HPA axis function and symptoms in adolescents at clinical high risk for schizophrenia
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Background Stress sensitivity and HPA axis activity may be relevant to the development and expression of psychotic disorders. Cortisol secretion has been associated with positive symptoms both in patients with psychotic disorders and in young people at clinical risk for psychosis. Herein, we aimed to replicate these findings, to determine which positive symptoms may be associated with cortisol levels, and to explore any associations with affective symptoms and impaired stress tolerance.Methods Thirty-one clinical high risk patients were evaluated in cross-section for associations between salivary cortisol levels upon clinic entry at 11 am, demographic variables, and clinical symptoms.Results Salivary cortisol levels were unrelated to medication exposure or demographics, except for higher levels in the ten females studied. Salivary cortisol bore no relationship to overall positive symptom severity but was associated with anxiety, as well as with suspiciousness and impaired stress tolerance, which were themselves highly intercorrelated.Conclusions Cortisol secretion in the context of a putative novel social situation (i.e. clinic entry) may be a biological correlate of suspiciousness, impaired stress tolerance and affective symptoms in individuals vulnerable to developing psychosis. These associations are consistent with findings from experience sampling studies in individuals at risk for psychosis as well as basic studies of animal models of schizophrenia.
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Biochemical, imaging, and electrophysiological measurements may help segregating patients into higher- and lower-risk groups.
“In addition, biochemical 140,141 , imaging 52,142,143 , and electrophysiological measurements 144 may help segregating patients into higher- and lower-risk groups.”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [140]
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- Authors
- Corcoran, C. M., Smith, C., McLaughlin, D., Auther, A., Malaspina, D., & Cornblatt, B.
- Affiliations
- New York State Psychiatric Institute (US)
- Zucker Hillside Hospital (US)
- Corresponding author
- Corcoran, C.M.
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 135
- Issue
- 1-3
- Pages
- 170-174
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC3716011
- OpenAlex
- W2051331751
- Cited by
- 85
- References
- 45
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 9 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 16 · 2015: 6 · 2014: 9 · 2013: 11 · 2012: 7
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH061523, MH-61523, P30MH060575, K23MH066279)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- hypothalamic-pituitary-adrenal axis, salivary cortisol
- MeSH terms
- Adolescent, Child, Cross-Sectional Studies, Female, Humans, Hydrocortisone, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Retrospective Studies, Risk Factors, Saliva, Schizophrenia, Sex Factors, Cohort Studies, Statistics, Nonparametric
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