Cited by 45Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Structure, biophysics, and circuit function of a “giant” cortical presynaptic terminal

Vandael, David, Jonas, Peter·2024·Science

Abstract

The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of the hippocampus. Because of its comparatively large size, this synapse is accessible to direct presynaptic recording, allowing a rigorous investigation of the biophysical mechanisms of synaptic transmission and plasticity. Furthermore, because of its placement in the very center of the hippocampal memory circuit, this synapse seems to be critically involved in several higher network functions, such as learning, memory, pattern separation, and pattern completion. Recent work based on new technologies in both nanoanatomy and nanophysiology, including presynaptic patch-clamp recording, paired recording, super-resolution light microscopy, and freeze-fracture and "flash-and-freeze" electron microscopy, has provided new insights into the structure, biophysics, and network function of this intriguing synapse. This brings us one step closer to answering a fundamental question in neuroscience: how basic synaptic properties shape higher network computations.

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Crossref · 10.1126/science.adg6757

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204 of 204 references verified0 citation errors · 0 not checkable

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Authors
Vandael, D., & Jonas, P.
Affiliations
  • Institute of Science and Technology Austria (AT)
  • Institute of Science and Technology Austria (ISTA), A-3400 Klosterneuburg, Austria.
Venue
Science
Published
2024-03-08
Volume
383
Issue
6687
Pages
eadg6757-eadg6757
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W4392544783
Cited by
45
References
205
Citations by year
2026: 13 · 2025: 19 · 2024: 13
FWCI
2.83
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
mossy fiber synapses, presynaptic terminals, hippocampus, dentate gyrus granule cells, CA3 pyramidal cells, synaptic transmission, synaptic plasticity, paired recordings, freeze-fracture electron microscopy, synaptic structure, trisynaptic circuit, pattern separation, pattern completion, memory
MeSH terms
Animals, Hippocampus, Humans, Synaptic Transmission, Synapses, Presynaptic Terminals, Pyramidal Cells, Mossy Fibers, Hippocampal, CA3 Region, Hippocampal

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