Cited by 190Pain Mechanisms and TreatmentsPain Management and TreatmentNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.

Mechanical Allodynia Circuitry in the Dorsal Horn Is Defined by the Nature of the Injury

Open access

Peirs, Cedric, Williams, Sean-Paul G., Zhao, Xinyi, Arokiaraj, Cynthia M., Ferreira, David W., Noh, Myung-chul, Smith, Kelly M., Halder, Priyabrata, Corrigan, Kelly A., Gedeon, Jeremy Y., Lee, Suh Jin, Gatto, Graziana, Chi, David, Ross, Sarah E., Goulding, Martyn, Seal, Rebecca P.·2021·Neuron

DOI 10.1016/j.neuron.2020.10.027PMC PMC7806207

Open this paper in CoChat — free account Open PDF

Abstract

The spinal dorsal horn is a major site for the induction and maintenance of mechanical allodynia, but the circuitry that underlies this clinically important form of pain remains unclear. The studies presented here provide strong evidence that the neural circuits conveying mechanical allodynia in the dorsal horn differ by the nature of the injury. Calretinin (CR) neurons in lamina II inner convey mechanical allodynia induced by inflammatory injuries, while protein kinase C gamma (PKCγ) neurons at the lamina II/III border convey mechanical allodynia induced by neuropathic injuries. Cholecystokinin (CCK) neurons located deeper within the dorsal horn (laminae III-IV) are important for both types of injuries. Interestingly, the Maf+ subset of CCK neurons is composed of transient vesicular glutamate transporter 3 (tVGLUT3) neurons, which convey primarily dynamic allodynia. Identification of an etiology-based circuitry for mechanical allodynia in the dorsal horn has important implications for the mechanistic and clinical understanding of this condition.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2020.10.027

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Quantitative assessment of tactile allodynia in the rat paw
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90144-9 · Cited by 7,740
Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis
Finnerup, N. B., Attal, N., Haroutounian, S., McNicol, E., Baron, R., Dworkin, R. H., Gilron, I., Haanpää, M., Hansson, P., Jensen, T. S., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70251-0 · Cited by 3,980
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., & Julius, D. (2000) · Science · doi:10.1126/science.288.5464.306 · Cited by 3,544
Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)
Bouhassira, D., Attal, N., Alchaar, H., Boureau, F., Brochet, B., Bruxelle, J., Cunin, G., Fermanian, J., Giniès, P., Grun-Overdyking, A., et al. (2005) · Pain · doi:10.1016/j.pain.2004.12.010 · Cited by 2,834
Spared nerve injury: an animal model of persistent peripheral neuropathic pain
Décosterd, I., & Woolf, C. J. (2000) · Pain · doi:10.1016/s0304-3959(00)00276-1 · Cited by 2,317
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
Usoskin, D., Furlan, A., Islam, S., Abdo, H., Lönnerberg, P., Lou, D., Hjerling-Leffler, J., Haeggström, J., Kharchenko, O., Kharchenko, P. V., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3881 · Cited by 2,136
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
Bautista, D. M., Jordt, S. E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., & Julius, D. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.023 · Cited by 1,921
Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors
Alexander, G. M., Rogan, S. C., Abbas, A. I., Armbruster, B. N., Pei, Y., Allen, J., Nonneman, R. J., Hartmann, J. F., Moy, S. S., Nicolelis, M. A. L., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.014 · Cited by 1,019

Show all 64 references

Sorted by citations

A harmonized atlas of mouse spinal cord cell types and their spatial organization
Russ, D. E., Cross, R. B. P., Li, L., Koch, S. C., Matson, K. J. E., Yadav, A., Alkaslasi, M. R., Lee, D. I., Le Pichon, C. E., Menon, V., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25125-1 · Cited by 255
Brain circuits for pain and its treatment
Lindsay, N. M., Chen, C., Gilam, G., Mackey, S., & Scherrer, G. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7360 · Cited by 246
A functional subdivision within the somatosensory system and its implications for pain research
Ma, Q. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.015 · Cited by 112
Mediators of Neuropathic Pain; Focus on Spinal Microglia, CSF-1, BDNF, CCL21, TNF-α, Wnt Ligands, and Interleukin 1β
Boakye, P. A., Tang, S.-J., & Smith, P. A. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.698157 · Cited by 102
Neuroplasticity related to chronic pain and its modulation by microglia
Hiraga, S.-I., Itokazu, T., Nishibe, M., & Yamashita, T. (2022) · Inflammation and Regeneration · doi:10.1186/s41232-022-00199-6 · Cited by 101
A Functional Topographic Map for Spinal Sensorimotor Reflexes
Gatto, G., Bourane, S., Ren, X., Di Costanzo, S., Fenton, P. K., Halder, P., Seal, R. P., & Goulding, M. D. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.003 · Cited by 92
Self-citation
Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets
Alles, S. R. A., & Smith, P. A. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.750583 · Cited by 96
scRNA-sequencing reveals subtype-specific transcriptomic perturbations in DRG neurons of PirtEGFPf mice in neuropathic pain condition
Zhang, C., Hu, M., Wang, X., Cui, X., Liu, J., Huang, Q., Cao, X., Zhou, F., Qian, J. X., He, S.-Q., et al. (2022) · eLife · doi:10.7554/elife.76063 · Cited by 64
Presynaptic Inhibition of Pain and Touch in the Spinal Cord: From Receptors to Circuits
Comitato, A., & Bardoni, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010414 · Cited by 61
Spinal cord retinoic acid receptor signaling gates mechanical hypersensitivity in neuropathic pain
Cao, B., Scherrer, G., & Chen, L. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.027 · Cited by 60
Cell type-specific calcium imaging of central sensitization in mouse dorsal horn
Warwick, C. A., Salsovic, J., Hachisuka, J., Smith, K. M., Sheahan, T. D., Chen, H., Ibinson, J. W., Koerber, H. R., & Ross, S. E. (2022) · Nature Communications · doi:10.1038/s41467-022-32608-2 · Cited by 50
Self-citation
Neuropathic pain; what we know and what we should do about it
Smith, P. A. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1220034 · Cited by 53
Electroacupuncture alleviates mechanical allodynia and anxiety‐like behaviors induced by chronic neuropathic pain via regulating rostral anterior cingulate cortex‐dorsal raphe nucleus neural circuit
Xu, Y., Zhu, X., Chen, Y., Chen, Y., Zhu, Y., Xiao, S., Wu, M., Wang, Y., Zhang, C., Wu, Z., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14328 · Cited by 47
Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain
Nelson, T. S., Sinha, G. P., dos Santos, D. F. D. S., Jukkola, P. I., Prasoon, P., Winter, M. K., McCarson, K. E., Smith, B. N., & Taylor, B. K. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204515119 · Cited by 47
Multiscale Computer Model of the Spinal Dorsal Horn Reveals Changes in Network Processing Associated with Chronic Pain
Medlock, L., Sekiguchi, K., Hong, S., Durá-Bernal, S., Lytton, W. W., & Prescott, S. A. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1199-21.2022 · Cited by 43
Glycine Receptors in Spinal Nociceptive Control—An Update
Zeilhofer, H., Werynska, K., Gingras, J., & Yévenes, G. E. (2021) · Biomolecules · doi:10.3390/biom11060846 · Cited by 37
Diversity of inhibitory and excitatory parvalbumin interneuron circuits in the dorsal horn
Gradwell, M. A., Boyle, K. A., Browne, T. J., Bell, A. M., Leonardo, J., Reyes, F. S. P., Dickie, A. C., Smith, K. M., Callister, R. J., Dayas, C. V., et al. (2021) · Pain · doi:10.1097/j.pain.0000000000002422 · Cited by 41
Self-citation
Parabrachial Calca neurons drive nociplasticity
Condon, L. F., Yu, Y., Park, S., Cao, F., Pauli, J. L., Nelson, T. S., & Palmiter, R. D. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114057 · Cited by 41
Targeted anatomical and functional identification of antinociceptive and pronociceptive serotonergic neurons that project to the spinal dorsal horn
Ganley, R. P., de Sousa, M. M., Werder, K., Öztürk, T., Mendes, R., Ranucci, M., Wildner, H., & Zeilhofer, H. U. (2023) · eLife · doi:10.7554/elife.78689 · Cited by 31
Spatial, transcriptomic, and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition
Arokiaraj, C. M., Leone, M. J., Kleyman, M., Chamessian, A. G., Noh, M., Phan, B. N., Lopes, B. C., Corrigan, K. A., Cherupally, V. K., Yeramosu, D., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114876 · Cited by 35
Self-citation
Electroacupuncture ameliorates pain in cervical spondylotic radiculopathy rat by inhibiting the CaMKII/CREB/BDNF signaling pathway and regulating spinal synaptic plasticity
Su, H., Chen, H., Zhang, X., Su, S.-Y., Li, J., Guo, Y., Wang, Q., Xie, C., & Yang, P. (2023) · Brain and Behavior · doi:10.1002/brb3.3177 · Cited by 29
A parabrachial hub for need-state control of enduring pain
Goldstein, N., Maes, A., Allen, H. N., Nelson, T. S., Kruger, K. A., Kindel, M., Yeung, A. T. M., Smith, N. K., Carty, J. R. E., Boccia, L., et al. (2025) · Nature · doi:10.1038/s41586-025-09602-x · Cited by 35
Advances and Barriers in Understanding Presynaptic N-Methyl-D-Aspartate Receptors in Spinal Pain Processing
Dedek, A., & Hildebrand, M. E. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.864502 · Cited by 28
Parabrachial neurons promote nociplastic pain
Palmiter, R. D. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.07.002 · Cited by 33
Neuron-specific spinal cord translatomes reveal a neuropeptide code for mouse dorsal horn excitatory neurons
Gupta, R. R. D., Scheurer, L., Pelczar, P., Wildner, H., & Zeilhofer, H. U. (2021) · Scientific Reports · doi:10.1038/s41598-021-84667-y · Cited by 27
Nerve injury disrupts temporal processing in the spinal cord dorsal horn through alterations in PV+ interneurons
Rankin, G., Chirila, A. M., Emanuel, A. J., Zhang, Z., Woolf, C. J., Drugowitsch, J., & Ginty, D. D. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113718 · Cited by 24
Differential modification of ascending spinal outputs in acute and chronic pain states
Yarmolinsky, D. A., Zeng, X., MacKinnon-Booth, N., Greene, C. A., Kim, C., Cheng, Y., Turnes, B. L., & Woolf, C. J. (2025) · Neuron · doi:10.1016/j.neuron.2025.01.031 · Cited by 29
Ontogeny of the spinal cord dorsal horn
Roome, R. B., Yadav, A., Flores, L., Puarr, A. K., Nardini, D., Richardson, A. J. W., Waclaw, R. R., Arkell, R. M., Menon, V., Johnson, J. E. B., et al. (2026) · Science · doi:10.1126/science.adx5781 · Cited by 24
Morphological and neurochemical characterization of glycinergic neurons in laminae I–IV of the mouse spinal dorsal horn
Miranda, C. O., Hegedűs, K., Wildner, H., Zeilhofer, H. U., & Antal, M. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25232 · Cited by 23
Dexmedetomidine alleviates pain in MPTP-treated mice by activating the AMPK/mTOR/NF-κB pathways in astrocytes
Chen, Y. S., Li, Y., Li, C., Zhu, D., Cheng, O., & Cui, J. G. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136933 · Cited by 23
Targeting the somatosensory system with AAV9 and AAV2retro viral vectors
Skorput, A. G. J., Gore, R., Schorn, R. E., Riedl, M. S., de Velasco, E. M. F., Hadlich, B., Kitto, K. F., Fairbanks, C. A., & Vulchanova, L. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264938 · Cited by 22
Neurochemical atlas of the cat spinal cord
Veshchitskii, A. A., Shkorbatova, P. Y., & Merkulyeva, N. S. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.1034395 · Cited by 22
Interactions Among Non-Coding RNAs and mRNAs in the Trigeminal Ganglion Associated with Neuropathic Pain
Fang, Z., Liao, H.-L., Tang, Q.-F., Liu, Y.-J., Zhang, Y., Lin, J., Yu, H., Zhou, C., Li, C., Liu, F., et al. (2022) · Journal of Pain Research · doi:10.2147/jpr.s382692 · Cited by 21
Spinal VGLUT3 lineage neurons drive visceral mechanical allodynia but not sensitized visceromotor reflexes
Qi, L., Lin, S.-H., & Ma, Q. (2022) · Neuron · doi:10.1016/j.neuron.2022.12.003 · Cited by 21
Alleviation of neuropathic pain with neuropeptide Y requires spinal Npy1r interneurons that coexpress Grp
Nelson, T. S., Allen, H. N., Basu, P., Prasoon, P., Nguyen, E. K., Arokiaraj, C. M., dos Santos, D. F. D. S., Seal, R. P., Ross, S. E., Todd, A. J., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.169554 · Cited by 21
Self-citation
Central control of opioid-induced mechanical hypersensitivity and tolerance in mice
Yin, G., Duan, K., Dong, D., Du, F., Guo, C., Zhang, C., Liu, X., Sun, Y., Huang, T., Cui, G.-F., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.09.014 · Cited by 20
The structure of sensory afferent compartments in health and disease
Middleton, S. J., Pérez-Sánchez, J., & Dawes, J. M. (2021) · Journal of Anatomy · doi:10.1111/joa.13544 · Cited by 23
Role of C-tactile fibers in pain modulation: animal and human perspectives
Larsson, M., & Nagi, S. S. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.09.005 · Cited by 24
The Known Biology of Neuropathic Pain and Its Relevance to Pain Management
Smith, P. A. (2023) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2023.10 · Cited by 20
Ventral Hippocampal CA1 Pyramidal Neurons Encode Nociceptive Information
Wang, Y., Liu, N., Ma, L., Yue, L., Cui, S., Liu, F., Yi, M., & Wan, Y. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01086-x · Cited by 20
Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice
Litke, C., Hagenston, A. M., Kenkel, A.-K., Páldy, E., Lu, J., Kuner, R., & Mauceri, D. (2022) · Nature Communications · doi:10.1038/s41467-022-28357-x · Cited by 19
Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking
Xie, M.-X., Lai, R.-C., Xiao, Y.-B., Zhang, X., Cao, X.-Y., Tian, X.-Y., Chen, Z., Chen, Z.-Y., Cao, Y., Li, X., et al. (2024) · Military Medical Research · doi:10.1186/s40779-024-00520-z · Cited by 17
Infralimbic-basolateral amygdala circuit associated with depression-like not anxiety-like behaviors induced by chronic neuropathic pain and the antidepressant effects of electroacupuncture
Xie, Y., Shen, Z., Zhu, X., Pan, Y., Sun, H., Xie, M., Gong, Q., Hu, Q., Chen, J., Wu, Z., et al. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111092 · Cited by 18
Identification of brain-to-spinal circuits controlling the laterality and duration of mechanical allodynia in mice
Huo, J., Du, F., Duan, K., Yin, G., Liu, X., Ma, Q., Dong, D., Sun, M., Hao, M., Su, D., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112300 · Cited by 18
Network model of nociceptive processing in the superficial spinal dorsal horn reveals mechanisms of hyperalgesia, allodynia, and spinal cord stimulation
Gilbert, J. E., Zhang, T. C., Esteller, R., & Grill, W. M. (2023) · Journal of Neurophysiology · doi:10.1152/jn.00186.2023 · Cited by 18
Modulation of Comorbid Chronic Neuropathic Pain and Anxiety-Like Behaviors by Glutamatergic Neurons in the Ventrolateral Periaqueductal Gray and the Analgesic and Anxiolytic Effects of Electroacupuncture
Zhu, X., Zhang, C., Hu, Y., Wang, Y., Xiao, S., Zhu, Y., Sun, H., Sun, J., Xu, C., Xu, Y., et al. (2024) · eNeuro · doi:10.1523/eneuro.0454-23.2024 · Cited by 17
Involvement of basolateral amygdala‐rostral anterior cingulate cortex in mechanical allodynia and anxiety‐like behaviors and potential mechanisms of electroacupuncture
Chen, Y., Tong, S., Xu, Y., Xu, Y., Wu, Z., Zhu, X., Wang, X., Li, C., Lin, C., Li, X., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70035 · Cited by 15
The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain states
Upadhyay, A., Gradwell, M. A., Vajtay, T. J., Conner, J., Sanyal, A. A., Azadegan, C., Patel, K., Thackray, J. K., Bohic, M., Imai, F., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115556 · Cited by 15
Transcriptome-wide analysis of trigeminal ganglion and subnucleus caudalis in a mouse model of chronic constriction injury-induced trigeminal neuralgia
Cui, X., Qin, B., Xia, C., Hong Li, A., Li, Z., Li, Z., Nasır, A., & Bai, Q. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1230633 · Cited by 15
Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cord
Zhang, D., Chen, Y., Wei, Y., Chen, H., Wu, Y., Wu, L., Li, J., Ren, Q., Miao, C., Zhu, T., et al. (2023) · eLife · doi:10.7554/elife.92046 · Cited by 38
CCK2 receptors in chronic pain
LaVigne, J. E., & Alles, S. R. A. (2022) · Neurobiology of Pain · doi:10.1016/j.ynpai.2022.100092 · Cited by 15
Spinal CCK1 Receptors Contribute to Somatic Pain Hypersensitivity Induced by Malocclusion via a Reciprocal Neuron-Glial Signaling Cascade
Xiang, T., Li, J., Su, H.-Y., Bai, K.-H., Wang, S., Traub, R. J., & Cao, D. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.05.009 · Cited by 15
c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy
Frezel, N., Ranucci, M., Foster, E., Wende, H., Pelczar, P., Mendes, R., Ganley, R. P., Werynska, K., d‘Aquin, S., Beccarini, C., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112295 · Cited by 13
Contribution of µ Opioid Receptor–expressing Dorsal Horn Interneurons to Neuropathic Pain–like Behavior in Mice
Qi, Y., Nelson, T. S., Prasoon, P., Norris, C., & Taylor, B. K. (2023) · Anesthesiology · doi:10.1097/aln.0000000000004735 · Cited by 12
Differential Neuronal Activation of Nociceptive Pathways in Neuropathic Pain After Spinal Cord Injury
He, Z., Zhang, J., Xu, J. L., Wang, Y., Zheng, X., & Wang, W. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01532-6 · Cited by 11
A Deep-Learning Driven Investigation of the Circuit Basis for Reflexive Hypersensitivity to Thermal Pain
Reddy, P., Vasudeva, J. S., Shah, D. P., Prajapati, J. N., Harikumar, N., & Barik, A. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.08.023 · Cited by 11
Thymus persicus (Ronniger ex Rech. f.) Jalas alleviates nociceptive and neuropathic pain behavior in mice: Multiple mechanisms of action
Abed, D. Z., Sadeghian, R., Mohammadi, S., & Akram, M. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114695 · Cited by 11
The T-Type Calcium Channel Cav3.2 in Somatostatin Interneurons in Spinal Dorsal Horn Participates in Mechanosensation and Mechanical Allodynia in Mice
Zhi, Y., Cao, F., Su, X.-J., Shu-wen, G., Zheng, H.-N., Jiang, J., Su, L., Liu, J., Wang, Y., Zhang, Y., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.875726 · Cited by 10
Chronic Pain–Related Jaw Muscle Motor Load and Sensory Processing
Nickel, J. C., Gonzalez, Y. M., Wu, Y. X., Liu, Y., Liu, H., & Iwasaki, L. R. (2022) · Journal of Dental Research · doi:10.1177/00220345221099885 · Cited by 10
Ca2+-Permeable AMPA Receptors Contribute to Changed Dorsal Horn Neuronal Firing and Inflammatory Pain
Kopach, O., Dobropolska, Y., Belan, P. V., & Voitenko, N. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032341 · Cited by 10
Intersectional genetic tools to study skilled reaching in mice
Nicola, F., Hua, I., & Levine, A. J. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113879 · Cited by 9
Modality-Specific Modulation of Temperature Representations in the Spinal Cord after Injury
Chen, R., Kamalani, G. N. A., & Chen, X. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1104-21.2021 · Cited by 9
Long-Term Two-Photon Imaging of Spinal Cord in Freely Behaving MicePreprint
Ju, F., Jian, W., Han, Y., Huang, T., Jin, K., Liu, Z., Cai, S., Liu, N., Wang, L., & Wei, P. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.09.475306 · Cited by 9
Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice
Aubert, N., Purcarea, M., Novarino, J., Schopp, J., Audibert, A., Li, W., Fornier, M., Cagnet, L., Naturel, M., Casrouge, A., et al. (2024) · eLife · doi:10.7554/elife.91359 · Cited by 8
Self-citation
Z-Guggulsterone Relieves Neuropathic Pain by Inhibiting the Expression of Astrocytes and Proinflammatory Cytokines in the Spinal Dorsal Horn
Dang, S.-J., Wei, W., Li, R.-L., Song, C.-X., & Xu, J. (2022) · Journal of Pain Research · doi:10.2147/jpr.s360126 · Cited by 8
What Is the Role of Dorsal Horn Astrocytes in Chronic Pain and Itch?
Benarroch, E. E. (2022) · Neurology · doi:10.1212/wnl.0000000000201505 · Cited by 9
Targeting Peripheral μ-opioid Receptors or μ-opioid Receptor-Expressing Neurons Does not Prevent Morphine-induced Mechanical Allodynia and Anti-allodynic Tolerance
Du, F., Yin, G., Han, L., Liu, X., Dong, D., Duan, K., Huo, J., Sun, Y., & Cheng, L. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-022-01009-2 · Cited by 8
Suppression of neuropathic pain in the circadian clock–deficient Per2m/m mice involves up-regulation of endocannabinoid system
Yamakawa, W., Yasukochi, S., Tsurudome, Y., Kusunose, N., Yamaguchi, Y., Tsuruta, A., Matsunaga, N., Ushijima, K., Koyanagi, S., & Ohdo, S. (2023) · PNAS Nexus · doi:10.1093/pnasnexus/pgad482 · Cited by 8
Sensory root demyelination: Transforming touch into pain
Ding, Y., & Qi, J. (2021) · Glia · doi:10.1002/glia.24097 · Cited by 7
Selective Involvement of a Subset of Spinal Dorsal Horn Neurons Operated by a Prodynorphin Promoter in Aβ Fiber-Mediated Neuropathic Allodynia-Like Behavioral Responses in Rats
Ishibashi, T., Yoshikawa, Y., Sueto, D., Tashima, R., Tozaki‐Saitoh, H., Koga, K., Yamaura, K., & Tsuda, M. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.911122 · Cited by 7
Synaptic Targets of Glycinergic Neurons in Laminae I–III of the Spinal Dorsal Horn
Miranda, C. O., Hegedűs, K., Kis, G. N., & Antal, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24086943 · Cited by 8
Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses
Lezgiyeva, K., Liu, J., Nguyen, K., DeLisle, M. M., Ko, F. C., Fullam, S., Obeidat, A. M., Turecek, J., Alkislar, I., Lehnert, B. P., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.06.014 · Cited by 7
Hypothalamic A11 Nuclei Regulate the Circadian Rhythm of Spinal Mechanonociception through Dopamine Receptors and Clock Gene Expression
Piña-Leyva, C., Lara-Lozano, M., Rodríguez-Sánchez, M., Vidal‐Cantú, G. C., Zavalza, E. B., Jiménez‐Estrada, I., Delgado‐Lezama, R., Rodríguez‐Sosa, L., Granados‐Soto, V., González-Barrios, J. A., et al. (2022) · Life · doi:10.3390/life12091411 · Cited by 8
lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway
Gan, Y., Long, J., Zeng, Y., Zhang, Y., & Tao, Y. (2022) · Mediators of Inflammation · doi:10.1155/2022/9923204 · Cited by 7
Spinal glycinergic currents are reduced in a rat model of neuropathic pain following partial nerve ligation but not chronic constriction injury
Natale, C. A., Christie, M. J., & Aubrey, K. R. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00451.2022 · Cited by 7
Mechanisms for dysregulation of excitatory-inhibitory balance underlying allodynia in dorsal horn neural subcircuits
Ginsberg, A. G., Lempka, S. F., Duan, B., Booth, V., & Crodelle, J. A. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012234 · Cited by 6
The Circadian Clock Component REV-ERB Is an Analgesic Target for Cancer-Induced Tactile Pain Hypersensitivity
Yasukochi, S., Yamakawa, W., Taniguchi, M., Itoyama, S., Tsuruta, A., Kusunose, N., Yamauchi, T., Nakamura, R., Matsunaga, N., Ohdo, S., et al. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1969-24.2025 · Cited by 6
The Kv4.3 channel on c-low threshold mechanoreceptors in DRG is a key mediator transforming tactile stimuli into nociceptive signals in chemotherapy-induced neuropathy
Zhang, J., Wang, X., Liu, X., Li, J., Qiao, K., Sun, J., Zuo, J., Zhao, W., He, T., Li, X., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.12.005 · Cited by 6
Pre-Synaptic GABAA in NaV1.8+ Primary Afferents Is Required for the Development of Punctate but Not Dynamic Mechanical Allodynia following CFA Inflammation
Liu, S., Bonalume, V., Gao, Q., Chen, J. T.-C., Rohr, K., Hu, J., & Carr, R. W. (2022) · Cells · doi:10.3390/cells11152390 · Cited by 6
Frequency-Dependent Neural Modulation of Dorsal Horn Neurons by Kilohertz Spinal Cord Stimulation in Rats
Wang, D., Lee, K. Y., KAGAN, Z. B., Bradley, K., & Lee, D. (2024) · Biomedicines · doi:10.3390/biomedicines12061346 · Cited by 6
Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain
Lister, K. C., Wong, C., Uttam, S., Parisien, M., Stecum, P., Brown, N., Cai, W., Ho-Tieng, D., Hooshmandi, M., Gu, N., et al. (2026) · eLife · doi:10.7554/elife.100451.3 · Cited by 6
Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain
Wong, C., Rodriguez-Hernandez, L. D., Lister, K. C., Gu, N., Cai, W., Hooshmandi, M., Fan, J., Brown, N., Nguyen, V., Ribeiro‐da‐Silva, A., et al. (2024) · Brain · doi:10.1093/brain/awae275 · Cited by 6
Protein phosphatase 2Cm-regulated branched-chain amino acid catabolic defect in dorsal root ganglion neurons drives pain sensitization
Lian, N., Li, F., Zhou, C., Yin, Y., Kang, Y., Luo, K., Lui, S., Li, T., & Lu, P. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01856-2 · Cited by 6
Persistent, neuropathic-like trigeminal pain after dental implant loading
Ndiaw, A., Braud, A., & Boucher, Y. (2022) · Journal of Clinical and Experimental Dentistry · doi:10.4317/jced.59248 · Cited by 6
Spinal cord microglia drive sex differences in ethanol-mediated PGE2-induced allodynia
Alexander, S. N., Reed, O. A., & Burton, M. D. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.08.026 · Cited by 6
Microglial Depletion does not Affect the Laterality of Mechanical Allodynia in Mice
Ma, Q., Su, D., Huo, J., Yin, G., Dong, D., Duan, K., Hong, C., Xu, H., Ma, J., Liu, D., et al. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-022-01017-2 · Cited by 5
Distinct expression profile reveals glia involvement in the trigeminal system attributing to post-traumatic headache
Nagarajan, G., & Zhang, Y. (2024) · The Journal of Headache and Pain · doi:10.1186/s10194-024-01897-x · Cited by 5
From nociception in aneural animals to human suffering: toward a comparative biology of pain
Walters, E. T. (2025) · Journal of Experimental Biology · doi:10.1242/jeb.251210 · Cited by 8
ACVR1 drives neuropathic pain by regulating NLRP3-Induced neuronal pyroptosis through the p38 and Smad1/5/8 pathways
Zhang, X., Miao, Y., Li, Z., Xu, H., & Niu, Z. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110469 · Cited by 5
Neurobiological mechanisms of central sensitisation underlying chronic pain states
Poisbeau, P., & Salvat, É. (2025) · BJA Education · doi:10.1016/j.bjae.2025.06.005 · Cited by 4
Astrocytic Kir4.1 ion channel deficit drives persistent inflammatory facial pain in males
Mountadem, S., Hérault, K., Peirs, C., Borges, G. D. S., Voisin, D. L., Antri, M., & Dallel, R. (2025) · Brain · doi:10.1093/brain/awaf122 · Cited by 5
Self-citation
High frequency alternating current neurostimulation decreases nocifensive behavior in a disc herniation model of lumbar radiculopathy
Dewberry, L. S., Porche, K. M., Koenig, T., Allen, K. D., & Otto, K. J. (2023) · Bioelectronic Medicine · doi:10.1186/s42234-023-00119-0 · Cited by 6
An improved conflict avoidance assay reveals modality-specific differences in pain hypersensitivity across sexes
Ferland, S., Wang, F., Koninck, Y. D., & Ferrini, F. (2024) · Pain · doi:10.1097/j.pain.0000000000003132 · Cited by 5
A novel Nav1.8-FLPo driver mouse for intersectional genetics to uncover the functional significance of primary sensory neuron diversity
Malapert, P., Robert, G., Brunet, E., Chemin, J., Bourinet, E., & Moqrich, A. (2024) · iScience · doi:10.1016/j.isci.2024.109396 · Cited by 4
Sensory Symphonies: How Excitatory Spinal Cord Modules Orchestrate Behavior
Gradwell, M. A., & Abraira, V. E. (2021) · Neuron · doi:10.1016/j.neuron.2020.12.012 · Cited by 4
Distribution of Calretinin-Immunopositive Neurons in the Cat Lumbar Spinal Cord
Veshchitskii, A. A., Евгеньевич, М. П., & Merkulyeva, N. S. (2021) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093021040074 · Cited by 4
Effects of Corticosterone on the Excitability of Glutamatergic and GABAergic Neurons of the Adolescent Mouse Superficial Dorsal Horn
Harbour, K., Cappel, Z., & Baccei, M. L. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.07.009 · Cited by 5
Combining Machine Learning and Multiplexed, In Situ Profiling to Engineer Cell Type and Behavioral SpecificityPreprint
Leone, M. J., van de Weerd, R., Brown, A. R., Noh, M., Phan, B. N., Wang, A. Z., Corrigan, K. A., Yeramosu, D., Sestili, H. H., Arokiaraj, C. M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.20.660790 · Cited by 4
Self-citation
Neuropathic Pain-Like Responses in a Chronic CNS Injury Model Are Mediated by Corticospinal-Targeted Spinal Interneurons
Guan, X., Zhu, Y., Zhong, J., & Hollis, E. R., II (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1264-24.2025 · Cited by 3
Influence of Early-Life Stress on the Excitability of Dynorphin Neurons in the Adult Mouse Dorsal Horn
Harbour, K., & Baccei, M. L. (2024) · Journal of Pain · doi:10.1016/j.jpain.2024.104609 · Cited by 3

Authors: Peirs, C., Williams, S.-P. G., Zhao, X., Arokiaraj, C. M., Ferreira, D. W., Noh, M.-C., Smith, K. M., Halder, P., Corrigan, K. A., Gedeon, J. Y., Lee, S. J., Gatto, G., Chi, D., Ross, S. E., Goulding, M., & Seal, R. P.
Affiliations: University of Pittsburgh (US)
Salk Institute for Biological Studies (US)
Corresponding author: Seal, Rebecca P.
ORCID: Peirs, Cedric
Williams, Sean-Paul G.
Zhao, Xinyi
Arokiaraj, Cynthia M.
Ferreira, David W.
Noh, Myung-chul
Smith, Kelly M.
Halder, Priyabrata
Gedeon, Jeremy Y.
Gatto, Graziana
Ross, Sarah E.
Goulding, Martyn
Seal, Rebecca P.
Venue: Neuron
Publisher: Elsevier BV
Published: 2021-01
Volume: 109
Issue: 1
Pages: 73-90.e7
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2020.10.027
PMC: PMC7806207
OpenAlex: W3100514562
Cited by: 190
References: 64
Citations by year: 2026: 26 · 2025: 26 · 2024: 42 · 2023: 35 · 2022: 38 · 2021: 21
FWCI: 14.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 370 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: mechanical allodynia, dorsal horn, central sensitization, VGLUT3, injury etiology, nociception
MeSH terms: Animals, Female, Hyperalgesia, Male, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Pain Measurement, Spinal Cord Injuries, Amino Acid Transport Systems, Acidic, Mice, Spinal Cord Dorsal Horn

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mechanical Allodynia Circuitry in the Dorsal Horn Is Defined by the Nature of the Injury

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks