The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
The relationship between episodic long-term memory and white matter integrity in normal aging
Abstract
It has been proposed that episodic long-term memory (LTM) declines in normal aging and may be affected by disruption of white matter networks. This was explored in 104 healthy adults aged 50-90 years in the GENIE study; white matter integrity was assessed using diffusion tensor imaging (DTI) in large regions of interest, with additional measures of white matter hyperintensities (WMH), normalized brain and hippocampal volumes. LTM was compared with executive function, working memory and information processing speed. LTM correlated significantly with DTI, WMH and whole brain volume, but not with hippocampal volume. Using linear regression, only DTI measures explained the variance (approximately 19%) in LTM; mediational analyses explored the extent to which other cognitive functions mediate the association between DTI changes and memory. The results suggest that reduced LTM performance in normal aging is related to reduced integrity of a distributed network dependent on white matter pathways supporting episodic memory.
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In the citing paper
“Similarly, episodic memory, relative to semantic memory, declines rapidly and dramatically with normal ageing [10–15].”
From Is episodic-like memory like episodic memory? (2024) · cites this paper as [11]
In the citing paper
“In humans, episodic memory is well known to decline with normal ageing [10,11] and deteriorates the earliest and most dramaticlly compared to other forms of memory [12–15].”
From Is episodic-like memory like episodic memory? (2024) · cites this paper as [11]
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Cited by
Sorted by citations
Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00363 · Cited by 1,416
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Structural network efficiency is associated with cognitive impairment in small-vessel disease
Lawrence, A. J., Chung, A. W., Morris, R. G., Markus, H. S., & Barrick, T. R. (2014) · Neurology · doi:10.1212/wnl.0000000000000612 · Cited by 285
Self-citationLongitudinal association between hippocampus atrophy and episodic-memory decline
Gorbach, T., Pudas, S., Lundquist, A., Orädd, G., Josefsson, M., Salami, A., de Luna, X., & Nyberg, L. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.12.002 · Cited by 245
Assessing cognitive decline in the aging brain: lessons from rodent and human studies
Brito, D. V. C., Esteves, F., Rajado, A. T., Silva, N., ALFA score Consortium, Andrade, R., Apolónio, J., Calado, S., Faleiro, L., Matos, C., et al. (2023) · npj Aging · doi:10.1038/s41514-023-00120-6 · Cited by 177
Metadata
- Authors
- Charlton, R. A., Barrick, T. R., Markus, H. S., & Morris, R. G.
- Affiliations
- St George's, University of London (GB)
- University of London (GB)
- Corresponding author
- Charlton, R.A.
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 48
- Issue
- 1
- Pages
- 114-122
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W1969439616
- Cited by
- 55
- References
- 82
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 6 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 1
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- episodic long-term memory, normal aging, white matter integrity, white matter hyperintensities, executive function, working memory, processing speed, brain volume, hippocampal volume, diffusion tensor imaging
- MeSH terms
- Aged, Aged, 80 and over, Aging, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Male, Memory, Middle Aged, Nerve Fibers, Myelinated, Neuropsychological Tests, Statistics as Topic, Diffusion Tensor Imaging
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- Charlton, R. A., Barrick, T. R., Markus, H. S., & Morris, R. G. (2010). The relationship between episodic long-term memory and white matter integrity in normal aging. Neuropsychologia. https://doi.org/10.1016/j.neuropsychologia.2009.08.018
