Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis

The functional anatomy of basal ganglia disorders

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The effects of infusions of CART 55–102 into the basolateral amygdala on amphetamine-induced conditioned place preference in rats

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Glucocorticoid receptor but not mineralocorticoid receptor mediates the activation of ERK pathway and CREB during morphine withdrawal

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Involvement of dopaminergic receptors of the rat nucleus accumbens in decreasing the conditioned place preference induced by lateral hypothalamus stimulation

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Availability of N-Methyl-d-Aspartate Receptor Coagonists Affects Cocaine-Induced Conditioned Place Preference and Locomotor Sensitization: Implications for Comorbid Schizophrenia and Substance Abuse

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Dissociable role of tumor necrosis factor alpha gene deletion in methamphetamine self-administration and cue-induced relapsing behavior in mice

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Flavour exposures after conditioned aversion or preference trigger different brain processes in anaesthetised pigs

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Functional interaction between the orexin-1 and CB1 receptors within the nucleus accumbens in the conditioned place preference induced by the lateral hypothalamus stimulation

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The role of nucleus accumbens shell GABA receptors on ventral tegmental area intracranial self-stimulation and a potential role for the 5-HT 2C receptor

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Adolescent high-fructose corn syrup consumption leads to dysfunction in adult affective behaviors and mesolimbic proteins in male Sprague-Dawley rats

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Brain stimulation reward is affected by D2 dopamine receptor manipulations in the extended amygdala but not the nucleus accumbens

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Virus-Mediated shRNA Knockdown of Prodynorphin in the Rat Nucleus Accumbens Attenuates Depression-Like Behavior and Cocaine Locomotor Sensitization

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Nucleus accumbens responses differentiate execution and restraint in reward-directed behavior

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c-Fos activity in the insular cortex, nucleus accumbens and basolateral amygdala following the intraperitoneal injection of saccharin and lithium chloride

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Neurochemical insights into the radiation protection of astronauts: Distinction between low- and moderate-LET radiation components

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Arachidonoyl serotonin (AA-5-HT) modulates general fear-like behavior and inhibits mesolimbic dopamine release

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Reduction of DNMT3a and RORA in the nucleus accumbens plays a causal role in post-traumatic stress disorder-like behavior: reversal by combinatorial epigenetic therapy

Warhaftig, G., Zifman, N., Sokolik, C. M., Massart, R., Gabay, O., Sapozhnikov, D. M., Vaisheva, F., Lichtenstein, Y., Confortti, N., Ahdoot, H. L., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01178-y · Cited by 16

A Nucleus Accumbens Tac1 Neural Circuit Regulates Avoidance Responses to Aversive Stimuli

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Synaptic and cellular endocannabinoid signaling mechanisms regulate stress-induced plasticity of nucleus accumbens somatostatin neurons

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Galanin‐induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2

Einstein, E. B., Asaka, Y., Yeckel, M. F., Higley, M. J., & Picciotto, M. R. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12151 · Cited by 15

Effect of co-injection of arachydonilcyclopropylamide and ethanol on conditioned place preference in rats

Rezayof, A., Ghandipour, M., & Nazari-Serenjeh, F. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.08.009 · Cited by 15

Methylenedioxypyrovalerone (MDPV) impairs working memory and alters patterns of dopamine signaling in mesocorticolimbic substrates

Bernstein, D. L., Nayak, S. U., Oliver, C. F., Rawls, S. M., & Rom, S. (2019) · Neuroscience Research · doi:10.1016/j.neures.2019.07.003 · Cited by 15

Brain expression of pCREB in rats exposed to consummatory successive negative contrast

Glueck, A. C., Dennis, T. S., Perrotti, L. I., Torres, C., & Papini, M. R. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.12.036 · Cited by 15

Cortico-Striatal Control over Adaptive Goal-Directed Responding Elicited by Cues Signaling Sucrose Reward or Punishment

Hamel, L., Cavdaroglu, B., Yeates, D., Nguyen, D., Riaz, S., Patterson, D., Khan, N., Kirolos, N., Roper, K., Ha, Q. A., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.2175-21.2022 · Cited by 16

Adolescent binge-like alcohol exposure dysregulates NPY and CGRP in rats: Behavioural and immunochemical evidence

Brancato, A., Castelli, V., Cannizzaro, C., & Tringali, G. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110699 · Cited by 14

Neuropeptide Y and representation of salience in human nucleus accumbens

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Evolution of brain-wide activity in the awake behaving mouse after acute fear by longitudinal manganese-enhanced MRI

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CB1 receptor activation in the nucleus accumbens core impairs contextual fear learning

Pedroza-Llinás, R., Méndez‐Díaz, M., Ruiz‐Contreras, A. E., & Prospero-Garcia, O. E. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.09.032 · Cited by 14

Cannabinoid receptors in the basolateral amygdala are involved in the potentiation of morphine rewarding properties in the acquisition, but not expression of conditioned place preference in rats

Haghparast, A., Shamsizadeh, A., Samandari, R., Omranifard, A., Vaziri, A., & Razavi, Y. (2014) · Brain Research · doi:10.1016/j.brainres.2014.04.003 · Cited by 14

Adolescent Emotional Maturation through Divergent Models of Brain Organization

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MHC class I in dopaminergic neurons suppresses relapse to reward seeking

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Glutamate Afferents From the Medial Prefrontal Cortex Mediate Nucleus Accumbens Activation by Female Sexual Behavior

Moore, K. M., Oelberg, W. L., Glass, M. R., Johnson, M. D., Been, L. E., & Meisel, R. L. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00227 · Cited by 13

Anti-obesity weight loss medications: Short-term and long-term use

Jeong, D., & Priefer, R. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120825 · Cited by 16

Brain structure alterations associated with weight changes in young females with anorexia nervosa: a case series

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Direct intra-accumbal infusion of a beta-adrenergic receptor antagonist abolishes WIN 55,212-2-induced aversion

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Amphetamine reward in food restricted mice lacking the melanin-concentrating hormone receptor-1

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Activation of nucleus accumbens NMDA receptors differentially affects appetitive or aversive taste learning and memory

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The presence of a social stimulus reduces cocaine-seeking in a place preference conditioning paradigm

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Target identification and validation in brain reward dysfunction

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The endocannabinoid arachidonylethanolamide attenuates aspects of lipopolysaccharide-induced changes in energy intake, energy expenditure and hypothalamic Fos expression

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Programming social behavior by the maternal fragile X protein

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Open field behavior and intra-nucleus accumbens dopamine release in vivo in virgin and lactating rats.

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Neurophysiological mechanisms underlying the differential effect of reward prospect on response selection and inhibition

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Effects of the neuroactive steroid allopregnanolone on intracranial self-stimulation in C57BL/6J Mice

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Behavioral Sensitization to Addictive Drugs: Clinical Relevance and Methodological Aspects

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Functional Connectivity of Nucleus Accumbens Is Associated with Lifelong Premature Ejaculation in Male Adults

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Reward magnitude tracking by neural populations in ventral striatum

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Comparative Transcriptional Analyses in the Nucleus Accumbens Identifies RGS2 as a Key Mediator of Depression-Related Behavior

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Effects of 3-methylmethcathinone on conditioned place preference and anxiety-like behavior: Comparison with methamphetamine

Chen, Y., Zhang, L., Ding, Z., Wu, X., Wang, G., & Shi, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.975820 · Cited by 11

Tracking Down the Molecular Substrates of Stress: New Roles for p38α MAPK and Kappa-Opioid Receptors

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Stathmin reduction and cytoskeleton rearrangement in rat nucleus accumbens in response to clozapine and risperidone treatment – Comparative proteomic study

Kędracka–Krok, S., Świderska, B., Jankowska, U., Skupień-Rabian, B., Solich, J., & Dziedzicka‐Wasylewska, M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.028 · Cited by 10

Structural imaging for addiction medicine

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Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking

Song, R. S., Tolentino, R. E., Sobie, E. A., & Neves, S. R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.749747 · Cited by 12

Effects of lithium and aripiprazole on brain stimulation reward and neuroplasticity markers in the limbic forebrain

Mavrikaki, M., Schintu, N., Kastellakis, A., Nomikos, G. G., Svenningsson, P., & Panagis, G. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.10.014 · Cited by 13

Protection Genes in Nucleus Accumbens Shell Affect Vulnerability to Nicotine Self-Administration across Isogenic Strains of Adolescent Rat

Chen, H., Luo, R., Gong, S., Matta, S. G., & Sharp, B. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086214 · Cited by 11

DeltaFosB is increased in the nucleus accumbens by amphetamine but not social housing or isolation in the prairie vole

Hostetler, C. M., & Bales, K. L. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.019 · Cited by 11

Anatomical analyses of collateral prefrontal cortex projections to the basolateral amygdala and the nucleus accumbens core in rats

Shih, C.-W., & Chang, C. (2023) · Brain Structure and Function · doi:10.1007/s00429-023-02722-y · Cited by 10

Wfs1-deficient mice display altered function of serotonergic system and increased behavioral response to antidepressants

Visnapuu, T., Raud, S., Loomets, M., Reimets, R., Sütt, S., Luuk, H., Plaas, M., Kõks, S., Volke, V., O’Leary, A., et al. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00132 · Cited by 10

Cannabinoids reward sensitivity in a neurodevelopmental animal model of schizophrenia: A brain stimulation reward study

Gallo, A., Bouchard, C., Fortier, E., Ducrot, C., & Rompré, P.-P. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.07.003 · Cited by 10

Effects of Injection of Gamma-Aminobutyric Acid Agonists into the Nucleus Accumbens on Naloxone-Induced Morphine Withdrawal

Topkara, B., Yananlı, H. R., Sakallı, E., & Demirkapu, M. J. (2017) · Pharmacology · doi:10.1159/000477548 · Cited by 10

Chronic light deprivation inhibits appetitive associative learning induced by ethanol and its respective c-Fos and pCREB expression

Varela, P., Escosteguy-Neto, J. C., Coelho, C. T., Mello, L. E., da Silveira, D. X., & Santos-Junior, J. G. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000480 · Cited by 10

Reward and aversion systems of the brain as a functional unit. Basic mechanisms and functions

Michel, A., Estañol, B., Senties, H., Chiquete, E., Delgado‐García, G. R., & Castillo, G. (2015) · Salud Mental · doi:10.17711/sm.0185-3325.2015.041 · Cited by 12

The pleasurable urge to move to music is unchanged in people with musical anhedonia

Romkey, I. D., Matthews, T. E., Foster, N. E. V., Bella, S. D., & Penhune, V. B. (2025) · PLoS ONE · doi:10.1371/journal.pone.0312030 · Cited by 12

Effects of muscimol in the nucleus accumbens shell on salt appetite and sucrose intake: A microstructural study with a comment on the sensitization of salt intake.

Wirtshafter, D., Covelo, I. R., Salija, I., & Stratford, T. R. (2012) · Behavioral Neuroscience · doi:10.1037/a0029641 · Cited by 9

The role of nucleus accumbens CREB attenuation in rescuing low voluntary running behavior in female rats

Grigsby, K. B., Childs, T. E., & Booth, F. W. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24698 · Cited by 9

Critical appraisal and systematic review of genes linked with cocaine addiction, depression and anxiety

Kaushik, S., Ahmad, F., Choudhary, S., Mathkor, D. M., Mishra, B. N., Singh, V., & Haque, S. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105270 · Cited by 9

Impaired memory and reduced sensitivity to the circadian period lengthening effects of methamphetamine in mice selected for high methamphetamine consumption

Olsen, R. H. J., Allen, C. N., Derkach, V. A., Phillips, T. J., Belknap, J. K., & Raber, J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.015 · Cited by 10

Differential effects of glutamate N-methyl-d-aspartate receptor antagonists on risky choice as assessed in the risky decision task

Yates, J. R., Horchar, M. J., Ellis, A. L., Kappesser, J. L., Mbambu, P., Sutphin, T. G., Dehner, D. S., Igwe, H. O., & Wright, M. R. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05664-z · Cited by 9

Behavioral and Neurochemical Characteristics of Two Months Old WAG/Rij Rats with Genetic Absence Epilepsy

Fedosova, E. A., Sarkisova, K. Y., Кудрин, В. С., Наркевич, В. Б., & Bazyan, A. S. (2015) · Clinical and experimental neurology · doi:10.12691/ijcen-3-2-2 · Cited by 9

Neurotensin: revealing a novel neuromodulator circuit in the nucleus accumbens–parabrachial nucleus projection of the domestic chick

Bálint, E., Balázsa, T., Zachár, G., Mezey, S. E., & Csillag, A. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0928-0 · Cited by 9

Neurochemical substrates of the rewarding effects of MDMA

Roger-Sánchez, C., García-Pardo, M. P., Rodríguez‐Arias, M., Miñarro, J., & Aguilar, M. A. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000210 · Cited by 9

Frontal EEG response to alcohol craving elicited by individually tailored video cues

Kim, J., Nam, S., Kim, D. H., Lee, S., Jung, H. W., Kim, C., Chang, J. G., & Roh, D. D. (2023) · Alcohol · doi:10.1016/j.alcohol.2023.05.005 · Cited by 8

Viscerosensory signalling to the nucleus accumbens via the solitary tract nucleus

McDougall, S. J., Ong, Z. Y., Heller, R., Horton, A., Thek, K. K., Choi, E. A., McNally, G. P., & Lawrence, A. J. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16180 · Cited by 7

Compensación química y adicción a opioides: evidencia, valoración de riesgo y manejo en pacientes con cuidados paliativos

Valle, M., Zertuche-Maldonado, T., & Bruera, E. D. (2018) · Medicina Paliativa · doi:10.1016/j.medipa.2016.12.002 · Cited by 8

A neuroimaging marker for predicting longitudinal changes in pain intensity of subacute back pain based on large-scale brain network interactions

Park, B., Lee, J., Kim, H. J., Woo, C., & Park, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-74217-3 · Cited by 9

Enjoyment of watching pimple popping videos: An fMRI investigation

Wabnegger, A., Höfler, C., Zussner, T., Freudenthaler, H. H., & Schienle, A. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113129 · Cited by 8

Neural Representation of Costs and Rewards in Decision Making

Chen, Y. (2021) · Brain Sciences · doi:10.3390/brainsci11081096 · Cited by 9

Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell

Johnson, C. S., Chapp, A. D., Lind, E. B., Thomas, M. J., & Mermelstein, P. G. (2023) · Biology of Sex Differences · doi:10.1186/s13293-023-00570-3 · Cited by 10

A method for conducting functional MRI studies in alert nonhuman primates: Initial results with opioid agonists in male cynomolgus monkeys.

Kaufman, M. J., Janes, A. C., Frederick, B. B., Brimson-Théberge, M., Tong, Y., McWilliams, S. B., Bear, A., Gillis, T. E., Schrode, K. M., Renshaw, P. F., et al. (2013) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0033062 · Cited by 8

Exploring aversion in an animal model of pre-motor stage Parkinson's disease

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Mu opioid receptor signaling in the nucleus accumbens shell increases responsiveness of satiety‐modulated lateral hypothalamus neurons

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