The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Pavlovian fear memory circuits and phenotype models of PTSD
Abstract
Pavlovian fear conditioning, also known as classical fear conditioning is an important model in the study of the neurobiology of normal and pathological fear. Progress in the neurobiology of Pavlovian fear also enhances our understanding of disorders such as posttraumatic stress disorder (PTSD) and with developing effective treatment strategies. Here we describe how Pavlovian fear conditioning is a key tool for understanding both the neurobiology of fear and the mechanisms underlying variations in fear memory strength observed across different phenotypes. First we discuss how Pavlovian fear models aspects of PTSD. Second, we describe the neural circuits of Pavlovian fear and the molecular mechanisms within these circuits that regulate fear memory. Finally, we show how fear memory strength is heritable; and describe genes which are specifically linked to both changes in Pavlovian fear behavior and to its underlying neural circuitry. These emerging data begin to define the essential genes, cells and circuits that contribute to normal and pathological fear. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'.
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“Fear conditioning provides a potential framework for studying these phenotypes [see Ref. (55, 56)].”
From Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors (2014) · cites this paper as [56]
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Cites
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BackgroundThe Emotional Brain, Fear, and the Amygdala
LeDoux, J. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1025048802629 · Cited by 1,818
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Psychometric Evaluation of the Moral Injury Events Scale
Nash, W. P., Carper, T. L. M., Mills, M. A., Au, T. M., Goldsmith, A. A., & Litz, B. T. (2013) · Military Medicine · doi:10.7205/milmed-d-13-00017 · Cited by 620
From Pavlov to PTSD: The extinction of conditioned fear in rodents, humans, and anxiety disorders
VanElzakker, M. B., Kathryn Dahlgren, M., Caroline Davis, F., Dubois, S., & Shin, L. M. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.014 · Cited by 482
Moral Injury: A Mechanism for War-Related Psychological Trauma in Military Family Members
Nash, W. P., & Litz, B. T. (2013) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-013-0146-y · Cited by 259
Lisieski, M. J., Eagle, A. L., Conti, A. C., Liberzon, I., & Perrine, S. A. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00196 · Cited by 233
Epigenetic Mechanisms in Learned Fear: Implications for PTSD
Zovkic, I. B., & Sweatt, J. D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.79 · Cited by 192
Metadata
- Authors
- Johnson, L. R., McGuire, J., Lazarus, R., & Palmer, A. A.
- Affiliations
- Uniformed Services University of the Health Sciences (US)
- University of Chicago (US)
- Corresponding author
- Johnson, Luke R.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 62
- Issue
- 2
- Pages
- 638-646
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2055555487
- Cited by
- 140
- References
- 101
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 8 · 2020: 6 · 2019: 11 · 2018: 12 · 2017: 7 · 2016: 17 · 2015: 10 · 2014: 8 · 2013: 14 · 2012: 6
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH079103, MH079103)
- National Institute of General Medical Sciences (R01GM097737)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- fear conditioning, post-traumatic stress disorder, fear memory, neurobiology of fear
- MeSH terms
- Animals, Association Learning, Brain, Conditioning, Classical, Disease Models, Animal, Fear, Nerve Net, Phenotype, Stress Disorders, Post-Traumatic
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