The DOI matches its Crossref record; 256 of the 256 references it cites were found in a registry or an index.
Circadian rhythms and depression: Human psychopathology and animal models
Abstract
Most organisms (including humans) developed daily rhythms in almost every aspect of their body. It is not surprising that rhythms are also related to affect in health and disease. In the present review we present data that demonstrate the evidence for significant interactions between circadian rhythms and affect from both human studies and animal models research. A number of lines of evidence obtained from human and from animal models research clearly demonstrate relationships between depression and circadian rhythms including (1) daily patterns of depression; (2) seasonal affective disorder; (3) connections between circadian clock genes and depression; (4) relationship between sleep disorders and depression; (5) the antidepressant effect of sleep deprivation; (6) the antidepressant effect of bright light exposure; and (7) the effects of antidepressant drugs on sleep and circadian rhythms. The integration of data suggests that the relationships between the circadian system and depression are well established but the underlying biology of the interactions is far from being understood. We suggest that an important factor hindering research into the underlying mechanisms is the lack of good animal models and we propose that additional efforts in that area should be made. One step in that direction could be the attempt to develop models utilizing diurnal animals which might have a better homology to humans with regard to their circadian rhythms. This article is part of a Special Issue entitled 'Anxiety and Depression'.
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In the citing paper
“Nearly all patients with affective disorders including depression show significant disruptions in circadian rhythms 83, 84, 85, 86, 87.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [84]
In the citing paper
“The relationships between depression and circadian rhythms in behavior and physiology are probably bidirectional”
From Digital Biomarkers for Depression Screening With Wearable Devices: Cross-sectional Study With Machine Learning Modeling (2021) · cites this paper as [65]
Citations
Cites
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Partitioning of time as an ecological resource
Kronfeld-Schor, N., & Dayan, T. (2003) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev.ecolsys.34.011802.132435 · Cited by 1,021 · cited 2×
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Saeb, S., Zhang, M., Karr, C. J., Schueller, S. M., Corden, M. E., Kording, K. P., & Mohr, D. C. (2015) · Journal of Medical Internet Research · doi:10.2196/jmir.4273 · Cited by 782
Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
Li, J. Z., Bunney, B. G., Meng, F., Hagenauer, M. H., Walsh, D. M., Vawter, M. P., Evans, S. J., Choudary, P. V., Cartagena, P., Barchas, J. D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305814110 · Cited by 589
The Circadian Syndrome: is the Metabolic Syndrome and much more!
Zimmet, P., Alberti, K. G. M. M., Stern, N., Bilu, C., El‐Osta, A., Einat, H., & Kronfeld‐Schor, N. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12924 · Cited by 387
Self-citationTiming of light exposure affects mood and brain circuits
Bedrosian, T. A., & Nelson, R. J. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.262 · Cited by 356
Landgraf, D., Long, J. E., Proulx, C. D., Barandas, R., Malinow, R., & Welsh, D. K. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.03.1050 · Cited by 212
Metadata
- Authors
- Kronfeld-Schor, N., & Einat, H.
- Affiliations
- University of Minnesota, Duluth (US)
- Corresponding author
- Einat, Haim
- ORCID
- Einat, Haim
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 62
- Issue
- 1
- Pages
- 101-114
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2077183950
- Semantic Scholar
- a939295057515d9c4a471d621f1ab83a66279463
- Cited by
- 166
- References
- 256
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 14 · 2020: 3 · 2019: 9 · 2018: 10 · 2017: 14 · 2016: 12 · 2015: 17 · 2014: 18 · 2013: 26 · 2012: 10
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian rhythm, depression, clock genes, seasonal affective disorder, sleep disorders, sleep deprivation, bright light therapy, antidepressant effects on sleep, circadian system, animal models of depression, affect
- MeSH terms
- Animals, Circadian Rhythm, Depression, Disease Models, Animal, Humans, Sleep Wake Disorders
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