Induction of long-term potentiation leads to increased reliability of evoked neocortical spindles in vivo
Abstract
Large amplitude electroencephalographic spindle waves (7-14 Hz) occur spontaneously in the neocortex during both sleep and awake immobility, and it has been proposed that synchronous neuronal activation during spindles may contribute to learning-related synaptic plasticity. Spindles can also be evoked in the sensorimotor cortex by electrical stimulation of cortical or thalamic inputs in the rat. To determine if strengthening cortical synapses can affect the initiation and maintenance of electrically evoked spindles, stimulation pulses were delivered at a range of intensities to the corpus callosum or ventrolateral thalamus in the awake rat before and after the induction of long-term potentiation (LTP) by tetanization of the corpus callosum. The morphology of evoked spindles was similar to that of naturally occurring spindles. Spindles were evoked less reliably during slow-wave sleep than during waking, and this was correlated with smaller synaptic responses during slow-wave sleep. Similar to previous findings, daily tetanization of the corpus callosum for 15 days decreased the early component and increased the late component of synaptic responses evoked by corpus callosum stimulation, but did not significantly affect synaptic responses evoked by thalamic stimulation. Similarly, LTP induction increased the reliability with which low-intensity corpus callosum stimulation evoked spindles, but increases in spindles evoked by thalamic stimulation were not significant. Synaptic pot…
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In vivo, synchronous spindle activity occurred more reliably in neocortical synaptic networks that had been previously potentiated through tetanic stimulation.
“In vivo, synchronous spindle activity occurred more reliably in neocortical synaptic networks that had been previously potentiated through tetanic stimulation (1315).”
From About Sleep's Role in Memory (2013) · cites this paper as [1315]
Cites
Abolition of spindle oscillations in thalamic neurons disconnected from nucleus reticularis thalami
Steriade, M., Deschenes, M., Domich, L., & Mulle, C. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.6.1473 · Cited by 624 · see citing works
Sensory gating mechanisms of the thalamus
McCormick, D. A., & Bal, T. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90056-6 · Cited by 392 · see citing works
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Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760 · see citing works
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
Boosting slow oscillations during sleep potentiates memory
Marshall, L., Helgadóttir, H., Mölle, M., & Born, J. (2006) · Nature · doi:10.1038/nature05278 · Cited by 1,792 · see citing works
The contribution of sleep to hippocampus-dependent memory consolidation
Marshall, L., & Born, J. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.09.001 · Cited by 667 · see citing works
Mölle, M., Bergmann, T. O., Marshall, L., & Born, J. (2011) · Sleep · doi:10.5665/sleep.1290 · Cited by 557 · see citing works
Wamsley, E. J., Tucker, M. A., Shinn, A. K., Ono, K. E., McKinley, S. K., Ely, A. V., Goff, D. C., Stickgold, R., & Manoach, D. S. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.08.008 · Cited by 492 · see citing works
Sleep spindle activity is associated with the integration of new memories and existing knowledge
Tamminen, J., Payne, J. D., Stickgold, R., Wamsley, E. J., & Gaskell, M. G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3028-10.2010 · Cited by 478 · see citing works
Mölle, M., Eschenko, O., Gais, S., Sara, S. J., & Born, J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06654.x · Cited by 322 · see citing works
Slow oscillations orchestrating fast oscillations and memory consolidation
Mölle, M., & Born, J. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00007-7 · Cited by 270 · see citing works
Bergmann, T. O., Mölle, M., Diedrichs, J., Born, J., & Siebner, H. R. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.036 · Cited by 228 · see citing works
Form and function of sleep spindles across the lifespan
Clawson, B. C., Durkin, J., & Aton, S. J. (2016) · Neural Plasticity · doi:10.1155/2016/6936381 · Cited by 178 · see citing works
“A fourth and final possibility is that intracortical plastic changes, initiated by sensory or motor experience, lead to subsequent changes in spindling via increased postsynaptic responses to TC input [61, 62] or increased CT feedback to the thalamus (Figure 1(b), black arrow) [63, 64].”
BackgroundClemens, Z., Fabó, D., & Halász, P. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.04.035 · Cited by 179 · see citing works
Sleep spindles as facilitators of memory formation and learning
Ulrich, D. (2016) · Neural Plasticity · doi:10.1155/2016/1796715 · Cited by 94 · see citing works
Fogel, S. M., Smith, C. T., & Beninger, R. J. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.03.002 · Cited by 80 · see citing works
A local signature of LTP‐ and LTD‐like plasticity in human NREM sleep
Bergmann, T. O., Mölle, M., Marshall, L., Kaya‐Yildiz, L., Born, J., & Roman Siebner, H. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06178.x · Cited by 67 · see citing works
- Authors
- Werk, C. M., Harbour, V. L., & Chapman, C. A.
- Affiliations
- Concordia University (CA)
- Corresponding author
- Chapman, C.A.
- ORCID
- Chapman, C.A.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 131
- Issue
- 4
- Pages
- 793-800
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2085829786
- Cited by
- 60
- References
- 2
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- long-term potentiation, slow-wave sleep, synaptic plasticity, corpus callosum, ventrolateral thalamic nucleus, tetanization, sensorimotor cortex, layer V neurons, synaptic potentiation
- MeSH terms
- Animals, Corpus Callosum, Electric Stimulation, Electrodes, Implanted, Electroencephalography, Evoked Potentials, Male, Sleep, Somatosensory Cortex, Wakefulness, Long-Term Potentiation, Neocortex, Rats, Long-Evans, Ventral Thalamic Nuclei, Rats
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