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Mechanical Allodynia Circuitry in the Dorsal Horn Is Defined by the Nature of the Injury
Open accessAbstract
The spinal dorsal horn is a major site for the induction and maintenance of mechanical allodynia, but the circuitry that underlies this clinically important form of pain remains unclear. The studies presented here provide strong evidence that the neural circuits conveying mechanical allodynia in the dorsal horn differ by the nature of the injury. Calretinin (CR) neurons in lamina II inner convey mechanical allodynia induced by inflammatory injuries, while protein kinase C gamma (PKCγ) neurons at the lamina II/III border convey mechanical allodynia induced by neuropathic injuries. Cholecystokinin (CCK) neurons located deeper within the dorsal horn (laminae III-IV) are important for both types of injuries. Interestingly, the Maf+ subset of CCK neurons is composed of transient vesicular glutamate transporter 3 (tVGLUT3) neurons, which convey primarily dynamic allodynia. Identification of an etiology-based circuitry for mechanical allodynia in the dorsal horn has important implications for the mechanistic and clinical understanding of this condition.
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“The Maf dorsal, the excitatory family was comprised of Excit-5, Excit-6, and Excit-7 which expressed markers of neurons involved in light touch46,48,50,56,57.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [57]
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Metadata
- Authors
- Peirs, C., Williams, S.-P. G., Zhao, X., Arokiaraj, C. M., Ferreira, D. W., Noh, M.-C., Smith, K. M., Halder, P., Corrigan, K. A., Gedeon, J. Y., Lee, S. J., Gatto, G., Chi, D., Ross, S. E., Goulding, M., & Seal, R. P.
- Affiliations
- University of Pittsburgh (US)
- Salk Institute for Biological Studies (US)
- Corresponding author
- Seal, Rebecca P.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 109
- Issue
- 1
- Pages
- 73-90.e7
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC7806207
- OpenAlex
- W3100514562
- Cited by
- 190
- References
- 64
- Citations by year
- 2026: 26 · 2025: 26 · 2024: 42 · 2023: 35 · 2022: 38 · 2021: 21
- FWCI
- 14.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- mechanical allodynia, dorsal horn, central sensitization, VGLUT3, injury etiology, nociception
- MeSH terms
- Animals, Female, Hyperalgesia, Male, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Pain Measurement, Spinal Cord Injuries, Amino Acid Transport Systems, Acidic, Mice, Spinal Cord Dorsal Horn
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