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Postnatal shifts of interneuron position in the neocortex of normal and reeler mice: evidence for inward radial migration
Abstract
During development, interneurons migrate to precise positions in the cortex by tangential and radial migration. The objectives of this study were to characterize the net radial migrations of interneurons during the first postnatal week, and to investigate the role of reelin signaling in regulating those migrations. To observe radial migrations, we compared the laminar positions of interneurons (immunoreactive for GABA or Dlx) in mouse neocortex on postnatal days (P) 0.5 and P7.5. In addition, we used bromodeoxyuridine birthdating to reveal the migrations of different interneuron cohorts. To study the effects of reelin deficiency, experiments were performed in reeler mutant mice. In normal P0.5 cortex, interneurons were most abundant in the marginal zone and layer 5. By P7.5, interneurons were least abundant in the marginal zone, and were distributed more evenly in the cortical plate. This change was attributed mainly to inward migration of middle- to late-born interneurons (produced on embryonic days (E) 13.5 to E16.5) from the marginal zone to layers 2-5. During the same interval, late-born projection neurons (non-immunoreactive for GABA or Dlx) migrated mainly outward, from the intermediate zone to upper cortical layers. In reeler cortex, middle- and late-born interneurons migrated from the superplate on P0.5, to the deep cortical plate on P7.5. Late-born projection neurons in reeler migrated in the opposite direction, from the intermediate zone to the deep cortical plate. We conclude that many middle- and late-born interneurons migrate radially inward, from the marginal zone (or superplate) to the cortical plate, during the first postnatal week in normal and reeler mice. We propose that within the cortical plate, interneuron laminar positions may be determined in part by interactions with projection neurons born on the same day in neurogenesis.
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In the citing paper
“Several lines of evidence suggest that the interneurons adopt their laminar distribution in response to cues provided by pyramidal cells.”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Hevner et al., 2004
In the citing paper
“First, interneurons systematically acquire their laminar position after the corresponding pyramidal cells have begun to differentiate into a particular cortical layer (Hevner et al., 2004; Miyoshi and Fishell, 2011; Pla et al., 2006).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Hevner et al., 2004
In the citing paper
“In the cortex of reeler mice, MGE-derived interneurons are inverted similar to PCs: early-born cells are found ectopically in superficial layers while those born later are found in the deep layers”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [489]
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Metadata
- Authors
- Hevner, R. F., Daza, R. A. M., Englund, C., Kohtz, J., & Fink, A.
- Affiliations
- University of Washington (US)
- Northwestern University (US)
- Corresponding author
- Hevner, R.F
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 124
- Issue
- 3
- Pages
- 605-618
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W1970617579
- Cited by
- 180
- References
- 70
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 13 · 2016: 5 · 2015: 12 · 2014: 7 · 2013: 13 · 2012: 8
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (7k08ns001973-06)
- National Institute of Neurological Disorders and Stroke (K08 NS01973)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD044745)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- interneuron migration, radial migration, in-migration, Reelin signaling, reeler mutant mice, neocortex, cortical lamination, marginal zone, cortical plate, projection neurons, GABAergic interneurons, postnatal development, neurogenesis
- MeSH terms
- Reelin Protein, Animals, Animals, Newborn, Bromodeoxyuridine, Cell Differentiation, Cell Division, Cell Movement, Cerebral Cortex, Fetus, gamma-Aminobutyric Acid, Immunohistochemistry, Interneurons, Mice, Neurologic Mutants, Nerve Tissue Proteins, Nervous System Malformations, Neural Inhibition, Neural Pathways, Serine Endopeptidases, Transcription Factors, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Apoptosis, Homeodomain Proteins, Cell Lineage, Body Patterning, Mice
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