Mifepristone decreases chronic voluntary ethanol consumption in Rhesus macaques
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= 9 monkeys). After establishment of chronic ethanol intake, a MIFE dosing regimen that modeled a study of rodent drinking and human alcohol craving was evaluated. Three doses of MIFE (17, 30, and 56 mg/kg per day) were each administered for four consecutive days. Both 30 and 56 mg/kg decreased ethanol intake compared with baseline drinking levels without a change in water intake. The dose of 56 mg/kg per day of MIFE produced the largest reduction in ethanol self-administration, with the average intake at 57% of baseline intakes. Cortisol was elevated during MIFE dosing, and a mediation analysis revealed that the effect on ethanol drinking was fully mediated through cortisol. During a forced abstinence phase, access to 1.5 g/kg ethanol resulted in relapse in all drinkers and was not altered by treatment with 56 mg/kg MIFE. Overall, these results show that during active drinking MIFE is efficacious in reducing heavy alcohol intake in a monkey model, an effect that was related to MIFE-induced increase in cortisol. However, MIFE treatment did not eliminate ethanol drinking. Further, cessation of MIFE treatment resulted in a rapid return to baseline intakes, and MIFE was not effective in preventing a relapse during early abstinence. SIGNIFICANCE STATEMENT: Mifepristone reliably decreases average daily ethanol self-administration in a nonhuman primate model. This effect was mediated by cortisol, was most effective during open-access conditions, and did not prevent or reduce relapse drinking.
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Mifepristone reduced heavy alcohol intake in non-human primates but did not eliminate baseline ethanol consumption.
“Jimenez et al. reported that mifepristone reduced heavy alcohol intake in non-human primates, but it did not eliminate baseline ethanol consumption.”
From Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats (2022) · cites this paper as Jimenez et al., 2020
Mifepristone did not prevent a relapse during early abstinence.
“mifepristone did not prevent a relapse during early abstinence (Jimenez et al., 2020).”
From Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats (2022) · cites this paper as Jimenez et al., 2020
Upon cessation of mifepristone treatment, animals rapidly returned to baseline alcohol consumption.
“Upon cessation of mifepristone treatment animals rapidly returned to baseline alcohol consumption”
From Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats (2022) · cites this paper as Jimenez et al., 2020
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mediation : R Package for Causal Mediation Analysis
Tingley, D. H., Yamamoto, T., Hirose, K., Keele, L. J., & Imai, K. (2014) · Journal of Statistical Software · doi:10.18637/jss.v059.i05 · Cited by 4,216 · see citing works
Hasin, D. S., Stinson, F. S., Ogburn, E., & Grant, B. F. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.7.830 · Cited by 2,908 · see citing works
Grant, B. F., Goldstein, R. B., Saha, T. D., Chou, S. P., Jung, J., Zhang, H., Pickering, R. P., Ruan, W. J., Smith, S. M., Huang, B., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0584 · Cited by 2,556 · see citing works
Halekoh, U., & Højsgaard, S. (2014) · Journal of Statistical Software · doi:10.18637/jss.v059.i09 · Cited by 1,324 · see citing works
Nongenomic actions of steroid hormones
Lösel, R., & Wehling, M. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1009 · Cited by 980 · see citing works
Advances in the science and treatment of alcohol use disorder
Witkiewitz, K. A., Litten, R. Z., & Leggio, L. (2019) · Science Advances · doi:10.1126/sciadv.aax4043 · Cited by 599 · see citing works
O’Malley, S. S., Krishnan‐Sarin, S., Farren, C. K., Sinha, R., & Kreek, M. J. (2002) · Psychopharmacology · doi:10.1007/s002130100919 · Cited by 492 · see citing works
Reus, V. I., Fochtmann, L. J., Bukstein, O., Eyler, A. E., Hilty, D. M., Horvitz-Lennon, M., Mahoney, J., Pasic, J., Weaver, M., Wills, C. D., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.1750101 · Cited by 372 · see citing works
Heterogeneity of Alcohol Use Disorder: Understanding Mechanisms to Advance Personalized Treatment
Litten, R. Z., Ryan, M. L., Falk, D. E., Reilly, M., Fertig, J. B., & Koob, G. F. (2015) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.12669 · Cited by 330 · see citing works
Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats
Vendruscolo, L. F., Barbier, E., Schlosburg, J. E., Misra, K. K., Whitfield, T. W., Logrip, M. L., Rivier, C., Repunte-Canonigo, V., Zorrilla, E. P., Sanna, P. P., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0069-12.2012 · Cited by 319 · see citing works
McGinty, E. E., Goldman, H. H., Pescosolido, B. A., & Barry, C. L. (2014) · Social Science & Medicine · doi:10.1016/j.socscimed.2014.12.010 · Cited by 268 · see citing works
Blunted Stress Cortisol Response in Abstinent Alcoholic and Polysubstance-Abusing Men
Lovallo, W. R., Dickensheets, S. L., Myers, D. A., Thomas, T. L., & Nixon, S. J. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb02036.x · Cited by 266 · see citing works
Stress and alcohol: epidemiologic evidence
Keyes, K. M. (2012) · Alcohol research · doi:10.35946/arcr.v34.4.03 · Cited by 260 · see citing works
Alcohol, stress, and glucocorticoids: From risk to dependence and relapse in alcohol use disorders
Blaine, S. K., & Sinha, R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.037 · Cited by 257 · cited 1× · see citing works
“Furthermore, stress is a salient risk factor for relapse (Blaine and Sinha, 2017), suggesting treatments that target the HPA response may be efficacious in treating AUD.”
BackgroundThe New Steroid Analog RU 486 Inhibits Glucocorticoid Action in Man
BERTAGNA, X. Y., BERTAGNA, C., LUTON, J. P., Husson, J., & Girard, F. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-1-25 · Cited by 235 · see citing works
Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals
Vendruscolo, L. F., Estey, D., Goodell, V., Macshane, L. G., Logrip, M. L., Schlosburg, J. E., McGinn, M. A., Zamora-Martinez, E. R., Belanoff, J. K., Hunt, H. J., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79828 · Cited by 218 · see citing works
Self-citationProgesterone receptor transcription and non-transcription signaling mechanisms
Leonhardt, S. A., Boonyaratanakornkit, V., & Edwards, D. P. (2003) · Steroids · doi:10.1016/s0039-128x(03)00129-6 · Cited by 217 · see citing works
Grant, K. A., Leng, X., Green, H. L., Szeliga, K. T., Rogers, L. S. M., & Gonzales, S. W. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00765.x · Cited by 204 · see citing works
Self-citationHarm reduction -a systematic review on effects of alcohol reduction on physical and mental symptoms
Charlet, K., & Heinz, A. (2016) · Addiction Biology · doi:10.1111/adb.12414 · Cited by 184 · see citing works
Vivian, J. A., Green, H. L., Young, J. E., Majerksy, L. S., Thomas, B. W., Shively, C. A., Tobin, J. R., Nader, M. A., & Grant, K. A. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200108000-00001 · Cited by 176 · see citing works
Self-citationEffects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumption
Becker, H. C. (2012) · Alcohol research · doi:10.35946/arcr.v34.4.09 · Cited by 171 · see citing works
Disturbances of hypothalamic-pituitary-adrenal axis functioning during ethanol withdrawal in six men
Adinoff, B. H., Risher‐Flowers, D., de Jong, J., Ravitz, B., Bone, G. H. A., Nutt, D., Roehrich, L., Martin, P. R., & Linnoila, M. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.8.1023 · Cited by 154 · see citing works
Witkiewitz, K. A., Kranzler, H. R., Hallgren, K. A., O’Malley, S. S., Falk, D. E., Litten, R. Z., Hasin, D. S., Mann, K. F., & Anton, R. F. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13897 · Cited by 135 · see citing works
Adinoff, B. H., Ruether, K., Krebaum, S. R., Iranmanesh, A., & Williams, M. J. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000087581.13912.64 · Cited by 133 · see citing works
Carlson, V. C. C., Seabold, G. K., Helms, C. M., Garg, N., Odagiri, M., Rau, A. R., Daunais, J. B., Alvarez, V. A., Lovinger, D. M., & Grant, K. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.140 · Cited by 126 · see citing works
Self-citationThe value of nonhuman primates in drug abuse research.
Weerts, E. M., Fantegrossi, W. E., & Goodwin, A. K. (2007) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.15.4.309 · Cited by 122 · see citing works
Baker, E. J., Farro, J. P., Gonzales, S. W., Helms, C. M., & Grant, K. A. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12547 · Cited by 108 · see citing works
Self-citationSimms, J. A., Haass-Koffler, C. L., Bito-Onon, J., Li, R., & Bartlett, S. E. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.268 · Cited by 97 · see citing works
Hendershot, C. S., Wardell, J. D., Samokhvalov, A. V., & Rehm, J. T. (2016) · Addiction Biology · doi:10.1111/adb.12425 · Cited by 96 · see citing works
Pharmacotherapy for Alcohol Use Disorder
Swift, R. M., & Aston, E. R. (2015) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000079 · Cited by 92 · see citing works
Koenig, H. N., & Olive, M. F. (2003) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.09.004 · Cited by 87 · see citing works
Variations in Adrenal Androgen Production Among (Nonhuman) Primates
Conley, A. J., Pattison, J. C., & Bird, I. M. (2004) · Seminars in Reproductive Medicine · doi:10.1055/s-2004-861548 · Cited by 83 · see citing works
Block, T. S., Kushner, H., Kalin, N., Nelson, C., Belanoff, J., & Schatzberg, A. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.008 · Cited by 78 · see citing works
24‐Hour Pulsatile and Orcadian Patterns of Cortisol Secretion in Alcoholic Men
Iranmanesh, A., Veldhuis, P. P., JOHNSON, M. L., & LIZARRALDE, G. (1989) · Journal of Andrology · doi:10.1002/j.1939-4640.1989.tb00062.x · Cited by 74 · see citing works
Adinoff, B., Krebaum, S. R., Chandler, P. A., Ye, W., Brown, M. B., & Williams, M. J. (2005) · Alcoholism: Clinical & Experimental Research · doi:10.1097/01.alc.0000158940.05529.0a · Cited by 74 · see citing works
Wand, G. S., McCaul, M. E., Gotjen, D., Reynolds, J., & Lee, S. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02327.x · Cited by 69 · see citing works
Adinoff, B. H., Krebaum, S. R., Chandler, P. A., Ye, W., Brown, M. B., & Williams, M. J. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000158939.25531.ee · Cited by 65 · see citing works
Knox, J., Wall, M. M., Witkiewitz, K. A., Kranzler, H. R., Falk, D. E., Litten, R. Z., Mann, K. F., O’Malley, S. S., Scodes, J. M., Anton, R. F., et al. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13884 · Cited by 65 · see citing works
Wemm, S., Larkin, C., Hermes, G., Tennen, H. A., & Sinha, R. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.107569 · Cited by 65 · see citing works
Medical Treatment of Cushing’s Syndrome: Glucocorticoid Receptor Antagonists and Mifepristone
Castinetti, F., Conte‐Devolx, B., & Brue, T. C. (2010) · Neuroendocrinology · doi:10.1159/000314224 · Cited by 64 · see citing works
Somkuwar, S. S., Vendruscolo, L. F., Fannon, M. J., Schmeichel, B. E., Nguyen, T. B., Guevara, J., Sidhu, H., Contet, C., Zorrilla, E. P., & Mandyam, C. D. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.06.006 · Cited by 64 · see citing works
Aoun, E. G., Jimenez, V. A., Vendruscolo, L. F., Walter, N. A. R., Barbier, E., Ferrulli, A., Haass-Koffler, C. L., Darakjian, P., Lee, M. R., Addolorato, G., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.97 · Cited by 60 · see citing works
Self-citationClinical heterogeneity of hypophysitis secondary to PD-1/PD-L1 blockade: insights from four cases
Lupi, I., Brancatella, A., Cosottini, M., Viola, N., Lanzolla, G., Sgrò, D., Dalmazi, G. D., Latrofa, F., Caturegli, P., & Marcocci, C. (2019) · Endocrinology Diabetes and Metabolism Case Reports · doi:10.1530/edm-19-0102 · Cited by 57 · see citing works
Repunte-Canonigo, V., Shin, W., Vendruscolo, L. F., Lefebvre, C., van der Stap, L., Kawamura, T., Schlosburg, J. E., Alvarez, M., Koob, G. F., Califano, A., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0593-5 · Cited by 52 · see citing works
Bertagna, X., Escourolle, H., Pinquier, J., Coste, J., Raux-Demay, M., Perles, P., Silvestre, L., Luton, J., & Strauch, G. (1994) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.78.2.8106625 · Cited by 50 · see citing works
Jacquot, C., Croft, A. P., Prendergast, M., Mulholland, P. J., Shaw, S., & Little, H. J. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00799.x · Cited by 49 · see citing works
Leggio, L., Ferrulli, A., Cardone, S., Miceli, A., Kenna, G. A., Gasbarrini, A., Swift, R. M., & Addolorato, G. (2008) · Alcohol · doi:10.1016/j.alcohol.2008.03.128 · Cited by 46 · see citing works
Monkey Alcohol Tissue Research Resource: Banking Tissues for Alcohol Research
Daunais, J. B., Davenport, A. T., Helms, C. M., Gonzales, S. W., Hemby, S. E., Friedman, D. P., Farro, J. P., Baker, E. J., & Grant, K. A. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12467 · Cited by 45 · see citing works
Self-citationMifepristone Pretreatment Reduces Ethanol Withdrawal Severity In Vivo
Sharrett-Field, L. J., Butler, T. R., Berry, J. N., Reynolds, A. R., & Prendergast, M. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12093 · Cited by 44 · see citing works
Peripheral and prefrontal stress system markers and risk of relapse in alcoholism
Blaine, S. K., Seo, D., & Sinha, R. (2015) · Addiction Biology · doi:10.1111/adb.12320 · Cited by 44 · see citing works
Membrane-initiated nuclear trafficking of the glucocorticoid receptor in hypothalamic neurons
Rainville, J. R., Weiss, G. L., Evanson, N. K., Herman, J. P., Vasudevan, N., & Tasker, J. G. (2017) · Steroids · doi:10.1016/j.steroids.2017.12.005 · Cited by 40 · see citing works
Cippitelli, A., Damadzic, R., Hamelink, C., Brunnquell, M., Thorsell, A., Heilig, M. A., & Eskay, R. L. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00451.x · Cited by 37 · see citing works
Studies using macaque monkeys to address excessive alcohol drinking and stress interactions
Jimenez, V. A., & Grant, K. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.03.027 · Cited by 37 · see citing works
Self-citationSavarese, A., Ozburn, A., Metten, P., Schlumbohm, J. P., Hack, W. R., LeMoine, K., Hunt, H., Hausch, F., Bauder, M., & Crabbe, J. (2020) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.14318 · Cited by 34 · see citing works
Self-citationRoy, A., Mittal, N., Zhang, H., & Pandey, S. C. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.2.774 · Cited by 33 · see citing works
Jimenez, V. A., Herman, M. A., Cuzon Carlson, V. C., Walter, N. A., Grant, K. A., & Roberto, M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0290-7 · Cited by 29 · see citing works
Self-citationBehavioral Flexibility in Alcohol‐Drinking Monkeys: The Morning After
Shnitko, T. A., Gonzales, S. W., Newman, N., & Grant, K. A. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14289 · Cited by 28 · see citing works
Self-citationEffect of repeated abstinence on chronic ethanol self-administration in the rhesus monkey
Allen, D. C., Gonzales, S. W., & Grant, K. A. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4748-9 · Cited by 26 · see citing works
Self-citationChronic Alcohol Drinking Slows Brain Development in Adolescent and Young Adult Nonhuman Primates
Shnitko, T. A., Liu, Z., Wang, X., Grant, K. A., & Kroenke, C. D. (2019) · eNeuro · doi:10.1523/eneuro.0044-19.2019 · Cited by 25 · see citing works
Self-citationRotter, A., Biermann, T., Amato, D., Schumann, G., Desrivières, S., Kornhuber, J., & Müller, C. P. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.05.007 · Cited by 21 · see citing works
Makhijani, V. H., Voorhies, K. J. V., & Besheer, J. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.07.011 · Cited by 21 · see citing works
de Kloet, E. R., & Joëls, M. (2020) · Oxford Research Encyclopedia of Neuroscience · doi:10.1093/acrefore/9780190264086.013.266 · Cited by 21 · see citing works
Pearson, M. R., Bravo, A. J., Kirouac, M., & Witkiewitz, K. A. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.11.015 · Cited by 19 · see citing works
Cholestatic Drug‐Induced Liver Injury Caused by Mifepristone
Funke, K., & Rockey, D. C. (2018) · Hepatology · doi:10.1002/hep.30465 · Cited by 15 · see citing works
Evaluation of mifepristone effects on alcohol-seeking and self-administration in baboons.
Holtyn, A. F., & Weerts, E. M. (2018) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000246 · Cited by 15 · see citing works
Hypokalemia associated with mifepristone use in the treatment of Cushing’s syndrome
Sai, K., Lal, A., Maradana, J. L., Velamala, P. R., & Nitin, T. (2019) · Endocrinology Diabetes and Metabolism Case Reports · doi:10.1530/edm-19-0064 · Cited by 13 · see citing works
Mifepristone: An Uncommon Cause of Drug-Induced Liver Injury
Shah, I., Putnam, T., Daugherty, E., Vyas, N., & Chuang, K. (2019) · Gastroenterology Research · doi:10.14740/gr1188 · Cited by 13 · see citing works
Yuen, K. C. J., Moraitis, A. G., & Nguyen, D. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2016-1097 · Cited by 11 · see citing works
Александровна, П. Н., Kuznetsova, N. V., Selyatitskaya, V. G., Черкасова, О. П., & Кузьмина, О. И. (2016) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-016-3390-6 · Cited by 9 · see citing works
Humayun, M. A., & Masding, M. (2016) · Clinical Diabetes · doi:10.2337/diaclin.34.3.161 · Cited by 2 · see citing works
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2 of the 72 references couldn’t be matched to a known paper.
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Novel Agents for the Pharmacological Treatment of Alcohol Use Disorder
Burnette, E. M., Nieto, S. J., Grodin, E. N., Meredith, L. R., Hurley, B., Miotto, K., Gillis, A. J., & Ray, L. A. (2022) · Drugs · doi:10.1007/s40265-021-01670-3 · Cited by 169 · see citing works
Koob, G. F., & Vendruscolo, L. F. (2023) · Current topics in behavioral neurosciences · doi:10.1007/7854_2023_424 · Cited by 44 · see citing works
Glucocorticoid receptor modulators decrease alcohol self-administration in male rats
McGinn, M. A., Tunstall, B. J., Schlosburg, J. E., Gregory-Flores, A., George, O., de Guglielmo, G., Mason, B. J., Hunt, H. J., Koob, G. F., & Vendruscolo, L. F. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108510 · Cited by 35 · see citing works
Self-citationKhom, S., Rodriguez, L., Gandhi, P., Kirson, D., Bajo, M., Oleata, C. S., Vendruscolo, L. F., Mason, B. J., & Roberto, M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105610 · Cited by 23 · see citing works
Haass‐Koffler, C. L., Magill, M., Cannella, N., Brown, J. C., Aoun, E. G., Cioe, P. A., Sinha, R., Swift, R. M., Ciccocioppo, R., & Leggio, L. (2023) · Addiction Biology · doi:10.1111/adb.13288 · Cited by 20 · see citing works
Pharmacological Treatments for Alcohol Use Disorder: Considering the Role of Sex and Gender
Kirsch, D. E., Belnap, M. A., Burnette, E. M., Grodin, E. N., & Ray, L. A. (2024) · Current Addiction Reports · doi:10.1007/s40429-023-00535-x · Cited by 16 · see citing works
A conceptual framework for the intersection of hyperalgesia and hyperkatifeia in alcohol addiction
Koob, G. F., & Vendruscolo, L. F. (2025) · Alcohol · doi:10.1016/j.alcohol.2025.08.004 · Cited by 13 · see citing works
Narrative Review: Glucocorticoids in Alcoholic Hepatitis—Benefits, Side Effects, and Mechanisms
Lü, H. (2022) · Journal of Xenobiotics · doi:10.3390/jox12040019 · Cited by 13 · see citing works
Khom, S., Borgonetti, V., Vozella, V., Kirson, D., Rodriguez, L., Gandhi, P. J., Bianchi, P., Snyder, A. E., Vlkolinský, R., Bajo, M., et al. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100547 · Cited by 12 · see citing works
Alcohol Use Disorder: Stress, Negative Reinforcement, and Negative Urgency
Vendruscolo, L. F., Koob, G. F., & Zorrilla, E. P. (2023) · Springer eBooks · doi:10.1007/978-3-031-32483-3_36 · Cited by 8 · see citing works
Savarese, A. M., Grigsby, K. B., Jensen, B. E., Borrego, M. B., Finn, D. A., Crabbe, J. C., & Ozburn, A. R. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.821859 · Cited by 8 · see citing works
Neuroendocrinology meets addiction: Emerging pharmacotherapies on the horizon
Loftén, A., Farokhnia, M., Vendruscolo, L. F., & Leggio, L. (2025) · Journal of Internal Medicine · doi:10.1111/joim.70021 · Cited by 7 · see citing works
HITZEMANN, R. J., Gao, L., Fei, S. S., Ray, K., Vigh‐Conrad, K. A., Phillips, T. J., Searles, R. P., Cervera‐Juanes, R. P., Khadka, R., Carlson, T. L., et al. (2024) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2024.12528 · Cited by 6 · see citing works
Self-citationWang, Y., Fahy, C., & Lü, H. (2024) · Liver Research · doi:10.1016/j.livres.2024.06.001 · Cited by 6 · see citing works
Impact of heavy alcohol consumption on cortical bone mechanical properties in male rhesus macaques
Shin, M., Kim, D. K., Jain, M., Martens, P. J., Turner, R. T., Iwaniec, U. T., Kruzic, J. J., & Gludovatz, B. (2024) · Bone · doi:10.1016/j.bone.2024.117041 · Cited by 5 · see citing works
Neurobiology of negative reinforcement as a driving force in alcohol addiction
Vendruscolo, L. F., & Koob, G. F. (2026) · Neuron · doi:10.1016/j.neuron.2026.04.038 · Cited by 4 · see citing works
Development of novel liver-targeting glucocorticoid prodrugs
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Haass‐Koffler, C. L., Magill, M., Cannella, N., Brown, J. C., Aoun, E. G., Cioe, P. A., Sinha, R., Swift, R. M., Ciccocioppo, R., & Leggio, L. (2023) · medRxiv · doi:10.1101/2023.01.02.23284122
Glucocorticoid receptor blockade reverses heroin and alcohol withdrawal-induced hyperalgesia in rats
Skandan, N., Acosta, V., Vendruscolo, J. C. M., McGinn, M. A., & Vendruscolo, L. F. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110896
- Authors
- Jimenez, V. A., Walter, N. A. R., Shnitko, T. A., Newman, N., Diem, K., Vanderhooft, L., Hunt, H., & Grant, K. A.
- Affiliations
- Oregon National Primate Research Center (US)
- Corresponding author
- Grant, Kathleen A.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 375
- Issue
- 2
- Pages
- 258-267
- ISSN
- 0022-3565 (ISSN-L)
- PMC
- PMC7590013
- OpenAlex
- W3082414567
- Cited by
- 20
- References
- 72
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 1
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (P51OD011092)
- National Institute on Alcohol Abuse and Alcoholism (U01AA013641, U24AA013641, U01AA013510, R24AA019431)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- mifepristone, ethanol self-administration, alcohol craving, cortisol, relapse, alcoholism treatment, rhesus monkeys, nonhuman primate model, mediation analysis
- MeSH terms
- Alcohol Drinking, Animals, Drinking, Macaca mulatta, Male, Self Administration, Mifepristone
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