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Pavlovian fear memory circuits and phenotype models of PTSD
Abstract
Pavlovian fear conditioning, also known as classical fear conditioning is an important model in the study of the neurobiology of normal and pathological fear. Progress in the neurobiology of Pavlovian fear also enhances our understanding of disorders such as posttraumatic stress disorder (PTSD) and with developing effective treatment strategies. Here we describe how Pavlovian fear conditioning is a key tool for understanding both the neurobiology of fear and the mechanisms underlying variations in fear memory strength observed across different phenotypes. First we discuss how Pavlovian fear models aspects of PTSD. Second, we describe the neural circuits of Pavlovian fear and the molecular mechanisms within these circuits that regulate fear memory. Finally, we show how fear memory strength is heritable; and describe genes which are specifically linked to both changes in Pavlovian fear behavior and to its underlying neural circuitry. These emerging data begin to define the essential genes, cells and circuits that contribute to normal and pathological fear. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'.
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“Fear conditioning provides a potential framework for studying these phenotypes [see Ref. (55, 56)].”
From Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors (2014) · cites this paper as [56]
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Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836 · cited 1×
“, 1993; Myers and Davis, 2007), as well as direct electrophysiological recordings (Milad and Quirk, 2002), indicate a key role for the mPFC in extinction.”
BackgroundThe Emotional Brain, Fear, and the Amygdala
LeDoux, J. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1025048802629 · Cited by 1,818
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder
Milad, M. R., Pitman, R. K., Ellis, C. B., Gold, A. L., Shin, L. M., Lasko, N. B., Zeidan, M. A., Handwerger, K., Orr, S. P., & Rauch, S. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.026 · Cited by 1,339
LeDoux, J. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.005 · Cited by 1,281
Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277
Probability of shock in the presence and absence of cs in fear conditioning.
Rescorla, R. A. (1968) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0025984 · Cited by 1,067 · cited 1×
“Second, the conditioning paradigm, including the number and contingency of CS and US associations influence the level of fear memory strength (Rescorla, 1968; Bauer et al., 2001).”
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Items 101–140 of 140
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Haug, L. I. (2024) · Elsevier eBooks · doi:10.1016/b978-0-7020-8214-6.00019-x · Cited by 3
Ahamed, S. K., Raut, S. B., James, F., Canales, J. J., Sohal, S. S., Caruso, V., & Johnson, L. R. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.08.023 · Cited by 6
Self-citationPTSD and Self-Directed Violence
Bryan, C. J. (2015) · Springer eBooks · doi:10.1007/978-3-319-08613-2_2-1 · Cited by 3
Sex differences in BNST signaling and BNST CRF in fear processing
Hon, O. J., Neira, S., Flanigan, M. E., Roland, A. V., Caira, C. M., Sides, T. R., D’Ambrosio, S., Lee, S., Simpson, Y., Buccini, M. C., et al. (2025) · eLife · doi:10.1101/2023.04.10.535848 · Cited by 2
Zamorina, T. A., Ivashkina, O. I., Toropova, K. A., & Anokhin, K. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126544 · Cited by 3
Ma, X., Chen, H., Xu, F., Xue, S., Zhou, C., Zhang, Y., Zhang, Y., Lv, R., Liu, N., Meng, Y., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178060 · Cited by 2
Fitri, & Liem, I. K. (2018) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1073/4/042050 · Cited by 2
PTSD and Self-Directed Violence
Bryan, C. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-08359-9_2 · Cited by 2
Starčević, A., Petricevic, S. M., Radojicic, Z. A., Djulejić, V., Ilanković, A. N., Starcević, B., & Filipović, B. (2016) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/j.kjms.2016.04.011 · Cited by 2
Rubinstein, D., Abargil, M., Duek, O. A., & Harpaz‐Rotem, I. (2025) · European Journal of Psychotraumatology · doi:10.1080/20008066.2025.2540141 · Cited by 1
Huckstep, K. L., Newton, B., Bailey, G., Charlton, A. J., Pearl, A. J., Maddern, X. J., Brown, R. M., McNally, G. P., Lubman, D. I., Arunogiri, S., et al. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02394-2 · Cited by 1
Posttraumatic Stress Disorder in Children and Adolescents
Grasso, D. J., & Kaufman, J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6599-7_10 · Cited by 1
Modified Fear Conditioning for Inducing Flight Behaviors in Mice
Furuyama, T., Yamamoto, R., Kato, N., & Ono, M. (2023) · Journal of Visualized Experiments · doi:10.3791/66266 · Cited by 1
Moral Injury, Self-Compassion, and Mental Health
Forkus, S. R. (2018) · doi:10.23860/thesis-forkus-shannon-2018 · Cited by 1
Rudenko, A. (2023) · doi:10.31234/osf.io/b84zx · Cited by 1
Catechol-O-Methyltransferase (COMT) val158met Polymorphism as a Risk Factor for PTSD
Valente, N. L. M., Fiks, J. P., & Mello, M. F. (2015) · Springer eBooks · doi:10.1007/978-3-319-08613-2_27-1
Influences of prenatal and postnatal stress on cognitive function and fear memory consolidation
Nazari, M., Rajabzadeh, H., Dadkhah, M., Boustani, A., & Kor, N. (2015) · Scientific Journal of Animal Science · doi:10.14196/sjbs.v4i8.2076
Translational Medicine in Post-Traumatic Stress Disorder
Liu, W., Taosheng, L. I. U., Wang, W., & Jin, Y. (2013) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2013.01976
Young, G. C. (2016) · Springer eBooks · doi:10.1007/978-3-319-24094-7_21
Nicotine and Posttraumatic Stress Disorder
Acheson, D. T., & Glenn, D. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802574-1.00016-8
Koo, S. (2017) · Queensland University of Technology · doi:10.5204/thesis.eprints.103629
Animal models of post-traumatic stress disorder:
Heltzel, L. C. M. W., & Homberg, J. R. (2019) · Oxford University Press eBooks · doi:10.1093/oso/9780198793014.003.0022
Investigation of Cellular and Molecular Mechanisms Involved in Contextual Fear Memory Encoding
Chaaya, N. (2019) · Queensland University of Technology · doi:10.5204/thesis.eprints.134258
Duque-Quintero, M., Garro, J. M. M., Guzmán-González, P. A., Sierra-Hincapié, G. M., & Torres, Y. (2020) · Revista de la Facultad de Medicina · doi:10.15446/revfacmed.v68n4.77723
Neurogenesis and neuroplasticity following olfactory fear conditioning
Hakim, M. (2019) · Queensland University of Technology · doi:10.5204/thesis.eprints.157474
Fear Memory Allocation in the Posterior Basal Amygdala
Inchauspé, J. (2020) · TSpace (University of Toronto)
Vivian, K., Strodl, E. S., Kitamura, H., & Johnson, L. R. (2022) · Clinical Psychologist · doi:10.1080/13284207.2022.2065913
Self-citationRole of Sleep Deprivation in Fear Conditioning and Extinction: Implications for Treatment of PTSD
Drummond, S. P. A. (2014) · Defense Technical Information Center (DTIC) · doi:10.21236/ada613608
Catechol-O-Methyltransferase (COMT) val158met Polymorphism as a Risk Factor for PTSD
Valente, N. L. M., Fiks, J. P., & Mello, M. F. (2016) · Springer eBooks · doi:10.1007/978-3-319-08359-9_27
Post-Traumatic Stress Disorder: Theoretical Approaches and Animal Models
Toropova, K. A., Ivashkina, O. I., & Anokhin, K. V. (2022) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-022-01296-2
Acute Stress Disorder: A General Overview
Fu, Y. (2023) · Lecture Notes in Education Psychology and Public Media · doi:10.54254/2753-7048/7/2022911
Hon, O. J., Flanigan, M. E., Roland, A. V., Caira, C. M., Sides, T. R., D’Ambrosio, S., Lee, S., Simpson, Y., Buccini, M. C., Machinski, S. N., et al. (2023) · eLife · doi:10.7554/elife.89189.1 · Cited by 1
Hon, O. J., Neira, S., Flanigan, M. E., Roland, A. V., Caira, C. M., Sides, T. R., D’Ambrosio, S., Lee, S., Simpson, Y., Buccini, M. C., et al. (2025) · eLife · doi:10.7554/elife.89189.2
tDCS to treat psychiatric disorders: Insights from animal studies
Etiévant, A., Kesyou, S., Bourasset, F., Peterschmitt, Y., Ramadan, B., Schuerbeek, A. V., Bundel, D. D., & Waes, V. V. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-26602-7.00009-9
Foreign language modulates neural responses to instructed fear: a neuroimaging study in bilinguals
Davydova, T., Marín-Marín, L., Baena-Pérez, M., Calderón-Rubio, E., García‐Palacios, A., & Costumero, V. (2026) · NeuroImage · doi:10.1016/j.neuroimage.2026.121836 · Cited by 1
Boukezzi, S. C. (2017) · theses.fr (ABES) · doi:10.70675/5b0e8a8ezbcb6z46f4zbb18z3c97e0bb31ae
Jones, L. C., Spooner, H., Waters, A. B., Penhale, S. H., Lamb, D. G., Levy, C. E., Malhotra, B., Stickley, K. S., Valldejuli, K., Kaimal, G., et al. (2026) · The Arts in Psychotherapy · doi:10.1016/j.aip.2026.102517
Metadata
- Authors
- Johnson, L. R., McGuire, J., Lazarus, R., & Palmer, A. A.
- Affiliations
- Uniformed Services University of the Health Sciences (US)
- University of Chicago (US)
- Corresponding author
- Johnson, Luke R.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 62
- Issue
- 2
- Pages
- 638-646
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2055555487
- Cited by
- 140
- References
- 101
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 8 · 2020: 6 · 2019: 11 · 2018: 12 · 2017: 7 · 2016: 17 · 2015: 10 · 2014: 8 · 2013: 14 · 2012: 6
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH079103, MH079103)
- National Institute of General Medical Sciences (R01GM097737)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- fear conditioning, post-traumatic stress disorder, fear memory, neurobiology of fear
- MeSH terms
- Animals, Association Learning, Brain, Conditioning, Classical, Disease Models, Animal, Fear, Nerve Net, Phenotype, Stress Disorders, Post-Traumatic
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