An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy

Millan, Mark J.·2013·Neuropharmacology

Cites (1,085)

Items 801–1,000 of 1,085

  1. Brief Report: Autistic Symptoms, Developmental Regression, Mental Retardation, Epilepsy, and Dyskinesias in CNS Folate Deficiency
    Paolo M. Moretti, Sarika U. Peters, Daniela del Gaudio, Trilochan Sahoo, Κ. Hyland, Teodoro Bottiglieri, Robert James Hopkin, Elizabeth Peach, Sang Hee Min, David Goldman et al. · 2007 · Journal of Autism and Developmental Disorders
  2. CDKL5-Related Disorders: From Clinical Description to Molecular Genetics
    Nadia Bahi‐Buisson, Thierry Bienvenu · 2011 · Molecular Syndromology
  3. An Update on Pharmacologic Treatments for Autism Spectrum Disorders
    Bryan H. King, Jeff Q. Bostic · 2006 · Child and Adolescent Psychiatric Clinics of North America
  4. Regulation of non-coding RNA networks in the nervous system—What's the REST of the story?
    Irfan Qureshi, Mark F. Mehler · 2009 · Neuroscience Letters
  5. Concise Review: The Promise of Human Induced Pluripotent Stem Cell-Based Studies of Schizophrenia
    Kristen Brennand, Fred H. Gage · 2011 · Stem Cells
  6. Genomic imprinting in the development and evolution of psychotic spectrum conditions
    Bernard J. Crespi · 2008 · Biological reviews/Biological reviews of the Cambridge Philosophical Society
  7. The DNA repair protein, O6-Methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein
    Kalkunte S. Srivenugopal, Francis Ali‐Osman · 2002 · Oncogene
  8. Histone chaperones link histone nuclear import and chromatin assembly
    Kristin M. Keck, Lucy F. Pemberton · 2011 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  9. Class I histone deacetylase inhibition ameliorates social cognition and cell adhesion molecule plasticity deficits in a rodent model of autism spectrum disorder
    Andrew Foley, Shane P. Gannon, Nanette Rombach, Alison Prendergast, Claire E. Barry, Andrew W. Cassidy, Ciaran M. Regan · 2012 · Neuropharmacology
  10. Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome
    Siarey, Richard J., Kline‐Burgess, Angelina, Cho, Madelaine, Balbo, Andrea, Best, Tyler K., Harashima, Chie, Klann, Eric, Galdzicki, Zygmunt · 2006 · Journal of Neurochemistry
  11. A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice
    Shiori Ogawa, Chang‐Hyuk Kwon, Jing Zhou, Della Koovakkattu, Luis F. Parada, Christopher M. Sinton · 2007 · Brain Research
  12. The complex relationship between folate/homocysteine metabolism and risk of Down syndrome
    Fabio Coppedè · 2009 · Mutation Research/Reviews in Mutation Research
  13. Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons
    Martin Fuhrmann, Tobias Bittner, Gerda Mitteregger, Nicole Haider, Sven Moosmang, Hans A. Kretzschmar, Jochen Wolfgang Herms · 2006 · Journal of Neurochemistry
  14. HPA axis function and symptoms in adolescents at clinical high risk for schizophrenia
    Corcoran, C.M., Smith, C., McLaughlin, D., Auther, A., Malaspina, D., Cornblatt, B. · 2012 · Schizophrenia Research
  15. A non-invasive method to isolate the neuronal linage from the nasal epithelium from schizophrenic and bipolar diseases
    Gloria Benítez‐King, Agustín Riquelme, Laura I. Ortiz-López, Carlos Berlanga, M.S. Rodríguez-Verdugo, F. Romo, Eduardo Calixto, Héctor Solís‐Chagoyán, M. Jímenez, Luis M. Montaño et al. · 2011 · Journal of Neuroscience Methods
  16. The role of deubiquitinating enzymes in chromatin regulation
    Boyko S. Atanassov, Evangelia Koutelou, Sharon Dent · 2010 · FEBS Letters
  17. DNA methylation changes in schizophrenia and bipolar disorder
    Caroline Connor, Schahram Akbarian · 2008 · Epigenetics
  18. PI3K/mTORC1 activation in hamartoma syndromes: Therapeutic prospects
    Vera P. Krymskaya, Elena A. Goncharova · 2009 · Cell Cycle
  19. Fragile X-associated tremor/ataxia syndrome
    Maureen A. Leehey, Paul J. Hagerman · 2011 · Handbook of clinical neurology
  20. Learning under stress: A role for the neural cell adhesion molecule NCAM
    Reto Bisaz, Lisa Conboy, Carmen Sandi · 2008 · Neurobiology of Learning and Memory
  21. SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome
    Rea Erika Biacsi, Daman Kumari, Karen Usdin · 2008 · PLoS Genetics
  22. Impact of a microRNA MIR137 Susceptibility Variant on Brain Function in People at High Genetic Risk of Schizophrenia or Bipolar Disorder
    Heather Clare Whalley, Martina Papmeyer, Liana Romaniuk, Emma Sprooten, Eve C. Johnstone, Jérémy Hall, Stephen M. Lawrie, Kathryn Louise Evans, Hilary P. Blumberg, Jessika Elizabeth Sussmann et al. · 2012 · Neuropsychopharmacology
  23. MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction
    Bin Xu, Pei-Ken Hsu, Maria Karayiorgou, Joseph A. Gogos · 2012 · Neurobiology of Disease
  24. ICF Syndrome Mutations Cause a Broad Spectrum of Biochemical Defects in DNMT3B-Mediated De Novo DNA Methylation
    Amir H. Moarefi, Frederic L. Chedin · 2011 · Journal of Molecular Biology
  25. Isoform-Specific Toxicity of Mecp2 in Postmitotic Neurons: Suppression of Neurotoxicity by FoxG1
    Somasish Ghosh Dastidar, Farah H. Bardai, Chi Ma, Valerie J. Price, Varun Rawat, Pragya Verma, Vinodh Narayanan, Santosh R. D’Mello · 2012 · Journal of Neuroscience
  26. Histone deacetylase inhibitors decrease reelin promoter methylation in vitro
    Colin P. Mitchell, Ying Chen, Marija Kundaković, Erminio Costa, Dennis R. Grayson · 2005 · Journal of Neurochemistry
  27. Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype
    Matthew W. State, John M. Greally, Adam C. Cuker, Peter N. Bowers, Octavian Henegariu, Thomas M. Morgan, Murat Günel, Michael L. DiLuna, Robert A. King, Carol J. Nelson-Williams et al. · 2003 · Proceedings of the National Academy of Sciences
  28. Zinc-Finger Nucleases for Somatic Gene Therapy: The Next Frontier
    Shamim H. Rahman, Morgan L. Maeder, J. Keith Joung, Toni Cathomen · 2011 · Human Gene Therapy
  29. Aberrant RNA processing events in neurological disorders
    Karen Anthony, Jean‐Marc Gallo · 2010 · Brain Research
  30. The role of fragile X mental retardation protein in major mental disorders
    Fatemi, S. Hossein, Folsom, Timothy D. · 2011 · Neuropharmacology
  31. The Genetic Variation of RELN Expression in Schizophrenia and Bipolar Disorder
    Galit Ovadia, Sagiv Shifman · 2011 · PLoS ONE
  32. Long nuclear-retained non-coding RNAs and allele-specific higher-order chromatin organization at imprinted snoRNA gene arrays
    Patrice Vitali, Hélène Royo, Virginie Marty, Marie‐Line Bortolin‐Cavaillé, Jérôme Cavaillé · 2009 · Journal of Cell Science
  33. Are we studying and treating schizophrenia correctly?
    Neal R. Swerdlow · 2011 · Schizophrenia Research
  34. Epigenetics in Autism and Other Neurodevelopmental Diseases
    Kunio Miyake, Takae Hirasawa, Tsuyoshi Koide, Takeo Kubota · 2012 · Advances in experimental medicine and biology
  35. Regulation of DNA methylation activity through Dnmt3L promoter methylation by Dnmt3 enzymes in embryonic development
    Ye-Guang Hu, Ryutaro Hirasawa, Jia-Lei Hu, Kenichiro Hata, Chunliang Li, Ying Jin, Taiping Chen, En Li, Muriel Rigolet, E. Viégas-Pèquignot et al. · 2008 · Human Molecular Genetics
  36. Homology modeling, docking and structure-based pharmacophore of inhibitors of DNA methyltransferase
    Jakyung Yoo, José L. Medina‐Franco · 2011 · Journal of Computer-Aided Molecular Design
  37. Modeling the functional genomics of autism using human neurons
    Geneviève Konopka, Eric Wexler, E Rosen, Zohar Mukamel, Gregory E. Osborn, L Chen, Daning Lu, Fuying Gao, Kun Gao, Jennifer K. Lowe et al. · 2011 · Molecular Psychiatry
  38. Phosphorylation of histone H3(T118) alters nucleosome dynamics and remodeling
    Justin A. North, Sarah Javaid, Michelle B. Ferdinand, Nilanjana Chatterjee, Jonathan W. Picking, Matthew A. Shoffner, Robin J. Nakkula, Blaine Bartholomew, Jennifer J. Ottesen, Richard A. Fishel et al. · 2011 · Nucleic Acids Research
  39. Culture and education: new frontiers in brain plasticity
    Daniel Ansari · 2011 · Trends in Cognitive Sciences
  40. Early continuous inhibition of group 1 mGlu signaling partially rescues dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome
    Su, Tao, Fan, Hong-Xing, Jiang, Tao, Sun, Wei-Wen, Den, Wei-Yi, Gao, Mei-Mei, Chen, Sheng-Qiang, Zhao, Qi-Hua, Yi, Yong-Hong · 2011 · Psychopharmacology
  41. Human endogenous retrovirus type W (HERV-W) in schizophrenia: A new avenue of research at the gene–environment interface
    Marion Leboyer, Ryad Tamouza, Dominique J Charron, Raphaël Faucard, Hervé Perron · 2011 · The World Journal of Biological Psychiatry
  42. Gene–environment interaction during early development in the heterozygous reeler mouse: Clues for modelling of major neurobehavioral syndromes
    Giovanni Laviola, Elisa Ognibene, Emilia Romano, Walter Adriani, Flavio Keller · 2008 · Neuroscience & Biobehavioral Reviews
  43. Imprinting regulates mammalian snoRNA-encoding chromatin decondensation and neuronal nucleolar size
    Karen Leung, Roxanne O. Vallero, Amanda J. DuBose, James L. Resnick, Janine M. LaSalle · 2009 · Human Molecular Genetics
  44. Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease
    Jennifer Lee, Pengbo Zhou · 2012 · Frontiers in Oncology
  45. Pharmacological Treatment Options for Autism Spectrum Disorders in Children and Adolescents
    Thomas J. Leskovec, Brieana M. Rowles, Robert L. Findling · 2008 · Harvard Review of Psychiatry
  46. Environmental Studies of Schizophrenia Through the Prism of Epigenetics
    Gabriel Oh, Artūras Petronis · 2008 · Schizophrenia Bulletin
  47. Methyl CpG-binding Protein Isoform MeCP2_e2 Is Dispensable for Rett Syndrome Phenotypes but Essential for Embryo Viability and Placenta Development
    Masayuki Itoh, Candice Ginn T. Tahimic, Shuhei Ide, Akihiro Otsuki, Toshikuni Sasaoka, Shigeru Noguchi, Mitsuo Oshimura, Yu‐ichi Goto, Akihiro Kurimasa · 2012 · Journal of Biological Chemistry
  48. Phosphatase and Tensin Homolog (PTEN) Gene Mutations and Autism: Literature Review and a Case Report of a Patient With Cowden Syndrome, Autistic Disorder, and Epilepsy
    Sara Conti, Maria Condò, Annio Posar, Francesca Mari, Nicoletta Resta, Alessandra Renieri, Iria Neri, Annalisa Patrizi, Antonia Parmeggiani · 2011 · Journal of Child Neurology
  49. MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation
    Malaika K. Singleton, Michael L. Gonzales, Karen Leung, Dag H. Yasui, Diane I. Schroeder, Keith W. Dunaway, Janine M. LaSalle · 2011 · Neurobiology of Disease
  50. Preliminary evidence for involvement of the folate gene polymorphism 19bp deletion-DHFR in occurrence of autism
    Michelle C. Adams, Mark David Lucock, JOHN E. STUART, Sean Fardell, Kerrie Baker, Xiaowei Ng · 2007 · Neuroscience Letters
  51. TCF4, Schizophrenia, and Pitt-Hopkins Syndrome
    Derek J. Blake, Marc P. Forrest, Ria M. Chapman, Caroline L. Tinsley, Michael C. O’Donovan, Michael John Owen · 2010 · Schizophrenia Bulletin
  52. Histone H1 Poly[ADP]-Ribosylation Regulates the Chromatin Alterations Required for Learning Consolidation
    Ángela Fontán‐Lozano, Irene Suárez‐Pereira, Angélica Horrillo, Yaiza del Pozo Martín, Abdelkrim Hmadcha, Ángel Manuel Carrión · 2010 · Journal of Neuroscience
  53. Imprinted noncoding RNAs
    Jo Peters, Joan E. Robson · 2008 · Mammalian Genome
  54. Epigenetic gene regulation in the adult mammalian brain: Multiple roles in memory formation
    Farah D. Lubin · 2011 · Neurobiology of Learning and Memory
  55. A novel classification system to predict the pathogenic effects of CHD7 missense variants in CHARGE syndrome
    Jorieke E. H. Bergman, Nicole Janssen, Almer M. van der Sloot, Hermien E. K. de Walle, Jeroen Schoots, Nanna Dahl Rendtorff, Lisbeth Tranebjærg, Lies H. Hoefsloot, Conny M.A. van Ravenswaaij‐Arts, Robert M.W. Hofstra · 2012 · Human Mutation
  56. Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders
    De Rubeis, Silvia, Bagni, Claudia · 2011 · Journal of Neurodevelopmental Disorders
  57. Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases
    James Dowden, Wei Hong, Richard V. Parry, Richard A. Pike, Stephen Geoffrey Ward · 2010 · Bioorganic & Medicinal Chemistry Letters
  58. Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders
    Paola A. Spadaro, Timothy William Bredy · 2012 · Frontiers in Genetics
  59. Human pluripotent stem cells for disease modelling and drug screening
    Yves Maury, Morgane Gauthier, Marc Peschanski, Cécile Martinat · 2011 · BioEssays
  60. The paternal hidden agenda: Epigenetic inheritance through sperm chromatin
    Deepika Puri, Jyotsna Dhawan, Rakesh K. Mishra · 2010 · Epigenetics
  61. DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures
    Michael Faller, Daniel B. Toso, Michio Matsunaga, Ivo C. Atanasov, Rachel Senturia, Yanqiu Chen, Z. Hong Zhou, Feng Guo · 2010 · RNA
  62. Disentangling the Myriad Genomics of Complex Disorders, Specifically Focusing on Autism, Epilepsy, and Schizophrenia
    Martin Poot, Jasper J. van der Smagt, Eva H. Brilstra, Thomas Bourgeron · 2011 · Cytogenetic and Genome Research
  63. Reading, writing and editing methylated lysines on histone tails: new insights from recent structural studies
    Neil Justin, Valeria De Marco, Rein Aasland, Steve J. Gamblin · 2010 · Current Opinion in Structural Biology
  64. Treatment with valproic acid ameliorates ADHD symptoms in fragile X syndrome boys
    Torrioli, MariaGiulia, Vernacotola, Silvia, Setini, Chiara, Bevilacqua, Francesca, Martinelli, Diego, Snape, Mike, Hutchison, Julie A, Di Raimo, Francesca Romana, Tabolacci, Elisabetta, Neri, Giovanni · 2010 · American Journal of Medical Genetics Part A
  65. Regulation of Alternative Splicing by snoRNAs
    Shivendra Kishore, Stefan Stamm · 2006 · Cold Spring Harbor Symposia on Quantitative Biology
  66. Biology and applications of small nucleolar RNAs
    Tomaž Bratkovič, Boris Rogelj · 2011 · Cellular and Molecular Life Sciences
  67. Histone acetylation deficits in lymphoblastoid cell lines from patients with Rubinstein–Taybi syndrome
    José P. López‐Atalaya, Cristina Gervasini, Federica Mottadelli, Silvia Spena, Maria Piccione, Gioacchino Scarano, Angelo Selicorni, Ángel Barco, Lidia Larizza · 2011 · Journal of Medical Genetics
  68. Matrix Metalloproteinases and Minocycline: Therapeutic Avenues for Fragile X Syndrome
    Saul S. Siller, Kendal S. Broadie · 2012 · Neural Plasticity
  69. The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice
    Maria Fernanda Vinueza Veloz, Ronald A.M. Buijsen, Rob Willemsen, Alexander Cupido, Laurens W. J. Bosman, Sebastiaan K. E. Koekkoek, Jan-Willem Potters, Ben A. Oostra, Chris I. De Zeeuw · 2012 · Genes Brain & Behavior
  70. Genetic and cognitive windows into circuit mechanisms of psychiatric disease
    P. Alexander Arguello, Joseph A. Gogos · 2011 · Trends in Neurosciences
  71. Cognitive remediation for schizophrenia: current status, biological correlates and predictors of response
    Matthew M. Kurtz · 2012 · Expert Review of Neurotherapeutics
  72. It takes guts to grow a brain: Increasing evidence of the important role of the intestinal microflora in neuro‐ and immune‐modulatory functions during development and adulthood
    Diamond, Betty, Huerta, Patricio T., Tracey, Kevin, Volpe, Bruce T. · 2011 · BioEssays
  73. Immunosuppression Using the Mammalian Target of Rapamycin (mTOR) Inhibitor Everolimus: Pilot Study Shows Significant Cognitive and Affective Improvement
    Undine Emmi Lang, J. Heger, Manuel Wilbring, Markus Domula, Klaus Matschke, Sems‐Malte Tugtekin · 2009 · Transplantation Proceedings
  74. Neurexin-1 and Frontal Lobe White Matter: An Overlapping Intermediate Phenotype for Schizophrenia and Autism Spectrum Disorders
    Aristotle N. Voineskos, Tristram A. P. Lett, Jason P. Lerch, Arun Kumar Tiwari, Stephanie Hope Ameis, Tarek K. Rajji, Daniel J. Müller, Benoit H. Mulsant, James L. Kennedy · 2011 · PLoS ONE
  75. 5-HT2C Receptor Agonists and the Control of Appetite
    Jason C. G. Halford, Joanne Allison Harrold · 2011 · Handbook of experimental pharmacology
  76. Klinefelter syndrome as a window on the aetiology of language and communication impairments in children: the neuroligin–neurexin hypothesis
    Dorothy Bishop, Gaia Scerif · 2011 · Acta Paediatrica
  77. Behavioral and Cerebellar Transmission Deficits in Mice Lacking the Autism-Linked Gene Islet Brain-2
    Giza, Joanna, Urbanski, Michael J., Prestori, Francesca, Bandyopadhyay, Bhaswati, Yam, Annie, Friedrich, Victor, Kelley, Kevin, D'Angelo, Egidio, Goldfarb, Mitchell · 2010 · The Journal of Neuroscience
  78. Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137
    E. Cummings, Gary J Donohoe, April Hargreaves, S. Moore, Ciara Fahey, Timothy G. Dinan, Colm McDonald, E. O’Callaghan, F. Anthony O’Neill, John L. Waddington et al. · 2012 · Neuroscience Letters
  79. Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome
    Wanda S. Layman, E. A. Hurd, Donna M. Martin · 2011 · Human Molecular Genetics
  80. Activation of Group II Metabotropic Glutamate Receptors Promotes DNA Demethylation in the Mouse Brain
    Francesco Matrisciano, Erbo Dong, David P. Gavin, Ferdinando Nicoletti, Alessandro Guidotti · 2011 · Molecular Pharmacology
  81. Current Management of Tuberous Sclerosis Complex
    D. Krueger, D. Franz · 2008 · Paediatric drugs
  82. Variation in the major histocompatibility complex [MHC] gene family in schizophrenia: Associations and functional implications
    Monojit Debnath, Dara M. Cannon, Ganesan Venkatasubramanian · 2012 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
  83. Pharmacology of epigenetics in brain disorders
    Pritika J. Narayan, Mike Dragunow · 2009 · British Journal of Pharmacology
  84. Reversibility of functional deficits in experimental models of Rett syndrome
    Cobb, Stuart, Guy, Jacky, Bird, Adrian · 2010 · Biochemical Society Transactions
  85. Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader–Willi syndrome
    Dinko Relkovic, Christine M. Doe, Trevor Humby, Karen A. Johnstone, James L. Resnick, Anthony John Holland, Jim J. Hagan, Lawrence S. Wilkinson, Anthony R Isles · 2009 · European Journal of Neuroscience
  86. The major histocompatibility complex and autism spectrum disorder
    Needleman, Leigh A., McAllister, A. Kimberley · 2012 · Developmental Neurobiology
  87. Protein Components of the microRNA Pathway and Human Diseases
    Marjorie P. Perron, Patrick Provost · 2008 · Methods in molecular biology
  88. DiGeorge Critical Region 8 (DGCR8) Is a Double-cysteine-ligated Heme Protein
    Ian Barr, Aaron T. Smith, Rachel Senturia, Yanqiu Chen, Brooke D. Scheidemantle, Judith N. Burstyn, Feng Guo · 2011 · Journal of Biological Chemistry
  89. MicroRNA in the regulation and expression of serotonergic transmission in the brain and other tissues
    Mark John Millan · 2011 · Current Opinion in Pharmacology
  90. Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype–phenotype correlation
    Sinitdhorn Rujirabanjerd, John W. Nelson, Patrick S. Tarpey, Anna Hackett, Sarah Edkins, Frances Lucy Raymond, Charles E. Schwartz, GILLIAN M. TURNER, Shigeki Iwase, Yang Shi et al. · 2009 · European Journal of Human Genetics
  91. Missense mutations in the DNA-binding/dimerization domain of NFIX cause Sotos-like features
    Yuriko Yoneda, Hirotomo Saitsu, Mayumi Touyama, Yoshio Makita, Akie Miyamoto, Keisuke Hamada, Naohiro Kurotaki, Hiroaki Tomita, Kiyomi Nishiyama, Yoshinori Tsurusaki et al. · 2012 · Journal of Human Genetics
  92. Teachers in the wild
    Gergely Csibra · 2007 · Trends in Cognitive Sciences
  93. Aggregated proteins in schizophrenia and other chronic mental diseases
    Carsten Korth · 2012 · Prion
  94. DNA methylation, the early-life social environment and behavioral disorders
    Moshe Szyf · 2011 · Journal of Neurodevelopmental Disorders
  95. Valproate for schizophrenia
    Christian J. Schwarz, Anja Volz, Chunbo Li, Stefan Leucht · 2008 · Cochrane Database of Systematic Reviews
  96. Social Phenotypes in Neurogenetic Syndromes
    Carl Feinstein, Sonia Singh · 2007 · Child and Adolescent Psychiatric Clinics of North America
  97. Neurodevelopmental defects resulting from ATRX overexpression in transgenic mice
    Nathalie G. Bérubé · 2002 · Human Molecular Genetics
  98. Abnormal folate metabolism in mothers with Down syndrome offspring: Review of the literature
    Tom K.A.B. Eskes · 2005 · European Journal of Obstetrics & Gynecology and Reproductive Biology
  99. A 1q42 deletion involving DISC1, DISC2, and TSNAX in an autism spectrum disorder
    Jaime M. Williams, T. Beck, David M. Pearson, Monica B. Proud, Sau Wai Cheung, Daryl A. Scott · 2009 · American Journal of Medical Genetics Part A
  100. A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing
    Steven W. Long, Jenny Y. Y. Ooi, Peter M. Yau, Peter L. Jones · 2010 · Bioscience Reports
  101. Autism spectrum disorders and underlying brain pathology in CHARGE association
    Maria Johansson, Maria Råstam, Eva Billstedt, Susanna Danielsson, Kerstin Strömland, Marilyn T. Miller, Christopher Gillberg · 2005 · Developmental Medicine & Child Neurology
  102. Plant homeodomain fingers form a helping hand for transcription
    Klaus Fortschegger, Ramin Shiekhattar · 2011 · Epigenetics
  103. A Fox stops the Wnt: implications for forebrain development and diseases
    Cathy Danesin, Corinne Houart · 2012 · Current Opinion in Genetics & Development
  104. The penetrance of an epigenetic trait in mice is progressively yet reversibly increased by selection and environment
    Jennifer E. Cropley, Thurston H. Y. Dang, David I. K. Martin, Catherine M. Suter · 2012 · Proceedings of the Royal Society B Biological Sciences
  105. The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression
    Julia Robertson, Adam B. Robertson, Arne Klungland · 2011 · Biochemical and Biophysical Research Communications
  106. Pitt-Hopkins Syndrome
    Maarit M. Peippo, Jaakko Ignatius · 2011 · Molecular Syndromology
  107. Disruption of the epigenetic code: An emerging mechanism in mental retardation
    Hans van Bokhoven, Jamie M. Kramer · 2010 · Neurobiology of Disease
  108. A novel nonsense mutation in CUL4B gene in three brothers with X‐linked mental retardation syndrome
    Magdalena Badura‐Stronka, Aleksander Jamsheer, Anna Materna‐Kiryluk, Anna Sowińska‐Seidler, Krzysztof Kiryluk, Bartłomiej Budny, Anna Latos‐Bieleńska · 2009 · Clinical Genetics
  109. A novel nonsense mutation in KDM5C/JARID1C gene causing intellectual disability, short stature and speech delay
    Cíntia Barros Santos-Rebouças, Natalia Fintelman Rodrigues, Lars Riff Jensen, Andreas Walter Kuss, Márcia Gonçalves Ribeiro, Mário Campos, Jussara Mendonça dos Santos, Márcia Mattos Gonçalves Pimentel · 2011 · Neuroscience Letters
  110. Epigenetics of Schizophrenia
    Schahram Akbarian · 2010 · Current topics in behavioral neurosciences
  111. An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases
    Anup K. Upadhyay, Dante Rotili, Ji Woong Han, Ruogu Hu, Yanqi Chang, Donatella Labella, Xing Zhang, Young‐sup Yoon, Antonello Mai, Xiaodong Cheng · 2011 · Journal of Molecular Biology
  112. Epigenomic communication systems in humans and honey bees: From molecules to behavior
    George L. Gabor Miklos, Ryszard Maleszka · 2010 · Hormones and Behavior
  113. Molecular Therapies for Tuberous Sclerosis and Neurofibromatosis
    Franz, David Neal, Weiss, Brian D. · 2012 · Current Neurology and Neuroscience Reports
  114. Protein phosphatase 1-dependent transcriptional programs for long-term memory and plasticity
    Johannes Gräff, Kyoko Koshibu, Anne Jouvenceau, P. Dutar, Isabelle M. Mansuy · 2010 · Learning & Memory
  115. ATR-X mutations cause impaired nuclear location and altered DNA binding properties of the XNP/ATR-X protein
    Carlos Cardoso, Yves Lutz, Cecile Mignon · 2000 · Journal of Medical Genetics
  116. Treating the Cognitive Deficits of Schizophrenia with Alpha4Beta2 Neuronal Nicotinic Receptor Agonists
    Richard J. Radek, Kathy L. Kohlhaas, Lynne E. Rueter · 2009 · Current Pharmaceutical Design
  117. Trisomy 21: From Chromosomes to Mental Retardation
    Pierre L. Roubertoux, Bernard Kerdelhué · 2006 · Behavior Genetics
  118. Regulation of alternative splicing by short non-coding nuclear RNAs
    Amit Khanna, Stefan Stamm · 2010 · RNA Biology
  119. Emerging Pharmacotherapies for Neurodevelopmental Disorders
    Daniel Z. Wetmore, Craig Curtis Garner · 2010 · Journal of Developmental & Behavioral Pediatrics
  120. Histone ubiquitylation and chromatin dynamics
    Duncan Edward Wright · 2011 · Frontiers in bioscience
  121. Genetic mechanisms involved in the phenotype of Down syndrome
    David Patterson · 2007 · Mental Retardation and Developmental Disabilities Research Reviews
  122. Effects of histone deacetylase inhibitor Trichostatin A on epigenetic changes and transcriptional activation of Bdnf promoter 1 by rat hippocampal neurons
    Feng Tian, Ann M. Marini, Robert H. Lipsky · 2010 · Annals of the New York Academy of Sciences
  123. Transgenic complementation of MeCP2 deficiency: phenotypic rescue of Mecp2-null mice by isoform-specific transgenes
    Bredford Kerr, Jessica Soto C, Mauricio Sáez, Alexander J. Abrams, Katherina Walz, Juan I. Young · 2011 · European Journal of Human Genetics
  124. Dendritic mRNA Targeting and Translation
    Stefan Kindler, Hans‐Jürgen Kreienkamp · 2012 · Advances in experimental medicine and biology
  125. Psychostimulant Alters Expression of DNA Methyltransferase mRNA in the Rat Brain
    Yohtaro Numachi, Sumiko Yoshida, Motoyasu Yamashita · 2004 · Annals of the New York Academy of Sciences
  126. Understanding the Pathogenesis of Angelman Syndrome through Animal Models
    Nihar Ranjan Jana · 2012 · Neural Plasticity
  127. In sickness and in health: the role of methyl-CpG binding protein 2 in the central nervous system
    Sol Díaz de León‐Guerrero, Gustavo Pedraza‐Alva, Leonor Pérez‐Martínez · 2011 · European Journal of Neuroscience
  128. Demethylation of Specific Wnt/β‐Catenin Pathway Genes and its Upregulation in Rat Brain Induced by Prenatal Valproate Exposure
    Zhongping Wang, Li Xu, Xinping Zhu, Weigang Cui, Yan Sun, Hisao Nishijo, Yuwen Peng, Ruixi Li · 2010 · The Anatomical Record
  129. NSD1 PHD domains bind methylated H3K4 and H3K9 using interactions disrupted by point mutations in human sotos syndrome
    Martina P. Pasillas, Meera Shah, Mark P. Kamps · 2010 · Human Mutation
  130. Ex Vivo Treatment with a Novel Synthetic Aminoglycoside NB54 in Primary Fibroblasts from Rett Syndrome Patients Suppresses MECP2 Nonsense Mutations
    Manuela Vecsler, Bruria Ben Zeev, Igor Nudelman, Yair Anikster, Amos J. Simon, Ninette Amariglio, Gideon Rechavi, Timor Baasov, Eva Gak · 2011 · PLoS ONE
  131. Mitochondrial DNA mutations and depletion in pediatric medicine
    Antonella Spinazzola · 2011 · Seminars in Fetal and Neonatal Medicine
  132. Functional organisation of the genome during interphase
    Ana Pombo, Miguel Ramos Branco · 2007 · Current Opinion in Genetics & Development
  133. Recent advances in postmortem pathology and neurochemistry in schizophrenia
    Brian Dean, Simone Boer, Andrew Stuart Gibbons, Tammie Money, Elizabeth Scarr · 2009 · Current Opinion in Psychiatry
  134. Proton Magnetic Resonance Spectroscopy in 22q11 Deletion Syndrome
    Fabiana da Silva Alves, Erik Boot, Nicole Schmitz, Aart Johannes Nederveen, Jacob A. S. Vorstman, Cristina Lavini, Petra J. W. Pouwels, Lieuwe de Haan, DON H. LINSZEN, Thérèse van Amelsvoort · 2011 · PLoS ONE
  135. Socio-Behavioral Characteristics of Children with Rubinstein-Taybi Syndrome
    Cédric Galéra, Emmanuelle Taupiac, Sonia Fraisse, Sophie Naudion, Eva Toussaint, Caroline Rooryck, Marie‐Ange Delrue, Benoı̂t Arveiler, Didier Lacombe, Manuel Pierre Bouvard · 2009 · Journal of Autism and Developmental Disorders
  136. Induced pluripotent stem cells: A new tool to confront the challenge of neuropsychiatric disorders
    Flora Maria Vaccarino, Hanna Elizabeth Stevens, Arif Murat Kocabas, Dean Palejev, Anna M. Szekely, Elena L. Grigorenko, Sherman M. Weissman · 2011 · Neuropharmacology
  137. Stress and the Prodromal Phase of Psychosis
    Carrie W. Holtzman, Daniel I. Shapiro, Hanan D. Trotman, Elaine F. Walker · 2012 · Current Pharmaceutical Design
  138. Epigenetics, Copy Number Variation, and Other Molecular Mechanisms Underlying Neurodevelopmental Disabilities: New Insights and Diagnostic Approaches
    Andrea Lynne Gropman, Mark L. Batshaw · 2010 · Journal of Developmental & Behavioral Pediatrics
  139. DNA demethylases: a new epigenetic frontier in drug discovery
    Nessa Carey, Cristina Joana Marques, Wolf Reik · 2011 · Drug Discovery Today
  140. Molecular and Cellular Aspects of Mental Retardation in the Fragile X Syndrome: From Gene Mutation/s to Spine Dysmorphogenesis
    De Rubeis, Silvia, Fernández, Esperanza, Buzzi, Andrea, Di Marino, Daniele, Bagni, Claudia · 2012 · Advances in Experimental Medicine and Biology
  141. Epigenetic regulation of self‐renewal and fate determination in neural stem cells
    Iqbal Mohamed Ariff, Arinjay Mitra, Anirban Basu · 2011 · Journal of Neuroscience Research
  142. Prion Protein Expression Regulates Embryonic Stem Cell Pluripotency and Differentiation
    Alberto Miranda Bedate, Eva Pericuesta, Miguel Ángel Ramírez · 2011 · PLoS ONE
  143. Differing effects of rapamycin and mTOR kinase inhibitors on protein synthesis
    Yilin Huo, Valentina Iadevaia, Christopher G. Proud · 2011 · Biochemical Society Transactions
  144. Epigenetic reprogramming: is deamination key to active DNA demethylation?
    Marta Teperek, Vincent Pasque, George E. Gentsch, Anne C. Ferguson‐Smith · 2011 · Reproduction
  145. Patient mutations alter ATRX targeting to PML nuclear bodies
    Nathalie G. Bérubé, Jasmine Healy, Chantal F. Medina, Shaobo Wu, Todd R Hodgson, Magdalena Jagla, David J. Picketts · 2007 · European Journal of Human Genetics
  146. The histone demethylase PHF8 is essential for cytoskeleton dynamics
    Asensio-Juan, Elena, Gallego, Carme, Martínez-Balbás, Marian A. · 2012 · Nucleic Acids Research
  147. Chromatin Conformation Signatures: Ideal Human Disease Biomarkers?
    Jennifer Lynn Crutchley, Xue Qing David Wang, Maria A. Ferraiuolo, Josée Dostie · 2010 · Biomarkers in Medicine
  148. Shaping the Genome with Non-Coding RNAs
    Xue Qing David Wang, Jennifer Lynn Crutchley, Josée Dostie · 2011 · Current Genomics
  149. Strategies and Correlates of Jigsaw Puzzle and Visuospatial Performance by Persons With Prader-Willi Syndrome
    Brian N. Verdine, Georgene L. Troseth, Robert M. Hodapp, Elisabeth M. Dykens · 2008 · American Journal on Mental Retardation
  150. Post-Translational Modifications of PTEN and their Potential Therapeutic Implications
    Gobind Singh, Andrew Man-Lok Chan · 2011 · Current Cancer Drug Targets
  151. Epigenetic Treatment of Neurological Disease
    Steven G. Gray · 2011 · Epigenomics
  152. Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components
    Alexander Strom, Gen‐Sheng Wang, David J. Picketts · 2011 · European Journal of Cell Biology
  153. Exposure to enriched environments during adolescence prevents abnormal behaviours associated with histone deacetylation in phencyclidine-treated mice
    Koseki, Takenao, Mouri, Akihiro, Mamiya, Takayoshi, Aoyama, Yuki, Toriumi, Kazuya, Suzuki, Shizuka, Nakajima, Azusa, Yamada, Takuma, Nagai, Taku, Nabeshima, Toshitaka · 2012 · The International Journal of Neuropsychopharmacology
  154. Targeting Phosphorylation of Eukaryotic Initiation Factor-2α to Treat Human Disease
    Melissa J. Fullwood, Wei Zhou, Shirish Shenolikar · 2012 · Progress in molecular biology and translational science
  155. Mechanisms for Nucleosome Movement by ATP-dependent Chromatin Remodeling Complexes
    Anjanabha Saha, Jacqueline Wittmeyer, Bradley Robert Cairns · 2006 · Results and problems in cell differentiation
  156. Proteins involved in establishment and maintenance of imprinted methylation marks
    Ruslan Strogantsev, Anne C. Ferguson‐Smith · 2012 · Briefings in Functional Genomics
  157. Histone H3 as a novel substrate for MAP kinase phosphatase-1
    Corttrell M. Kinney, Unni M. Chandrasekharan, Lin Yang, Jianzhong Shen, Michael T Kinter, Michael S. McDermott, Paul E. DiCorleto · 2008 · American Journal of Physiology-Cell Physiology
  158. Parent-of-origin effects in attention-deficit hyperactivity disorder
    Lisa M. Goos, Payam Ezzatian, Russell James Schachar · 2006 · Psychiatry Research
  159. Astrocytes conspire with neurons during progression of neurological disease
    James C. McGann, Daniel T. Lioy, Gail Mandel · 2012 · Current Opinion in Neurobiology
  160. Epigenetic and post-transcriptional dysregulation of gene expression in schizophrenia and related disease
    David P. Gavin, Schahram Akbarian · 2011 · Neurobiology of Disease
  161. Normal social seeking behavior, hypoactivity and reduced exploratory range in a mouse model of Angelman syndrome
    Melody Lyn Allensworth, Anand Saha, Lawrence T. Reiter, Detlef H. Heck · 2011 · BMC Genetics
  162. Studying synaptic plasticity in the human brain and opportunities for drug discovery
    Pradeep J. Nathan, Stuart Cobb, Bai Lu, Edward Thomas Bullmore, Ceri H. Davies · 2011 · Current Opinion in Pharmacology
  163. CUL4B-deficiency in humans: Understanding the clinical consequences of impaired Cullin 4-RING E3 ubiquitin ligase function
    Claudia Kerzendorfer, Lesley Hart, Rita Colnaghi, Gillian Carpenter, Diana Alcantara, Emily A. Outwin, Antony M. Carr, Mark O’Driscoll · 2011 · Mechanisms of Ageing and Development
  164. A Double-Blind Randomized Trial of Mood Stabilizer Augmentation Using Lamotrigine and Valproate for Patients With Schizophrenia Who Are Stabilized and Partially Responsive
    Ira D. Glick, Jackie Bosch, Daniel E. Casey · 2009 · Journal of Clinical Psychopharmacology
  165. Role of H3K4 Demethylases in Complex Neurodevelopmental Diseases
    Christopher Wynder, Leanne Stalker, Martin L. Doughty · 2010 · Epigenomics
  166. A novel c.2T > C mutation of the KDM5C/JARID1C gene in one large family with X-linked intellectual disability
    Katrin Õunap, Helen Puusepp‐Benazzouz, Maire Peters, Ulvi Vaher, Reet Rein, Anné Proos, Mike Field, Tiia Reimand · 2012 · European Journal of Medical Genetics
  167. Mechanisms of activation of the paternally expressed genes by the Prader-Willi imprinting center in the Prader-Willi/Angelman syndromes domains
    Shiri Rabinovitz, Yotam Kaufman, Guy Ludwig, Aharon Razin, Ruth Shemer · 2012 · Proceedings of the National Academy of Sciences
  168. Disorders of the genome architecture: a review
    Dhavendra Kumar · 2008 · Genomic Medicine
  169. Progressive structural brain changes in schizophrenia
    Basant K. Puri · 2009 · Expert Review of Neurotherapeutics
  170. Histone tyrosine phosphorylation comes of age
    Rakesh Kumar Singh, Akash Gunjan · 2011 · Epigenetics
  171. Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome
    Chantal F. Medina, Chantal J. Mazerolle, Yaping Wang, Nathalie G. Bérubé, Stuart Glenn Coupland, Richard J. Gibbons, Valerie A. Wallace, David J. Picketts · 2008 · Human Molecular Genetics
  172. Targeting Epigenetic Networks with Polypharmacology: A New Avenue to Tackle Cancer
    Gianluigi Franci, Marco Miceli, Lucia Altucci · 2010 · Epigenomics
  173. A peculiar mutation in the DNA-binding/dimerization domain of NFIX causes Sotos-like overgrowth syndrome: A new case
    Manuela Priolo, Enrico Grosso, Corrado Mammì · 2012 · Gene
  174. MicroRNAs and neuronal development
    Dario Motti, John L. Bixby, Vance Lemmon · 2012 · Seminars in Fetal and Neonatal Medicine
  175. Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder
    Yuka Yasuda, Ryota Hashimoto, Hidenaga Yamamori, Kazutaka Ohi, Motoyuki Fukumoto, Satomi Umeda‐Yano, Ikuko Mohri, Akira Itô, Masako Taniike, Masatoshi Takeda · 2011 · Molecular Autism
  176. Selective α4β2 Nicotinic Acetylcholine Receptor Agonists Target Epigenetic Mechanisms in Cortical GABAergic Neurons
    Ekrem Maloku, Bashkim Kadriu, Adrian Zhubi, Erbo Dong, Fabio Pibiri, Rosalba Satta, Alessandro Guidotti · 2011 · Neuropsychopharmacology
  177. Coffin–Lowry syndrome: A role for RSK2 in mammalian neurogenesis
    Sagar B. Dugani, Annie Paquin, David R. Kaplan, Freda D. Miller · 2010 · Developmental Biology
  178. Embryology, Epigenetics and Biogenetics
    C. H. Waddington · 1956 · Nature
  179. Analysis of Human Syndromes with Disordered Chromatin Reveals the Impact of Heterochromatin on the Efficacy of ATM-Dependent G2/M Checkpoint Arrest
    Holly Brunton, Aaron A. Goodarzi, Angela T. Noon, Amruta Shrikhande, R. Scott Hansen, Penny Ann Jeggo, Atsushi Shibata · 2011 · Molecular and Cellular Biology
  180. Makorin Ring Zinc Finger Protein 1 (MKRN1), a Novel Poly(A)-binding Protein-interacting Protein, Stimulates Translation in Nerve Cells
    Hatmone Miroci, Claudia Schob, Stefan Kindler, Janin Ölschläger‐Schütt, Susanne Fehr, Tassilo Jungenitz, Stephan Wolfgang Schwarzacher, Claudia Bagni, Evita Mohr · 2011 · Journal of Biological Chemistry
  181. Adults with Sotos syndrome: Review of 21 adults with molecularly confirmed NSD1 alterations, including a detailed case report of the oldest person
    Matthew R. Fickie, Pablo Daniel Lapunzina, Jennifer K. Gentile et al. · 2011 · American Journal of Medical Genetics Part A
  182. Impairment of cognitive performance after reelin knockdown in the medial prefrontal cortex of pubertal or adult rats
    Brosda, Jan, Dietz, Frank, Koch, Michael · 2011 · Neurobiology of Disease
  183. Immunodeficiency, centromeric instability, facial anomalies (ICF) syndrome, due to ZBTB24 mutations, presenting with large cerebral cyst
    Manuela Cerbone, Jun Wang, Silvère M. van der Maarel · 2012 · American Journal of Medical Genetics Part A
  184. A new deletion refines the boundaries of the murine Prader-Willi syndrome imprinting center
    Amanda J. DuBose, Emily Y. Smith, Thomas P. Yang, Karen A. Johnstone, James L. Resnick · 2011 · Human Molecular Genetics
  185. In search of the psychosis gene in people with Prader‐Willi syndrome
    Tessa P. Webb, Esther N. Maina, Sarita Soni, Joyce E. Whittington, Harm Boer, David Clarke, Anthony John Holland · 2008 · American Journal of Medical Genetics Part A
  186. ATRX in chromatin assembly and genome architecture during development and disease
    Nathalie G. Bérubé · 2011 · Biochemistry and Cell Biology
  187. The in vivo Down syndrome genomic library in mouse
    Yann Hérault, Arnaud Duchon, Émilie Velot, Damien Maréchal, Véronique Brault · 2012 · Progress in brain research
  188. Reversing DNA Methylation: New Insights from Neuronal Activity–Induced Gadd45b in Adult Neurogenesis
    Hao Wu, Yi Eve Sun · 2009 · Science Signaling
  189. Alternative-Splicing in the Exon-10 Region of GABAA Receptor β2 Subunit Gene: Relationships between Novel Isoforms and Psychotic Disorders
    Cunyou Zhao, Zhiwen Xu, Feng Wang et al. · 2009 · PLoS ONE
  190. The PrP-like proteins Shadoo and Doppel.
    D. Westaway, N. Daude, Serene L. Wohlgemuth, Paul M. Harrison · 2011 · Topics in current chemistry
  191. Novel proteins associated with MHC class I antigens in cells expressing the adenovirus protein E3/19K.
    Dominik Feuerbach, Hans-Gerhard Burgert · 1993 · The EMBO Journal
  192. Neurofibromin 1 Is a miRNA Target in Neurons
    Maria Paschou, Epaminondas Doxakis · 2012 · PLoS ONE
  193. Mouse imprinting defect mutations that model Angelman syndrome
    Mei‐Yi Wu, Ken‐Shiung Chen, Jan Bressler, Aihua Hou, Ting‐Fen Tsai, Arthur L. Beaudet · 2006 · genesis
  194. Epigenetic therapies for non-oncology indications
    Jonathan D. Best, Nessa Carey · 2010 · Drug Discovery Today
  195. miR-135A Regulates Preimplantation Embryo Development through Down-Regulation of E3 Ubiquitin Ligase Seven in Absentia Homolog 1A (SIAH1A) Expression
    Ronald T.K. Pang, Weimin Liu, Carmen O.N. Leung, Tian-Min Ye, Peter Kwan Chun-kit, Ckf Lee, William S.B. Yeung · 2011 · PLoS ONE
  196. Epigenetic alteration of microRNAs in DNMT3B-mutated patients of ICF syndrome
    Sole Gatto, Floriana Della Ragione, Amelia Cimmino, Maria Strazzullo, Muller Fabbri, Margherita Mutarelli, Lorenzo Ferraro, Alessandro Weisz, Maurizio D’Esposito, Maria Rosaria Matarazzo · 2010 · Epigenetics
  197. CRF1 Not Glucocorticoid Receptors Mediate Prepulse Inhibition Deficits in Mice Overexpressing CRF
    Lucianne Groenink, Anneloes Dirks, P. Monika Verdouw, Marijke de Graaff, Bernard W. M. M. Peeters, Mark John Millan, Berend Olivier · 2007 · Biological Psychiatry
  198. The peculiar interaction between mammalian prion protein and RNA
    Mariana P. B. Gomes, Yraima Cordeiro, Jerson Lima Silva · 2008 · Prion
  199. MeCP2 deficiency down-regulates specific nuclear proteins that could be partially recovered by valproic acid in vitro
    Manuela Vecsler, Amos J. Simon, Ninette Amariglio · 2010 · Epigenetics
  200. Annual Research Review: Transgenic mouse models of childhood‐onset psychiatric disorders
    Holly R. Robertson, Guoping Feng · 2011 · Journal of Child Psychology and Psychiatry