Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

Li, Jun Z.; Bunney, Blynn G.; Meng, Fan; Hagenauer, Megan H.; Walsh, David M.; Vawter, Marquis P.; Evans, Simon J.; Choudary, Prabhakara V.; Cartagena, Preston; Barchas, Jack D.; Schatzberg, Alan F.; Jones, Edward G.; Myers, Richard M.; Watson, Stanley J.; Akil, Huda; Bunney, William E.

doi:10.1073/pnas.1305814110

Cited by 589Circadian rhythm and melatoninTreatment of Major DepressionSleep and Wakefulness Research

Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

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Li, Jun Z., Bunney, Blynn G., Meng, Fan, Hagenauer, Megan H., Walsh, David M., Vawter, Marquis P., Evans, Simon J., Choudary, Prabhakara V. +8 more·2013·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1305814110PMC PMC3683716

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Abstract

A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns. However, to date, there is no direct evidence of circadian clock dysregulation in the brains of patients who have MDD. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but its presence and variability in the human brain were difficult to characterize. Here, we applied time-of-death analysis to gene expression data from high-quality postmortem brains, examining 24-h cyclic patterns in six cortical and limbic regions of 55 subjects with no history of psychiatric or neurological illnesses (“controls”) and 34 patients with MDD. Our dataset covered ∼12,000 transcripts in the dorsolateral prefrontal cortex, anterior cingulate cortex, hippocampus, amygdala, nucleus accumbens, and cerebellum. Several hundred transcripts in each region showed 24-h cyclic patterns in controls, and >100 transcripts exhibited consistent rhythmicity and phase synchrony across regions. Among the top-ranked rhythmic genes were the canonical clock genes BMAL1(ARNTL), PER1-2-3, NR1D1(REV-ERBa), DBP, BHLHE40 (DEC1) , and BHLHE41(DEC2) . The phasing of known circadian genes was consistent with data derived from other diurnal mammals. Cyclic patterns were much weaker in the brains of patients with MDD due to shifted peak timing and potentially disrupted phase relationships between individual circadian genes. This transcriptome-wide analysis of the human brain demonstrates a rhythmic rise and fall of gene expression in regions outside of the suprachiasmatic nucleus in control subjects. The description of its breakdown in MDD suggests potentially important molecular targets for treatment of mood disorders.

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Neural systems associated with affect, such as limbic brain regions, monoamine neurotransmitters, and the hypothalamic-pituitary-adrenal axis, are all under circadian regulation.
“Notably, neural systems associated with affect, such as the limbic brain regions, monoamine neurotransmitters, and the hypothalamic–pituitary–adrenal axis (HPA), are all under circadian regulation27–31.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [27]
Examination of circadian patterns of gene expression within postmortem brains of patients with major depressive disorder demonstrates reduced amplitude, shifted peaks, and altered phase relationship between genes, particularly in canonical clock genes.
“Further, examination of circadian patterns of gene expression within postmortem brains of patients with MDD demonstrate reduced amplitude, shifted peaks, and altered phase relationship between genes, particularly in canonical clock genes27.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [27]

R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603 · see citing works
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658 · see citing works
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,185 · see citing works
Summaries of Affymetrix GeneChip probe level data
Irizarry, R. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng015 · Cited by 4,906 · see citing works
Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162 · see citing works
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900 · see citing works
KEGG for representation and analysis of molecular networks involving diseases and drugs
Kanehisa, M., Goto, S., Furumichi, M., Tanabe, M., & Hirakawa, M. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp896 · Cited by 2,322 · see citing works
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works
Resetting central and peripheral circadian oscillators in transgenic rats
Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907 · see citing works
Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
Dai, M. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni179 · Cited by 1,797 · see citing works
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611 · see citing works
Mania-like behavior induced by disruption of <i>CLOCK</i>
Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609625104 · Cited by 803 · see citing works
Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus
Akhtar, R. A., Reddy, A. B., Maywood, E. S., Clayton, J. D., King, V. M., Smith, A. G., Gant, T. W., Hastings, M. H., & Kyriacou, C. P. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00759-5 · Cited by 777 · see citing works
Chronobiology: biological timekeeping
(2004) · Choice Reviews Online · doi:10.5860/choice.41-2795 · Cited by 679 · see citing works
Harmonics of Circadian Gene Transcription in Mammals
Hughes, M. E., DiTacchio, L., Hayes, K. R., Vollmers, C., Pulivarthy, S. R., Baggs, J. E., Panda, S., & Hogenesch, J. B. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000442 · Cited by 674 · see citing works
The human circadian clock entrains to sun time
Roenneberg, T., Kumar, C., & Merrow, M. W. (2007) · Current Biology · doi:10.1016/j.cub.2006.12.011 · Cited by 464 · see citing works
The Protein Information Resource
Wu, C. H. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg040 · Cited by 455 · see citing works
Clocks not winding down: unravelling circadian networks
Zhang, E. E., & Kay, S. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2995 · Cited by 446 · see citing works
REM latency: a psychobiologic marker for primary depressive disease.
Dj, K. (1976) · PubMed · Cited by 445 · see citing works
Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS)Preprint
Vanselow, K., Vanselow, J. T., Westermark, P. O., Reischl, S., Maier, B., Korte, T., Herrmann, A., Herzel, H., Schlösser, A., & Kramer, A. (2006) · Genes & Development · doi:10.1101/gad.397006 · Cited by 383 · see citing works
The Role of Hypocretins (Orexins) in Sleep Regulation and Narcolepsy
Taheri, S., Zeitzer, J. M., & Mignot, E. J.-M. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142826 · Cited by 333 · see citing works
Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain
Tomita, H., Vawter, M. P., Walsh, D. M., Evans, S. J., Choudary, P. V., Li, J., Overman, K. M., Atz, M. E., Myers, R. M., Jones, E. G., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.013 · Cited by 331 · see citing works
Self-citation
Spitz and Fisher's Medicolegal Investigation of Death: Guidelines for the Application of Pathology to Crime Investigation
Spitz, W. U., Spitz, D. J., & Fisher, R. S. (2005) · Medical Entomology and Zoology · Cited by 324 · see citing works
The Period Length of Fibroblast Circadian Gene Expression Varies Widely among Human Individuals
Brown, S. A., Fleury-Olela, F., Nagoshi, E., Hauser, C., Juge-Aubry, C. E., Meier, C. A., Chicheportiche, R., Dayer, J., Albrecht, U., & Schibler, U. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030338 · Cited by 315 · see citing works
Analysis of Gene Regulatory Networks in the Mammalian Circadian Rhythm
Yan, J., Wang, H., Liu, Y., & Shao, C. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000193 · Cited by 297 · see citing works
Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression
Partonen, T., Treutlein, J., Alpman, A., Frank, J., Johansson, C. H., Depner, M., Aron, L., Rietschel, M., Wellek, S., Soronen, P., et al. (2007) · Annals of Medicine · doi:10.1080/07853890701278795 · Cited by 264 · see citing works
Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions
Li, J. Z., Vawter, M. P., Walsh, D. M., Tomita, H., Evans, S. J., Choudary, P. V., Lopez, J. F., Avelar, A., Shokoohi, V., Chung, T., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh065 · Cited by 261 · see citing works
Self-citation
Mammalian circadian clock and metabolism – the epigenetic link
Bellet, M. M., & Sassone‐Corsi, P. (2010) · Journal of Cell Science · doi:10.1242/jcs.051649 · Cited by 237 · see citing works
A light‐independent oscillatory gene mPer3 in mouse SCN and OVLT
Takumi, T., Taguchi, K., Miyake, S., Sakakida, Y., Takashima, N., Matsubara, C., Maebayashi, Y., Okumura, K., Takekida, S., Yamamoto, S., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.16.4753 · Cited by 236 · see citing works
Regulation of metabolism: the circadian clock dictates the time
Sahar, S., & Sassone-Corsi, P. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.10.005 · Cited by 222 · see citing works
Gender-Specific Gene Expression in Post-Mortem Human Brain: Localization to Sex Chromosomes
Vawter, M. P., Evans, S. J., Choudary, P. V., Tomita, H., Meador-Woodruff, J., Molnar, M., Li, J. Z., López, J. F., Myers, R. M., Cox, D. R., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300337 · Cited by 204 · see citing works
Self-citation
Noninvasive method for assessing the human circadian clock using hair follicle cells
Akashi, M., Soma, H., Yamamoto, T., Tsugitomi, A., Yamashita, S., Yamamoto, T., Nishida, E., Yasuda, A., Liao, J. K., & Node, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003878107 · Cited by 192 · see citing works
LRpath: a logistic regression approach for identifying enriched biological groups in gene expression data
Sartor, M. A., Leikauf, G. D., & Medvedovic, M. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn592 · Cited by 178 · see citing works
Circadian Clock Gene Expression in Brain Regions of Alzheimer ’s Disease Patients and Control Subjects
Cermakian, N., Waddington Lamont, E., Boudreau, P., & Boivin, D. B. (2011) · Journal of Biological Rhythms · doi:10.1177/0748730410395732 · Cited by 175 · see citing works
Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the “master clock”
Wu, Y., Fischer, D. F., Kalsbeek, A., Garidou, M., van der Vliet, J., Heijningen, C. L. V., Liu, R., Zhou, J., & Swaab, D. F. (2006) · The FASEB Journal · doi:10.1096/fj.05-4446fje · Cited by 175 · see citing works
Circadian rhythms and depression: Human psychopathology and animal models
Kronfeld-Schor, N., & Einat, H. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.020 · Cited by 166 · see citing works
Plasticity and specificity of the circadian epigenome
Masri, S., & Sassone‐Corsi, P. (2010) · Nature Neuroscience · doi:10.1038/nn.2668 · Cited by 132 · see citing works
Circadian profile and photic regulation of clock genes in the suprachiasmatic nucleus of a diurnal mammal arvicanthis ansorgei
Caldelas, I., Poirel, V.-J., Sicard, B., Pévet, P., & Challet, É. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00654-1 · Cited by 125 · see citing works
Cycle of period Gene Expression in a Diurnal Mammal ( Spermophilus tridecemlineatus ): Implications for Nonphotic Phase Shifting
Mrosovsky, N., Edelstein, K., Hastings, M. H., & Maywood, E. S. (2001) · Journal of Biological Rhythms · doi:10.1177/074873001129002141 · Cited by 109 · see citing works
Analysis of cell-cycle-specific gene expression in human cells as determined by microarrays and double-thymidine block synchronization
Shedden, K., & Cooper, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062569899 · Cited by 103 · see citing works
Proof-by-synthesis of the transcriptional logic of mammalian circadian clocks
Ukai‐Tadenuma, M., Kasukawa, T., & Ueda, H. R. (2008) · Nature Cell Biology · doi:10.1038/ncb1775 · Cited by 101 · see citing works
Oxysterols: Novel biologic roles for the 21st century
Javitt, N. B. (2007) · Steroids · doi:10.1016/j.steroids.2007.10.004 · Cited by 94 · see citing works
Experiences with a compound method for estimating the time since death
Henssge, C., Althaus, L. G., Bolt, J., Freislederer, A., Haffner, H. T., Henssge, C., Hoppe, B., & Schneider, V. (2000) · International Journal of Legal Medicine · doi:10.1007/s004149900090 · Cited by 93 · see citing works
Chronic unpredictable stress induces a reversible change of PER2 rhythm in the suprachiasmatic nucleus
Jiang, W., Li, S., Zhou, S., Sun, Y., Shi, J., & Lü, L. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.001 · Cited by 83 · see citing works
Sleep and manipulations of the sleep–wake rhythm in depression
Berger, M., Van Calker, D., & Riemann, D. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.108.s418.17.x · Cited by 82 · see citing works
Rapid-acting antidepressant strategies: mechanisms of action
Bunney, B. G., & Bunney, W. E. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000927 · Cited by 79 · see citing works
Self-citation
Estimation of the time of death based on the assessment of post mortem processes with emphasis on body cooling
Kaliszan, M., Häuser, R., & Kernbach‐Wighton, G. (2009) · Legal Medicine · doi:10.1016/j.legalmed.2008.12.002 · Cited by 77 · see citing works
Medicolegal investigation of death;: Guidelines for the application of pathology to crime investigation,
Fisher, M., & Spitz, W. U. (1973) · Medical Entomology and Zoology · Cited by 65 · see citing works
Sleep Electroencephalography in Depressive Illness a Collaborative Study by the World Health Organization
Mendlewicz, J., & Kerkhofs, M. (1991) · The British Journal of Psychiatry · doi:10.1192/bjp.159.4.505 · Cited by 62 · see citing works
Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathways
Hoffman, A. E., Zheng, T., Ba, Y., Stevens, R. G., Yi, C., Leaderer, D., & Zhu, Y. L. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-110 · Cited by 58 · see citing works
DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles
Evans, S. J., Choudary, P. V., Vawter, M. P., Li, J., Meador‐Woodruff, J. H., López, J. F., Burke, S., Thompson, R. C., Myers, R., Jones, E. G., et al. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00126-8 · Cited by 52 · see citing works
Self-citation
The negative transcription factor E4BP4 is associated with circadian clock protein PERIOD2
Ohno, T., Onishi, Y., & Ishida, N. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.084 · Cited by 46 · see citing works
Period gene expression in the diurnal degu (Octodon degus) differs from the nocturnal laboratory rat (Rattus norvegicus)
Vosko, A. M., Hagenauer, M. H., Hummer, D. L., & Lee, T. M. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90392.2008 · Cited by 45 · see citing works
Self-citation
Circadian Expression of Clock- and Tumor Suppressor Genes in Human Oral Mucosa
Zieker, D., Jenne, I., Koenigsrainer, I., Zdichavsky, M., Nieselt, K., Buck, K., Zieker, J., Beckert, S., Glatzle, J., Spanagel, R., et al. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000320547 · Cited by 44 · see citing works
Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex
Yang, S., Wang, K., Valladares, O., Hannenhalli, S. S., & Bućan, M. (2007) · Genome biology · doi:10.1186/gb-2007-8-11-r247 · Cited by 42 · see citing works
Day–night expression patterns of clock genes in the human pineal gland
Ackermann, K., Dehghani, F., Bux, R., Kauert, G. F., & Stehle, J. H. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00461.x · Cited by 26 · see citing works
Sample matching by inferred agonal stress in gene expression analyses of the brain
Li, J. Z., Meng, F., Tsavaler, L., Evans, S. J., Choudary, P. V., Tomita, H., Vawter, M. P., Walsh, D. M. A., Shokoohi, V., Chung, T. R., et al. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-336 · Cited by 19 · see citing works
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Fang, H., Tu, S., Sheng, J., & Shao, A. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14170 · Cited by 1,152 · see citing works
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Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0694-0 · Cited by 1,030 · see citing works
Sex-specific transcriptional signatures in human depression
Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4386 · Cited by 748 · see citing works
Diurnal transcriptome atlas of a primate across major neural and peripheral tissues
Mure, L. S., Le, H. D., Benegiamo, G., Chang, M. W., Ríos, L., Jillani, N., Ngotho, M., Kariuki, T., Dkhissi‐Benyahya, O., Cooper, H. M., et al. (2018) · Science · doi:10.1126/science.aao0318 · Cited by 783 · see citing works
Revisiting the Stress Concept: Implications for Affective Disorders
McEwen, B. S., & Akil, H. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.0733-19.2019 · Cited by 686 · see citing works
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Giuntella, O., Hyde, K., Saccardo, S., & Sadoff, S. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016632118 · Cited by 592 · see citing works
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Allada, R., & Bass, J. (2021) · New England Journal of Medicine · doi:10.1056/nejmra1802337 · Cited by 519 · see citing works
Disturbance of the Circadian System in Shift Work and Its Health Impact
Boivin, D. B., Boudreau, P., & Kosmadopoulos, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211064218 · Cited by 537 · see citing works
Circuits and functions of the lateral habenula in health and in disease
Hu, H., Cui, Y., & Yang, Y. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0292-4 · Cited by 471 · see citing works
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Fishbein, A. B., Knutson, K. L., & Zee, P. C. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148286 · Cited by 468 · see citing works
Melatonin and inflammation-Story of a double-edged blade
Hardeland, R. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12525 · Cited by 455 · see citing works
Treatment resistant depression: A multi-scale, systems biology approach
Akil, H., Gordon, J. A., Hen, R., Javitch, J. A., Mayberg, H. S., McEwen, B. S., Meaney, M. J., & Nestler, E. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.019 · Cited by 443 · see citing works
Self-citation
Effects of aging on circadian patterns of gene expression in the human prefrontal cortex
Chen, C.-Y., Logan, R. W., Ma, T., Lewis, D. A., Tseng, G. C., Sibille, E., & McClung, C. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508249112 · Cited by 277 · see citing works
Chronotype, circadian rhythm, and psychiatric disorders: Recent evidence and potential mechanisms
Zou, H., Zhou, H., Yan, R., Yao, Z., & Lu, Q. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.811771 · Cited by 279 · see citing works
Methods for determining time of death
Madea, B. (2016) · Forensic Science Medicine and Pathology · doi:10.1007/s12024-016-9776-y · Cited by 259 · see citing works
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Jagannath, A., Taylor, L., Wakaf, Z., Vasudevan, S. R., & Foster, F. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx240 · Cited by 258 · see citing works
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Daut, R. A., & Fonken, L. K. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.04.003 · Cited by 226 · see citing works
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Landgraf, D., Long, J. E., Proulx, C. D., Barandas, R., Malinow, R., & Welsh, D. K. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.03.1050 · Cited by 212 · see citing works
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Kervezee, L., Kosmadopoulos, A., & Boivin, D. B. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14216 · Cited by 216 · see citing works
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Kelley, K. W., Nakao-Inoue, H., Molofsky, A. V., & Oldham, M. C. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0216-z · Cited by 198 · see citing works
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Vadnie, C. A., & McClung, C. A. (2017) · Neural Plasticity · doi:10.1155/2017/1504507 · Cited by 199 · see citing works
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Self-citation
Clock Genes and Altered Sleep–Wake Rhythms: Their Role in the Development of Psychiatric Disorders
Charrier, A., Olliac, B., Roubertoux, P. L., & Tordjman, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050938 · Cited by 182 · see citing works
Agomelatine: Mechanism of action and pharmacological profile in relation to antidepressant properties
Guardiola‐Lemaitre, B., De Bodinat, C., Delagrange, P., Millan, M. J., Munoz, C., & Mocaër, E. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12720 · Cited by 182 · see citing works
Circadian rhythms and mood disorders: Time to see the light
Dollish, H. K., Tsyglakova, M., & McClung, C. A. (2023) · Neuron · doi:10.1016/j.neuron.2023.09.023 · Cited by 182 · see citing works
How sleep and wakefulness influence circadian rhythmicity: effects of insufficient and mistimed sleep on the animal and human transcriptome
Archer, S. N., & Oster, H. (2015) · Journal of Sleep Research · doi:10.1111/jsr.12307 · Cited by 171 · see citing works
Circadian Clock and Stress Interactions in the Molecular Biology of Psychiatric Disorders
Landgraf, D., McCarthy, M. J., & Welsh, D. K. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0483-7 · Cited by 170 · see citing works
The Role of Norepinephrine and Its α-Adrenergic Receptors in the Pathophysiology and Treatment of Major Depressive Disorder and Schizophrenia: A Systematic Review
Maletic, V., Eramo, A., Gwin, K., Offord, S. J., & Duffy, R. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00042 · Cited by 171 · see citing works
The Circadian System: A Regulatory Feedback Network of Periphery and Brain
Buijs, F. N., Mercado, L. L., Guzmán‐Ruiz, M. A., Guerrero‐Vargas, N. N., Romo‐Nava, F., & Buijs, R. M. (2016) · Physiology · doi:10.1152/physiol.00037.2015 · Cited by 158 · see citing works
A psychiatric disease-related circular RNA controls synaptic gene expression and cognition
Zimmerman, A. J., Hafez, A. K., Amoah, S. K., Rodriguez, B. A., Dell’Orco, M., Lozano, E., Hartley, B. J., Alural, B., Lalonde, J., Chander, P. N., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0653-4 · Cited by 152 · see citing works
Chronic Stress Induces Brain Region-Specific Alterations of Molecular Rhythms that Correlate with Depression-like Behavior in Mice
Logan, R. W., Edgar, N. M., Gillman, A. G., Hoffman, D., Zhu, X., & McClung, C. A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.01.011 · Cited by 154 · see citing works
Melatonin: A review of its potential functions and effects on neurological diseases
Günata, M., Parlakpınar, H., & Acet, A. (2019) · Revue Neurologique · doi:10.1016/j.neurol.2019.07.025 · Cited by 154 · see citing works
Neurodegeneration and the Circadian Clock
Hood, S., & Amir, S. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00170 · Cited by 150 · see citing works
Stress-Related and Circadian Secretion and Target Tissue Actions of Glucocorticoids: Impact on Health
Nicolaides, N. C., Charmandari, E., Kino, T., & Chrousos, G. P. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00070 · Cited by 149 · see citing works
Neuronal correlates of depression
Chaudhury, D., Liu, H., & Han, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2044-6 · Cited by 142 · see citing works
Circadian rhythms and addiction: Mechanistic insights and future directions.
Logan, R. W., Williams, W. P., & McClung, C. A. (2014) · Behavioral Neuroscience · doi:10.1037/a0036268 · Cited by 142 · see citing works
Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1
Cronin, P., McCarthy, M. J., Lim, A. S. P., Salmon, D. P., Galasko, D. R., Masliah, E., Jager, P. L. D., Bennett, D. A., & Desplats, P. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.10.003 · Cited by 140 · see citing works
Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors
Hurley, K., Ding, J., Villacorta-Martín, C., Herriges, M. J., Jacob, A., Vedaie, M., Alysandratos, K., Sun, Y. L., Lin, C. H., Werder, R. B., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2019.12.009 · Cited by 141 · see citing works
Neuropeptide and small transmitter coexistence: Fundamental studies and relevance to mental illness
Hökfelt, T., Barde, S., Xu, Z.-Q. D., Kuteeva, E., Rüegg, J., Le Maitre, E., Risling, M., Kehr, J., Ihnatko, R., Theodorsson, E., et al. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00106 · Cited by 139 · see citing works
Clocking in: chronobiology in rheumatoid arthritis
Buttgereit, F., Smolen, J. S., Coogan, A. N., & Cajochen, C. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.31 · Cited by 137 · see citing works
Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease
Johnson, M. R., Shkura, K., Langley, S. R., Delahaye‐Duriez, A., Srivastava, P. K., Hill, W. D., Rackham, O. J. L., Davies, G., Harris, S. E., Moreno‐Moral, A., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4205 · Cited by 132 · see citing works
Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi‐disciplinary literature review and agenda for future research from the ISBD task force on chronobiology
McCarthy, M. J., Gottlieb, J. F., Gonzalez, R., McClung, C. A., Alloy, L. B., Cain, S., Dulcis, D., Etain, B., Frey, B. N., Garbazza, C., et al. (2022) · Bipolar Disorders · doi:10.1111/bdi.13165 · Cited by 136 · see citing works
Psychiatric Disorders and Sleep Issues
Sutton, E. L. (2014) · Medical Clinics of North America · doi:10.1016/j.mcna.2014.06.009 · Cited by 119 · see citing works
The circadian system of patients with bipolar disorder differs in episodes of mania and depression
Nováková, M., Praško, J., Látalová, K., Sládek, M., & Sumová, A. (2015) · Bipolar Disorders · doi:10.1111/bdi.12270 · Cited by 123 · see citing works
A Circadian Genomic Signature Common to Ketamine and Sleep Deprivation in the Anterior Cingulate Cortex
Orozco-Solis, R., Montellier, E., Aguilar-Arnal, L., Sato, S., Vawter, M. P., Bunney, B. G., Bunney, W. E., & Sassone-Corsi, P. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.1176 · Cited by 119 · see citing works
Self-citation
Adrenal Clocks and the Role of Adrenal Hormones in the Regulation of Circadian Physiology
Leliavski, A., Dumbell, R., Ott, V., & Oster, H. (2014) · Journal of Biological Rhythms · doi:10.1177/0748730414553971 · Cited by 119 · see citing works
Circadian depression: A mood disorder phenotype
Carpenter, J. S., Crouse, J. J., Scott, E. M., Naismith, S. L., Wilson, C., Scott, J., Merikangas, K. R., & Hickie, I. B. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.045 · Cited by 114 · see citing works
Glucocorticoid hormones are both a major circadian signal and major stress signal: How this shared signal contributes to a dynamic relationship between the circadian and stress systems
Spencer, R. L., Chun, L. E., Hartsock, M. J., & Woodruff, E. R. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.12.005 · Cited by 113 · see citing works
Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder
McCarthy, M. J., Wei, H., Nievergelt, C. M., Stautland, A., Maihofer, A. X., Welsh, D. K., Shilling, P. D., Alda, M., Alliey‐Rodriguez, N., Anand, A., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0273-8 · Cited by 115 · see citing works
Role and possible mechanisms of Sirt1 in depression
Lu, G., Li, J., Zhang, H., Zhao, X., Yan, L.-J., & Yang, X. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8596903 · Cited by 106 · see citing works
Self-citation
FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory
Sawicka, K., Hale, C. R., Park, C. Y., Fak, J. J., Gresack, J. E., Driesche, S. J. V., Kang, J. J., Darnell, J. C., & Darnell, R. B. (2019) · eLife · doi:10.7554/elife.46919 · Cited by 113 · see citing works
Shared Transcriptional Signatures in Major Depressive Disorder and Mouse Chronic Stress Models
Scarpa, J. R., Fatma, M., Loh, Y. E., Traore, S. R., Stefan, T., Chen, T. H., Nestler, E. J., & Labonté, B. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.12.029 · Cited by 111 · see citing works
DEC1 and DEC2 Crosstalk between Circadian Rhythm and Tumor Progression
Sato, F., BHAWAL, U. K., Yoshimura, T., & Muragaki, Y. (2015) · Journal of Cancer · doi:10.7150/jca.13748 · Cited by 110 · see citing works
Diurnal rhythms in gene expression in the prefrontal cortex in schizophrenia
Seney, M. L., Cahill, K., Enwright, J. F., Logan, R. W., Huo, Z., Zong, W., Tseng, G., & McClung, C. A. (2019) · Nature Communications · doi:10.1038/s41467-019-11335-1 · Cited by 108 · see citing works
Variations in Phase and Amplitude of Rhythmic Clock Gene Expression across Prefrontal Cortex, Hippocampus, Amygdala, and Hypothalamic Paraventricular and Suprachiasmatic Nuclei of Male and Female Rats
Chun, L. E., Woodruff, E. R., Morton, S. J., Hinds, L. R., & Spencer, R. L. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730415598608 · Cited by 103 · see citing works
Evidence for widespread dysregulation of circadian clock progression in human cancer
Shilts, J., Chen, G., & Hughey, J. (2018) · PeerJ · doi:10.7717/peerj.4327 · Cited by 99 · see citing works
The human histaminergic system in neuropsychiatric disorders
Shan, L., Bao, A., & Swaab, D. F. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.12.008 · Cited by 101 · see citing works
Phenotyping of PER3 variants reveals widespread effects on circadian preference, sleep regulation, and health
Archer, S. N., Schmidt, C., Vandewalle, G., & Dijk, D. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.10.008 · Cited by 100 · see citing works
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target
Srivastava, P. K., van Eyll, J. M., Godard, P., Mazzuferi, M., Delahaye‐Duriez, A., Steenwinckel, J. V., Gressèns, P., Danis, B., Vandenplas, C., Foerch, P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06008-4 · Cited by 100 · see citing works
Circadian misalignment increases mood vulnerability in simulated shift work
Chellappa, S. L., Morris, C. J., & Scheer, F. A. J. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-75245-9 · Cited by 98 · see citing works
Circadian rhythms and pain
Bumgarner, J. R., Walker, W. H., & Nelson, R. J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.08.004 · Cited by 96 · see citing works
Allostasis, action and affect in depression: Insights from the theory of constructed emotion
Shaffer, C., Westlin, C., Quigley, K. S., Whitfield-Gabrieli, S., & Barrett, L. F. (2022) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-081219-115627 · Cited by 94 · see citing works
Motor-Activity Markers of Circadian Timekeeping Are Related to Ketamine’s Rapid Antidepressant Properties
Duncan, W. C., Slonena, E., Hejazi, N. S., Brutsche, N., Yu, K. C., Park, L., Ballard, E. D., & Zarate, C. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.03.011 · Cited by 93 · see citing works
Circadian rhythms have broad implications for understanding brain and behavior
Silver, R., & Kriegsfeld, L. J. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12593 · Cited by 92 · see citing works
Synchrony and desynchrony in circadian clocks: impacts on learning and memoryPreprint
Krishnan, H. C., & Lyons, L. C. (2015) · Learning & Memory · doi:10.1101/lm.038877.115 · Cited by 91 · see citing works
24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex
Lim, A. S. P., Srivastava, G. P., Yu, L., Chibnik, L. B., Xu, J., Buchman, A. S., Schneider, J. A., Myers, A., Bennett, D. A., & Jager, P. L. D. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004792 · Cited by 88 · see citing works
Retracted
Circadian regulation of slow waves in human sleep: Topographical aspects
Lázár, A. S., Lázár, Z. I., & Dijk, D. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.05.012 · Cited by 86 · see citing works
The circadian dynamics of the hippocampal transcriptome and proteome is altered in experimental temporal lobe epilepsy
Dębski, K. J., Ceglia, N., Ghestem, A., Ivanov, A., Brancati, G. E., Bröer, S., Bot, A. M., Müller, J. A., Schoch, S., Becker, A. J., et al. (2020) · Science Advances · doi:10.1126/sciadv.aat5979 · Cited by 84 · see citing works
Molecular Mechanism for Stress-Induced Depression Assessed by Sequencing miRNA and mRNA in Medial Prefrontal Cortex
Ma, K., Guo, L., Xu, A., Cui, S., & Wang, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159093 · Cited by 84 · see citing works
Coupling the Circadian Clock to Homeostasis: The Role of Period in Timing Physiology
Kim, P., Oster, H., Lehnert, H., Schmid, S. M., Salamat, N., Barclay, J. L., Maronde, E., Inder, W. J., & Rawashdeh, O. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00049 · Cited by 83 · see citing works
Circadian Rhythms and Mood Disorders: Are the Phenomena and Mechanisms Causally Related?
Bechtel, W. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00118 · Cited by 82 · see citing works
The role of CLOCK gene in psychiatric disorders: Evidence from human and animal research
Schuch, J. B., Genro, J. P., Bastos, C. R., Ghisleni, G., & Tovo‐Rodrigues, L. (2017) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32599 · Cited by 79 · see citing works
Sleep and dreaming are for important matters
Perogamvros, L., Dang-Vu, T. T., Desseilles, M., & Schwartz, S. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00474 · Cited by 77 · see citing works
The role of the circadian clock in animal models of mood disorders.
Landgraf, D., McCarthy, M. J., & Welsh, D. K. (2014) · Behavioral Neuroscience · doi:10.1037/a0036029 · Cited by 77 · see citing works
Diurnal and seasonal variation of the brain serotonin system in healthy male subjects
Matheson, G. J., Schain, M., Almeida, R., Lundberg, J., Cselényi, Z., Borg, J., Varrone, A., Farde, L., & Červenka, S. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.03.007 · Cited by 78 · see citing works
A systematic review of agomelatine-induced liver injury
Freiesleben, S. D., & Furczyk, K. (2015) · Journal of Molecular Psychiatry · doi:10.1186/s40303-015-0011-7 · Cited by 77 · see citing works
Sexually Dimorphic Changes of Hypocretin (Orexin) in Depression
Lu, J., Zhao, J., Balesar, R., Fronczek, R., Zhu, Q.-B., Wu, X.-Y., Hu, S.-H., Bao, A.-M., & Swaab, D. F. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.043 · Cited by 77 · see citing works
Circadian Rhythms of Perineuronal Net Composition
Pantazopoulos, H., Gisabella, B., Rexrode, L., Benefield, D., Yıldız, E., Seltzer, P., Valeri, J., Chelini, G., Reich, A., Ardelt, M., et al. (2020) · eNeuro · doi:10.1523/eneuro.0034-19.2020 · Cited by 73 · see citing works
Dysregulated fibroblast growth factor (FGF) signaling in neurological and psychiatric disorders
Turner, C. A., Eren‐Koçak, E., Inui, E. G., Watson, S. J., & Akil, H. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.10.003 · Cited by 75 · see citing works
Self-citation
Circadian Mechanisms Underlying Reward-Related Neurophysiology and Synaptic Plasticity
Parekh, P. K., & McClung, C. A. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00187 · Cited by 75 · see citing works
Circadian and photic modulation of daily rhythms in diurnal mammals
Yan, L., Smale, L., & Núñez, A. A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14172 · Cited by 75 · see citing works
Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body
Evans, J. A., Suen, T.-C., Callif, B. L., Mitchell, A. S., Castañón‐Cervantes, O., Baker, K. M., Kloehn, I., Baba, K., Teubner, B. J. W., Ehlen, J. C., et al. (2015) · BMC Biology · doi:10.1186/s12915-015-0157-x · Cited by 75 · see citing works
Nocturnal Wakefulness Is Associated With Next-Day Suicidal Ideation in Major Depressive Disorder and Bipolar Disorder
Ballard, E. D., Voort, J. L. V., Bernert, R. A., Luckenbaugh, D. A., Richards, E. M., Niciu, M. J., Furey, M. L., Duncan, W. C., & Zarate, C. A. (2016) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.15m09943 · Cited by 75 · see citing works
Inference of cell type content from human brain transcriptomic datasets illuminates the effects of age, manner of death, dissection, and psychiatric diagnosis
Hagenauer, M. H., Schulmann, A., Li, J. Z., Vawter, M. P., Walsh, D. M. A., Thompson, R. C., Turner, C. A., Bunney, W. E., Myers, R., Barchas, J. D., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200003 · Cited by 76 · see citing works
Self-citation
Altered Expression Pattern of Clock Genes in a Rat Model of Depression
Christiansen, S. L., Bouzinova, E., Fahrenkrug, J., & Wiborg, O. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw061 · Cited by 73 · see citing works
Machine learning identifies a compact gene set for monitoring the circadian clock in human blood
Hughey, J. (2017) · Genome Medicine · doi:10.1186/s13073-017-0406-4 · Cited by 72 · see citing works
Glymphatic Dysfunction: A Bridge Between Sleep Disturbance and Mood Disorders
Yan, T., Qiu, Y., Yu, X., & Yang, L. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.658340 · Cited by 75 · see citing works
Depression‐like behaviour in mice is associated with disrupted circadian rhythms in nucleus accumbens and periaqueductal grey
Landgraf, D., Long, J. E., & Welsh, D. K. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13085 · Cited by 72 · see citing works
Social jetlag and depression status: Results obtained from the Netherlands Study of Depression and Anxiety
Knapen, S. E., Riemersma-van der Lek, R. F., Antypa, N., Meesters, Y., Penninx, B. W. J. H., & Schoevers, R. A. (2018) · Chronobiology International · doi:10.1080/07420528.2017.1374966 · Cited by 70 · see citing works
Circadian neurons in the lateral habenula: Clocking motivated behaviors
Mendoza, J. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.06.013 · Cited by 69 · see citing works
Molecular analyses of circadian gene variants reveal sex-dependent links between depression and clocks
Shi, S.-Q., White, M. J., Borsetti, H., Pendergast, J. S., Hida, A., Ciarleglio, C. M., de Verteuil, P. A., Cadar, A. G., Cala, C. M., McMahon, D. G., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.9 · Cited by 70 · see citing works
Implications of Circadian Rhythm in Dopamine and Mood Regulation
Kim, J., Jang, S.-W., Choe, H. K., Chung, S., Son, G. H., & Kim, K. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.0065 · Cited by 69 · see citing works
The emergence of melatonin in oncology: Focus on colorectal cancer
Gil‐Martín, E., Egea, J., Reiter, R. J., & Romero, A. (2019) · Medicinal Research Reviews · doi:10.1002/med.21582 · Cited by 67 · see citing works
The role of the circadian system in the etiology of depression
de Leeuw, M., Verhoeve, S. I., van der Wee, N. J. A., van Hemert, A. M., Vreugdenhil, E., & Coomans, C. P. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105383 · Cited by 72 · see citing works
Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer’s disease
Lim, A. S. P., Klein, H., Yu, L., Chibnik, L. B., Ali, S., Xu, J., Bennett, D. A., & Jager, P. L. D. (2017) · Nature Communications · doi:10.1038/ncomms14931 · Cited by 66 · see citing works
Contributions of the lateral habenula to circadian timekeeping
Baño‐Otálora, B., & Piggins, H. D. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.06.007 · Cited by 63 · see citing works
Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms
McCarthy, M. J., Roux, M. J. L., Wei, H., Beesley, S., Kelsoe, J. R., & Welsh, D. K. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.017 · Cited by 65 · see citing works
Microglia recapitulate a hematopoietic master regulator network in the aging human frontal cortex
Wehrspaun, C. C., Haerty, W., & Ponting, C. P. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.04.008 · Cited by 64 · see citing works

Major depressive disorder: A loss of circadian synchrony?
Edgar, N. M., & McClung, C. A. (2013) · BioEssays · doi:10.1002/bies.201300086 · Cited by 52 · see citing works
357. Altered Molecular Rhythmicity of the Human Nucleus Accumbens in Major Depressive Disorder
Perez, M., Yin, R., Shelton, M., Horan, N. L., Scott, M. R., Glausier, J. R., Lewis, D., Tseng, G., McClung, C. A., Seney, M. L., et al. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.03.591
Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder
Bunney, B. G., Li, J. Z., Walsh, D. M. A., Stein, R., Vawter, M. P., Cartagena, P. M., Barchas, J. D., Schatzberg, A. F., Myers, R., Watson, S. J., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.138 · Cited by 185 · see citing works
Self-citation
EXPERT REVIEW Circadian dysregulation of clock genes: clues to rapid
(2016)
Mining key circadian biomarkers for major depressive disorder by integrating bioinformatics and machine learning
Shi, Y., Zhu, J., Hou, C., Li, X., & Tong, Q. (2024) · Aging · doi:10.18632/aging.205930 · Cited by 4 · see citing works

Authors: Li, J. Z., Bunney, B. G., Meng, F., Hagenauer, M. H., Walsh, D. M., Vawter, M. P., Evans, S. J., Choudary, P. V., Cartagena, P., Barchas, J. D., Schatzberg, A. F., Jones, E. G., Myers, R. M., Watson, S. J., Akil, H., & Bunney, W. E.
Affiliations: University of Michigan (US)
University of California, Irvine (US)
University of California, Davis (US)
Weill Cornell Medicine (US)
Stanford University (US)
HudsonAlpha Institute for Biotechnology (US)
ORCID: Li, Jun Z.
Bunney, Blynn G.
Meng, Fan
Hagenauer, Megan H.
Walsh, David M.
Vawter, Marquis P.
Evans, Simon J.
Choudary, Prabhakara V.
Barchas, Jack D.
Schatzberg, Alan F.
Jones, Edward G.
Myers, Richard M.
Watson, Stanley J.
Akil, Huda
Bunney, William E.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2013-05-13
Volume: 110
Issue: 24
Pages: 9950-9955
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1305814110
PMC: PMC3683716
OpenAlex: W2027764072
Cited by: 589
References: 59
Citations by year: 2026: 26 · 2025: 37 · 2024: 44 · 2023: 39 · 2022: 52 · 2021: 54 · 2020: 60 · 2019: 49 · 2018: 49 · 2017: 48 · 2016: 35 · 2015: 52 · 2014: 35 · 2013: 9
FWCI: 23.61
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: other-oa
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (NIMH R01MH085801)
National Institute of Mental Health (P50MH60398, R01MH085801, P50MH060398)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: major depressive disorder, circadian rhythm, clock genes, gene expression rhythms, human brain transcriptome, postmortem brain, dorsolateral prefrontal cortex, anterior cingulate cortex, hippocampus, amygdala, nucleus accumbens, cerebellum, Bmal1, per gene, DBP, BHLHE40, BHLHE41, mood disorders
MeSH terms: Adult, Aged, Autopsy, Brain, Circadian Rhythm, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Homeodomain Proteins, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Basic Helix-Loop-Helix Proteins, ARNTL Transcription Factors, Period Circadian Proteins, Nuclear Receptor Subfamily 1, Group D, Member 1, Circadian Clocks

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Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

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