Cited by 154Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationIon Channels and Receptors

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The cellular and molecular basis of somatosensory neuron development

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Meltzer, Shan, Santiago, Celine, Sharma, Nikhil, Ginty, David D.·2021·Neuron

DOI 10.1016/j.neuron.2021.09.004PMC PMC8639614

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Abstract

Primary somatosensory neurons convey salient information about our external environment and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of innocuous and noxious stimuli. Pseudo-unipolar in shape, and among the largest (longest) cells of most mammals, dorsal root ganglia (DRG) somatosensory neurons have peripheral axons that extend into skin, muscle, viscera, or bone and central axons that innervate the spinal cord and brainstem, where they synaptically engage the central somatosensory circuitry. Here, we review the diversity of mammalian DRG neuron subtypes and the intrinsic and extrinsic mechanisms that control their development. We describe classical and contemporary advances that frame our understanding of DRG neurogenesis, transcriptional specification of DRG neurons, and the establishment of morphological, physiological, and synaptic diversification across somatosensory neuron subtypes.

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Authors: Meltzer, S., Santiago, C., Sharma, N., & Ginty, D. D.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Ginty, David D.
ORCID: Meltzer, Shan
Santiago, Celine
Sharma, Nikhil
Ginty, David D.
Venue: Neuron
Publisher: Elsevier BV
Published: 2021-12
Volume: 109
Issue: 23
Pages: 3736-3757
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2021.09.004
PMC: PMC8639614
OpenAlex: W3202416243
Cited by: 149
References: 199
Citations by year: 2026: 38 · 2025: 33 · 2024: 39 · 2023: 23 · 2022: 15 · 2021: 1
FWCI: 3.12
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
Israel National Road Safety Authority (5F32NS106807-03)
National Institutes of Health (1R01 AT011447-01, R35 5R35NS097344-05)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: somatosensory neurons, dorsal root ganglia, neuronal development, peripheral nervous system development, nociception
MeSH terms: Animals, Axons, Ganglia, Spinal, Mammals, Neurons, Spinal Cord, Neurogenesis

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The cellular and molecular basis of somatosensory neuron development

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