The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
NMDA receptors in nervous system diseases
Open accessAbstract
NMDA receptor (NMDAR) dysfunction has emerged as a common theme in several major nervous system disorders, including ischemic brain injury, chronic neurodegenerative diseases, pain, depression and schizophrenia. Either hyperactivity or hypofunction of NMDARs could contribute to disease pathophysiology. It is likely that distinct subtypes of NMDARs (as defined by subunit composition and/or subsynaptic location) are differentially involved in central nervous system diseases. Here we focus on a few examples of nervous system diseases where the contribution of NMDARs is relatively well characterized and discuss the implications for potential treatment of these illnesses. This article is part of the Special Issue entitled 'Glutamate Receptor-Dependent Synaptic Plasticity'.
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Cites
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Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain
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NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
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Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
Ittner, L. M., Ke, Y. D., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wölfing, H., Chieng, B. C., Christie, M. J., Napier, I. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.036 · Cited by 1,821
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2911 · Cited by 1,644 · cited 4×
“…2002;HardinghamandBading, 2010). ba Localization Model Sub Stimulating synaptic NMDARs activates cAMP response elementbinding protein (CREB) signaling and promotes survival, while activation of extrasynaptic NMDARs attenuates CREB signaling and promotes cell death (Hardingham and Bading, 2010).”
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Self-citation
Cited by
Reelin and neuropsychiatric disorders
Ishii, K., Kubo, K.-I., & Nakajima, K. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00229 · Cited by 185
Regulation of NMDA glutamate receptor functions by the GluN2 subunits
Vieira, M., Yong, X. L. H., Roche, K. W., & Anggono, V. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14970 · Cited by 151
“NMDAR dysfunction has long been thought to have a paramount role in a variety of neurological disorders, ranging from acute (e.g. stroke and global cerebral ischaemia) to chronic disorders such as Alzheimer's or Huntington's disease (Zhou & Sheng, 2013; Ittner & Gotz, 2011).”
BackgroundSociability development in mice with cell-specific deletion of the NMDA receptor NR1 subunit gene
Ferri, S. L., Pallathra, A. A., Kim, H., Dow, H. C., Raje, P., McMullen, M., Bilker, W. B., Siegel, S. J., Abel, T., & Brodkin, E. S. (2020) · Genes, Brain and Behavior · doi:10.1111/gbb.12624 · Cited by 15
Metadata
- Authors
- Zhou, Q., & Sheng, M.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 74
- Pages
- 69-75
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2107099794
- Cited by
- 298
- References
- 27
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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