Structure, biophysics, and circuit function of a “giant” cortical presynaptic terminal
Abstract
The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of the hippocampus. Because of its comparatively large size, this synapse is accessible to direct presynaptic recording, allowing a rigorous investigation of the biophysical mechanisms of synaptic transmission and plasticity. Furthermore, because of its placement in the very center of the hippocampal memory circuit, this synapse seems to be critically involved in several higher network functions, such as learning, memory, pattern separation, and pattern completion. Recent work based on new technologies in both nanoanatomy and nanophysiology, including presynaptic patch-clamp recording, paired recording, super-resolution light microscopy, and freeze-fracture and "flash-and-freeze" electron microscopy, has provided new insights into the structure, biophysics, and network function of this intriguing synapse. This brings us one step closer to answering a fundamental question in neuroscience: how basic synaptic properties shape higher network computations.
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Chemical potentiation markedly regulates the conditional detonation properties of the synapse.
“Thus, chemical potentiation markedly regulates the conditional detonation properties of the synapse [25,50,51].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [25]
The hippocampal mossy fiber-CA3 pyramidal neuron synapse is an ideal synapse to tackle these questions.
“The hippocampal mossy fiber–CA3 pyramidal neuron (PN) synapse, formed between dentate gyrus granule cells (GCs) and CA3 PNs, is an ideal synapse to tackle these questions [24,25].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [25]
Neuromodulator-dependent strengthening of the hippocampal teacher synapse could be involved in the memory-enhancing effects of locus coeruleus stimulation.
“Our results suggest that neuromodulator-dependent strengthening of the hippocampal teacher synapse could be involved in these complex effects [25].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [25]
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- Authors
- Vandael, D., & Jonas, P.
- Affiliations
- Institute of Science and Technology Austria (AT)
- Institute of Science and Technology Austria (ISTA), A-3400 Klosterneuburg, Austria.
- Venue
- Science
- Published
- 2024-03-08
- Volume
- 383
- Issue
- 6687
- Pages
- eadg6757-eadg6757
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4392544783
- Cited by
- 45
- References
- 205
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 13
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- mossy fiber synapses, presynaptic terminals, hippocampus, dentate gyrus granule cells, CA3 pyramidal cells, synaptic transmission, synaptic plasticity, paired recordings, freeze-fracture electron microscopy, synaptic structure, trisynaptic circuit, pattern separation, pattern completion, memory
- MeSH terms
- Animals, Hippocampus, Humans, Synaptic Transmission, Synapses, Presynaptic Terminals, Pyramidal Cells, Mossy Fibers, Hippocampal, CA3 Region, Hippocampal
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