The DOI matches its Crossref record; 197 of the 199 references it cites were found in a registry or an index.
The cellular and molecular basis of somatosensory neuron development
Open accessAbstract
Primary somatosensory neurons convey salient information about our external environment and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of innocuous and noxious stimuli. Pseudo-unipolar in shape, and among the largest (longest) cells of most mammals, dorsal root ganglia (DRG) somatosensory neurons have peripheral axons that extend into skin, muscle, viscera, or bone and central axons that innervate the spinal cord and brainstem, where they synaptically engage the central somatosensory circuitry. Here, we review the diversity of mammalian DRG neuron subtypes and the intrinsic and extrinsic mechanisms that control their development. We describe classical and contemporary advances that frame our understanding of DRG neurogenesis, transcriptional specification of DRG neurons, and the establishment of morphological, physiological, and synaptic diversification across somatosensory neuron subtypes.
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“We have identified that sensory neurons in skin organoids form ganglia and fasciculated axons mimicking the architecture of a dorsal root or trigeminal ganglion/nerve in the body”
From Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells (2022) · cites this paper as [44]
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Self-citationTrophic factors and neuronal survival
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Human assembloid model of the ascending neural sensory pathway
Kim, J., Imaizumi, K., Jurjuţ, O. F., Kelley, K. W., Wang, D., Thete, M. V., Hudáčová, Z., Amin, N. D., Levy, R. J., Scherrer, G., et al. (2025) · Nature · doi:10.1038/s41586-025-08808-3 · Cited by 152
Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells
Lee, J., van der Valk, W. H., Serdy, S. A., Deakin, C., Kim, J., Le, A. P., & Koehler, K. R. (2022) · Nature Protocols · doi:10.1038/s41596-022-00681-y · Cited by 132
A functional subdivision within the somatosensory system and its implications for pain research
Ma, Q. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.015 · Cited by 112
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Representation and control of pain and itch by distinct prefrontal neural ensembles
Pan, Q., Guo, S.-S., Chen, M., Su, X., Gao, Z., Wang, Q., Xu, T., Liu, M., & Hu, J. (2023) · Neuron · doi:10.1016/j.neuron.2023.04.032 · Cited by 73
Metadata
- Authors
- Meltzer, S., Santiago, C., Sharma, N., & Ginty, D. D.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Ginty, David D.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 109
- Issue
- 23
- Pages
- 3736-3757
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC8639614
- OpenAlex
- W3202416243
- Cited by
- 149
- References
- 199
- Citations by year
- 2026: 38 · 2025: 33 · 2024: 39 · 2023: 23 · 2022: 15 · 2021: 1
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Israel National Road Safety Authority (5F32NS106807-03)
- National Institutes of Health (1R01 AT011447-01, R35 5R35NS097344-05)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- somatosensory neurons, dorsal root ganglia, neuronal development, peripheral nervous system development, nociception
- MeSH terms
- Animals, Axons, Ganglia, Spinal, Mammals, Neurons, Spinal Cord, Neurogenesis
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