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AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs

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Díaz-Alonso, Javier, Nicoll, Roger A.·2021·Neuropharmacology
DOI 10.1016/j.neuropharm.2021.108710PMC PMC9122021
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Abstract

AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity which contributes to learning and memory formation, relies on the accumulation of AMPARs at the postsynapse. This phenomenon requires the coordinated recruitment of different elements in the AMPAR complex. Based on recent research reviewed herein, we propose an updated AMPAR trafficking and LTP model which incorporates both extracellular as well as intracellular mechanisms. This article is part of the special Issue on 'Glutamate Receptors - AMPA receptors'.

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Crossref · 10.1016/j.neuropharm.2021.108710

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  • Synaptic capture of AMPARs requires the PDZ domain interaction between TARPs and PSD-95.

    “It is also agreed that the synaptic capture of AMPARs requires the PDZ domain interaction between TARPs and PSD-95 (275, 279, 294, 440).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [440]

    The section on TARP/MAGUK interactions says TARP–PSD-95 interactions stabilize AMPARs at the postsynaptic density and involve PSD-95 PDZ domains. It calls these interactions the most plausible AMPAR capture sites, but does not establish that this specific interaction is universally required; the reported requirement for the TARP binding motif comes from particular experimental conditions. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • SAP97 acts as an adaptor between GluA1 and Myosin V and is essential for intracellular trafficking and targeting of AMPARs during LTP.

    “Synapse-associated protein 97 (SAP97), another MAGUK family protein, acts as an adaptor between GluA1 and Myosin V, being essential for intracellular trafficking and targeting of AMPARs during LTP [47].”

    From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [47]

    The Introduction section on the GluA1 C-terminal domain (page unavailable) says that GluA1 binds the MAGUK SAP97, supporting their association. It does not describe SAP97 as an adaptor to Myosin V or establish that SAP97 is essential for AMPAR trafficking and targeting during LTP. Instead, it reports normal LTP when the GluA1 SAP97-binding motif is absent and says the motif’s role remains unclear. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

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Authors
Díaz-Alonso, J., & Nicoll, R. A.
Affiliations
  • University of California, Irvine (US)
  • University of California, San Francisco (US)
Corresponding author
  • Díaz-Alonso, Javier
  • Nicoll, Roger A.
ORCID
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2021-10
Volume
197
Pages
108710
ISSN
0028-3908 (ISSN-L)
DOI
10.1016/j.neuropharm.2021.108710
PMC
PMC9122021
OpenAlex
W3179784151
Cited by
66
References
27
Citations by year
2026: 9 · 2025: 8 · 2024: 13 · 2023: 19 · 2022: 14 · 2021: 3
FWCI
1.85
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuropharmacology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion, cc-by-nc-nd)
  • eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
Funders
  • National Institute of Mental Health (R01MH070957, R01MH117139)
  • University of California, Irvine
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
AMPA receptors, receptor trafficking, long-term potentiation, synaptic plasticity, synaptic transmission, C-terminal domain, N-terminal domain, TARP, learning and memory
MeSH terms
Animals, Humans, Long-Term Potentiation, Receptors, AMPA

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