Cited by 561Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.

Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis

Open access

Carlezon, William A., Thomas, Mark J.·2009·Neuropharmacology

DOI 10.1016/j.neuropharm.2008.06.075PMC PMC2635333

Open this paper in CoChat — free account

Abstract

The nucleus accumbens (NAc) is a critical element of the mesocorticolimbic system, a brain circuit implicated in reward and motivation. This basal forebrain structure receives dopamine (DA) input from the ventral tegmental area (VTA) and glutamate (GLU) input from regions including the prefrontal cortex (PFC), amygdala (AMG), and hippocampus (HIP). As such, it integrates inputs from limbic and cortical regions, linking motivation with action. The NAc has a well-established role in mediating the rewarding effects of drugs of abuse and natural rewards such as food and sexual behavior. However, accumulating pharmacological, molecular, and electrophysiological evidence has raised the possibility that it also plays an important (and sometimes underappreciated) role in mediating aversive states. Here we review evidence that rewarding and aversive states are encoded in the activity of NAc medium spiny GABAergic neurons, which account for the vast majority of the neurons in this region. While admittedly simple, this working hypothesis is testable using combinations of available and emerging technologies, including electrophysiology, genetic engineering, and functional brain imaging. A deeper understanding of the basic neurobiology of mood states will facilitate the development of well-tolerated medications that treat and prevent addiction and other conditions (e.g., mood disorders) associated with dysregulation of brain motivation systems.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuropharm.2008.06.075

Cites

134 of 134 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The functional anatomy of basal ganglia disorders
Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967
A psychomotor stimulant theory of addiction.
Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
The mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059
Self-citation
Brain Dopamine and Reward
Wise, R. A., & Rompre, P.-P. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.001203 · Cited by 1,968
Opioids excite dopamine neurons by hyperpolarization of local interneurons
Johnson, S., & North, R. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00483.1992 · Cited by 1,637
Ca2 + Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition
Hollmann, M., Hartley, M., & Heinemann, S. F. (1991) · Science · doi:10.1126/science.1709304 · Cited by 1,450
The many faces of CREB
Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,382
Self-citation
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons
Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.008 · Cited by 1,203
Dopamine in drug abuse and addiction: results from imaging studies and treatment implications
Volkow, N. D., Fowler, J. S., Wang, G.-J., & Swanson, J. M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001507 · Cited by 1,101
Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
Grace, A. A., Floresco, S. B., Goto, Y., & Lodge, D. J. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.003 · Cited by 1,034
Neuroleptics and operant behavior: The anhedonia hypothesis
Wise, R. A. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00010372 · Cited by 1,028
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
Spanagel, R., Herz, A., & Shippenberg, T. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.6.2046 · Cited by 1,005
Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning
Kelley, A. E. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.015 · Cited by 942
Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
Nicola, S. M., Surmeier, D. J., & Malenka, R. C. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.185 · Cited by 931
Psychotomimesis Mediated by κ Opiate Receptors
Pfeiffer, A., Brantl, V., Herz, A., & Emrich, H. M. (1986) · Science · doi:10.1126/science.3016896 · Cited by 857
Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine
Aghajanian, G. K. (1978) · Nature · doi:10.1038/276186a0 · Cited by 800
Addictive Drugs and Brain Stimulation Reward
Wise, R. A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001535 · Cited by 792
Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey
Kessler, R. C., Zhao, S., Blazer, D. G., & Swartz, M. (1997) · Journal of Affective Disorders · doi:10.1016/s0165-0327(97)00056-6 · Cited by 790
Regulation of cocaine reward by CREB
Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767
Self-citation
Synaptic interactions among excitatory afferents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input
O’Donnell, P., & Grace, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03622.1995 · Cited by 760
Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens
Roberts, D. C. S., Koob, G. F., Klonoff, P., & Fibiger, H. C. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90166-5 · Cited by 730
Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
Kelz, M. B., Chen, J., Carlezon, W. A., Whisler, K., Gilden, L., Beckmann, A. M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D. W., et al. (1999) · Nature · doi:10.1038/45790 · Cited by 641
Self-citation
Dopamine in Drug Abuse and Addiction: Results of Imaging Studies and Treatment Implications
Volkow, N. D., Fowler, J. S., Wang, G.-J., Swanson, J. M., & Telang, F. (2007) · Archives of Neurology · doi:10.1001/archneur.64.11.1575 · Cited by 605
Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.
Bals-Kubik, R., Ableitner, A., Herz, A., & Shippenberg, T. S. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10296-6 · Cited by 525
Limbic and Motor Circuitry Underlying Footshock-Induced Reinstatement of Cocaine-Seeking Behavior
McFarland, K., Davidge, S. B., Lapish, C. C., & Kalivas, P. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4177-03.2004 · Cited by 524
Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens
Pliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., & Carlezon, W. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07397.2001 · Cited by 509
Self-citation
Intracranial self-administration of morphine into the ventral tegmental area in rats
Bozarth, M. A., & Wise, R. A. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90148-x · Cited by 507
Cortical Dopaminergic Involvement in Cocaine Reinforcement
Goeders, N. E., & Smith, J. E. (1983) · Science · doi:10.1126/science.6879176 · Cited by 493
Single-Channel Properties of Recombinant AMPA Receptors Depend on RNA Editing, Splice Variation, and Subunit Composition
Swanson, G. T., Kamboj, S. K., & Cull-Candy, S. G. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00058.1997 · Cited by 489
Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats
Mague, S. D., Pliakas, A. M., Todtenkopf, M. S., Tomasiewicz, H. C., Zhang, Y., Stevens, W. C., Jones, R. M., Portoghese, P. S., & Carlezon, W. A. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.046433 · Cited by 485
Self-citation
Nucleus Accumbens Neurons Are Innately Tuned for Rewarding and Aversive Taste Stimuli, Encode Their Predictors, and Are Linked to Motor Output
Roitman, M. F., Wheeler, R. A., & Carelli, R. M. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.055 · Cited by 453
Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum
Smith, K. S., & Berridge, K. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4205-06.2007 · Cited by 450
Cocaine Experience Controls Bidirectional Synaptic Plasticity in the Nucleus Accumbens
Kourrich, S., Rothwell, P. E., Klug, J. R., & Thomas, M. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1859-07.2007 · Cited by 444
Self-citation
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors
Maldonado, R. J., Saiardi, A., Valverde, O., Samad, T. A., Roques, B. P., & Borrelli, E. (1997) · Nature · doi:10.1038/41567 · Cited by 436
FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains
Lobo, M. K., Karsten, S. L., Gray, M., Geschwind, D. H., & Yang, X. W. (2006) · Nature Neuroscience · doi:10.1038/nn1654 · Cited by 411
Depressive-Like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats
Carlezon, W. A., Béguin, C., DiNieri, J. A., Baumann, M. H., Richards, M. R., Todtenkopf, M. S., Rothman, R. B., Ma, Z., Lee, D. Y.-W., & Cohen, B. M. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.092304 · Cited by 390
Self-citation
Functional–anatomical implications of the nucleus accumbens core and shell subterritories
ZAHM, D. S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09264.x · Cited by 384
Limbic Activation to Cigarette Smoking Cues Independent of Nicotine Withdrawal: A Perfusion fMRI Study
Franklin, T. R., wang, Z., Wang, J., Sciortino, N., Harper, D., Li, Y., Ehrman, R., Kampman, K. M., O’Brien, C. P., Detre, J. A., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301371 · Cited by 368
Self-injection of amphetamine directly into the brain
Hoebel, B. G., Monaco, A. P., Hernandez, L., Aulisi, E. F., Stanley, B. G., & Lenard, L. (1983) · Psychopharmacology · doi:10.1007/bf00429012 · Cited by 367
CREB modulates excitability of nucleus accumbens neurons
Dong, Y., Green, T. A., Saal, D. B., Marie, H., Neve, R. L., Nestler, E. J., & Malenka, R. C. (2006) · Nature Neuroscience · doi:10.1038/nn1661 · Cited by 356
Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex
Carlezon, & Wise, R. A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-09-03112.1996 · Cited by 327
Regulation of Phosphorylation of the GluR1 AMPA Receptor in the Neostriatum by Dopamine and PsychostimulantsIn Vivo
Snyder, G. L., Allen, P. B., Fienberg, A. A., Valle, C. G., Huganir, R. L., Nairn, A. C., & Greengard, P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04480.2000 · Cited by 318
Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal
Stinus, L., Le Moal, M., & Koob, G. F. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90106-e · Cited by 317
Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect
Newton, S. S., Thome, J., Wallace, T. L., Shirayama, Y., Schlesinger, L., Sakai, N., Chen, J., Neve, R., Nestler, E. J., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10883.2002 · Cited by 313
Evidence That Separate Neural Circuits in the Nucleus Accumbens Encode Cocaine Versus “Natural” (Water and Food) Reward
Carelli, R. M., Ijames, S. G., & Crumling, A. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04255.2000 · Cited by 310
Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse?
Carlezon, W. A., & Nestler, E. J. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02289-0 · Cited by 281
Self-citation
Sensitization to Morphine Induced by Viral-Mediated Gene Transfer
Carlezon, W. A., Boundy, V. A., Haile, C. N., Lane, S. B., Kalb, R. G., Neve, R. L., & Nestler, E. J. (1997) · Science · doi:10.1126/science.277.5327.812 · Cited by 279
Self-citation
Rethinking Substance Abuse: What the Science Shows, and What We Should Do About It
Woolf‐King, S. E., & Maisto, S. A. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.02022_1.x · Cited by 273
Effects of κ-opioid receptor ligands on intracranial self-stimulation in rats
Todtenkopf, M. S., Marcus, J. F., Portoghese, P. S., & Carlezon, W. A. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1680-y · Cited by 273
Self-citation
Role of Dopamine D1and D2Receptors in the Nucleus Accumbens in Mediating Reward
Ikemoto, S., Glazier, B. S., Murphy, J. M., & McBride, W. J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08580.1997 · Cited by 265
Reinforcing effects of morphine in the nucleus accumbens
OLDS, M. E. (1982) · Brain Research · doi:10.1016/0006-8993(82)90454-1 · Cited by 258
Dopamine D 1 Activation Potentiates Striatal NMDA Receptors by Tyrosine Phosphorylation-Dependent Subunit Trafficking
Hallett, P. J., Spoelgen, R., Hyman, B. T., Standaert, D. G., & Dunah, A. W. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0792-06.2006 · Cited by 244
Ventral pallidum firing codes hedonic reward: when a bad taste turns good
Tindell, A. J., Smith, K. S., Peciña, S., Berridge, K. C., & Aldridge, J. W. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00576.2006 · Cited by 241
The Ventral Tegmental Area Is Required for the Behavioral and Nucleus Accumbens Neuronal Firing Responses to Incentive Cues
Yun, I. A., Wakabayashi, K. T., Fields, H. L., & Nicola, S. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5282-03.2004 · Cited by 238
Repeated Cocaine Alters Glutamate Receptor Subunit Levels in the Nucleus Accumbens and Ventral Tegmental Area of Rats that Develop Behavioral Sensitization
Churchill, L., Swanson, C. J., Urbina, M., & Kalivas, P. W. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722397.x · Cited by 237
Morphine-dopamine interaction: Ventral tegmental morphine increases nucleus accumbens dopamine release
Leone, P., Pocock, D., & Wise, R. A. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90210-s · Cited by 226
Encoding of Palatability and Appetitive Behaviors by Distinct Neuronal Populations in the Nucleus Accumbens
Taha, S. A., & Fields, H. L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3975-04.2005 · Cited by 217
The Synaptic Framework for Chemical Signaling in Nucleus Accumbens
Meredith, G. E. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09266.x · Cited by 215
Involvement of D2 dopamine receptors in the nucleus accumbens in the opiate withdrawal syndrome
Harris, G. C., & Aston‐Jones, G. (1994) · Nature · doi:10.1038/371155a0 · Cited by 214
Whole-Cell Plasticity in Cocaine Withdrawal: Reduced Sodium Currents in Nucleus Accumbens Neurons
Zhang, X.-F., Hu, X., & White, F. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00488.1998 · Cited by 203
Coordinated Accumbal Dopamine Release and Neural Activity Drive Goal-Directed Behavior
Cheer, J. F., Aragona, B. J., Heien, M. L., Seipel, A. T., Carelli, R. M., & Wightman, R. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.021 · Cited by 202
Similar effects of daily cocaine and stress on mesocorticolimbic dopamine neurotransmission in the rat
Kalivas, P. W., & Duffy, P. (1989) · Biological Psychiatry · doi:10.1016/0006-3223(89)90271-0 · Cited by 199
Involvement of the Olfactory Tubercle in Cocaine Reward: Intracranial Self-Administration Studies
Ikemoto, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09305.2003 · Cited by 188
Investigation of the effects of opiate antagonists infused into the nucleus accumbens on feeding and sucrose drinking in rats.
Kelley, A. E., Bless, E. P., & Swanson, C. J. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20805-9 · Cited by 185
Stress‐Related Activation of Cerebral Dopaminergic Systemsa
Dunn, A. J. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb42106.x · Cited by 185
Behavioral and Electrophysiological Indices of Negative Affect Predict Cocaine Self-Administration
Wheeler, R. A., Twining, R. C., Jones, J. L., Slater, J. M., Grigson, P. S., & Carelli, R. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.024 · Cited by 171
Habit-forming actions of nomifensine in nucleus accumbens
Carlezon, W. A., Devine, D. P., & Wise, R. A. (1995) · Psychopharmacology · doi:10.1007/bf02246095 · Cited by 170
Self-citation
L-Type Ca2+Channels Are Essential for Glutamate-Mediated CREB Phosphorylation andc-fosGene Expression in Striatal Neurons
Rajadhyaksha, A. M., Barczak, A. K., Macias‐Konstantopoulos, W., Leveque, J., Lewis, S. E., & Konradi, C. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06348.1999 · Cited by 165
D1 dopamine receptor stimulation increases the rate of AMPA receptor insertion onto the surface of cultured nucleus accumbens neurons through a pathway dependent on protein kinase A
Mangiavacchi, S., & Wolf, M. E. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02248.x · Cited by 164
Cocaine-induced potentiation of synaptic strength in dopamine neurons: Behavioral correlates in GluRA(–/–) mice
Dong, Y., Saal, D., Thomas, M., Faust, R., Bonci, A., Robinson, T., & Malenka, R. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401553101 · Cited by 158
Self-citation
Cellular Sites for Dynorphin Activation of κ-Opioid Receptors in the Rat Nucleus Accumbens Shell
Svingos, A. L., Colago, E. E. O., & Pickel, V. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-05-01804.1999 · Cited by 157
Adverse Subjective Experience With Antipsychotics and Its Relationship to Striatal and Extrastriatal D 2 Receptors: a PET Study in Schizophrenia
Mizrahi, R., Rusjan, P., Agid, O., Graff, A., Mamo, D. C., Zipursky, R. B., & Kapur, S. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.4.630 · Cited by 152
Effects of Feeding and Drinking on Acetylcholine Release in the Nucleus Accumbens, Striatum, and Hippocampus of Freely Behaving Rats
Mark, G. P., Rada, P. V., Pothos, E. N., & Hoebel, B. G. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10973.x · Cited by 151
Effects of Dopamine D1-like and D2-likeAgonists in Rats that Self-Administer Cocaine
Caine, S. B., Negus, S. S., Mello, N. K., & Bergman, J. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35108-0 · Cited by 151
Phasic Firing of Single Neurons in the Rat Nucleus Accumbens Correlated with the Timing of Intravenous Cocaine Self-Administration
Peoples, L. L., & West, M. O. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03459.1996 · Cited by 150
Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: implications for intracranial self-stimulation
Cheer, J. F., Heien, M. L. A. V., Garris, P. A., Carelli, R. M., & Wightman, R. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509607102 · Cited by 143
Neurobiology of sexual behavior
Pfaus, J. G. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00034-3 · Cited by 135
Firing of Nucleus Accumbens Neurons During the Consummatory Phase of a Discriminative Stimulus Task Depends on Previous Reward Predictive Cues
Nicola, S. M., Yun, I. A., Wakabayashi, K. T., & Fields, H. L. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00658.2003 · Cited by 135
Enhanced CREB phosphorylation and changes in c-Fos and FRA expression in striatum accompany amphetamine sensitization
Turgeon, S. M., Pollack, A. E., & Fink, J. S. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01316-9 · Cited by 128
Ventral Pallidal Representation of Pavlovian Cues and Reward: Population and Rate Codes
Tindell, A. J., Berridge, K. C., & Aldridge, J. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1437-03.2004 · Cited by 128
D1 dopamine receptor stimulation increases GluR1 surface expression in nucleus accumbens neurons
Chao, S. Z., Ariano, M. A., Peterson, D. A., & Wolf, M. E. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01164.x · Cited by 126
General, μ and κ opioid antagonists in the nucleus accumbens alter food intake under deprivation, glucoprivic and palatable conditions
Bodnar, R. J., Glass, M. J., Ragnauth, A. K., & Cooper, M. L. (1995) · Brain Research · doi:10.1016/0006-8993(95)00957-r · Cited by 124
Opiate Withdrawal-Induced Fos Immunoreactivity in the Rat Extended Amygdala Parallels the Development of Conditioned Place Aversion
Gracy, K. N. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00186-x · Cited by 124
A Review of the Properties of Spiradoline: A Potent and Selective k‐Opioid Receptor Agonist
Wadenberg, M.-L. (2003) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2003.tb00248.x · Cited by 123
Adverse Subjective Experience With Antipsychotics and Its Relationship to Striatal and Extrastriatal D 2 Receptors: a PET Study in Schizophrenia
Mizrahi, R. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.4.630 · Cited by 122
Acute and Chronic Dopamine Receptor Stimulation Modulates AMPA Receptor Trafficking in Nucleus Accumbens Neurons Cocultured with Prefrontal Cortex Neurons
Sun, X., Milovanovic, M., Zhao, Y., & Wolf, M. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0258-08.2008 · Cited by 111
Rethinking substance abuse: what the science shows, and what we should do about it.
Miller, W. R., & Carroll, K. M. (2006) · Cited by 108
Adherence to pharmacotherapy in patients with alcohol and opioid dependence
Weiss, R. D. (2004) · Addiction · doi:10.1111/j.1360-0443.2004.00884.x · Cited by 107
Morphine-Induced Dependence and Sensitization Are Altered in Mice Deficient in AMPA-Type Glutamate Receptor-A Subunits
Vekovischeva, O. Y., Zamanillo, D., Echenko, O., Seppälä, T., Uusi‐Oukari, M., Honkanen, A., Seeburg, P. H., Sprengel, R., & Korpi, E. R. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04451.2001 · Cited by 103
Contrasting effects of dopamine and glutamate receptor antagonist injection in the nucleus accumbens suggest a neural mechanism underlying cue‐evoked goal‐directed behavior
Yun, I. A., Nicola, S. M., & Fields, H. L. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03476.x · Cited by 100
Cdk5 Modulates Cocaine Reward, Motivation, and Striatal Neuron Excitability
Benavides, D. R., Quinn, J. J., Zhong, P., Hawasli, A. H., Dileone, R., Kansy, J. W., Olausson, P., Yan, Z., Taylor, J. R., & Bibb, J. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4061-07.2007 · Cited by 97
Cholinergic modulation of nucleus accumbens medium spiny neurons
de Rover, M., Lodder, J. C., Kits, K. S., Schoffelmeer, A. N. M., & Brussaard, A. B. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02289.x · Cited by 96
Benzodiazepine-induced decreases in extracellular concentrations of dopamine in the nucleus accumbens after acute and repeated administration
Finlay, J. M., Damsma, G., & Fibiger, H. C. (1992) · Psychopharmacology · doi:10.1007/bf02801973 · Cited by 95
Desmethylimipramine attenuates cocaine withdrawal in rats
Markou, A., Hauger, R. L., & Koob, G. F. (1992) · Psychopharmacology · doi:10.1007/bf02245878 · Cited by 94
Collateral projections from the supramammillary nucleus to the medial septum and hippocampus
Vertes, R. P., & McKenna, J. T. (2000) · Synapse · doi:10.1002/1098-2396(20001201)38:3 · Cited by 92
Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine
Welter, M., Vallone, D., Samad, T. A., Méziane, H., Usiello, A., & Borrelli, E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610790104 · Cited by 87
Behavioral and Molecular Effects of Dopamine D1 Receptor Stimulation during Naloxone-Precipitated Morphine Withdrawal
Chartoff, E. H., Mague, S. D., Barhight, M. F., Smith, A. M., & Carlezon, W. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0491-06.2006 · Cited by 85
Self-citation
Neuronal responses in prefrontal cortex and nucleus accumbens during heroin self-administration in freely moving rats
Chang, J.-Y., Zhang, L., Janak, P. H., & Woodward, D. J. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00012-7 · Cited by 83
Opiate influences on nucleus accumbens neuronal electrophysiology: dopamine and non-dopamine mechanisms
Hakan, R. L., & Henriksen, S. J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-10-03538.1989 · Cited by 81
Dopaminergic Reduction of Excitability in Nucleus Accumbens Neurons Recorded in Vitro
O’Donnell, P. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00177-f · Cited by 80
Repeated Cocaine Administration Suppresses HVA-Ca2+Potentials and Enhances Activity of K+Channels in Rat Nucleus Accumbens Neurons
Hu, X., Basu, S., & White, F. J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00217.2004 · Cited by 79
Dual Role of Medial A10 Dopamine Neurons in Affective Encoding
Liu, Z., Shin, R. S., & Ikemoto, S. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.4 · Cited by 73
Effects of dopamine D 1-like and D 2-like agonists on cocaine self-administration in rhesus monkeys: rapid assessment of cocaine dose-effect functions
Caine, S. B., Negus, S. S., & Mello, N. K. (2000) · Psychopharmacology · doi:10.1007/s002130050023 · Cited by 73
Kappa agonist-induced reduction in dopamine release: site of action and tolerance.
Ba, D., Js, A., Mm, P., & Voigtlander, P. F. V. (1992) · PubMed · Cited by 73
Locally evoked potentials in slices of the rat nucleus accumbens: NMDA and non-NMDA receptor mediated components and modulation by GABA
Pennartz, C. M. A., Boeijinga, P. H., & Lopes, F. H. D. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90808-o · Cited by 72
Neural substrates of opiate reinforcement
Bozarth, M. A., & Wise, R. A. (1983) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(83)90027-1 · Cited by 70
Neuronal spike activity in the nucleus accumbens of behaving rats during ethanol self-administration
Janak, P. H., Chang, J.-Y., & Woodward, D. J. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01245-1 · Cited by 66
Brain Reward Regulated by AMPA Receptor Subunits in Nucleus Accumbens Shell
Todtenkopf, M. S., Parsegian, A., Naydenov, A. V., Neve, R. L., Konradi, C. L., & Carlezon, W. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3070-06.2006 · Cited by 65
Self-citation
Actions of GABAergic agents on dopamine metabolism in the nigrostriatal pathway of the rat.
Wood, P. L. (1982) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33260-x · Cited by 62
Opioid receptors: past, present and future
Mansour, A., Watson, S. J., & Akil, H. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80024-v · Cited by 60
Opposite effects of midazolam and β-carboline-3-carboxylate ethyl ester on the release of dopamine from rat nucleus accumbens measured by in vivo mudialysis
Murai, T., Koshikawa, N., Kanayama, T., Takada, K., Tomiyama, K., & Kobayashi, M. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90301-8 · Cited by 60
Membrane properties and synaptic responses of the guinea pig nucleus accumbens neurons in vitro
Uchimura, N., Higashi, H., & Nishi, S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.4.769 · Cited by 58
AMPA-Receptor GluR1 Subunits are Involved in the Control Over Behavior by Cocaine-Paired Cues
Mead, A. N., Zamanillo, D., Becker, N., & Stephens, D. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301045 · Cited by 53
Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice
Mead, A. N., Brown, G., Le Merrer, J., & Stephens, D. N. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2071-8 · Cited by 52
L-type calcium channels modulate glutamate-driven bursting activity in the nucleus accumbens in vivo
Cooper, D., & White, F. J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02868-7 · Cited by 45
Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient mice
Elmer, G. I., Pieper, J. O., Levy, J., Rubinstein, M., Low, M. J., Grandy, D. K., & Wise, R. A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0051-2 · Cited by 44
Lesions of the nucleus accumbens in rats reduce opiate reward but do not alter context-specific opiate tolerance.
Kelsey, J. E., Carlezon, W. A., & Falls, W. A. (1989) · Behavioral Neuroscience · doi:10.1037//0735-7044.103.6.1327 · Cited by 42
Self-citation
Benzodiazepine self-administration in animals and humans: a comprehensive literature review.
Griffiths, R. R., & Na, A. (1980) · PubMed · Cited by 39
Amphetamine enhances extracellular concentrations of dopamine and acetylcholine in dorsolateral striatum and nucleus accumbens of freely moving rats
Guix, T., Hurd, Y. L., & Ungerstedt, U. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90490-x · Cited by 39
Cocaine releases limbic acetylcholine through endogenous dopamine action on D1 receptors
Impérato, A., Obinu, M. C., Demontis, M. V., & Gessa, G. L. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90565-l · Cited by 38
The Role of Accumbal Hypoactivity in Cocaine Addiction.
Peoples, L. L., Kravitz, A. V., & Guillem, K. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.266 · Cited by 38
Effects of naltrexone on nucleus accumbens, lateral hypothalamic and ventral tegmental self-stimulation rate—frequency functions
West, T. E. G., & Wise, R. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)90594-x · Cited by 37
Lesions of the nucleus accumbens in rats reduce opiate reward but do not alter context-specific opiate tolerance.
Kelsey, J. E., Carlezon, W. A., & Falls, W. A. (1989) · Behavioral Neuroscience · doi:10.1037/0735-7044.103.6.1327 · Cited by 37
Self-citation
Opioid receptors: past, present and future
Mansour, A. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93876-y · Cited by 32
Opiate antagonists and self-stimulation: extinction-like response patterns suggest selective reward deficit
Trujillo, K. A., Belluzzi, J. D., & Stein, L. (1989) · Brain Research · doi:10.1016/0006-8993(89)90884-6 · Cited by 29
Microinjection of the L-Type Calcium Channel Antagonist Diltiazem into the Ventral Nucleus Accumbens Shell Facilitates Cocaine-Induced Conditioned Place Preferences
Chartoff, E. H., Pliakas, A. M., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.024 · Cited by 27
Self-citation
Disruption of conditioned taste aversion in the rat by stimulation of amygdala: A conditioning effect, not amnesia.
Phillips, A. G., & LePiane, F. G. (1980) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077701 · Cited by 22
SEXUAL BEHAVIOR, EATING AND MESOLIMBIC DOPAMINE
Fibiger, H. C., Nomikos, G. G., Pfaus, J. G., & Damsma, G. (1992) · Clinical Neuropharmacology · doi:10.1097/00002826-199201001-00294 · Cited by 21
Intracerebral dopaminergic transplants are not activated by electrical footshock stress activating in situ mesocorticolimbic neurons
Herman, J. P., Rivet, J., Abrous, D. N., & Moal, M. L. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90791-4 · Cited by 17
Depressant actions of enkephalins on neurones in the nucleus accumbens [proceedings].
McCarthy, P. S., Walker, R. J., & Gn, W. (1977) · PubMed · Cited by 7

Research works printed but not linked: 2

Chen, M.C., Parsegian, A., Carlezon Jr., W.A., 2008. Effect of mesocorticolimbic microinjections of the kappa-opioid agonist U50,488 on intracranial self-stimulation in rats. Soc. Neurosci. Abstr. 34, in press.
DiNieri, 2006, Inducible disruption of CREB activity within nucleus accumbens alters sensitivity to rewarding and prodepressive drugs, Soc. Neurosci. Abstr., 32

Sorted by citations

Pleasure Systems in the Brain
Berridge, K. C., & Kringelbach, M. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.018 · Cited by 1,730
Dopamine: Functions, Signaling, and Association with Neurological Diseases
Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0632-3 · Cited by 1,073
Reward Processing by the Opioid System in the Brain
Le Merrer, J., Becker, J. A. J., Befort, K., & Kieffer, B. L. (2009) · Physiological Reviews · doi:10.1152/physrev.00005.2009 · Cited by 1,013
Cortico-Basal Ganglia Reward Network: Microcircuitry
Sesack, S. R., & Grace, A. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.93 · Cited by 985
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward
Lobo, M. K., Covington, H. E., Chaudhury, D., Friedman, A. K., Sun, H., Damez-Werno, D., Dietz, D. M., Zaman, S., Koo, J. W., Kennedy, P. J., et al. (2010) · Science · doi:10.1126/science.1188472 · Cited by 880

See all 561

Authors: Carlezon, W. A., & Thomas, M. J.
Affiliations: Harvard University (US)
University of Minnesota (US)
Corresponding author: Carlezon, William A.
ORCID: Carlezon, William A.
Thomas, Mark J.
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2009-01
Volume: 56
Pages: 122-132
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2008.06.075
PMC: PMC2635333
OpenAlex: W1977266070
Cited by: 561
References: 131
Citations by year: 2026: 11 · 2025: 17 · 2024: 21 · 2023: 17 · 2022: 12 · 2021: 22 · 2020: 31 · 2019: 63 · 2018: 25 · 2017: 31 · 2016: 32 · 2015: 33 · 2014: 44 · 2013: 45 · 2012: 47
FWCI: 3.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (R01DA012736, R01DA019666, DA019666, DA012736)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: nucleus accumbens, reward, aversion, aversive states, mesocorticolimbic system, medium spiny neurons, GABAergic neurons, dopamine, glutamate, ventral tegmental area, prefrontal cortex, amygdala, hippocampus, motivation, addiction, mood disorders, drug reward
MeSH terms: Animals, Avoidance Learning, Nucleus Accumbens, Reward, Illicit Drugs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks