) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.11.005 · Cited by 196 · see citing works
Walgrave, H., Balusu, S., Snoeck, S., Eynden, E. V., Craessaerts, K., Thrupp, N., Wolfs, L., Horré, K., Fourne, Y., Ronisz, A., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.05.001 · Cited by 193 · see citing works
Khacho, M., Clark, A., Svoboda, D. S., MacLaurin, J. G., Lagace, D. C., Park, D. S., & Slack, R. S. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx217 · Cited by 192 · see citing works
In Vivo Imaging of Dentate Gyrus Mossy Cells in Behaving Mice
Danielson, N., Turi, G. F., Ladow, M. A., Chavlis, S., Petrantonakis, P. C., Poirazi, P., & Losonczy, A. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.019 · Cited by 185 · see citing works
Self-citationRecalibrating the Relevance of Adult Neurogenesis
Snyder, J. S. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2018.12.001 · Cited by 183 · see citing works
Adult Hippocampal Neurogenesis: A Coming-of-Age Story
Kuhn, H. G., Toda, T., & Gage, F. H. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2144-18.2018 · Cited by 181 · see citing works
Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons
Drew, L. J., Kheirbek, M. A., Luna, V. M., Denny, C. A., Cloidt, M. A., Wu, M. V., Jain, S., Scharfman, H. E., & Hen, R. (2016) · Hippocampus · doi:10.1002/hipo.22557 · Cited by 169 · see citing works
Self-citationDevelopment of the hypothalamus: conservation, modification and innovation
Xie, Y., & Dorsky, R. I. (2017) · Development · doi:10.1242/dev.139055 · Cited by 169 · see citing works
A Distributed Neural Code in the Dentate Gyrus and in CA1
Stefanini, F., Kushnir, L., Jimenez, J., Jennings, J. H., Woods, N. I., Stuber, G. D., Kheirbek, M. A., Hen, R., & Fusi, S. (2020) · Neuron · doi:10.1016/j.neuron.2020.05.022 · Cited by 155 · see citing works
Self-citationSparse activity of identified dentate granule cells during spatial exploration
Diamantaki, M., Frey, M., Berens, P., Preston‐Ferrer, P., & Burgalossi, A. (2016) · eLife · doi:10.7554/elife.20252 · Cited by 162 · see citing works
Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates
Baptista, P., & Andrade, J. P. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00044 · Cited by 162 · see citing works
The Human Dentate Gyrus Plays a Necessary Role in Discriminating New Memories
Baker, S., Vieweg, P., Gao, F., Gilboa, A., Wolbers, T., Black, S. E., & Rosenbaum, R. S. (2016) · Current Biology · doi:10.1016/j.cub.2016.07.081 · Cited by 148 · see citing works
Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease
Arredondo, S. B., Valenzuela-Bezanilla, D., Mardones, M. D., & Varela‐Nallar, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00860 · Cited by 153 · see citing works
Li, Y., Luo, Y., Chen, Z.-K., Quintanilla, L., Chérasse, Y., Zhang, L., Lazarus, M., Huang, Z., & Song, J. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01065-x · Cited by 153 · see citing works
Functions of adult-born neurons in hippocampal memory interference and indexing
Miller, S. M., & Sahay, A. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0484-2 · Cited by 146 · see citing works
Kumar, D., Koyanagi, I., Carrier‐Ruiz, A., Vergara, P., Srinivasan, S., Sugaya, Y., Kasuya, M., Yu, T., Vogt, K. E., Muratani, M., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.05.008 · Cited by 144 · see citing works
Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion
Zaremba, J. D., Diamantopoulou, A., Danielson, N., Grosmark, A., Kaifosh, P., Bowler, J. C., Liao, Z., Sparks, F. T., Gogos, J. A., & Losonczy, A. (2017) · Nature Neuroscience · doi:10.1038/nn.4634 · Cited by 124 · see citing works
Self-citationAssessments of dentate gyrus function: discoveries and debates
Borzello, M., Ramirez, S., Treves, A., Lee, I., Scharfman, H. E., Stark, C. E. L., Knierim, J. J., & Rangel, L. M. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00710-z · Cited by 138 · see citing works
Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis
Yun, S., Reynolds, R. P., Masiulis, I., & Eisch, A. J. (2016) · Nature Medicine · doi:10.1038/nm.4218 · Cited by 127 · see citing works
Surget, A., & Belzung, C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01136-8 · Cited by 122 · see citing works
Sharif, F., Tayebi, B., Buzsáki, G., Royer, S., & Fernandez-Ruiz, A. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.034 · Cited by 111 · see citing works
Brainstem nucleus incertus controls contextual memory formation
Szőnyi, A., Sos, K. E., Nyilas, R., Schlingloff, D., Domonkos, A., Takács, V. T., Pósfai, B., Hegedüs, P., Priestley, J. B., Gundlach, A. L., et al. (2019) · Science · doi:10.1126/science.aaw0445 · Cited by 108 · see citing works
Self-citationFu, C.-H., Iascone, D. M., Petrof, I., Hazra, A., Zhang, X., Pyfer, M. S., Tosi, U., Corbett, B. F., Cai, J., Lee, J., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.101 · Cited by 107 · see citing works
Adult hippocampal neurogenesis and its impairment in Alzheimer’s disease
Kim, T. A., Syty, M. D., Wu, K., & Ge, S. (2022) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2021.479 · Cited by 114 · see citing works
Lybrand, Z. R., Goswami, S., Zhu, J., Jarzabek, V., Merlock, N., Aktar, M., Smith, C., Zhang, L., Varma, P., Cho, K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21649-8 · Cited by 91 · see citing works
Functional Imaging of Dentate Granule Cells in the Adult Mouse Hippocampus
Pilz, G.-A., Carta, S., Stäuble, A., Ayaz, A., Jessberger, S., & Helmchen, F. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3065-15.2016 · Cited by 98 · see citing works
Contributions of adult neurogenesis to dentate gyrus network activity and computations
Tuncdemir, S. N., Lacefield, C., & Hen, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112112 · Cited by 97 · see citing works
Self-citationDorsal and ventral hippocampal adult-born neurons contribute to context fear memory
Huckleberry, K. A., Shue, F., Copeland, T., Chitwood, R. A., Yin, W., & Drew, M. R. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0109-6 · Cited by 91 · see citing works
Plasticity-dependent, full detonation at hippocampal mossy fiber-CA3 pyramidal neuron synapses
Vyleta, N. P., Borges-Merjane, C., & Jonas, P. (2016) · eLife · doi:10.7554/elife.17977 · Cited by 91 · see citing works
Radial glial cells in the adult dentate gyrus: what are they and where do they come from?
Berg, D. A., Bond, A. M., Ming, G.-L., & Song, H. (2018) · F1000Research · doi:10.12688/f1000research.12684.1 · Cited by 89 · see citing works
Arredondo, S. B., Guerrero, F. G., Herrera-Soto, A., Jensen-Flores, J., Bustamante, D., Oñate‐Ponce, A., Henny, P., Varas‐Godoy, M., Inestrosa, N. C., & Varela‐Nallar, L. (2019) · Stem Cells · doi:10.1002/stem.3121 · Cited by 85 · see citing works
Adult-born dentate granule cells promote hippocampal population sparsity
McHugh, S. B., Lopes‐dos‐Santos, V., Gava, G. P., Hartwich, K., Tam, S. K. E., Bannerman, D. M., & Dupret, D. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01176-5 · Cited by 89 · see citing works
Parallel processing streams in the hippocampus
Lee, H., GoodSmith, D., & Knierim, J. J. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.03.004 · Cited by 92 · see citing works
AAV ablates neurogenesis in the adult murine hippocampus
Johnston, S., Parylak, S. L., Kim, S., Mac, N., Lim, C., Gallina, I., Bloyd, C., Newberry, A., Saavedra, C. D., Novak, O., et al. (2021) · eLife · doi:10.7554/elife.59291 · Cited by 87 · see citing works
Supramammillary regulation of locomotion and hippocampal activity
Farrell, J. S., Lovett-Barron, M., Klein, P., Sparks, F. T., Gschwind, T., Ortiz, A. L., Ahanonu, B., Bradbury, S., Terada, S., Oijala, M., et al. (2021) · Science · doi:10.1126/science.abh4272 · Cited by 87 · see citing works
Self-citationLi, Y., Luo, Y., Xie, L., Tart, D. S., Sheehy, R. N., Zhang, L., Coleman, L. G., Chen, X., & Song, J. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.02.006 · Cited by 87 · see citing works
Allegra, M., Posani, L., Gómez-Ocádiz, R., & Schmidt‐Hieber, C. (2020) · Neuron · doi:10.1016/j.neuron.2020.09.032 · Cited by 83 · see citing works
A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing
Seo, D.-O., Zhang, E. T., Piantadosi, S. C., Marcus, D. J., Motard, L. E., Kan, B. K., Gomez, A. M., Nguyen, T. K., Li, X., & Bruchas, M. R. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.006 · Cited by 82 · see citing works
Exercise Reverses Behavioral and Synaptic Abnormalities after Maternal Inflammation
Andoh, M., Shibata, K., Okamoto, K., Onodera, J., Morishita, K., Miura, Y., Ikegaya, Y., & Koyama, R. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.015 · Cited by 85 · see citing works
Resilience and Vulnerability to Pain and Inflammation in the Hippocampus
Vasić, V., & Schmidt, M. H. H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040739 · Cited by 84 · see citing works
Jaeger, B. N., Linker, S. B., Parylak, S., Barron, J. J., Gallina, I. S., Saavedra, C. D., Fitzpatrick, C., Lim, C. K., Schafer, S. T., Lacar, B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05418-8 · Cited by 83 · see citing works
The ontogeny of memory persistence and specificity
Ramsaran, A. I., Schlichting, M. L., & Frankland, P. W. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.09.002 · Cited by 82 · see citing works
A Compact Head‐Mounted Endoscope for In Vivo Calcium Imaging in Freely Behaving Mice
Jacob, A. D., Ramsaran, A. I., Mocle, A. J., Tran, L. M., Yan, C., Frankland, P. W., & Josselyn, S. A. (2018) · Current Protocols in Neuroscience · doi:10.1002/cpns.51 · Cited by 82 · see citing works
The Dentate Gyrus Classifies Cortical Representations of Learned Stimuli
Woods, N. I., Stefanini, F., Apodaca-Montano, D. L., Tan, I. M. C., Biane, J. S., & Kheirbek, M. A. (2020) · Neuron · doi:10.1016/j.neuron.2020.04.002 · Cited by 78 · see citing works
Self-citationThe State of the NIH BRAIN Initiative
Koroshetz, W. J., Gordon, J. A., Adams, A. B., Beckel-Mitchener, A. C., Churchill, J. D., Farber, G. K., Freund, M. P., Gnadt, J., Hsu, N. S., Langhals, N. B., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3174-17.2018 · Cited by 77 · see citing works
Dendrites of dentate gyrus granule cells contribute to pattern separation by controlling sparsity
Chavlis, S., Petrantonakis, P. C., & Poirazi, P. (2016) · Hippocampus · doi:10.1002/hipo.22675 · Cited by 87 · see citing works
Erwin, S. R., Sun, W., Copeland, M., Lindo, S. E., Spruston, N., & Cembrowski, M. S. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107551 · Cited by 77 · see citing works
Adult Neurogenesis and the Promise of Adult Neural Stem Cells
Ghosh, H. S. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519856876 · Cited by 77 · see citing works
The hippocampus converts dynamic entorhinal inputs into stable spatial maps
Cholvin, T., Hainmueller, T., & Bartos, M. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.019 · Cited by 75 · see citing works
Hippocampal function in rodents
Zemla, R., & Basu, J. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.04.005 · Cited by 71 · see citing works
Eliwa, H., Brizard, B., Guisquet, A. L., Hen, R., Belzung, C., & Surget, A. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105097 · Cited by 73 · see citing works
Self-citationPattern separation of spiketrains in hippocampal neurons
Madar, A. D., Ewell, L. A., & Jones, M. V. (2019) · Scientific Reports · doi:10.1038/s41598-019-41503-8 · Cited by 72 · see citing works
Impact of Traumatic Brain Injury on Neurogenesis
Ngwenya, L. B., & Danzer, S. C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.01014 · Cited by 71 · see citing works
GoodSmith, D., Lee, H., Neunuebel, J. P., Song, H., & Knierim, J. J. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0940-19.2019 · Cited by 65 · see citing works
Three brain states in the hippocampus and cortex
Kay, K., & Frank, L. M. (2018) · Hippocampus · doi:10.1002/hipo.22956 · Cited by 63 · see citing works
H ippocampal neurogenesis and pattern separation: A meta‐analysis of behavioral data
França, T. F. A., Bitencourt, A. M., Maximilla, N. R., Barros, D. M., & Monserrat, J. M. (2017) · Hippocampus · doi:10.1002/hipo.22746 · Cited by 65 · see citing works
From Engrams to Pathologies of the Brain
Denny, C. A., Lebois, E. P., & Ramirez, S. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00023 · Cited by 64 · see citing works
Self-citationGeigenmüller, J. N., Tari, A. R., Wisløff, U., & Walker, T. L. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14179 · Cited by 64 · see citing works
Probing Deep Brain Circuitry: New Advances in in Vivo Calcium Measurement Strategies
Girven, K. S., & Sparta, D. R. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00307 · Cited by 61 · see citing works
Separation or binding? Role of the dentate gyrus in hippocampal mnemonic processing
Lee, J. W., & Jung, M. W. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.049 · Cited by 55 · see citing works
Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus
Kim, S., Jung, D., & Royer, S. (2020) · Nature Communications · doi:10.1038/s41467-020-18351-6 · Cited by 54 · see citing works
Li, W., Su, X., Hu, N.-Y., Hu, J., Li, X., Yang, J., & Gao, T. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.04.019 · Cited by 61 · see citing works
Bowler, J. C., & Losonczy, A. (2023) · Neuron · doi:10.1016/j.neuron.2023.09.013 · Cited by 55 · see citing works
Self-citationSynchronous activity patterns in the dentate gyrus during immobility
Pofahl, M., Nikbakht, N., Haubrich, A. N., Nguyen, T. M., Masala, N., Distler, F. J., Braganza, O., Macke, J. H., Ewell, L. A., Gölcük, K., et al. (2021) · eLife · doi:10.7554/elife.65786 · Cited by 54 · see citing works
Zimmermann, T., Maroso, M., Beer, A., Baddenhausen, S., Ludewig, S., Fan, W., Vennin, C., Loch, S., Berninger, B., Hofmann, C., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy258 · Cited by 52 · see citing works
Early survival and delayed death of developmentally‐born dentate gyrus neurons
Cahill, S. P., Yu, R. Q., Green, D., Todorova, E., & Snyder, J. S. (2017) · Hippocampus · doi:10.1002/hipo.22760 · Cited by 53 · see citing works
Sparks, F. T., Liao, Z., Li, W., Grosmark, A., Soltész, I., & Losonczy, A. (2020) · Nature Communications · doi:10.1038/s41467-020-19969-2 · Cited by 53 · see citing works
Self-citationNeuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit
Prince, L. Y., Bacon, T., Tigaret, C. M., & Mellor, J. R. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2016.00032 · Cited by 51 · see citing works
Kirschen, G. W., Shen, J., Tian, M., Schroeder, B., Wang, J., Man, G., Wu, S., & Ge, S. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3417-16.2017 · Cited by 49 · see citing works
Treating Brain Disorders by Targeting Adult Neural Stem Cells
Bao, H., & Song, J. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.10.001 · Cited by 51 · see citing works
Functional neurogenesis over the years
Snyder, J. S., & Drew, M. R. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112470 · Cited by 51 · see citing works
Maximally selective single-cell target for circuit control in epilepsy models
Hadjiabadi, D. H., Lovett-Barron, M., Raikov, I., Sparks, F. T., Liao, Z., Baraban, S. C., Leskovec, J., Losonczy, A., Deisseroth, K. A., & Soltész, I. (2021) · Neuron · doi:10.1016/j.neuron.2021.06.007 · Cited by 51 · see citing works
Self-citationTemporal Embryonic Origin Critically Determines Cellular Physiology in the Dentate Gyrus
Save, L., Baude, A., & Cossart, R. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy132 · Cited by 49 · see citing works
Forte, N. R., Boccella, S., Tunisi, L., Fernández-Rilo, A. C., Imperatore, R., Iannotti, F. A., Risi, M. D., Iannotta, M., Piscitelli, F., Capasso, R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26388-4 · Cited by 47 · see citing works
Modulation of Aversive Memory by Adult Hippocampal Neurogenesis
Drew, M. R., & Huckleberry, K. A. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0528-9 · Cited by 47 · see citing works
Whoolery, C. W., Yun, S., Reynolds, R. P., Lucero, M. J., Soler, I., Tran, F. H., Ito, N., Redfield, R. L., Richardson, D. R., Shih, H.-Y., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59419-z · Cited by 49 · see citing works
Hippocampus-Dependent Goal Localization by Head-Fixed Mice in Virtual Reality
Sato, M., Kawano, M., Mizuta, K., Islam, T., Lee, M. G., & Hayashi, Y. (2017) · eNeuro · doi:10.1523/eneuro.0369-16.2017 · Cited by 45 · see citing works
Targeting Adult Neurogenesis to Optimize Hippocampal Circuits in Aging
McAvoy, K. M., & Sahay, A. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0539-6 · Cited by 44 · see citing works
Adult-born neurons promote cognitive flexibility by improving memory precision and indexing
Berdugo-Vega, G., Lee, C.-C., Garthe, A., Kempermann, G., & Calegari, F. (2020) · bioRxiv · doi:10.1002/hipo.23373 · Cited by 37 · see citing works
Selective Routing of Spatial Information Flow from Input to Output in Hippocampal Granule Cells
Zhang, X., Schlögl, A., & Jonas, P. (2020) · Neuron · doi:10.1016/j.neuron.2020.07.006 · Cited by 44 · see citing works
Flexible encoding of objects and space in single cells of the dentate gyrus
GoodSmith, D., Kim, S. H., Puliyadi, V., Ming, G., Song, H., Knierim, J. J., & Christian, K. M. (2022) · Current Biology · doi:10.1016/j.cub.2022.01.023 · Cited by 44 · see citing works
- Authors
- Danielson, N. B., Kaifosh, P., Zaremba, J. D., Lovett-Barron, M., Tsai, J., Denny, C. A., Balough, E. M., Goldberg, A. R., Drew, L. J., Hen, R., Losonczy, A., & Kheirbek, M. A.
- Affiliations
- Columbia University (US)
- New York State Psychiatric Institute (US)
- University of California, San Francisco (US)
- Corresponding author
- Losonczy, Attila
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 90
- Issue
- 1
- Pages
- 101-112
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4962695
- OpenAlex
- W2293303303
- Cited by
- 352
- References
- 62
- Citations by year
- 2026: 20 · 2025: 28 · 2024: 34 · 2023: 27 · 2022: 26 · 2021: 35 · 2020: 46 · 2019: 39 · 2018: 37 · 2017: 38 · 2016: 21 · 2015: 1
- FWCI
- 23.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (R01AG043688)
- National Institute of Mental Health (R37MH068542, R01MH083862, K01MH099371, T32MH015174, R01MH100631)
- National Institute of Neurological Disorders and Stroke (U01NS090583, R01NS094668, F30NS090819)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, hippocampal granule cells, context encoding, spatial representation, pattern separation, spatial tuning, spatial remapping, optogenetic silencing, two-photon calcium imaging, awake behaving mice, context discrimination
- MeSH terms
- Animals, Calcium, Cell Differentiation, Hippocampus, Neurons, Dentate Gyrus, Microscopy, Fluorescence, Multiphoton, Mice, Neurogenesis, Optogenetics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
