Cited by 50Vestibular and auditory disordersNeuroscience and Neuropharmacology ResearchVisual perception and processing mechanisms

Central Vestibular Tuning Arises from Patterned Convergence of Otolith Afferents

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Liu, Zhikai, Kimura, Yukiko, Higashijima, Shin-ichi, Hildebrand, David G.C., Morgan, Joshua L., Bagnall, Martha W.·2020·Neuron

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Abstract

As sensory information moves through the brain, higher-order areas exhibit more complex tuning than lower areas. Though models predict that complexity arises via convergent inputs from neurons with diverse response properties, in most vertebrate systems, convergence has only been inferred rather than tested directly. Here, we measure sensory computations in zebrafish vestibular neurons across multiple axes in vivo. We establish that whole-cell physiological recordings reveal tuning of individual vestibular afferent inputs and their postsynaptic targets. Strong, sparse synaptic inputs can be distinguished by their amplitudes, permitting analysis of afferent convergence in vivo. An independent approach, serial-section electron microscopy, supports the inferred connectivity. We find that afferents with similar or differing preferred directions converge on central vestibular neurons, conferring more simple or complex tuning, respectively. Together, these results provide a direct, quantifiable demonstration of feedforward input convergence in vivo.

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Authors
Liu, Z., Kimura, Y., Higashijima, S.-I., Hildebrand, D. G. C., Morgan, J. L., & Bagnall, M. W.
Affiliations
  • Washington University in St. Louis (US)
  • National Institute for Basic Biology (JP)
  • Rockefeller University (US)
Corresponding author
Bagnall, Martha W.
Venue
Neuron
Publisher
Elsevier BV
Published
2020-11
Volume
108
Issue
4
Pages
748-762.e4
ISSN
0896-6273 (ISSN-L)
OpenAlex
W3086057402
Cited by
50
References
84
Citations by year
2026: 6 · 2025: 11 · 2024: 12 · 2023: 6 · 2022: 10 · 2021: 5
FWCI
2.02
Type
journal article
Language
en
Update notices
erratum (2021-03-03)
Open access
Locations
  • Neuron (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Eye Institute
  • National Institute on Deafness and Other Communication Disorders
Topics
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords
afferent convergence, otolith afferents, preferred direction, serial section electron microscopy, whole-cell recording, sensory processing
MeSH terms
Animals, Electric Stimulation, Evoked Potentials, Somatosensory, Microscopy, Electron, Neurons, Neurons, Afferent, Otolithic Membrane, Vestibular Nuclei, Zebrafish, Gene Knock-In Techniques

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