Postsynaptic Density-95 Mimics and Occludes Hippocampal Long-Term Potentiation and Enhances Long-Term Depression
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Previous studies have shown that overexpression of the protein PSD-95 (postsynaptic density-95) selectively enhances AMPA receptor-mediated synaptic responses in hippocampal pyramidal cells. To determine whether this effect is related to synaptic plasticity at these synapses, we examined whether PSD-95 expression mimics long-term potentiation (LTP), and also whether it influences LTP and long-term depression (LTD) in hippocampal slice cultures. Using simultaneous recording from transfected or infected cells and control pyramidal cells, we found that PSD-95, similar to LTP, increases the amplitude and frequency of miniature EPSCs. It also converts silent synapses to functional synapses, as does LTP. In addition, LTP is completely occluded in cells expressing PSD-95, whereas LTD is greatly enhanced. These results suggest that common mechanisms are involved in controlling synaptic AMPA receptors by PSD-95 and synaptic plasticity.
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Overexpression of PSD-95 potentiates AMPAR EPSCs and occludes LTP, and the S73D mutant causes similar potentiation.
“since overexpression of PSD-95 on its own potentiates AMPAR EPSCs and occludes LTP (131, 297, 298) and the S73D mutant causes a similar potentiation.”
From Synaptic memory and CaMKII (2023) · cites this paper as [297]
The quantity of surface receptors controls synaptic strength.
“The quantity of surface receptors controls synaptic strength [57-59]; therefore, reduction of both synaptic transmission and plasticity in the Shank3 heterozygotes would support a mechanism involving altered AMPA receptor trafficking.”
From Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication (2010) · cites this paper as [59]
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Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729 · see citing works
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works
Liao, D., Hessler, N. A., & Malinow, R. (1995) · Nature · doi:10.1038/375400a0 · Cited by 1,365 · see citing works
PSD-95 Involvement in Maturation of Excitatory Synapses
El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., & Bredt, D. S. (2000) · Science · doi:10.1126/science.290.5495.1364 · Cited by 1,303 · see citing works
Self-citationEvidence for silent synapses: Implications for the expression of LTP
Isaac, J. T. R., Nicoll, R. A., & Malenka, R. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90046-2 · Cited by 1,233 · see citing works
Self-citationMigaud, M., Charlesworth, P., Dempster, M., Webster, L. C., Watabe, A. M., Makhinson, M., He, Y., Ramsay, M. F., Morris, R. G. M., Morrison, J. H., et al. (1998) · Nature · doi:10.1038/24790 · Cited by 1,160 · see citing works
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111 · see citing works
Self-citationPostsynaptic signaling and plasticity mechanisms
Sheng, M., & Kim, M. J. (2002) · Science · doi:10.1126/science.1075333 · Cited by 731 · see citing works
Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number
Schnell, E., Sizemore, M., Karimzadegan, S., Chen, L., Bredt, D. S., & Nicoll, R. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172511199 · Cited by 691 · see citing works
Self-citationSynaptic Strength Regulated by Palmitate Cycling on PSD-95
El-Husseini, A., Schnell, E., Dakoji, S., Sweeney, N. T., Zhou, Q., Prange, O., Gauthier-Campbell, C., Aguilera-Moreno, A., Nicoll, R. A., & Bredt, D. S. (2002) · Cell · doi:10.1016/s0092-8674(02)00683-9 · Cited by 569 · see citing works
Self-citationPostsynaptic organisation and regulation of excitatory synapses
Scannevin, R. H., & Huganir, R. L. (2000) · Nature reviews. Neuroscience · doi:10.1038/35039075 · Cited by 460 · see citing works
PSD‐95 regulates synaptic transmission and plasticity in rat cerebral cortex
Béïque, J.-C., & Andrade, R. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.031369 · Cited by 313 · see citing works
Bidirectional Control of Quantal Size by Synaptic Activity in the Hippocampus
Oliet, S. H. R., Malenka, R. C., & Nicoll, R. A. (1996) · Science · doi:10.1126/science.271.5253.1294 · Cited by 209 · cited 3× · see citing works
“C, Cumulative frequency distributions of the interevent intervals of mEPSCs recorded in control cells (closed circles) and PSD-95-expressing cells (open circles). is, expressing PSD-95 enhances both the amplitude and frequency of mEPSCs, as has been reported previously for LTP (Oliet et al., 1996).”
BackgroundResultInfluentialSelf-citationRapid, High Level Protein Production Using DNA-based Semliki Forest Virus Vectors
DiCiommo, D. P., & Bremner, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18060 · Cited by 123 · see citing works
Recent Excitement in the Ionotropic Glutamate Receptor Field
Ziff, E. B. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11315.x · Cited by 25 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323 · see citing works
PDZ domain proteins of synapses
Kim, E., & Sheng, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1517 · Cited by 1,565 · see citing works
AMPA receptor trafficking at excitatory synapses
Bredt, D. S., & Nicoll, R. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00640-8 · Cited by 1,150 · see citing works
Self-citationHomeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function
Turrigiano, G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005736 · Cited by 1,139 · see citing works
Receptor trafficking and synaptic plasticity
Collingridge, G. L., Isaac, J. T. R., & Wang, Y. T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1556 · Cited by 1,046 · see citing works
Postsynaptic BDNF‐TrkB signaling in synapse maturation, plasticity, and disease
Yoshii, A., & Constantine‐Paton, M. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20765 · Cited by 744 · see citing works
The Postsynaptic Organization of Synapses
Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603 · see citing works
The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking
Bats, C., Groc, L., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.030 · Cited by 590 · see citing works
Bozdagi, O., Sakurai, T., Papapetrou, D., Wang, X., Dickstein, D. L., Takahashi, N., Kajiwara, Y., Yang, M., Katz, A. M., Scattoni, M. L., et al. (2010) · Molecular Autism · doi:10.1186/2040-2392-1-15 · Cited by 584 · see citing works
Ehrlich, I., & Malinow, R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4733-03.2004 · Cited by 567 · see citing works
Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
Colledge, M., Snyder, E. M., Crozier, R. A., Soderling, J. A., Jin, Y., Langeberg, L. K., Lu, H., Bear, M. F., & Scott, J. D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00687-1 · Cited by 567 · see citing works
Identification of PSD-95 Palmitoylating Enzymes
Fukata, M., Fukata, Y., Adesnik, H., Nicoll, R. A., & Bredt, D. S. (2004) · Neuron · doi:10.1016/j.neuron.2004.12.005 · Cited by 532 · see citing works
Self-citationStargazin modulates AMPA receptor gating and trafficking by distinct domains
Tomita, S., Adesnik, H., Sekiguchi, M., Zhang, W., Wada, K., Howe, J. R., Nicoll, R. A., & Bredt, D. S. (2005) · Nature · doi:10.1038/nature03624 · Cited by 486 · see citing works
Self-citationPSD-95 is required for activity-driven synapse stabilization.
Ehrlich, I., Klein, M., Rumpel, S., & Malinow, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609307104 · Cited by 470 · see citing works
Spine Dynamics: Are They All the Same?
Berry, K., & Nedivi, E. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.008 · Cited by 464 · see citing works
MEMBRANE-ASSOCIATED GUANYLATE KINASES REGULATE ADHESION AND PLASTICITY AT CELL JUNCTIONS
Funke, L., Dakoji, S., & Bredt, D. S. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133339 · Cited by 469 · see citing works
Self-citationOh, M. C., Derkach, V. A., Guire, E. S., & Soderling, T. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509677200 · Cited by 456 · see citing works
Long-Term Potentiation: From CaMKII to AMPA Receptor Trafficking
Herring, B. E., & Nicoll, R. A. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071753 · Cited by 425 · see citing works
Self-citationElias, G. M., Funke, L., Stein, V., Grant, S., Bredt, D., & Nicoll, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.012 · Cited by 413 · see citing works
Self-citationCaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin
Opazo, P., Labrecque, S., Tigaret, C. M., Frouin, A., Wiseman, P. W., Koninck, P. D., & Choquet, D. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.007 · Cited by 403 · see citing works
Synapse-specific regulation of AMPA receptor function by PSD-95.
Béïque, J.-C., Lin, D.-T., Kang, M.-G., Aizawa, H., Takamiya, K., & Huganir, R. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608492103 · Cited by 398 · see citing works
Astroglial networks scale synaptic activity and plasticity
Pannasch, U., Vargová, L., Reingruber, J., Ezan, P., Holcman, D., Giaume, C., Syková, E., & Rouach, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016650108 · Cited by 383 · see citing works
Identification of PSD-95 as a Regulator of Dopamine-Mediated Synaptic and Behavioral Plasticity
Yao, W., Gainetdinov, R. R., Arbuckle, M. I., Sotnikova, T. D., Cyr, M., Beaulieu, J., Torres, G. E., Grant, S. G. N., & Caron, M. G. (2004) · Neuron · doi:10.1016/s0896-6273(04)00048-0 · Cited by 380 · see citing works
A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin
Prange, O., Wong, T. P., Gerrow, K., Wang, Y. T., & El-Husseini, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405939101 · Cited by 363 · see citing works
Glutamate receptor dynamics in dendritic microdomains.
Newpher, T. M., & Ehlers, M. D. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.030 · Cited by 356 · see citing works
Yoshii, A., & Constantine-Paton, M. (2007) · Nature Neuroscience · doi:10.1038/nn1903 · Cited by 345 · see citing works
ORGANELLES AND TRAFFICKING MACHINERY FOR POSTSYNAPTIC PLASTICITY
Kennedy, M. J., & Ehlers, M. D. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112808 · Cited by 346 · see citing works
Rapid Redistribution of Synaptic PSD-95 in the Neocortex In Vivo
Gray, N. W., Weimer, R. M., Bureau, I., & Svoboda, K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040370 · Cited by 338 · see citing works
Bidirectional Synaptic Plasticity Regulated by Phosphorylation of Stargazin-like TARPs
Tomita, S., Stein, V., Stocker, T. J., Nicoll, R. A., & Bredt, D. S. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.009 · Cited by 343 · see citing works
Self-citationPostsynaptic expression of homeostatic plasticity at neocortical synapses
Wierenga, C. J., Ibata, K., & Turrigiano, G. G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5217-04.2005 · Cited by 306 · see citing works
Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins
Elias, G. M., & Nicoll, R. A. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.005 · Cited by 288 · see citing works
Self-citationKim, M. J., Futai, K., Jo, J., Hayashi, Y., Cho, K., & Sheng, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.007 · Cited by 278 · see citing works
Roselli, F., Tirard, M., Lu, J., Hutzler, P., Lamberti, P., Livrea, P., Morabito, M. A., & Almeida, O. F. X. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3034-05.2005 · Cited by 276 · see citing works
Steiner, P., Higley, M. J., Xu, W., Czervionke, B. L., Malenka, R. C., & Sabatini, B. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.014 · Cited by 259 · see citing works
SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons
Rumbaugh, G., Adams, J. P., Kim, J. H., & Huganir, R. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600084103 · Cited by 260 · see citing works
Schlüter, O. M., Xu, W., & Malenka, R. C. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.016 · Cited by 254 · see citing works
Receptor compartmentalization and trafficking at glutamate synapses: a developmental proposal
van Zundert, B., Yoshii, A., & Constantine‐Paton, M. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.010 · Cited by 252 · see citing works
Nakagawa, T., Futai, K., Lashuel, H. A., Lo, I., Okamoto, K., Walz, T., Hayashi, Y., & Sheng, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.012 · Cited by 214 · see citing works
Regulation of AMPA receptor surface diffusion by PSD-95 slots
Opazo, P., Sainlos, M., & Choquet, D. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.010 · Cited by 234 · see citing works
Synaptic nanomodules underlie the organization and plasticity of spine synapses
Hruska, M., Henderson, N., Le Marchand, S. J., Jafri, H., & Dalva, M. B. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0138-9 · Cited by 233 · see citing works
Identification of PSD-95 Depalmitoylating Enzymes
Yokoi, N., Fukata, Y., Sekiya, A., Murakami, T., Kobayashi, K., & Fukata, M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0419-16.2016 · Cited by 229 · see citing works
GluR1 Links Structural and Functional Plasticity at Excitatory Synapses
Kopec, C. D., Réal, É., Kessels, H. W. H. G., & Malinow, R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3503-07.2007 · Cited by 220 · see citing works
Elias, G. M., Elias, L. A. B., Apostolides, P. F., Kriegstein, A. R., & Nicoll, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811025106 · Cited by 223 · see citing works
Self-citationExcitation control: balancing PSD-95 function at the synapse
Keith, D. J. (2008) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.004.2008 · Cited by 206 · see citing works
Kuriu, T., Inoue, A., Bito, H., Sobue, K., & Okabe, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0522-06.2006 · Cited by 206 · see citing works
The neuroligin and neurexin families: from structure to function at the synapse
Lisé, M.-F., & El-Husseini, A. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6061-3 · Cited by 204 · see citing works
Wnt-5a/JNK Signaling Promotes the Clustering of PSD-95 in Hippocampal Neurons
Farı́as, G. G., Alfaro, I. E., Cerpa, W. F., Grabowski, C. P., Godoy, J. A., Bonansco, C., & Inestrosa, N. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808986200 · Cited by 200 · see citing works
Lee, C.-C., Huang, C., Wu, M.-Y., & Hsu, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414112200 · Cited by 199 · see citing works
Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD.
Xu, W., Schlüter, O. M., Steiner, P., Czervionke, B. L., Sabatini, B., & Malenka, R. C. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.027 · Cited by 193 · see citing works
A three-step model for the synaptic recruitment of AMPA receptors
Opazo, P., & Choquet, D. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.08.014 · Cited by 190 · see citing works
Nithianantharajah, J., Barkus, C., Murphy, M., & Hannan, A. J. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.11.006 · Cited by 187 · see citing works
Emerging Roles for Ubiquitin and Protein Degradation in Neuronal Function
Yi, J. J., & Ehlers, M. D. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.1.4 · Cited by 224 · see citing works
A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors
Bhattacharyya, S., Biou, V., Xu, W., Schlüter, O., & Malenka, R. C. (2009) · Nature Neuroscience · doi:10.1038/nn.2249 · Cited by 185 · see citing works
Docosahexaenoic acid: one molecule diverse functions
Hashimoto, M., Hossain, S., Mamun, A. A., Matsuzaki, K., & Arai, H. (2016) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2016.1207153 · Cited by 186 · see citing works
PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling
Nikonenko, I., Boda, B., Steen, S., Knott, G. W., Welker, E., & Müller, D. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200805132 · Cited by 173 · see citing works
Carlisle, H. J., Fink, A. E., Grant, S. G. N., & O’Dell, T. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.163469 · Cited by 172 · see citing works
PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity
Xu, W. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.03.001 · Cited by 171 · see citing works
Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome
Cao, C., Rioult-Pedotti, M. S., Migani, P., Yu, C. J., Tiwari, R. K., Parang, K., Spaller, M. R., Goebel, D. J., & Marshall, J. J. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001478 · Cited by 170 · see citing works
Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic Transmission
Zeng, M., Díaz-Alonso, J., Ye, F., Chen, X., Xu, J., Ji, Z., Nicoll, R. A., & Zhang, M. (2019) · Neuron · doi:10.1016/j.neuron.2019.08.001 · Cited by 171 · see citing works
Self-citationLong-Term Relationships between Synaptic Tenacity, Synaptic Remodeling, and Network Activity
Minerbi, A., Kahana, R., Goldfeld, L., Kaufman, M., Marom, S., & Ziv, N. E. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000136 · Cited by 166 · see citing works
TARP Phosphorylation Regulates Synaptic AMPA Receptors through Lipid Bilayers
Sumioka, A., Yan, D., & Tomita, S. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.035 · Cited by 167 · see citing works
Synaptic adhesion molecules and PSD-95
Han, K., & Kim, E. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.011 · Cited by 163 · see citing works
S-Nitrosylation and S-Palmitoylation Reciprocally Regulate Synaptic Targeting of PSD-95
Ho, G. P. H., Selvakumar, B., Mukai, J., Hester, L. D., Wang, Y., Gogos, J. A., & Snyder, S. H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.033 · Cited by 162 · see citing works
Wiegert, O., Joëls, M., & Krugers, H. (2006) · Learning & Memory · doi:10.1101/lm.87706 · Cited by 162 · see citing works
PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane
Arendt, K. L., Royo, M., Fernández‐Monreal, M., Knafo, S., Petrok, C. N., Martens, J. R., & Esteban, J. A. (2009) · Nature Neuroscience · doi:10.1038/nn.2462 · Cited by 158 · see citing works
Neurogranin enhances synaptic strength through its interaction with calmodulin
Zhong, L., Cherry, T., Bies, C. E., Florence, M. A., & Gerges, N. Z. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.236 · Cited by 158 · see citing works
Huang, C. S., Shi, S.-H., Ule, J., Ruggiu, M., Barker, L. A., Darnell, R. B., Jan, Y. N., & Jan, L. Y. (2005) · Cell · doi:10.1016/j.cell.2005.07.033 · Cited by 157 · see citing works
Chocyk, A., Bobula, B., Dudys, D., Przyborowska, A., Majcher-Maślanka, I., Hess, G., & Wędzony, K. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12208 · Cited by 153 · see citing works
PSD-95 protects synapses from β-amyloid
Dore, K., Carrico, Z., Alfonso, S., Marino, M., Koymans, K., Kessels, H. W., & Malinow, R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109194 · Cited by 149 · see citing works
Gerges, N. Z., Backos, D. S., & Esteban, J. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404982200 · Cited by 147 · see citing works
Dahlhaus, R., Hines, R. M., Eadie, B. D., Kannangara, T. S., Hines, D. J., Brown, C. E., Christie, B. R., & El-Husseini, A. (2009) · Hippocampus · doi:10.1002/hipo.20630 · Cited by 145 · see citing works
VanGuilder, H. D., Farley, J. A., Han, Y., Kirk, C. A. V., Mitschelen, M. C., Sonntag, W. E., & Freeman, W. M. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.03.012 · Cited by 144 · see citing works
Sturgill, J. F., Steiner, P., Czervionke, B. L., & Sabatini, B. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1841-09.2009 · Cited by 133 · see citing works
A single episode of neonatal seizures permanently alters glutamatergic synapses
Cornejo, B. J., Mesches, M. H., Coultrap, S. J., Browning, M. D., & Benke, T. A. (2007) · Annals of Neurology · doi:10.1002/ana.21071 · Cited by 137 · see citing works
Compans, B., Camus, C., Kallergi, E., Sposini, S., Martineau, M., Butler, C., Kechkar, A., Klaassen, R. V., Retailleau, N., B, T. J. S. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23133-9 · Cited by 136 · see citing works
Nelson, C. D., Kim, M. J., Hsin, H., Chen, Y., & Sheng, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0131-13.2013 · Cited by 136 · see citing works
PSD-95 and PSD-93 Play Critical But Distinct Roles in Synaptic Scaling Up and Down
Sun, Q., & Turrigiano, G. G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5616-10.2011 · Cited by 135 · see citing works
Daoud, F., Candelario‐Martínez, A., Billard, J., Avital, A., Khelfaoui, M., Rozenvald, Y., Guégan, M., Mornet, D., Jaillard, D., Nudel, U., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006574 · Cited by 135 · see citing works
Synaptic protein degradation by the ubiquitin proteasome system
Bingol, B., & Schuman, E. M. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.08.016 · Cited by 129 · see citing works
Corticosterone Alters AMPAR Mobility and Facilitates Bidirectional Synaptic Plasticity
Martin, S., Henley, J. M., Holman, D., Zhou, M., Wiegert, O., van Spronsen, M., Joëls, M., Hoogenraad, C. C., & Krugers, H. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004714 · Cited by 130 · see citing works
Regulation of AMPA receptor gating and pharmacology by TARP auxiliary subunits
Milstein, A. D., & Nicoll, R. A. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.04.004 · Cited by 132 · see citing works
Self-citationDoublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation
Shin, E., Kashiwagi, Y., Kuriu, T., Iwasaki, H., Tanaka, T., Koizumi, H., Gleeson, J. G., & Okabe, S. (2013) · Nature Communications · doi:10.1038/ncomms2443 · Cited by 134 · see citing works
Progressive maturation of silent synapses governs the duration of a critical period
Huang, X., Stodieck, S. K., Goetze, B., Cui, L., Wong, M. H., Wenzel, C., Hosang, L., Dong, Y., Löwel, S., & Schlüter, O. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506488112 · Cited by 131 · see citing works
The role of SAP97 in synaptic glutamate receptor dynamics
Howard, M. A., Elias, G. M., Elias, L. A. B., Swat, W., & Nicoll, R. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914422107 · Cited by 119 · see citing works
Self-citationNicoll, R. A., & Schulman, H. (2023) · Physiological Reviews · doi:10.1152/physrev.00034.2022 · Cited by 126 · see citing works
“However, the results are dif fi cult to interpret, since overexpression of PSD-95 on its own potentiates AMPAR EPSCs and occludes LTP (131, 297, 298) and the S73D mutant causes a similar potentiation.”
BackgroundSelf-citationCaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory
Park, J., Chávez, A. E., Mineur, Y. S., Morimoto-Tomita, M., Lutzu, S., Kim, K. S., Picciotto, M. R., Castillo, P. E., & Tomita, S. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.002 · Cited by 121 · see citing works
Zhang, Y., Meredith, G. E., Mendoza‐Elias, N., Rademacher, D. J., Tseng, K. Y., & Steece‐Collier, K. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0288-13.2013 · Cited by 121 · see citing works
AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking
Bissen, D., Foss, F., & Acker-Palmer, A. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03068-7 · Cited by 92 · see citing works
Fukata, Y., Iwanaga, T., & Fukata, M. (2006) · Methods · doi:10.1016/j.ymeth.2006.05.015 · Cited by 114 · see citing works
Early Postnatal Plasticity in Neocortex of <i>Fmr1</i> Knockout Mice
Desai, N. S., Casimiro, T. M., Gruber, S. M., & Vanderklish, P. W. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00221.2006 · Cited by 92 · see citing works
Hafner, A.-S., Penn, A. C., Grillo-Bosch, D., Retailleau, N., Poujol, C., Philippat, A., Coussen, F., Sainlos, M., Opazo, P., & Choquet, D. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.013 · Cited by 101 · see citing works
Ganeshina, O., Berry, R. W., Petralia, R. S., Nicholson, D. A., & Geinisman, Y. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.02.025 · Cited by 108 · see citing works
Horne, E. A., & Dell’Acqua, M. L. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4340-06.2007 · Cited by 107 · see citing works
Dahlhaus, R., & El-Husseini, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.019 · Cited by 102 · see citing works
Sperow, M., Berry, R. B., Bayazitov, I. T., Zhu, G. G., Baker, S. J., & Zakharenko, S. S. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.220236 · Cited by 101 · see citing works
Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition
Vogl, A. M., Brockmann, M. M., Giusti, S. A., Maccarrone, G., Vercelli, C. A., Bauder, C. A., Richter, J. S., Roselli, F., Hafner, A., Dedic, N., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3912 · Cited by 99 · see citing works
Self-citationEye Opening Rapidly Induces Synaptic Potentiation and Refinement
Lü, W., & Constantine‐Paton, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.031 · Cited by 101 · see citing works
Role of the Neurogranin Concentrated in Spines in the Induction of Long-Term Potentiation
Zhabotinsky, A. M., Camp, R. N., Epstein, I. R., & Lisman, J. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0729-06.2006 · Cited by 95 · see citing works
Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity
Matt, L., Kim, K., Chowdhury, D., & Hell, J. W. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00008 · Cited by 96 · see citing works
Prefrontal Deficits in a Murine Model Overexpressing the Down Syndrome Candidate GeneDyrk1a
Thomazeau, A., Lassalle, O., Iafrati, J., Souchet, B., Guedj, F., Janel, N., Chavis, P., Delabar, J. M., & Manzoni, O. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2852-13.2014 · Cited by 93 · see citing works
- Authors
- Stein, V., House, D. R. C., Bredt, D. S., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-07-02
- Volume
- 23
- Issue
- 13
- Pages
- 5503-5506
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6741246
- OpenAlex
- W2155715182
- Cited by
- 341
- References
- 15
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 11 · 2023: 13 · 2022: 10 · 2021: 10 · 2020: 18 · 2019: 16 · 2018: 11 · 2017: 15 · 2016: 15 · 2015: 14 · 2014: 15 · 2013: 18 · 2012: 11
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Bristol-Myers Squibb
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- Center for Neuroscience Research
- National Cancer Institute (R01CA094143)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- PSD-95, postsynaptic density, long-term potentiation, long-term depression, synaptic plasticity, AMPA receptors, hippocampal pyramidal neurons, miniature EPSCs, silent synapses, synaptic transmission, hippocampal slice cultures
- MeSH terms
- Disks Large Homolog 4 Protein, Animals, Cells, Cultured, Hippocampus, Humans, Luminescent Proteins, Membrane Proteins, Nerve Tissue Proteins, Neuronal Plasticity, Recombinant Fusion Proteins, Synapses, Transfection, Long-Term Potentiation, Pyramidal Cells, Receptors, AMPA, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Intracellular Signaling Peptides and Proteins, Green Fluorescent Proteins, Rats, In Vitro Techniques
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