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The cellular and molecular basis of somatosensory neuron development
Open accessAbstract
Primary somatosensory neurons convey salient information about our external environment and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of innocuous and noxious stimuli. Pseudo-unipolar in shape, and among the largest (longest) cells of most mammals, dorsal root ganglia (DRG) somatosensory neurons have peripheral axons that extend into skin, muscle, viscera, or bone and central axons that innervate the spinal cord and brainstem, where they synaptically engage the central somatosensory circuitry. Here, we review the diversity of mammalian DRG neuron subtypes and the intrinsic and extrinsic mechanisms that control their development. We describe classical and contemporary advances that frame our understanding of DRG neurogenesis, transcriptional specification of DRG neurons, and the establishment of morphological, physiological, and synaptic diversification across somatosensory neuron subtypes.
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“We have identified that sensory neurons in skin organoids form ganglia and fasciculated axons mimicking the architecture of a dorsal root or trigeminal ganglion/nerve in the body”
From Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells (2022) · cites this paper as [44]
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Metadata
- Authors
- Meltzer, S., Santiago, C., Sharma, N., & Ginty, D. D.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Ginty, David D.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 109
- Issue
- 23
- Pages
- 3736-3757
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC8639614
- OpenAlex
- W3202416243
- Cited by
- 149
- References
- 199
- Citations by year
- 2026: 38 · 2025: 33 · 2024: 39 · 2023: 23 · 2022: 15 · 2021: 1
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Israel National Road Safety Authority (5F32NS106807-03)
- National Institutes of Health (1R01 AT011447-01, R35 5R35NS097344-05)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- somatosensory neurons, dorsal root ganglia, neuronal development, peripheral nervous system development, nociception
- MeSH terms
- Animals, Axons, Ganglia, Spinal, Mammals, Neurons, Spinal Cord, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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