Specific Roles of AMPA Receptor Subunit GluR1 (GluA1) Phosphorylation Sites in Regulating Synaptic Plasticity in the CA1 Region of Hippocampus
Open accessAbstract
Activity-dependent changes in excitatory synaptic transmission in the CNS have been shown to depend on the regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). In particular, several lines of evidence suggest that reversible phosphorylation of AMPAR subunit glutamate receptor 1 (GluR1, also referred to as GluA1 or GluR-A) plays a role in long-term potentiation (LTP) and long-term depression (LTD). We previously reported that regulation of serines (S) 831 and 845 on the GluR1 subunit may play a critical role in bidirectional synaptic plasticity in the Schaffer collateral inputs to CA1. Specifically, gene knockin mice lacking both S831 and S845 phosphorylation sites ("double phosphomutants"), where both serine residues were replaced by alanines (A), showed a faster decaying LTP and a deficit in LTD. To determine which of the two phosphorylation sites was responsible for the phenotype, we have now generated two lines of gene knockin mice: one that specifically lacks S831 (S831A mutants) and another that lacks only S845 (S845A mutants). We found that S831A mutants display normal LTP and LTD, whereas S845A mutants show a specific deficit in LTD. Taken together with our previous results from the "double phosphomutants," our data suggest that either S831 or S845 alone may support LTP, whereas the S845 site is critical for LTD expression.
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GluA1 S845/831A and S845A knock-in mice are deficient in LTD, but S831A mice express normal LTD, indicating that LTD requires regulation of only S845 phosphorylation.
“GluA1 S845/831A and S845A knock-in mice are deficient in LTD, but S831A mice express normal LTD, further indicating that LTD requires regulation of only S845 phosphorylation”
From AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca<sup>2+</sup>-Permeable AMPA Receptors (2012) · cites this paper as Lee et al., 2010
Dephosphorylation and endocytosis of the extrasynaptic GluA1 pool is required for LTD, explaining why S845A knock-in mice that lack this receptor pool are deficient in LTD.
“dephosphorylation and endocytosis of this pool of GluA1 is required for LTD, explaining why S845A knock-in mice that lack this receptor pool are deficient in LTD”
From AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca<sup>2+</sup>-Permeable AMPA Receptors (2012) · cites this paper as Lee et al., 2010
LTD is impaired in GluA1-S845A knock-in mice, where S845 phosphorylation stabilizes GluA1 homomers in extrasynaptic locations where they exchange in and out of the synapse but are removed by LTD.
“LTD is impaired in GluA1-S845A knock-in mice (Lee et al., 2010), where it was found that S845 phosphorylation stabilizes GluA1 homomers in extrasynaptic locations where they exchange in and out of the synapse but are removed by LTD”
From AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca<sup>2+</sup>-Permeable AMPA Receptors (2012) · cites this paper as Lee et al., 2010
Replacement by alanine of either S831 or S845 does not affect LTP.
“A further issue is that replacement by alanine of either one of these residues does not affect LTP (271)”
From Synaptic memory and CaMKII (2023) · cites this paper as [271]
GluA1 S845 dephosphorylation is critical for hippocampal LTD, as the GluA1 S845A mutation results in impaired LTD.
“GluA1 S845 dephosphorylation is critical for hippocampal LTD, as the GluA1 S845A mutation results in impaired LTD (Lee et al., 2003, Lee et al., 2010), indicating that the induction of LTD requires PKA phosphorylation of GluA1 even though receptors are eventually dephosphorylated (Huganir and Nicoll, 2013).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Lee et al., 2010
Cites
Dudek, S. M., & Bear, M. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4363 · Cited by 1,708 · see citing works
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M. F., & Huganir, R. L. (2000) · Nature · doi:10.1038/35016089 · Cited by 1,116 · see citing works
Self-citationShi, S.-H., Hayashi, Y., Esteban, J. A., & Malinow, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00321-x · Cited by 1,094 · see citing works
Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression
Mulkey, R. M., Endo, S., Shenolikar, S., & Malenka, R. C. (1994) · Nature · doi:10.1038/369486a0 · Cited by 1,083 · see citing works
Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
Barria, A., Muller, D., Derkach, V., Griffith, L. C., & Soderling, T. R. (1997) · Science · doi:10.1126/science.276.5321.2042 · Cited by 1,049 · see citing works
Larson, J., Wong, D., & Lynch, G. (1986) · Brain Research · doi:10.1016/0006-8993(86)90579-2 · Cited by 1,037 · see citing works
PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
Esteban, J. A., Shi, S.-H., Wilson, C., Nuriya, M., Huganir, R. L., & Malinow, R. (2003) · Nature Neuroscience · doi:10.1038/nn997 · Cited by 894 · see citing works
Self-citationEvidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons
Wenthold, R., Petralia, R., Blahos J, II, & Niedzielski, A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-01982.1996 · Cited by 850 · see citing works
Derkach, V., Barria, A., & Soderling, T. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3269 · Cited by 842 · see citing works
Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit
Roche, K. W., O'Brien, R. J., Mammen, A. L., Bernhardt, J., & Huganir, R. L. (1996) · Neuron · doi:10.1016/s0896-6273(00)80144-0 · Cited by 812 · see citing works
Self-citationLee, H.-K., Takamiya, K., Han, J.-S., Man, H., Kim, C.-H., Rumbaugh, G., Yu, S., Ding, L., He, C., Petralia, R. S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00122-3 · Cited by 802 · see citing works
Self-citationImportance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning
Zamanillo, D., Sprengel, R., Hvalby, Ø., Jensen, V., Burnashev, N., Rozov, A., Kaiser, K. M. M., Köster, H. J., Borchardt, T., Worley, P., et al. (1999) · Science · doi:10.1126/science.284.5421.1805 · Cited by 791 · see citing works
Regulatory mechanisms of AMPA receptors in synaptic plasticity
Derkach, V. A., Oh, M. C., Guire, E. S., & Soderling, T. R. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2055 · Cited by 708 · see citing works
Lee, H.-K., Kameyama, K., Huganir, R. L., & Bear, M. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80632-7 · Cited by 668 · see citing works
Self-citationSubunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Lu, W., Shi, Y., Jackson, A. C., Bjorgan, K., During, M. J., Sprengel, R., Seeburg, P. H., & Nicoll, R. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.027 · Cited by 660 · see citing works
Chung, H. J., Xia, J., Scannevin, R. H., Zhang, X., & Huganir, R. L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07258.2000 · Cited by 558 · see citing works
Self-citationPlant, K., Pelkey, K. A., Bortolotto, Z. A., Morita, D., Terashima, A., McBain, C. J., Collingridge, G. L., & Isaac, J. T. R. (2006) · Nature Neuroscience · doi:10.1038/nn1678 · Cited by 542 · see citing works
Modulation of AMPA receptor unitary conductance by synaptic activity
Benke, T. A., Lüthi, A., Isaac, J. T. R., & Collingridge, G. L. (1998) · Nature · doi:10.1038/31709 · Cited by 533 · see citing works
Zeng, H., Chattarji, S., Barbarosie, M., Rondi-Reig, L., Philpot, B. D., Miyakawa, T., Bear, M. F., & Tonegawa, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00585-2 · Cited by 498 · see citing works
Emotion Enhances Learning via Norepinephrine Regulation of AMPA-Receptor Trafficking
Hu, H., Real, E., Takamiya, K., Kang, M.-G., Ledoux, J., Huganir, R. L., & Malinow, R. (2007) · Cell · doi:10.1016/j.cell.2007.09.017 · Cited by 496 · see citing works
Self-citationTargeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex
Colledge, M., Dean, R. A., Scott, G. K., Langeberg, L. K., Huganir, R. L., & Scott, J. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00013-1 · Cited by 467 · see citing works
Self-citationOh, M. C., Derkach, V. A., Guire, E. S., & Soderling, T. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509677200 · Cited by 456 · see citing works
Role of ampa receptor endocytosis in synaptic plasticity
Carroll, R. C., Beattie, E. C., von Zastrow, M., & Malenka, R. C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072500 · Cited by 448 · see citing works
Mammen, A. L., Kameyama, K., Roche, K. W., & Huganir, R. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32528 · Cited by 441 · see citing works
Self-citationLee, S. H., Liu, L., Wang, Y. T., & Sheng, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01024-3 · Cited by 441 · see citing works
Postnatal synaptic potentiation: delivery of GluR4-containing AMPA receptors by spontaneous activity
Zhu, J. J., Esteban, J. A., Hayashi, Y., & Malinow, R. (2000) · Nature Neuroscience · doi:10.1038/80614 · Cited by 437 · see citing works
Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity
Seol, G. H., Ziburkus, J., Huang, S., Song, L., Kim, I. T., Takamiya, K., Huganir, R. L., Lee, H.-K., & Kirkwood, A. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.013 · Cited by 429 · see citing works
Self-citationBarría, A., Derkach, V. A., & Soderling, T. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32727 · Cited by 392 · see citing works
Xia, J., Chung, H. J., Wihler, C., Huganir, R. L., & Linden, D. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)00128-8 · Cited by 383 · see citing works
Self-citationBoehm, J., Kang, M.-G., Johnson, R. C., Esteban, J., Huganir, R. L., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.013 · Cited by 382 · see citing works
Self-citationKim, C., Chung, H. J., Lee, H., & Huganir, R. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211132798 · Cited by 358 · see citing works
Self-citationRequirement of AMPA Receptor GluR2 Phosphorylation for Cerebellar Long-Term Depression
Chung, H. J., Steinberg, J. P., Huganir, R. L., & Linden, D. J. (2003) · Science · doi:10.1126/science.1082915 · Cited by 335 · see citing works
Self-citationDaw, M. I., Chittajallu, R., Bortolotto, Z. A., Dev, K. K., Duprat, F., Henley, J. M., Collingridge, G. L., & Isaac, J. T. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00160-4 · Cited by 318 · see citing works
Man, H.-Y., Sekine-Aizawa, Y., & Huganir, R. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611698104 · Cited by 311 · see citing works
Self-citationMolecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation
Heynen, A. J., Yoon, B.-J., Liu, C.-H., Chung, H. J., Huganir, R. L., & Bear, M. F. (2003) · Nature Neuroscience · doi:10.1038/nn1100 · Cited by 305 · see citing works
Self-citationHippocampal LTD Expression Involves a Pool of AMPARs Regulated by the NSF–GluR2 Interaction
Lüthi, A., Chittajallu, R., Duprat, F., Palmer, M. J., Benke, T. A., Kidd, F. L., Henley, J. M., Isaac, J. T. R., & Collingridge, G. L. (1999) · Neuron · doi:10.1016/s0896-6273(00)80852-1 · Cited by 295 · see citing works
Steinberg, J. P., Takamiya, K., Shen, Y., Xia, J., Rubio, M. E., Yu, S., Jin, W., Thomas, G. M., Linden, D. J., & Huganir, R. L. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.025 · Cited by 288 · see citing works
Self-citationMatsuda, S., Launey, T., Mikawa, S., & Hirai, H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.12.2765 · Cited by 272 · see citing works
Subunit Rules Governing the Sorting of Internalized AMPA Receptors in Hippocampal Neurons
Lee, S. H., Simonetta, A., & Sheng, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.015 · Cited by 268 · see citing works
Matsuda, S., Mikawa, S., & Hirai, H. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.731765.x · Cited by 263 · see citing works
Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3
Meng, Y., Zhang, Y., & Jia, Z. (2003) · Neuron · doi:10.1016/s0896-6273(03)00368-4 · Cited by 251 · see citing works
The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity
Kim, J. H., Lee, H.-K., Takamiya, K., & Huganir, R. L. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01119.2003 · Cited by 240 · see citing works
Self-citationSeidenman, K. J., Steinberg, J. P., Huganir, R., & Malinow, R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09220.2003 · Cited by 225 · see citing works
Self-citationTavalin, S. J., Colledge, M., Hell, J. W., Langeberg, L. K., Huganir, R. L., & Scott, J. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03044.2002 · Cited by 222 · see citing works
Self-citationConservation of Glutamate Receptor 2-Containing AMPA Receptors during Long-Term Potentiation
Adesnik, H., & Nicoll, R. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0325-07.2007 · Cited by 213 · see citing works
Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience
Goel, A., Jiang, B., Xu, L. W., Song, L., Kirkwood, A., & Lee, H.-K. (2006) · Nature Neuroscience · doi:10.1038/nn1725 · Cited by 210 · see citing works
Self-citationStabilization of Ca 2+ -permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation
He, K., Song, L., Cummings, L. W., Goldman, J. W., Huganir, R. L., & Lee, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910338106 · Cited by 189 · see citing works
Self-citationHuang, C., Liang, Y., & Hsu, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106388200 · Cited by 152 · see citing works
Smith, K. E., Gibson, E. S., & Dell’Acqua, M. L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3092-05.2006 · Cited by 141 · see citing works
Jensen, V., Kaiser, K. M. M., Borchardt, T., Adelmann, G., Rozov, A. V., Burnashev, N., Brix, C., Frotscher, M., Andersen, P. N., Hvalby, Ø., et al. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.053637 · Cited by 139 · see citing works
NMDA receptor–independent long-term depression correlates with successful aging in rats
Lee, H., Min, S. S., Gallagher, M., & Kirkwood, A. (2005) · Nature Neuroscience · doi:10.1038/nn1586 · Cited by 126 · see citing works
Self-citationDominant role of the GluR2 subunit in regulation of AMPA receptors by CaMKII
Oh, M. C., & Derkach, V. A. (2005) · Nature Neuroscience · doi:10.1038/nn1476 · Cited by 118 · see citing works
Glutamatergic Plasticity by Synaptic Delivery of GluR-Blong-Containing AMPA Receptors
Kolleker, A., Zhu, J., Schupp, B. J., Qin, Y., Mack, V., Borchardt, T., Köhr, G., Malinow, R., Seeburg, P. H., & Osten, P. (2003) · Neuron · doi:10.1016/s0896-6273(03)00722-0 · Cited by 97 · see citing works
Steinberg, J. P., Huganir, R. L., & Linden, D. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408278102 · Cited by 73 · see citing works
Self-citationAKAP150‐anchored PKA activity is important for LTD during its induction phase
Lü, Y., Zhang, M., Lim, I. A., Hall, D. D., Allen, M., Medvedeva, Y. V., McKnight, G. S., Usachev, Y. M., & Hell, J. W. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.151662 · Cited by 72 · see citing works
Endocytosis and recycling of AMPA receptors lacking GluR2/3
Biou, V., Bhattacharyya, S., & Malenka, R. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711412105 · Cited by 66 · see citing works
Delgado, J. Y., Coba, M., Anderson, C. N. G., Thompson, K. R., Gray, E. E., Heusner, C. L., Martin, K. C., Grant, S. G. N., & O'Dell, T. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3056-07.2007 · Cited by 62 · see citing works
Lee, H., Takamiya, K., Kameyama, K., He, K., Yu, S., Rossetti, L., Wilen, D., & Huganir, R. L. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.06.003 · Cited by 49 · see citing works
Self-citationA necessary role for GluR1 serine 831 phosphorylation in appetitive incentive learning
Crombag, H. S., Sutton, J. M., Takamiya, K., Lee, H., Holland, P. C., Gallagher, M., & Huganir, R. L. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.026 · Cited by 45 · see citing works
Self-citationLü, Y.-F., Hayashi, Y., Moriwaki, A., Tomizawa, K., & Matsui, H. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12384-3 · Cited by 35 · see citing works
Crombag, H. S., Sutton, J. M., Takamiya, K., Holland, P. C., Gallagher, M., & Huganir, R. L. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06299.x · Cited by 33 · see citing works
Self-citationHolman, D., Feligioni, M., & Henley, J. M. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.05.022 · Cited by 27 · see citing works
Panicker, S., Brown, K., & Nicoll, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711313105 · Cited by 26 · see citing works
Yang, Y., Takeuchi, K., Rodenas-Ruano, A., Takayasu, Y., Bennett, M. V. L., & Zukin, R. S. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.013 · Cited by 23 · see citing works
Lee, H., & Huganir, R. L. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00035-8 · Cited by 15 · see citing works
Self-citation
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Lisman, J., Yasuda, R., & Raghavachari, S. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3192 · Cited by 1,134 · see citing works
AMPARs and Synaptic Plasticity: The Last 25 Years
Huganir, R. L., & Nicoll, R. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.025 · Cited by 968 · see citing works
Self-citationThe AMPA Receptor Code of Synaptic Plasticity
Diering, G. H., & Huganir, R. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.018 · Cited by 844 · see citing works
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Lee, H., & Kirkwood, A. (2011) · Cited by 692 · see citing works
Self-citationSynaptic AMPA receptor composition in development, plasticity and disease
Henley, J. M., & Wilkinson, K. A. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.37 · Cited by 506 · see citing works
Izquierdo, I., Furini, C. R. G., & Myskiw, J. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00018.2015 · Cited by 453 · see citing works
CaMKII: a central molecular organizer of synaptic plasticity, learning and memory
Yasuda, R., Hayashi, Y., & Hell, J. W. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-022-00624-2 · Cited by 431 · see citing works
The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity
Chater, T. E., & Goda, Y. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00401 · Cited by 342 · see citing works
Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression
Nabavi, S., Kessels, H. W. H. G., Alfonso, S., Aow, J., Fox, R., & Malinow, R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219454110 · Cited by 280 · see citing works
Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating
Kristensen, A. S., Jenkins, M. A., Banke, T. G., Schousboe, A., Makino, Y., Johnson, R. C., Huganir, R., & Traynelis, S. F. (2011) · Nature Neuroscience · doi:10.1038/nn.2804 · Cited by 286 · see citing works
Self-citationReich, N., & Hölscher, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.970925 · Cited by 248 · see citing works
AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging
Henley, J. M., & Wilkinson, K. A. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/jhenley · Cited by 236 · see citing works
Fioriti, L., Myers, C., Huang, Y.-Y., Li, X., Stephan, J. S., Trifilieff, P., Colnaghi, L., Kosmidis, S., Drisaldi, B., Pavlopoulos, E., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.021 · Cited by 221 · see citing works
Sanderson, J. L., Gorski, J. A., & Dell’Acqua, M. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.043 · Cited by 210 · see citing works
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Löhmann, C., & Kessels, H. W. H. G. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.235119 · Cited by 176 · see citing works
Cai, X., Kallarackal, A. J., Kvarta, M. D., Goluskin, S., Gaylor, K., Bailey, A. M., Lee, H.-K., Huganir, R. L., & Thompson, S. M. (2013) · Nature Neuroscience · doi:10.1038/nn.3355 · Cited by 180 · see citing works
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Diering, G. H., Gustina, A. S., & Huganir, R. L. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.024 · Cited by 153 · see citing works
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Sanderson, J. L., Gorski, J. A., Gibson, E. S., Lam, P., Freund, R. K., Chick, W. S., & Dell'Acqua, M. L. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3326-12.2012 · Cited by 137 · see citing works
“In addition, it was found that dephosphorylation and endocytosis of this pool of GluA1 is required for LTD, explaining why S845A knock-in mice that lack this receptor pool are deficient in LTD (He et al., 2009; Lee et al., 2010).”
BackgroundInfluentialChandran, A., Iyo, A. H., Jernigan, C. S., Legutko, B., Austin, M. C., & Karolewicz, B. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.08.001 · Cited by 137 · see citing works
Kelly, M. P., Adamowicz, W. O., Bove, S. E., Hartman, A., Mariga, A., Pathak, G., Reinhart, V., Romegialli, A., & Kleiman, R. J. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.10.007 · Cited by 138 · see citing works
Shonesy, B. C., Jalan‐Sakrikar, N., Cavener, V. S., & Colbran, R. J. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-420170-5.00003-9 · Cited by 134 · see citing works
Nicoll, R. A., & Schulman, H. (2023) · Physiological Reviews · doi:10.1152/physrev.00034.2022 · Cited by 126 · see citing works
“A further issue is that replacement by alanine of either one of these residues does not affect LTP (271); only the double phosphonull mutant partially impaired LTP in adult, but not young, mice (272).”
BackgroundCaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory
Park, J., Chávez, A. E., Mineur, Y. S., Morimoto-Tomita, M., Lutzu, S., Kim, K. S., Picciotto, M. R., Castillo, P. E., & Tomita, S. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.002 · Cited by 121 · see citing works
Purkey, A., & Dell’Acqua, M. L. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00008 · Cited by 113 · see citing works
Qian, H., Patriarchi, T., Price, J. L., Matt, L., Lee, B. R., Nieves‐Cintrón, M., Buonarati, O. R., Chowdhury, D., Nanou, E., Nystoriak, M. A., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aaf9659 · Cited by 114 · see citing works
LTP induction by structural rather than enzymatic functions of CaMKII
Tullis, J. E., Larsen, M. E., Rumian, N. L., Freund, R. K., Boxer, E. E., Brown, C. N., Coultrap, S. J., Schulman, H., Aoto, J., Dell’Acqua, M. L., et al. (2023) · Nature · doi:10.1038/s41586-023-06465-y · Cited by 112 · see citing works
Keith, D. J., Sanderson, J. L., Gibson, E. S., Woolfrey, K. M., Robertson, H. R., Olszewski, K., Kang, R., El-Husseini, A., & Dell'Acqua, M. L. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0784-12.2012 · Cited by 108 · see citing works
Park, P., Sanderson, T. M., Amici, M., Choi, S.-L., Bortolotto, Z. A., Zhuo, M., Kaang, B., & Collingridge, G. L. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3625-15.2016 · Cited by 109 · see citing works
Whitcomb, D. J., Hogg, E. L., Regan, P. L., Piers, T. M., Narayan, P. S., Whitehead, G., Winters, B. L., Kim, D.-H., Kim, E., George‐Hyslop, P. S., et al. (2015) · Scientific Reports · doi:10.1038/srep10934 · Cited by 105 · see citing works
Goel, A., Xu, L. W., Snyder, K. P., Song, L., Goenaga-Vazquez, Y., Megill, A., Takamiya, K., Huganir, R. L., & Lee, H.-K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018264 · Cited by 103 · see citing works
Self-citationMiñano-Molina, A. J., España, J., Martín, E., Barneda‐Zahonero, B., Fadó, R., Solé, M., Trullás, R., Saura, C. A., & Rodrı́guez-Álvarez, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.227504 · Cited by 103 · see citing works
Roles of subunit phosphorylation in regulating glutamate receptor function
Wang, J. Q., Guo, M., Jin, D.-Z., Xue, B., Fibuch, E. E., & Mao, L. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.11.019 · Cited by 91 · see citing works
Extensive phosphorylation of AMPA receptors in neurons
Diering, G. H., Heo, S., Hussain, N. K., Liu, B., & Huganir, R. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610631113 · Cited by 90 · see citing works
Self-citationEmerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity
Jang, S.-S., & Chung, H. J. (2016) · Neural Plasticity · doi:10.1155/2016/7969272 · Cited by 89 · see citing works
Jürgensen, S., Antonio, L. L., Mussi, G. E. A., Brito-Moreira, J., Bomfim, T. R., De Felice, F. G., Garrido-Sanabria, E. R., Cavalheiro, É. A., & Ferreira, S. T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.177790 · Cited by 88 · see citing works
Homeostatic synaptic plasticity as a metaplasticity mechanism — a molecular and cellular perspective
Li, J., Park, E., Zhong, L. R., & Chen, L. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.08.010 · Cited by 81 · see citing works
Kharlamov, E. A., Lepsveridze, E., Meparishvili, M., Solomonia, R. O., Lu, B., Miller, E. R., Kelly, K. M., & Mtchedlishvili, Z. (2011) · Epilepsy Research · doi:10.1016/j.eplepsyres.2011.02.008 · Cited by 81 · see citing works
Buonarati, O. R., Hammes, E. A., Watson, J. F., Greger, I. H., & Hell, J. W. (2019) · Science Signaling · doi:10.1126/scisignal.aar6889 · Cited by 81 · see citing works
β2-Adrenergic receptor supports prolonged theta tetanus-induced LTP
Qian, H., Matt, L., Zhang, M., Nguyen, M., Patriarchi, T., Koval, O. M., Anderson, M. E., He, K., Lee, H., & Hell, J. W. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00374.2011 · Cited by 82 · see citing works
Self-citationAMPA receptor regulation during synaptic plasticity in hippocampus and neocortex
Lee, H., & Kirkwood, A. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.06.007 · Cited by 769 · see citing works
Self-citationLopes, M. W., Soares, F. M. S., de Mello, N., Nunes, J. C., Cajado, A. G., de Brito, D., de Cordova, F. M., da Cunha, R. M. S., Walz, R., & Leal, R. B. (2013) · Experimental Brain Research · doi:10.1007/s00221-013-3421-8 · Cited by 78 · see citing works
Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation
Hasegawa, S., Fukushima, H., Hosoda, H., Serita, T., Ishikawa, R., Rokukawa, T., Kawahara‐Miki, R., Zhang, Y., Ohta, M., Okada, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13554-y · Cited by 77 · see citing works
Monfort, P., Gómez‐Giménez, B., Llansola, M., & Felipo, V. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00096 · Cited by 77 · see citing works
AMPA Receptor Trafficking in Natural and Pathological Aging
Jurado, S. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00446 · Cited by 73 · see citing works
Sanderson, J. L., Scott, J. D., & Dell’Acqua, M. L. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2362-17.2018 · Cited by 75 · see citing works
Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease
Megill, A., Tran, T., Eldred, K. C., Lee, N. J., Wong, P. C., Hoe, H., Kirkwood, A., & Lee, H. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5289-14.2015 · Cited by 70 · see citing works
Self-citationAn Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity?
Sciaccaluga, M., Megaro, A., Bellomo, G., Ruffolo, G., Romoli, M., Palma, E., & Costa, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115991 · Cited by 70 · see citing works
Uzunova, G., Hollander, E., & Shepherd, J. D. (2014) · Current Neuropharmacology · doi:10.2174/1570159x113116660046 · Cited by 70 · see citing works
Patriarchi, T., Buonarati, O. R., & Hell, J. W. (2018) · The EMBO Journal · doi:10.15252/embj.201899771 · Cited by 65 · see citing works
Urban air pollutants reduce synaptic function of CA 1 neurons via an NMDA /NȮ pathway in vitro
Davis, D. A., Akopian, G. K., Walsh, J. P., Sioutas, C., Morgan, T. E., & Finch, C. E. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12395 · Cited by 68 · see citing works
Ca2+-permeable AMPA receptors in homeostatic synaptic plasticity
Lee, H. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00017 · Cited by 68 · see citing works
Self-citationAubele, T., & Kritzer, M. F. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr258 · Cited by 68 · see citing works
Drago, A., Crisafulli, C., Sidoti, A., & Serretti, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.009 · Cited by 68 · see citing works
Qu, W., Yuan, B., Li, R., Liu, Q., Zhang, X., Cui, R., Yang, W., & Li, B. (2020) · Cell Proliferation · doi:10.1111/cpr.12959 · Cited by 64 · see citing works
Jiang, W., Yu, Q., Gong, M., Chen, L., Wen, E. Y., Bi, Y., Zhang, Y., Shi, Y., Qü, P., Liu, Y., et al. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07697.x · Cited by 67 · see citing works
AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs
Díaz-Alonso, J., & Nicoll, R. A. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108710 · Cited by 66 · see citing works
Zhang, M., Patriarchi, T., Stein, I. S., Qian, H., Matt, L., Nguyen, M., Xiang, Y. K., & Hell, J. W. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.449462 · Cited by 66 · see citing works
Purkey, A., Woolfrey, K. M., Crosby, K. C., Stich, D., Chick, W. S. H., Aoto, J. N., & Dell’Acqua, M. L. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.085 · Cited by 65 · see citing works
Argyrousi, E. K., Heckman, P. R. A., & Prickaerts, J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.004 · Cited by 64 · see citing works
Glutamate Plasticity in the Drunken Amygdala
McCool, B. A., Christian, D., Diaz, M. R., & Läck, A. K. (2010) · International review of neurobiology · doi:10.1016/s0074-7742(10)91007-6 · Cited by 62 · see citing works
Fear Extinction Induces mGluR5-Mediated Synaptic and Intrinsic Plasticity in Infralimbic Neurons
Sepulveda-Orengo, M. T., López, A. V., Soler‐Cedeño, O., & Porter, J. T. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5198-12.2013 · Cited by 61 · see citing works
Calcineurin mediates homeostatic synaptic plasticity by regulating retinoic acid synthesis
Arendt, K. L., Zhang, Z., Ganesan, S., Hintze, M., Shin, M. M., Tang, Y., Cho, A., Graef, I. A., & Chen, L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510239112 · Cited by 60 · see citing works
STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs
García-Alvarez, G., Lu, B., Yap, K. A. F., Wong, L. C., Thevathasan, J. V., Lim, L., Ji, F., Tan, K. W., Mancuso, J. J., Tang, W., et al. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-07-1222 · Cited by 59 · see citing works
Sanderson, J. L., Freund, R. K., Gorski, J. A., & Dell’Acqua, M. L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109786 · Cited by 60 · see citing works
Wang, H., Megill, A., He, K., Kirkwood, A., & Lee, H. (2012) · Neural Plasticity · doi:10.1155/2012/272374 · Cited by 59 · see citing works
Self-citationWoolfrey, K. M., O’Leary, H., Goodell, D. J., Robertson, H. R., Horne, E. A., Coultrap, S. J., Dell’Acqua, M. L., & Bayer, K. U. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.813808 · Cited by 56 · see citing works
Pochwat, B., Sowa-Kućma, M., Kotarska, K., Misztak, P., Nowak, G., & Szewczyk, B. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3671-6 · Cited by 55 · see citing works
Mechanisms of AMPA Receptor Endosomal Sorting
Parkinson, G. T., & Hanley, J. G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00440 · Cited by 53 · see citing works
Re-Opening the Critical Window for Estrogen Therapy
Bean, L. A., Kumar, A., Rani, A., Guidi, M., Rosario, A. M., Cruz, P. E., Golde, T. E., & Foster, T. C. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1890-15.2015 · Cited by 53 · see citing works
Interplay of enzymatic and structural functions of Ca MKII in long‐term potentiation
Kim, K., Saneyoshi, T., Hosokawa, T., Okamoto, K., & Hayashi, Y. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13672 · Cited by 51 · see citing works
VEGF counteracts amyloid-β-induced synaptic dysfunction
Martin, L., Bouvet, P., Chounlamountri, N., Watrin, C., Besançon, R., Pinatel, D., Meyronet, D., Honnorat, J., Buisson, A., Salin, P. A., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109121 · Cited by 49 · see citing works
Kim, M., Park, A. J., Havekes, R., Chay, A., Guercio, L. A., Oliveira, R. F., Abel, T. G., & Blackwell, K. T. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002084 · Cited by 50 · see citing works
Blair, L. J., Criado‐Marrero, M., Zheng, D., Wang, X., Kamath, S. G., Nordhues, B. A., Weeber, E. J., & Dickey, C. A. (2019) · eNeuro · doi:10.1523/eneuro.0242-18.2019 · Cited by 47 · see citing works
Synaptic Plasticity Regulated by Protein–Protein Interactions and Posttranslational Modifications
Yokoi, N., Fukata, M., & Fukata, Y. (2012) · International review of cytology · doi:10.1016/b978-0-12-394308-8.00001-7 · Cited by 48 · see citing works
GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal
Lee, S., Song, B., Kim, J., Park, K., Hong, I., An, B., Song, S.-H., Lee, J., Park, S., Kim, J., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3491 · Cited by 47 · see citing works
Sodium channel endocytosis drives axon initial segment plasticity
Freal, A., Jamann, N., ten Bos, J., Jansen, J., Petersen, N., Ligthart, T. W., Hoogenraad, C. C., & Kole, M. H. P. (2023) · Science Advances · doi:10.1126/sciadv.adf3885 · Cited by 47 · see citing works
CaMKII‐dependent phosphorylation of GluK5 mediates plasticity of kainate receptors
Carta, M., Opazo, P., Veran, J., Athané, A., Choquet, D., Coussen, F., & Mulle, C. (2013) · The EMBO Journal · doi:10.1038/emboj.2012.334 · Cited by 47 · see citing works
Ionotropic Glutamate Receptors: Regulation by G-Protein-Coupled Receptors
Rojas, A., & Dingledine, R. J. (2013) · Molecular Pharmacology · doi:10.1124/mol.112.083352 · Cited by 47 · see citing works
He, K., Lee, A., Song, L., Kanold, P. O., & Lee, H. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00913.2010 · Cited by 43 · see citing works
Self-citationA revised view of the role of CaMKII in learning and memory
Bayer, K. U., & Giese, K.-P. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01809-x · Cited by 50 · see citing works
Persistent Reversal of Enhanced Amphetamine Intake by Transient CaMKII Inhibition
Loweth, J. A., Li, D., Cortright, J. J., Wilke, G. A., Jeyifous, O., Neve, R. L., Bayer, K. U., & Vezina, P. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4386-13.2013 · Cited by 42 · see citing works
Pougnet, J.-T., Compans, B., Martínez, A., Choquet, D., Hosy, E., & Boué‐Grabot, É. (2016) · Scientific Reports · doi:10.1038/srep31836 · Cited by 43 · see citing works
Stafford, J. A., Brownlow, M. L., Qualley, A., & Jankord, R. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.11.002 · Cited by 41 · see citing works
Stockwell, J., Chen, Z., Niazi, M., Nosib, S., & Cayabyab, F. S. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.11.018 · Cited by 41 · see citing works
Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit
Díaz-Alonso, J., Morishita, W., Incontro, S., Simms, J., Holtzman, J., Gill, M., Mucke, L., Malenka, R. C., & Nicoll, R. A. (2020) · eLife · doi:10.7554/elife.58042 · Cited by 37 · see citing works
Chan, E. S., Shetty, M. S., Sajikumar, S., Chen, C., Soong, T. W., & Wong, B.-S. (2016) · Scientific Reports · doi:10.1038/srep26119 · Cited by 39 · see citing works
Palmitoylation-mediated synaptic regulation of AMPA receptor trafficking and function
Sohn, H., & Park, M. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01134-z · Cited by 40 · see citing works
Hearing, M. C., Schwendt, M., & McGinty, J. F. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001173 · Cited by 39 · see citing works
CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice
Vingtdeux, V., Chang, E. H., Frattini, S. A., Zhao, H., Chandakkar, P., Adrien, L. R., Strohl, J. J., Gibson, E. L., Ohmoto, M., Matsumoto, I., et al. (2016) · Scientific Reports · doi:10.1038/srep24250 · Cited by 36 · see citing works
The Shaping of AMPA Receptor Surface Distribution by Neuronal Activity
Chater, T. E., & Goda, Y. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.833782 · Cited by 37 · see citing works
Doboszewska, U., Szewczyk, B., Sowa-Kućma, M., Młyniec, K., Rafało-Ulińska, A., Ostachowicz, B., Lankosz, M., & Nowak, G. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.03.064 · Cited by 38 · see citing works
Burgdorf, C. E., Schierberl, K. C., Lee, A. S., Fischer, D. K., Kempen, T. A. V., Mudragel, V., Huganir, R. L., Milner, T. A., Glass, M. J., & Rajadhyaksha, A. M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2397-17.2017 · Cited by 36 · see citing works
Self-citationSerwach, K., & Gruszczynska‐Biegala, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092289 · Cited by 36 · see citing works
Genetic analysis of neuronal ionotropic glutamate receptor subunits
Granger, A. J., Gray, J. A., Lü, W., & Nicoll, R. A. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.213033 · Cited by 35 · see citing works
- Authors
- Lee, H.-K., Takamiya, K., He, K., Song, L., & Huganir, R. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Maryland, College Park (US)
- Corresponding author
- Huganir, Richard L.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2010-01
- Volume
- 103
- Issue
- 1
- Pages
- 479-489
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- PMC
- PMC2807233
- OpenAlex
- W2162552344
- Cited by
- 261
- References
- 65
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 13 · 2023: 13 · 2022: 17 · 2021: 14 · 2020: 18 · 2019: 17 · 2018: 18 · 2017: 11 · 2016: 24 · 2015: 22 · 2014: 19 · 2013: 23 · 2012: 13
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Eye Institute (R01EY014882)
- National Institute of Neurological Disorders and Stroke (R01NS036715)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- GluR1, AMPA receptors, GluR1 phosphorylation, long-term potentiation, long-term depression, bidirectional synaptic plasticity, hippocampal CA1, Schaffer collaterals, excitatory synaptic transmission
- MeSH terms
- Aging, Amino Acid Sequence, Animals, Base Sequence, Male, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Mutation, Synaptic Transmission, Neurons, Phosphorylation, Synapses, Long-Term Potentiation, Receptors, AMPA, Long-Term Synaptic Depression, Mice, Gene Knock-In Techniques, CA1 Region, Hippocampal, In Vitro Techniques
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