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Cited by 135Neural and Behavioral Psychology StudiesParkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatments

Executive impairment in Parkinson's disease: response automaticity and task switching

Cameron, Ian G.M., Watanabe, Masayuki, Pari, Giovanna, Munoz, Douglas P.·2010·Neuropsychologia
DOI 10.1016/j.neuropsychologia.2010.03.015
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Abstract

Patients with Parkinson's disease (PD) show slowed movement initiation and can have deficits in executive function, leading to impairments in controlling involuntary behavior. This results in difficulties performing an antisaccade, which requires one to suppress an automatic eye movement (a prosaccade) to a visual stimulus, and execute a voluntary eye movement in the opposite direction. Antisaccade deficits are similar to those seen in task switching, whereby one is required to change a response after performing a different behavior. Both antisaccade (Hood et al., 2007) and task switching (Cools, Barker, Sahakian, & Robbins, 2001) deficits in PD have been attributed to fronto-basal ganglia (BG) dysfunction. Previously, we demonstrated with functional magnetic resonance imaging that BG circuitry is important to both task switching and voluntary saccade generation, as greater caudate activation was seen when healthy young adults first prepared a prosaccade, but then switched to an antisaccade (Cameron, Coe, et al., 2009). Therefore, we hypothesized that PD patients would have difficulty switching from one saccade response to the other, with particular impairment in switching from a pro to an antisaccade. Here, we not only confirmed this prediction, but also showed that PD patients performed better than controls in switching from an anti to a prosaccade. This suggests that task switching deficits in PD are particularly pronounced when more automatic behavior needs to be overridden with alternative behavior. We suggest that this occurs primarily at the level of establishing the appropriate task set, which is an internalized rule that governs how to respond.

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  • Accumulating evidence suggests neuroplasticity within the corticostriatal circuit is impaired under conditions of dopamine denervation.

    “However, accumulating evidence suggest that neuroplasticity within this corticostriatal circuit is also impaired under conditions of DA denervation 41–44”

    From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [41]

  • Exercise can alter the storage and release of glutamate in presynaptic terminals that may improve circuit function and diminish the increased inhibitory drive of the dopamine depleted striatum.

    “In addition to its receptors, exercise can also alter the storage and release of glutamate in presynaptic terminals that may also improve circuit function and diminish the increased inhibitory drive of the DA depleted striatum 41–44.”

    From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [41]

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Authors
Cameron, I. G. M., Watanabe, M., Pari, G., & Munoz, D. P.
Affiliations
Queen's University (CA)
Corresponding author
Munoz, Douglas P.
ORCID
Venue
Neuropsychologia
Publisher
Elsevier BV
Published
2010-06
Volume
48
Issue
7
Pages
1948-1957
ISSN
0028-3932 (ISSN-L)
DOI
10.1016/j.neuropsychologia.2010.03.015
OpenAlex
W2045617402
Cited by
135
References
61
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 9 · 2022: 5 · 2021: 10 · 2020: 3 · 2019: 6 · 2018: 7 · 2017: 12 · 2016: 11 · 2015: 15 · 2014: 9 · 2013: 19 · 2012: 14
FWCI
7.37
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropsychologia (publishedVersion)
  • PubMed (publishedVersion)
Funders
British Heart Foundation (MOP-97741)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
Parkinson's disease, executive function, task switching, antisaccades, prosaccades, eye movements, caudate nucleus, task sets, movement initiation
MeSH terms
Adult, Aged, Aged, 80 and over, Attention, Cognition Disorders, Electrooculography, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease, Photic Stimulation, Reaction Time, Saccades, Severity of Illness Index, Statistics as Topic, Visual Perception, Executive Function

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