Cited by 140Memory and Neural MechanismsPosttraumatic Stress Disorder ResearchNeuroscience and Neuropharmacology Research

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Pavlovian fear memory circuits and phenotype models of PTSD

Johnson, Luke R., McGuire, Jennifer, Lazarus, Rachel, Palmer, Abraham A.·2012·Neuropharmacology

DOI 10.1016/j.neuropharm.2011.07.004

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Abstract

Pavlovian fear conditioning, also known as classical fear conditioning is an important model in the study of the neurobiology of normal and pathological fear. Progress in the neurobiology of Pavlovian fear also enhances our understanding of disorders such as posttraumatic stress disorder (PTSD) and with developing effective treatment strategies. Here we describe how Pavlovian fear conditioning is a key tool for understanding both the neurobiology of fear and the mechanisms underlying variations in fear memory strength observed across different phenotypes. First we discuss how Pavlovian fear models aspects of PTSD. Second, we describe the neural circuits of Pavlovian fear and the molecular mechanisms within these circuits that regulate fear memory. Finally, we show how fear memory strength is heritable; and describe genes which are specifically linked to both changes in Pavlovian fear behavior and to its underlying neural circuitry. These emerging data begin to define the essential genes, cells and circuits that contribute to normal and pathological fear. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'.

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Authors: Johnson, L. R., McGuire, J., Lazarus, R., & Palmer, A. A.
Affiliations: Uniformed Services University of the Health Sciences (US)
University of Chicago (US)
Corresponding author: Johnson, Luke R.
ORCID: Johnson, Luke R.
McGuire, Jennifer
Palmer, Abraham A.
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2012-02
Volume: 62
Issue: 2
Pages: 638-646
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2011.07.004
OpenAlex: W2055555487
Cited by: 140
References: 101
Citations by year: 2026: 3 · 2025: 7 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 8 · 2020: 6 · 2019: 11 · 2018: 12 · 2017: 7 · 2016: 17 · 2015: 10 · 2014: 8 · 2013: 14 · 2012: 6
FWCI: 4.54
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (R01MH079103, MH079103)
National Institute of General Medical Sciences (R01GM097737)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: fear conditioning, post-traumatic stress disorder, fear memory, neurobiology of fear
MeSH terms: Animals, Association Learning, Brain, Conditioning, Classical, Disease Models, Animal, Fear, Nerve Net, Phenotype, Stress Disorders, Post-Traumatic

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Pavlovian fear memory circuits and phenotype models of PTSD

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