Adolescent nicotine and tobacco smoke exposure enhances nicotine self-administration in female rats
Open accessAbstract
Most people start experimenting with tobacco products or e-cigarettes in early adolescence and become habitual smokers in late adolescence or adulthood. These studies investigated if exposure to tobacco smoke or nicotine during early and mid-adolescence affects nicotine intake in late adolescence and early adulthood. Male and female rats were exposed to tobacco smoke from low- and high-nicotine SPECTRUM cigarettes or nicotine (0.3 mg/kg, twice a day) from postnatal day (P) 24-42. The self-administration sessions started at P55. The rats self-administered nicotine for 14-15 days under a fixed-ratio 1 schedule, and on the first day, the maximum number of infusions was twenty. Exposure to smoke from high, but not low, nicotine cigarettes during adolescence increased nicotine self-administration in female but not male rats. Adolescent treatment with nicotine facilitated nicotine self-administration. On the first day of nicotine self-administration, nicotine-treated rats reached the maximum number of infusions before the saline-treated control rats. Nicotine intake was also higher in the nicotine-treated female rats than in the saline-treated females. There was no sex difference in nicotine intake in controls when the data from the studies were combined. Smoke exposure led to a dose-dependent increase in plasma nicotine and cotinine levels in adolescent rats. Exposure to smoke from high-nicotine cigarettes and 0.3 mg/kg of nicotine led to plasma nicotine and cotinine levels that are similar to those in tobacco users. These findings indicate that in females, but not males, exposure to nicotine during adolescence may facilitate smoking and e-cigarette use later in life.
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Exposure to high-nicotine tobacco smoke increased later nicotine self-administration in adolescent female rats but not males.
“Another study found that exposure to high-nicotine tobacco smoke increased later nicotine self-administration in adolescent female rats but not males [221].”
From Consequences of adolescent drug use (2023) · cites this paper as [221]
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Cites
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“In contrast, a place condition study with male mice suggests that exposure to nicotine during adolescence increases the rewarding effects of nicotine in adulthood (Kota et al., 2009).”
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Self-citation
- Authors
- Chellian, R., Behnood-Rod, A., Wilson, R., Kamble, S. H., Sharma, A., McCurdy, C. R., & Bruijnzeel, A. W.
- Affiliations
- University of Florida (US)
- Corresponding author
- Bruijnzeel, Adriaan W.
- ORCID
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 176
- Pages
- 108243
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC7660018
- OpenAlex
- W3044822492
- Cited by
- 23
- References
- 60
- Citations by year
- 2025: 3 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 3
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse
- U.S. Food and Drug Administration (DA042530, DA046411)
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- adolescent nicotine exposure, tobacco smoke exposure, nicotine self-administration, sex differences, female rats, vaping, nicotine dependence, adolescent smoking initiation
- MeSH terms
- Age Factors, Animals, Female, Male, Nicotine, Self Administration, Tobacco Smoke Pollution, Behavior, Addictive, Nicotinic Agonists, Inhalation Exposure, Rats
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