Hippocampal miR-211-5p regulates neurogenesis and depression-like behaviors in the rat
Abstract
Emerging evidence has shown that microRNAs (miRNAs) contribute to the pathogenesis of depression, a potentially life-threatening and disabling mental disorder caused by the interaction of genetic and environmental factors. However, the specific miRNAs and their underlying molecular mechanisms as involved in the pathogenesis and development of depression remain largely unknown. In the present study, we screened miRNA expression profiles and found that miR-211-5p was significantly down-regulated within the dentate gyrus (DG) hippocampus in the chronic unpredictable mild stress (CUMS) induced rat model of depression. Deficits in miR-211-5p were accompanied with reductions in neurogenesis and increased apoptosis in these CUMS rats. In contrast, an up-regulation of miR-211-5p within the DG area in CUMS rats promoted neuronal neurogenesis, reduced neuronal apoptosis via suppression of the Dyrk1A/STAT3 signaling pathway and relieved depression-like behaviors in these CUMS rats. In rats subjected to a knock-down of miR-211-5p in the DG there was an increase in neuronal apoptosis and a decrease in neuronal regeneration, effects which were accompanied with an induction of depression-like behaviors. Taken together, the results of our study reveal that altered levels of miR-211-5p in the hippocampal DG area exert a significant impact on neurogenesis, apoptosis and thus depression-like behaviors in rats. These findings suggest that the miR-211-5p/Dyrk1A pathway plays an important role in the pathogenesis of depression and may serve as a potential therapeutic target for the treatment of depression.
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Low hippocampal miR-211-5p can inhibit neuronal neurogenesis and induce depression-like behaviors via promotion of the Dyrk1A/STAT3 signaling pathway.
“Low hippocampal miR-211-5p can inhibit neuronal neurogenesis and induce depression-like behaviors via the promotion of the Dyrk1A/STAT3 signaling pathway.265”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [265]
Cites
Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 7,295 · see citing works
Vos, T., Allen, C., Arora, M., Barber, R. M., Bhutta, Z. A., Brown, A., Carter, A., Casey, D. C., Charlson, F. J., Chen, A. Z., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31678-6 · Cited by 7,253 · see citing works
Depression: a new animal model sensitive to antidepressant treatments
PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451 · see citing works
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works
From genomics to chemical genomics: new developments in KEGG
Kanehisa, M. I. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj102 · Cited by 3,126 · see citing works
The contribution of de novo coding mutations to autism spectrum disorder
Iossifov, I., O’Roak, B. J., Sanders, S. J., Ronemus, M., Krumm, N., Levy, D., Stessman, H. A., Witherspoon, K. T., Vives, L., Patterson, K. E., et al. (2014) · Nature · doi:10.1038/nature13908 · Cited by 2,585 · see citing works
Gene silencing by microRNAs: contributions of translational repression and mRNA decay
Huntzinger, E., & Izaurralde, E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2936 · Cited by 2,339 · see citing works
Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
Cameron, H. A., & Mckay, R. D. G. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1040 · Cited by 1,585 · see citing works
Kempton, M. J., Salvador, Z., Munafò, M. R., Geddes, J. R., Simmons, A., Frangou, S., & Williams, S. C. R. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.60 · Cited by 886 · see citing works
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
Irwin, D. J., Lee, V. M. ‐., & Trojanowski, J. Q. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3549 · Cited by 875 · see citing works
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
Cheng, L.-C., Pastrana, E., Tavazoie, M., & Doetsch, F. (2009) · Nature Neuroscience · doi:10.1038/nn.2294 · Cited by 865 · see citing works
The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex
Liu, W., Ge, T., Leng, Y., Pan, Z., Fan, J., Yang, W., & Cui, R. (2017) · Neural Plasticity · doi:10.1155/2017/6871089 · Cited by 640 · see citing works
Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus
Anacker, C., Luna, V. M., Stevens, G. S., Millette, A., Shores, R., Jimenez, J. C., Chen, B., & Hen, R. (2018) · Nature · doi:10.1038/s41586-018-0262-4 · Cited by 605 · see citing works
Targeted electrode-based modulation of neural circuits for depression.
Mayberg, H. S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38454 · Cited by 542 · see citing works
DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways
Vlachos, I. S., Kostoulas, N., Vergoulis, T., Georgakilas, G. K., Reczko, M., Maragkakis, M., Paraskevopoulou, M. D., Prionidis, K., Dalamagas, T., & Hatzigeorgiou, A. G. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks494 · Cited by 523 · see citing works
Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide
Savitz, J., & Drevets, W. C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.004 · Cited by 494 · see citing works
Depression in the Primary Care Setting
Park, L. T., & Zarate, C. A. (2019) · New England Journal of Medicine · doi:10.1056/nejmcp1712493 · Cited by 474 · see citing works
Kubera, M., Obuchowicz, E., Goehler, L., Brzeszcz, J., & Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.08.026 · Cited by 443 · see citing works
Epigenetic mechanisms in neurogenesis
Yao, B., Christian, K. M., He, C., Jin, P., Ming, G., & Song, H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.70 · Cited by 391 · see citing works
A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment
Duman, C. H., Schlesinger, L., Kodama, M., Russell, D., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.047 · Cited by 338 · see citing works
Cole, J., Costafreda, S. G., McGuffin, P., & Fu, C. H. Y. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.05.057 · Cited by 319 · see citing works
Jovičić, A., Roshan, R., Moisoi, N., Pradervand, S., Moser, R., Pillai, B., & Luthi-Carter, R. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0600-12.2013 · Cited by 251 · see citing works
Kawashima, H., Numakawa, T., Kumamaru, E., Adachi, N., Mizuno, H., Ninomiya, M., Kunugi, H., & Hashido, K. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.057 · Cited by 200 · see citing works
DYRK1A and cognition: A lifelong relationship
Arbonés, M. L., Thomazeau, A., Nakano-Kobayashi, A., Hagiwara, M., & Delabar, J. M. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.09.010 · Cited by 165 · see citing works
DYRK1A: A master regulatory protein controlling brain growth
Guedj, F., Pereira, P. L., Najas, S., Barallobre, M. J., Chabert, C., Souchet, B., Sebrié, C., Verney, C., Hérault, Y., Arbonés, M. L., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.01.007 · Cited by 155 · see citing works
p53 downregulates Down syndrome‐associated DYRK1A through miR‐1246
Zhang, Y., Liao, J., Zeng, S. X., & Lu, H. (2011) · EMBO Reports · doi:10.1038/embor.2011.98 · Cited by 146 · see citing works
Mao, Q., Ip, S., Ko, K., Tsai, S.-H., & Che, C. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.07.002 · Cited by 136 · see citing works
Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells
Park, J., Oh, Y., Yoo, L., Jung, M.-S., Song, W.-J., Lee, S.-H., Seo, H., & Chung, K. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.147520 · Cited by 134 · see citing works
Yu, Y., He, J., Zhang, Y., Luo, H., Zhu, S., Yang, Y., Zhao, T., Wu, J., Huang, Y., Kong, J., et al. (2009) · Hippocampus · doi:10.1002/hipo.20587 · Cited by 126 · see citing works
Ishihara, K., Amano, K., Takaki, E., Shimohata, A., Sago, H., Epstein, C. J., & Yamakawa, K. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp176 · Cited by 106 · see citing works
García-Cerro, S., Rueda, N., Vidal, V., Lantigua, S., & Martínez-Cué, C. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.06.010 · Cited by 100 · see citing works
Neurogenesis and antidepressant action
Park, S. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-03043-5 · Cited by 99 · see citing works
Fan, C., Song, Q., Wang, P., Li, Y., Yang, M., & Yu, S. Y. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00516 · Cited by 98 · see citing works
Self-citationDang, T., Duan, W. Y., Yu, B., Tong, D. L., Cheng, C., Zhang, Y. F., Wu, W., Ye, K., Zhang, W. X., Wu, M., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.253 · Cited by 76 · see citing works
Mechanism of dual specificity kinase activity of DYRK 1 A
Walte, A., Rüben, K., Birner‐Gruenberger, R., Preisinger, C., Bamberg‐Lemper, S., Hilz, N., Bracher, F., & Becker, W. B. (2013) · FEBS Journal · doi:10.1111/febs.12411 · Cited by 75 · see citing works
DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model
Kurabayashi, N., Nguyen, M. D., & Sanada, K. (2015) · EMBO Reports · doi:10.15252/embr.201540374 · Cited by 57 · see citing works
ID2: A negative transcription factor regulating oligodendroglia differentiation
Chen, X., Zhang, Y., Cai, Q., & Yao, Z. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.22826 · Cited by 54 · see citing works
Peng, Z., Li, M., Tan, X., Xiang, P., Wang, H., Luo, Y., Yang, Y., Huang, H., Chen, Z., Xia, H., et al. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113983 · Cited by 50 · see citing works
Self-citationTian, R., Bai, Y., Li, J.-Y., & Guo, K.-M. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146472 · Cited by 48 · see citing works
Plasma DYRK1A as a novel risk factor for Alzheimer’s disease
Janel, N., Sarazin, M., Corlier, F. W., Corne, H., de Souza, L. C., Hamelin, L., Aka, A., Lagarde, J., Bléhaut, H., Hindie, V., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.61 · Cited by 45 · see citing works
Assessing the Risk Factors for Difficult-to-Treat Depression and Treatment-Resistant Depression
Gaynes, B. N. (2016) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14077su1c.01 · Cited by 42 · see citing works
Janel, N., Alexopoulos, P., Badel, A., Lamari, F., Camproux, A., Lagarde, J., Simon, S., Feraudet‐Tarisse, C., Lamourette, P., Arbonés, M. L., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.123 · Cited by 40 · see citing works
Kaczmarski, W., Barua, M., Mazur‐Kolecka, B., Frackowiak, J., Dowjat, W. K., Mehta, P. D., Bolton, D., Hwang, Y., Rabe, A., Albertini, G., et al. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23279 · Cited by 28 · see citing works
Park, H. J., Hong, M., Bronson, R. T., Israel, M. A., Frankel, W. N., & Yun, K. (2013) · Stem Cells · doi:10.1002/stem.1351 · Cited by 23 · see citing works
Could the inhibitor of DNA binding 2 and 4 play a role in white matter injury?
Gou, X., Tang, Y., Qu, Y., Xiao, D.-Q., Ying, J.-J., & Mu, D. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0090 · Cited by 4 · see citing works
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Gupta, R. V., Advani, D., Yadav, D., Ambasta, R. K., & Kumar, P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03502-9 · Cited by 58 · see citing works
Li, X., Quan, P., Si, Y., Liu, F., Fan, Y., Ding, F., Sun, L., Liu, H., Huang, S., Sun, L., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-023-03009-z · Cited by 51 · see citing works
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Gao, Y., Yong-qian, Z., Wang, H., Deng, Y., & Li, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094555 · Cited by 37 · see citing works
Wang, G., Liu, Y., Zhu, X., Lin, K., Li, M., Wu, Z., Zhang, R., Zheng, Q., Li, D., & An, T. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109154 · Cited by 28 · see citing works
Ma, Z., Feng, D., Rui, W., & Wang, Z. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114299 · Cited by 23 · see citing works
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Hamada, Y., Takata, T., Iwama, H., Kawakita, R., Nonaka, W., Deguchi, K., Kobara, H., Morishita, A., Miyamoto, O., Nakamura, T., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28875 · Cited by 3 · see citing works
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Qi, W., Dong, N., Peiru, W. U., Fu, W., Liu, Q., Zhang, X., Wu, H., He, X., Wu, L., Ward, N., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4458094/v1
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Li, X., Quan, P., Si, Y., Liu, F., Fan, Y., Ding, F., Sun, L., Liu, H., Huang, S., Sun, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26665108
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Self-citation
- Authors
- Li, Y., Fan, C., Gao, R., Lan, T., Wang, W., & Yu, S. Y.
- Affiliations
- Shandong University (CN)
- Jinan Vocational College of Nursing (CN)
- Corresponding author
- Yu, Shu Yan
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 194
- Pages
- 108618
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W3164118098
- Cited by
- 29
- References
- 45
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 10 · 2023: 6 · 2022: 6
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundamental Research Fund of Shandong University (2018JC008)
- National Natural Science Foundation of China (82071513, NSFC81873796)
- Natural Science Foundation of Shandong Province (ZR2020ZD25)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- miR-211-5p, depression, hippocampus, dentate gyrus, neurogenesis, neuronal apoptosis, chronic unpredictable mild stress, depression-like behavior, miRNA expression profiling, therapeutic target
- MeSH terms
- Animals, Depression, Hippocampus, Male, Stress, Psychological, Rats, Wistar, Apoptosis, MicroRNAs, Rats, Neurogenesis
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